Organic Electroluminescent Materials and Devices

ABSTRACT

This invention relates to the development of heterocyclic materials for use as blue phosphorescent materials in OLED devices. The materials were determined computationally to have appropriate triplet energies for use as blue emitters and to possess sufficient chemical stability for use in devices.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Patent ApplicationSer. No. 62/260,812, filed Nov. 30, 2015, the entire contents of whichis incorporated herein by reference.

PARTIES TO A JOINT RESEARCH AGREEMENT

The claimed invention was made by, on behalf of, and/or in connectionwith one or more of the following parties to a joint universitycorporation research agreement: The Regents of the University ofMichigan, Princeton University, University of Southern California, andthe Universal Display Corporation. The agreement was in effect on andbefore the date the claimed invention was made, and the claimedinvention was made as a result of activities undertaken within the scopeof the agreement.

FIELD

The present invention relates to compounds for use as emitters, anddevices, such as organic light emitting diodes, including the same.

BACKGROUND

Opto-electronic devices that make use of organic materials are becomingincreasingly desirable for a number of reasons. Many of the materialsused to make such devices are relatively inexpensive, so organicopto-electronic devices have the potential for cost advantages overinorganic devices. In addition, the inherent properties of organicmaterials, such as their flexibility, may make them well suited forparticular applications such as fabrication on a flexible substrate.Examples of organic opto-electronic devices include organic lightemitting diodes/devices (OLEDs), organic phototransistors, organicphotovoltaic cells, and organic photodetectors. For OLEDs, the organicmaterials may have performance advantages over conventional materials.For example, the wavelength at which an organic emissive layer emitslight may generally be readily tuned with appropriate dopants.

OLEDs make use of thin organic films that emit light when voltage isapplied across the device. OLEDs are becoming an increasinglyinteresting technology for use in applications such as flat paneldisplays, illumination, and backlighting. Several OLED materials andconfigurations are described in U.S. Pat. Nos. 5,844,363, 6,303,238, and5,707,745, which are incorporated herein by reference in their entirety.

One application for phosphorescent emissive molecules is a full colordisplay. Industry standards for such a display call for pixels adaptedto emit particular colors, referred to as “saturated” colors. Inparticular, these standards call for saturated red, green, and bluepixels. Alternatively the OLED can be designed to emit white light. Inconventional liquid crystal displays emission from a white backlight isfiltered using absorption filters to produce red, green and blueemission. The same technique can also be used with OLEDs. The white OLEDcan be either a single EML device or a stack structure. Color may bemeasured using CIE coordinates, which are well known to the art.

One example of a green emissive molecule is tris(2-phenylpyridine)iridium, denoted Ir(ppy)₃, which has the following structure:

In this, and later figures herein, we depict the dative bond fromnitrogen to metal (here, Ir) as a straight line.

As used herein, the term “organic” includes polymeric materials as wellas small molecule organic materials that may be used to fabricateorganic opto-electronic devices. “Small molecule” refers to any organicmaterial that is not a polymer, and “small molecules” may actually bequite large. Small molecules may include repeat units in somecircumstances. For example, using a long chain alkyl group as asubstituent does not remove a molecule from the “small molecule” class.Small molecules may also be incorporated into polymers, for example as apendent group on a polymer backbone or as a part of the backbone. Smallmolecules may also serve as the core moiety of a dendrimer, whichconsists of a series of chemical shells built on the core moiety. Thecore moiety of a dendrimer may be a fluorescent or phosphorescent smallmolecule emitter. A dendrimer may be a “small molecule,” and it isbelieved that all dendrimers currently used in the field of OLEDs aresmall molecules.

As used herein, “top” means furthest away from the substrate, while“bottom” means closest to the substrate. Where a first layer isdescribed as “disposed over” a second layer, the first layer is disposedfurther away from substrate. There may be other layers between the firstand second layer, unless it is specified that the first layer is “incontact with” the second layer. For example, a cathode may be describedas “disposed over” an anode, even though there are various organiclayers in between.

As used herein, “solution processible” means capable of being dissolved,dispersed, or transported in and/or deposited from a liquid medium,either in solution or suspension form.

A ligand may be referred to as “photoactive” when it is believed thatthe ligand directly contributes to the photoactive properties of anemissive material. A ligand may be referred to as “ancillary” when it isbelieved that the ligand does not contribute to the photoactiveproperties of an emissive material, although an ancillary ligand mayalter the properties of a photoactive ligand

As used herein, and as would be generally understood by one skilled inthe art, a first “Highest Occupied Molecular Orbital” (HOMO) or “LowestUnoccupied Molecular Orbital” (LUMO) energy level is “greater than” or“higher than” a second HOMO or LUMO energy level if the first energylevel is closer to the vacuum energy level. Since ionization potentials(IP) are measured as a negative energy relative to a vacuum level, ahigher HOMO energy level corresponds to an IP having a smaller absolutevalue (an IP that is less negative). Similarly, a higher LUMO energylevel corresponds to an electron affinity (EA) having a smaller absolutevalue (an EA that is less negative). On a conventional energy leveldiagram, with the vacuum level at the top, the LUMO energy level of amaterial is higher than the HOMO energy level of the same material. A“higher” HOMO or LUMO energy level appears closer to the top of such adiagram than a “lower” HOMO or LUMO energy level.

As used herein, and as would be generally understood by one skilled inthe art, a first work function is “greater than” or “higher than” asecond work function if the first work function has a higher absolutevalue. Because work functions are generally measured as negative numbersrelative to vacuum level, this means that a “higher” work function ismore negative. On a conventional energy level diagram, with the vacuumlevel at the top, a “higher” work function is illustrated as furtheraway from the vacuum level in the downward direction. Thus, thedefinitions of HOMO and LUMO energy levels follow a different conventionthan work functions.

More details on OLEDs, and the definitions described above, can be foundin U.S. Pat. No. 7,279,704, which is incorporated herein by reference inits entirety.

The performance of blue emitter PHOLED materials have been limited bythe lifetime of the devices. To date, devices degrade too rapidly to becommercially viable. One limitation is thought to be the chemicalstability of the blue phosphorescent material.

There is a need in the art for novel blue emitter PHOLED materials withimproved properties, such as chemical stability. The present inventionaddresses this need in the art.

SUMMARY

According to an embodiment, a compound is provided that has a ligandL_(A) selected from the group consisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclicring;

wherein Z is nitrogen or carbon;

wherein R¹ and R³ each represent from mono-substitution to the possiblemaximum number of substitution, or no substitution;

wherein Z¹, Z², Z³, and Z⁴ are each independently selected from thegroup consisting of N and CR;

wherein at least one of Z¹, Z², Z³, and Z⁴ is nitrogen;

wherein X is selected from the group consisting of O, S, and Se;

wherein each R, R¹ R², and R³ are independently selected from the groupconsisting of hydrogen, deuterium, halide, alkyl, cycloalkyl,heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl,cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl,carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl,sulfonyl, phosphino, and combinations thereof;

wherein any adjacent substituents of R, R¹ R², and R³ are optionallyjoined or fused into a ring;

wherein the ligand L_(A) is coordinated to a metal M; and

wherein the ligand L_(A) is optionally linked with other ligands tocomprise a tridentate, tetradentate, pentadentate or hexadentate ligand.

According to another embodiment, an organic light emitting diode/device(OLED) is also provided. The OLED can include an anode, a cathode, andan organic layer, disposed between the anode and the cathode. Theorganic layer can include a compound that has a ligand L_(A) selectedfrom the group consisting of Formula I and Formula II. According to yetanother embodiment, the organic light emitting device is incorporatedinto a device selected from a consumer product, an electronic componentmodule, and/or a lighting panel.

According to another embodiment, the invention provides a formulationcomprising a compound that has a ligand L_(A) selected from the groupconsisting of Formula I and Formula II.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an organic light emitting device.

FIG. 2 shows an inverted organic light emitting device that does nothave a separate electron transport layer.

DETAILED DESCRIPTION

Generally, an OLED comprises at least one organic layer disposed betweenand electrically connected to an anode and a cathode. When a current isapplied, the anode injects holes and the cathode injects electrons intothe organic layer(s). The injected holes and electrons each migratetoward the oppositely charged electrode. When an electron and holelocalize on the same molecule, an “exciton,” which is a localizedelectron-hole pair having an excited energy state, is formed. Light isemitted when the exciton relaxes via a photoemissive mechanism. In somecases, the exciton may be localized on an excimer or an exciplex.Non-radiative mechanisms, such as thermal relaxation, may also occur,but are generally considered undesirable.

The initial OLEDs used emissive molecules that emitted light from theirsinglet states (“fluorescence”) as disclosed, for example, in U.S. Pat.No. 4,769,292, which is incorporated by reference in its entirety.Fluorescent emission generally occurs in a time frame of less than 10nanoseconds.

More recently, OLEDs having emissive materials that emit light fromtriplet states (“phosphorescence”) have been demonstrated. Baldo et al.,“Highly Efficient Phosphorescent Emission from OrganicElectroluminescent Devices,” Nature, vol. 395, 151-154, 1998;(“Baldo-I”) and Baldo et al., “Very high-efficiency green organiclight-emitting devices based on electrophosphorescence,” Appl. Phys.Lett., vol. 75, No. 3, 4-6 (1999) (“Baldo-II”), are incorporated byreference in their entireties. Phosphorescence is described in moredetail in U.S. Pat. No. 7,279,704 at cols. 5-6, which are incorporatedby reference.

FIG. 1 shows an organic light emitting device 100. The figures are notnecessarily drawn to scale. Device 100 may include a substrate 110, ananode 115, a hole injection layer 120, a hole transport layer 125, anelectron blocking layer 130, an emissive layer 135, a hole blockinglayer 140, an electron transport layer 145, an electron injection layer150, a protective layer 155, a cathode 160, and a barrier layer 170.Cathode 160 is a compound cathode having a first conductive layer 162and a second conductive layer 164. Device 100 may be fabricated bydepositing the layers described, in order. The properties and functionsof these various layers, as well as example materials, are described inmore detail in U.S. Pat. No. 7,279,704 at cols. 6-10, which areincorporated by reference.

More examples for each of these layers are available. For example, aflexible and transparent substrate-anode combination is disclosed inU.S. Pat. No. 5,844,363, which is incorporated by reference in itsentirety. An example of a p-doped hole transport layer is m-MTDATA dopedwith F₄-TCNQ at a molar ratio of 50:1, as disclosed in U.S. PatentApplication Publication No. 2003/0230980, which is incorporated byreference in its entirety. Examples of emissive and host materials aredisclosed in U.S. Pat. No. 6,303,238 to Thompson et al., which isincorporated by reference in its entirety. An example of an n-dopedelectron transport layer is BPhen doped with Li at a molar ratio of 1:1,as disclosed in U.S. Patent Application Publication No. 2003/0230980,which is incorporated by reference in its entirety. U.S. Pat. Nos.5,703,436 and 5,707,745, which are incorporated by reference in theirentireties, disclose examples of cathodes including compound cathodeshaving a thin layer of metal such as Mg:Ag with an overlyingtransparent, electrically-conductive, sputter-deposited ITO layer. Thetheory and use of blocking layers is described in more detail in U.S.Pat. No. 6,097,147 and U.S. Patent Application Publication No.2003/0230980, which are incorporated by reference in their entireties.Examples of injection layers are provided in U.S. Patent ApplicationPublication No. 2004/0174116, which is incorporated by reference in itsentirety. A description of protective layers may be found in U.S. PatentApplication Publication No. 2004/0174116, which is incorporated byreference in its entirety.

FIG. 2 shows an inverted OLED 200. The device includes a substrate 210,a cathode 215, an emissive layer 220, a hole transport layer 225, and ananode 230. Device 200 may be fabricated by depositing the layersdescribed, in order. Because the most common OLED configuration has acathode disposed over the anode, and device 200 has cathode 215 disposedunder anode 230, device 200 may be referred to as an “inverted” OLED.Materials similar to those described with respect to device 100 may beused in the corresponding layers of device 200. FIG. 2 provides oneexample of how some layers may be omitted from the structure of device100.

The simple layered structure illustrated in FIGS. 1 and 2 is provided byway of non-limiting example, and it is understood that embodiments ofthe invention may be used in connection with a wide variety of otherstructures. The specific materials and structures described areexemplary in nature, and other materials and structures may be used.Functional OLEDs may be achieved by combining the various layersdescribed in different ways, or layers may be omitted entirely, based ondesign, performance, and cost factors. Other layers not specificallydescribed may also be included. Materials other than those specificallydescribed may be used. Although many of the examples provided hereindescribe various layers as comprising a single material, it isunderstood that combinations of materials, such as a mixture of host anddopant, or more generally a mixture, may be used. Also, the layers mayhave various sublayers. The names given to the various layers herein arenot intended to be strictly limiting. For example, in device 200, holetransport layer 225 transports holes and injects holes into emissivelayer 220, and may be described as a hole transport layer or a holeinjection layer. In one embodiment, an OLED may be described as havingan “organic layer” disposed between a cathode and an anode. This organiclayer may comprise a single layer, or may further comprise multiplelayers of different organic materials as described, for example, withrespect to FIGS. 1 and 2.

Structures and materials not specifically described may also be used,such as OLEDs comprised of polymeric materials (PLEDs) such as disclosedin U.S. Pat. No. 5,247,190 to Friend et al., which is incorporated byreference in its entirety. By way of further example, OLEDs having asingle organic layer may be used. OLEDs may be stacked, for example asdescribed in U.S. Pat. No. 5,707,745 to Forrest et al, which isincorporated by reference in its entirety. The OLED structure maydeviate from the simple layered structure illustrated in FIGS. 1 and 2.For example, the substrate may include an angled reflective surface toimprove out-coupling, such as a mesa structure as described in U.S. Pat.No. 6,091,195 to Forrest et al., and/or a pit structure as described inU.S. Pat. No. 5,834,893 to Bulovic et al., which are incorporated byreference in their entireties.

Unless otherwise specified, any of the layers of the various embodimentsmay be deposited by any suitable method. For the organic layers,preferred methods include thermal evaporation, ink-jet, such asdescribed in U.S. Pat. Nos. 6,013,982 and 6,087,196, which areincorporated by reference in their entireties, organic vapor phasedeposition (OVPD), such as described in U.S. Pat. No. 6,337,102 toForrest et al., which is incorporated by reference in its entirety, anddeposition by organic vapor jet printing (OVJP), such as described inU.S. Pat. No. 7,431,968, which is incorporated by reference in itsentirety. Other suitable deposition methods include spin coating andother solution based processes. Solution based processes are preferablycarried out in nitrogen or an inert atmosphere. For the other layers,preferred methods include thermal evaporation. Preferred patterningmethods include deposition through a mask, cold welding such asdescribed in U.S. Pat. Nos. 6,294,398 and 6,468,819, which areincorporated by reference in their entireties, and patterning associatedwith some of the deposition methods such as ink-jet and OVID. Othermethods may also be used. The materials to be deposited may be modifiedto make them compatible with a particular deposition method. Forexample, substituents such as alkyl and aryl groups, branched orunbranched, and preferably containing at least 3 carbons, may be used insmall molecules to enhance their ability to undergo solution processing.Substituents having 20 carbons or more may be used, and 3-20 carbons isa preferred range. Materials with asymmetric structures may have bettersolution processibility than those having symmetric structures, becauseasymmetric materials may have a lower tendency to recrystallizeDendrimer substituents may be used to enhance the ability of smallmolecules to undergo solution processing.

Devices fabricated in accordance with embodiments of the presentinvention may further optionally comprise a barrier layer. One purposeof the barrier layer is to protect the electrodes and organic layersfrom damaging exposure to harmful species in the environment includingmoisture, vapor and/or gases, etc. The barrier layer may be depositedover, under or next to a substrate, an electrode, or over any otherparts of a device including an edge. The barrier layer may comprise asingle layer, or multiple layers. The barrier layer may be formed byvarious known chemical vapor deposition techniques and may includecompositions having a single phase as well as compositions havingmultiple phases. Any suitable material or combination of materials maybe used for the barrier layer. The barrier layer may incorporate aninorganic or an organic compound or both. The preferred barrier layercomprises a mixture of a polymeric material and a non-polymeric materialas described in U.S. Pat. No. 7,968,146, PCT Pat. Application Nos.PCT/US2007/023098 and PCT/US2009/042829, which are herein incorporatedby reference in their entireties. To be considered a “mixture”, theaforesaid polymeric and non-polymeric materials comprising the barrierlayer should be deposited under the same reaction conditions and/or atthe same time. The weight ratio of polymeric to non-polymeric materialmay be in the range of 95:5 to 5:95. The polymeric material and thenon-polymeric material may be created from the same precursor material.In one example, the mixture of a polymeric material and a non-polymericmaterial consists essentially of polymeric silicon and inorganicsilicon.

Devices fabricated in accordance with embodiments of the invention canbe incorporated into a wide variety of electronic component modules (orunits) that can be incorporated into a variety of electronic products orintermediate components. Examples of such electronic products orintermediate components include display screens, lighting devices suchas discrete light source devices or lighting panels, etc. that can beutilized by the end-user product manufacturers. Such electroniccomponent modules can optionally include the driving electronics and/orpower source(s). Devices fabricated in accordance with embodiments ofthe invention can be incorporated into a wide variety of consumerproducts that have one or more of the electronic component modules (orunits) incorporated therein. Such consumer products would include anykind of products that include one or more light source(s) and/or one ormore of some type of visual displays. Some examples of such consumerproducts include flat panel displays, computer monitors, medicalmonitors, televisions, billboards, lights for interior or exteriorillumination and/or signaling, heads-up displays, fully or partiallytransparent displays, flexible displays, laser printers, telephones,cell phones, tablets, phablets, personal digital assistants (PDAs),wearable device, laptop computers, digital cameras, camcorders,viewfinders, micro-displays, 3-D displays, virtual reality or augmentedreality displays, vehicles, a large area wall, theater or stadiumscreen, or a sign. Various control mechanisms may be used to controldevices fabricated in accordance with the present invention, includingpassive matrix and active matrix. Many of the devices are intended foruse in a temperature range comfortable to humans, such as 18 degrees C.to 30 degrees C., and more preferably at room temperature (20-25 degreesC.), but could be used outside this temperature range, for example, from−40 degree C. to +80 degree C.

The materials and structures described herein may have applications indevices other than OLEDs. For example, other optoelectronic devices suchas organic solar cells and organic photodetectors may employ thematerials and structures. More generally, organic devices, such asorganic transistors, may employ the materials and structures.

The term “halo,” “halogen,” or “halide” as used herein includesfluorine, chlorine, bromine, and iodine.

The term “alkyl” as used herein contemplates both straight and branchedchain alkyl radicals. Preferred alkyl groups are those containing fromone to fifteen carbon atoms and includes methyl, ethyl, propyl,1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, pentyl,1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl,1,2-dimethylpropyl, 2,2-dimethylpropyl, and the like. Additionally, thealkyl group may be optionally substituted.

The term “cycloalkyl” as used herein contemplates cyclic alkyl radicals.Preferred cycloalkyl groups are those containing 3 to 10 ring carbonatoms and includes cyclopropyl, cyclopentyl, cyclohexyl, adamantyl, andthe like. Additionally, the cycloalkyl group may be optionallysubstituted.

The term “alkenyl” as used herein contemplates both straight andbranched chain alkene radicals. Preferred alkenyl groups are thosecontaining two to fifteen carbon atoms. Additionally, the alkenyl groupmay be optionally substituted.

The term “alkynyl” as used herein contemplates both straight andbranched chain alkyne radicals. Preferred alkynyl groups are thosecontaining two to fifteen carbon atoms. Additionally, the alkynyl groupmay be optionally substituted.

The terms “aralkyl” or “arylalkyl” as used herein are usedinterchangeably and contemplate an alkyl group that has as a substituentan aromatic group. Additionally, the aralkyl group may be optionallysubstituted.

The term “heterocyclic group” as used herein contemplates aromatic andnon-aromatic cyclic radicals. Hetero-aromatic cyclic radicals also meansheteroaryl. Preferred hetero-non-aromatic cyclic groups are thosecontaining 3 to 7 ring atoms which includes at least one hetero atom,and includes cyclic amines such as morpholino, piperdino, pyrrolidino,and the like, and cyclic ethers, such as tetrahydrofuran,tetrahydropyran, and the like. Additionally, the heterocyclic group maybe optionally substituted.

The term “aryl” or “aromatic group” as used herein contemplatessingle-ring groups and polycyclic ring systems. The polycyclic rings mayhave two or more rings in which two carbons are common to two adjoiningrings (the rings are “fused”) wherein at least one of the rings isaromatic, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl,heterocycles, and/or heteroaryls. Preferred aryl groups are thosecontaining six to thirty carbon atoms, preferably six to twenty carbonatoms, more preferably six to twelve carbon atoms. Especially preferredis an aryl group having six carbons, ten carbons or twelve carbons.Suitable aryl groups include phenyl, biphenyl, triphenyl, triphenylene,tetraphenylene, naphthalene, anthracene, phenalene, phenanthrene,fluorene, pyrene, chrysene, perylene, and azulene, preferably phenyl,biphenyl, triphenyl, triphenylene, fluorene, and naphthalene.Additionally, the aryl group may be optionally substituted.

The term “heteroaryl” as used herein contemplates single-ringhetero-aromatic groups that may include from one to five heteroatoms.The term heteroaryl also includes polycyclic hetero-aromatic systemshaving two or more rings in which two atoms are common to two adjoiningrings (the rings are “fused”) wherein at least one of the rings is aheteroaryl, e.g., the other rings can be cycloalkyls, cycloalkenyls,aryl, heterocycles, and/or heteroaryls. Preferred heteroaryl groups arethose containing three to thirty carbon atoms, preferably three totwenty carbon atoms, more preferably three to twelve carbon atoms.Suitable heteroaryl groups include dibenzothiophene, dibenzofuran,dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene,benzoselenophene, carbazole, indolocarbazole, pyridylindole,pyrrolodipyridine, pyrazole, imidazole, triazole, oxazole, thiazole,oxadiazole, oxatriazole, dioxazole, thiadiazole, pyridine, pyridazine,pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine,indole, benzimidazole, indazole, indoxazine, benzoxazole, benzisoxazole,benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline,quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine,phenazine, phenothiazine, phenoxazine, benzofuropyridine,furodipyridine, benzothienopyridine, thienodipyridine,benzoselenophenopyridine, and selenophenodipyridine, preferablydibenzothiophene, dibenzofuran, dibenzoselenophene, carbazole,indolocarbazole, imidazole, pyridine, triazine, benzimidazole,1,2-azaborine, 1,3-azaborine, 1,4-azaborine, borazine, and aza-analogsthereof. Additionally, the heteroaryl group may be optionallysubstituted.

The alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heterocyclic group,aryl, and heteroaryl may be unsubstituted or may be substituted with oneor more substituents selected from the group consisting of deuterium,halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, cyclic amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl,alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ether,ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, andcombinations thereof.

As used herein, “substituted” indicates that a substituent other than His bonded to the relevant position, such as carbon. Thus, for example,where R¹ is mono-substituted, then one R¹ must be other than H.Similarly, where R¹ is di-substituted, then two of R¹ must be other thanH. Similarly, where R¹ is unsubstituted, R¹ is hydrogen for allavailable positions.

The “aza” designation in the fragments described herein, i.e.aza-dibenzofuran, aza-dibenzothiophene, etc. means that one or more ofthe C—H groups in the respective fragment can be replaced by a nitrogenatom, for example, and without any limitation, azatriphenyleneencompasses both dibenzo[f,h]quinoxaline and dibenzo[f,h]quinoline. Oneof ordinary skill in the art can readily envision other nitrogen analogsof the aza-derivatives described above, and all such analogs areintended to be encompassed by the terms as set forth herein.

It is to be understood that when a molecular fragment is described asbeing a substituent or otherwise attached to another moiety, its namemay be written as if it were a fragment (e.g. phenyl, phenylene,naphthyl, dibenzofuryl) or as if it were the whole molecule (e.g.benzene, naphthalene, dibenzofuran). As used herein, these differentways of designating a substituent or attached fragment are considered tobe equivalent.

The performance of blue emitter PHOLED materials have been limited bythe lifetime of the devices. To date, devices degrade too rapidly to becommercially viable. One limitation is thought to be the chemicalstability of the blue phosphorescent material. In one aspect, thepresent invention relates to the development of new phosphorescentmaterials with appropriate color and chemical stability.

Compounds of the Invention

In one aspect, the invention includes a compound comprising a ligandL_(A) selected from the group consisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclicring;

wherein Z is nitrogen or carbon;

wherein R¹ and R³ each represent from mono-substitution to the possiblemaximum number of substitution, or no substitution;

wherein Z¹, Z², Z³, and r are each independently selected from the groupconsisting of N and CR;

wherein at least one of Z¹, Z², Z³, and r is nitrogen;

wherein X is selected from the group consisting of O, S, and Se;

wherein each R, R¹ R², and R³ are independently selected from the groupconsisting of hydrogen, deuterium, halide, alkyl, cycloalkyl,heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl,cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl,carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl,sulfonyl, phosphino, and combinations thereof;

wherein any adjacent substituents of R, R¹ R², and R³ are optionallyjoined or fused into a ring;

wherein the ligand L_(A) is coordinated to a metal M; and

wherein the ligand L_(A) is optionally linked with other ligands tocomprise a tridentate, tetradentate, pentadentate or hexadentate ligand.

Any 5-membered or 6-membered carbocyclic or heterocyclic ring iscontemplated for A, as would be understood by one of ordinary skill inthe art. In one embodiment, A is selected from the group consisting ofpyridine, imidazole, isoimidazole, and pyrazole.

Any metal M is contemplated by the present invention, as would beunderstood by one of ordinary skill in the art. In one embodiment, M isselected from the group consisting of Ir, Rh, Re, Ru, Os, Pt, Au, andCu. In another embodiment, M is Ir or Pt.

In one embodiment, the compound is homoleptic. In another embodiment,the compound is heteroleptic.

In one embodiment, X is O. In another embodiment, X is S.

In one embodiment, one of Z¹, Z², Z³, and Z⁴ is nitrogen, and three ofZ¹, Z², Z³, and Z⁴ is CR.

In one embodiment, ligand L_(A) is selected from the group consistingof:

In one embodiment, ligand L_(A) is selected from the group consistingof:

LA1 to LA318 based on the chemical structure:

LA # R11 R12 R13 R14 R31 R32 R33 1 CD3 CD3 H H H H H 2 CD3 CH3 H H H H H3 CD3 H 2,6DIP H H H H 4 CD3 H 2,6DMB H H H H 5 CD3 H CD3 H H H H 6 CD3H CH3 H H H H 7 CD3 H H 2,6DIP H H H 8 CD3 H H 2,6DMB H H H 9 CD3 H HCD3 H H H 10 CD3 H H CH3 H H H 11 CD3 H H H 2,6DIP H H 12 CD3 H H H2,6DMB H H 13 CD3 H H H CD3 H H 14 CD3 H H H CH3 H H 15 CD3 H H H H2,6DIP H 16 CD3 H H H H 2,6DMB H 17 CD3 H H H H CD3 H 18 CD3 H H H H CH3H 19 CD3 H H H H H 2,6DIP 20 CD3 H H H H H 2,6DMB 21 CD3 H H H H H CD322 CD3 H H H H H CH3 23 CD3 H H H H H H 24 CD3 H H H H H i-Pr 25 CD3 H HH H i-Pr H 26 CD3 H H H i-Pr H H 27 CD3 H H i-Pr H H H 28 CD3 H i-Pr H HH H 29 CD3 i-Pr H H H H H 30 CH3 CD3 H H H H H 31 CH3 CH3 H H H H H 32CH3 H 2,6DIP H H H H 33 CH3 H 2,6DMB H H H H 34 CH3 H CD3 H H H H 35 CH3H CH3 H H H H 36 CH3 H H 2,6DIP H H H 37 CH3 H H 2,6DMB H H H 38 CH3 H HCD3 H H H 39 CH3 H H CH3 H H H 40 CH3 H H H 2,6DIP H H 41 CH3 H H H2,6DMB H H 42 CH3 H H H CD3 H H 43 CH3 H H H CH3 H H 44 CH3 H H H H2,6DIP H 45 CH3 H H H H 2,6DMB H 46 CH3 H H H H CD3 H 47 CH3 H H H H CH3H 48 CH3 H H H H H 2,6DIP 49 CH3 H H H H H 2,6DMB 50 CH3 H H H H H CD351 CH3 H H H H H CH3 52 CH3 H H H H H H 53 CH3 H H H H H i-Pr 54 CH3 H HH H i-Pr H 55 CH3 H H H i-Pr H H 56 CH3 H H i-Pr H H H 57 CH3 H i-Pr H HH H 58 CH3 i-Pr H H H H H 59 H 2,6DIP H CD3 H H H 60 H 2,6DIP H CH3 H HH 61 H 2,6DIP H H CD3 H H 62 H 2,6DIP H H CH3 H H 63 H 2,6DIP H H H CD3H 64 H 2,6DIP H H H CH3 H 65 H 2,6DIP H H H H CD3 66 H 2,6DIP H H H HCH3 67 H 2,6DIP H H H H H 68 H 2,6DMB H CD3 H H H 69 H 2,6DMB H CH3 H HH 70 H 2,6DMB H H CD3 H H 71 H 2,6DMB H H CH3 H H 72 H 2,6DMB H H H CD3H 73 H 2,6DMB H H H CH3 H 74 H 2,6DMB H H H H CD3 75 H 2,6DMB H H H HCH3 76 H 2,6DMB H H H H H 77 H CD3 CD3 H H H H 78 H CD3 CH3 H H H H 79 HCD3 H 2,6DIP H H H 80 H CD3 H 2,6DMB H H H 81 H CD3 H CD3 H H H 82 H CD3H CH3 H H H 83 H CD3 H H 2,6DIP H H 84 H CD3 H H 2,6DMB H H 85 H CD3 H HCD3 H H 86 H CD3 H H CH3 H H 87 H CD3 H H H 2,6DIP H 88 H CD3 H H H2,6DMB H 89 H CD3 H H H CD3 H 90 H CD3 H H H CH3 H 91 H CD3 H H H H2,6DIP 92 H CD3 H H H H 2,6DMB 93 H CD3 H H H H CD3 94 H CD3 H H H H CH395 H CD3 H H H H H 96 H CD3 H H H H i-Pr 97 H CD3 H H H i-Pr H 98 H CD3H H i-Pr H H 99 H CD3 H i-Pr H H H 100 H CD3 i-Pr H H H H 101 H CH3 CD3H H H H 102 H CH3 CH3 H H H H 103 H CH3 H 2,6DIP H H H 104 H CH3 H2,6DMB H H H 105 H CH3 H CD3 H H H 106 H CH3 H CH3 H H H 107 H CH3 H H2,6DIP H H 108 H CH3 H H 2,6DMB H H 109 H CH3 H H CD3 H H 110 H CH3 H HCH3 H H 111 H CH3 H H H 2,6DIP H 112 H CH3 H H H 2,6DMB H 113 H CH3 H HH CD3 H 114 H CH3 H H H CH3 H 115 H CH3 H H H H 2,6DIP 116 H CH3 H H H H2,6DMB 117 H CH3 H H H H CD3 118 H CH3 H H H H CH3 119 H CH3 H H H H H120 H CH3 H H H H i-Pr 121 H CH3 H H H i-Pr H 122 H CH3 H H i-Pr H H 123H CH3 H i-Pr H H H 124 H CH3 i-Pr H H H H 125 H H 2,6DIP H CD3 H H 126 HH 2,6DIP H CH3 H H 127 H H 2,6DIP H H CD3 H 128 H H 2,6DIP H H CH3 H 129H H 2,6DIP H H H CD3 130 H H 2,6DIP H H H CH3 131 H H 2,6DIP H H H H 132H H 2,6DMB H CD3 H H 133 H H 2,6DMB H CH3 H H 134 H H 2,6DMB H H CD3 H135 H H 2,6DMB H H CH3 H 136 H H 2,6DMB H H H CD3 137 H H 2,6DMB H H HCH3 138 H H 2,6DMB H H H H 139 H H CD3 CD3 H H H 140 H H CD3 CH3 H H H141 H H CD3 H 2,6DIP H H 142 H H CD3 H 2,6DMB H H 143 H H CD3 H CD3 H H144 H H CD3 H CH3 H H 145 H H CD3 H H 2,6DIP H 146 H H CD3 H H 2,6DMB H147 H H CD3 H H CD3 H 148 H H CD3 H H CH3 H 149 H H CD3 H H H 2,6DIP 150H H CD3 H H H 2,6DMB 151 H H CD3 H H H CD3 152 H H CD3 H H H CH3 153 H HCD3 H H H H 154 H H CD3 H H H i-Pr 155 H H CD3 H H i-Pr H 156 H H CD3 Hi-Pr H H 157 H H CD3 i-Pr H H H 158 H H CH3 CD3 H H H 159 H H CH3 CH3 HH H 160 H H CH3 H 2,6DIP H H 161 H H CH3 H 2,6DMB H H 162 H H CH3 H CD3H H 163 H H CH3 H CH3 H H 164 H H CH3 H H 2,6DIP H 165 H H CH3 H H2,6DMB H 166 H H CH3 H H CD3 H 167 H H CH3 H H CH3 H 168 H H CH3 H H H2,6DIP 169 H H CH3 H H H 2,6DMB 170 H H CH3 H H H CD3 171 H H CH3 H H HCH3 172 H H CH3 H H H H 173 H H CH3 H H H i-Pr 174 H H CH3 H H i-Pr H175 H H CH3 H i-Pr H H 176 H H CH3 i-Pr H H H 177 H H H 2,6DIP CD3 H H178 H H H 2,6DIP CH3 H H 179 H H H 2,6DIP H CD3 H 180 H H H 2,6DIP H CH3H 181 H H H 2,6DIP H H CD3 182 H H H 2,6DIP H H CH3 183 H H H 2,6DIP H HH 184 H H H 2,6DMB CD3 H H 185 H H H 2,6DMB CH3 H H 186 H H H 2,6DMB HCD3 H 187 H H H 2,6DMB H CH3 H 188 H H H 2,6DMB H H CD3 189 H H H 2,6DMBH H CH3 190 H H H 2,6DMB H H H 191 H H H CD3 2,6DIP H H 192 H H H CD32,6DMB H H 193 H H H CD3 CD3 H H 194 H H H CD3 CH3 H H 195 H H H CD3 H2,6DIP H 196 H H H CD3 H 2,6DMB H 197 H H H CD3 H CD3 H 198 H H H CD3 HCH3 H 199 H H H CD3 H H 2,6DIP 200 H H H CD3 H H 2,6DMB 201 H H H CD3 HH CD3 202 H H H CD3 H H CH3 203 H H H CD3 H H H 204 H H H CD3 H H i-Pr205 H H H CD3 H i-Pr H 206 H H H CD3 i-Pr H H 207 H H H CH3 2,6DIP H H208 H H H CH3 2,6DMB H H 209 H H H CH3 CD3 H H 210 H H H CH3 CH3 H H 211H H H CH3 H 2,6DIP H 212 H H H CH3 H 2,6DMB H 213 H H H CH3 H CD3 H 214H H H CH3 H CH3 H 215 H H H CH3 H H 2,6DIP 216 H H H CH3 H H 2,6DMB 217H H H CH3 H H CD3 218 H H H CH3 H H CH3 219 H H H CH3 H H H 220 H H HCH3 H H i-Pr 221 H H H CH3 H i-Pr H 222 H H H CH3 i-Pr H H 223 H H H H2,6DIP H CD3 224 H H H H 2,6DIP H CH3 225 H H H H 2,6DIP H H 226 H H H H2,6DMB H CD3 227 H H H H 2,6DMB H CH3 228 H H H H 2,6DMB H H 229 H H H HCD3 CD3 H 230 H H H H CD3 CH3 H 231 H H H H CD3 H 2,6DIP 232 H H H H CD3H 2,6DMB 233 H H H H CD3 H CD3 234 H H H H CD3 H CH3 235 H H H H CD3 H H236 H H H H CD3 H i-Pr 237 H H H H CD3 i-Pr H 238 H H H H CH3 CD3 H 239H H H H CH3 CH3 H 240 H H H H CH3 H 2,6DIP 241 H H H H CH3 H 2,6DMB 242H H H H CH3 H CD3 243 H H H H CH3 H CH3 244 H H H H CH3 H H 245 H H H HCH3 H i-Pr 246 H H H H CH3 i-Pr H 247 H H H H H 2,6DIP CD3 248 H H H H H2,6DIP CH3 249 H H H H H 2,6DIP H 250 H H H H H 2,6DMB CD3 251 H H H H H2,6DMB CH3 252 H H H H H 2,6DMB H 253 H H H H H CD3 2,6DIP 254 H H H H HCD3 2,6DMB 255 H H H H H CD3 CD3 256 H H H H H CD3 CH3 257 H H H H H CD3H 258 H H H H H CD3 i-Pr 259 H H H H H CH3 2,6DIP 260 H H H H H CH32,6DMB 261 H H H H H CH3 CD3 262 H H H H H CH3 CH3 263 H H H H H CH3 H264 H H H H H CH3 i-Pr 265 H H H H H H 2,6DIP 266 H H H H H H 2,6DMB 267H H H H H H CD3 268 H H H H H H CH3 269 H H H H H H H 270 H H H H H Hi-Pr 271 H H H H H i-Pr CD3 272 H H H H H i-Pr CH3 273 H H H H H i-Pr H274 H H H H i-Pr CD3 H 275 H H H H i-Pr CH3 H 276 H H H H i-Pr H CD3 277H H H H i-Pr H CH3 278 H H H H i-Pr H H 279 H H H i-Pr CD3 H H 280 H H Hi-Pr CH3 H H 281 H H H i-Pr H CD3 H 282 H H H i-Pr H CH3 H 283 H H Hi-Pr H H CD3 284 H H H i-Pr H H CH3 285 H H H i-Pr H H H 286 H H i-PrCD3 H H H 287 H H i-Pr CH3 H H H 288 H H i-Pr H CD3 H H 289 H H i-Pr HCH3 H H 290 H H i-Pr H H CD3 H 291 H H i-Pr H H CH3 H 292 H H i-Pr H H HCD3 293 H H i-Pr H H H CH3 294 H H i-Pr H H H H 295 H i-Pr CD3 H H H H296 H i-Pr CH3 H H H H 297 H i-Pr H CD3 H H H 298 H i-Pr H CH3 H H H 299H i-Pr H H CD3 H H 300 H i-Pr H H CH3 H H 301 H i-Pr H H H CD3 H 302 Hi-Pr H H H CH3 H 303 H i-Pr H H H H CD3 304 H i-Pr H H H H CH3 305 Hi-Pr H H H H H 306 i-Pr CD3 H H H H H 307 i-Pr CH3 H H H H H 308 i-Pr HCD3 H H H H 309 i-Pr H CH3 H H H H 310 i-Pr H H CD3 H H H 311 i-Pr H HCH3 H H H 312 i-Pr H H H CD3 H H 313 i-Pr H H H CH3 H H 314 i-Pr H H H HCD3 H 315 i-Pr H H H H CH3 H 316 i-Pr H H H H H CD3 317 i-Pr H H H H HCH3 318 i-Pr H H H H H HLA319 to LA628 based on the structure:

LA # R11 R12 R13 R14 R31 R32 R34 319 CD3 CD3 H H H H H 320 CD3 CH3 H H HH H 321 CD3 H 2,6DIP H H H H 322 CD3 H 2,6DMB H H H H 323 CD3 H CD3 H HH H 324 CD3 H CH3 H H H H 325 CD3 H H 2,6DIP H H H 326 CD3 H H 2,6DMB HH H 327 CD3 H H CD3 H H H 328 CD3 H H CH3 H H H 329 CD3 H H H 2,6DIP H H330 CD3 H H H 2,6DMB H H 331 CD3 H H H CD3 H H 332 CD3 H H H CH3 H H 333CD3 H H H H 2,6DIP H 334 CD3 H H H H 2,6DMB H 335 CD3 H H H H CD3 H 336CD3 H H H H CH3 H 337 CD3 H H H H H 2,6DIP 338 CD3 H H H H H 2,6DMB 339CD3 H H H H H CD3 340 CD3 H H H H H CH3 341 CD3 H H H H H H 342 CD3 H HH H H i-Pr 343 CD3 H H H H i-Pr H 344 CD3 H H H i-Pr H H 345 CD3 H Hi-Pr H H H 346 CD3 H i-Pr H H H H 347 CD3 i-Pr H H H H H 348 CH3 CD3 H HH H H 349 CH3 CH3 H H H H H 350 CH3 H 2,6DIP H H H H 351 CH3 H 2,6DMB HH H H 352 CH3 H CD3 H H H H 353 CH3 H CH3 H H H H 354 CH3 H H 2,6DIP H HH 355 CH3 H H 2,6DMB H H H 356 CH3 H H CD3 H H H 357 CH3 H H CH3 H H H358 CH3 H H H 2,6DIP H H 359 CH3 H H H 2,6DMB H H 360 CH3 H H H CD3 H H361 CH3 H H H CH3 H H 362 CH3 H H H H 2,6DIP H 363 CH3 H H H H 2,6DMB H364 CH3 H H H H CD3 H 365 CH3 H H H H CH3 H 366 CH3 H H H H H 2,6DIP 367CH3 H H H H H 2,6DMB 368 CH3 H H H H H CD3 369 CH3 H H H H H CH3 370 CH3H H H H H H 371 CH3 H H H H H i-Pr 372 CH3 H H H H i-Pr H 373 CH3 H H Hi-Pr H H 374 CH3 H H i-Pr H H H 375 CH3 H i-Pr H H H H 376 CH3 i-Pr H HH H H 377 H 2,6DIP H CD3 H H H 378 H 2,6DIP H CH3 H H H 379 H 2,6DIP H HCD3 H H 380 H 2,6DIP H H CH3 H H 381 H 2,6DIP H H H CD3 H 382 H 2,6DIP HH H CH3 H 383 H 2,6DIP H H H H CD3 384 H 2,6DIP H H H H CH3 385 H 2,6DIPH H H H H 386 H 2,6DMB H CD3 H H H 387 H 2,6DMB H CH3 H H H 388 H 2,6DMBH H CD3 H H 389 H 2,6DMB H H CH3 H H 390 H 2,6DMB H H H CD3 H 391 H2,6DMB H H H CH3 H 392 H 2,6DMB H H H H CD3 393 H 2,6DMB H H H H CH3 394H 2,6DMB H H H H H 395 H CD3 CD3 H H H H 396 H CD3 CH3 H H H H 397 H CD3H 2,6DIP H H H 398 H CD3 H 2,6DMB H H H 399 H CD3 H CD3 H H H 400 H CD3H CH3 H H H 401 H CD3 H H 2,6DIP H H 402 H CD3 H H 2,6DMB H H 403 H CD3H H CD3 H H 404 H CD3 H H CH3 H H 405 H CD3 H H H 2,6DIP H 406 H CD3 H HH 2,6DMB H 407 H CD3 H H H CD3 H 408 H CD3 H H H CH3 H 409 H CD3 H H H H2,6DIP 410 H CD3 H H H H 2,6DMB 411 H CD3 H H H H CD3 412 H CD3 H H H HCH3 413 H CD3 H H H H H 414 H CD3 H H H H i-Pr 415 H CD3 H H H i-Pr H416 H CD3 H H i-Pr H H 417 H CD3 H i-Pr H H H 418 H CD3 i-Pr H H H H 419H CH3 CD3 H H H H 420 H CH3 CH3 H H H H 421 H CH3 H 2,6DIP H H H 422 HCH3 H 2,6DMB H H H 423 H CH3 H CD3 H H H 424 H CH3 H CH3 H H H 425 H CH3H H 2,6DIP H H 426 H CH3 H H 2,6DMB H H 427 H CH3 H H CD3 H H 428 H CH3H H CH3 H H 429 H CH3 H H H 2,6DIP H 430 H CH3 H H H 2,6DMB H 431 H CH3H H H CD3 H 432 H CH3 H H H CH3 H 433 H CH3 H H H H 2,6DIP 434 H CH3 H HH H 2,6DMB 435 H CH3 H H H H CD3 436 H CH3 H H H H CH3 437 H CH3 H H H HH 438 H CH3 H H H H i-Pr 439 H CH3 H H H i-Pr H 440 H CH3 H H i-Pr H H441 H CH3 H i-Pr H H H 442 H CH3 i-Pr H H H H 443 H H 2,6DIP H CD3 H H444 H H 2,6DIP H CH3 H H 445 H H 2,6DIP H H CD3 H 446 H H 2,6DIP H H CH3H 447 H H 2,6DIP H H H CD3 448 H H 2,6DIP H H H CH3 449 H H 2,6DIP H H HH 450 H H 2,6DMB H CD3 H H 451 H H 2,6DMB H CH3 H H 452 H H 2,6DMB H HCD3 H 453 H H 2,6DMB H H CH3 H 454 H H 2,6DMB H H H CD3 455 H H 2,6DMB HH H CH3 456 H H 2,6DMB H H H H 457 H H CD3 CD3 H H H 458 H H CD3 CH3 H HH 459 H H CD3 H 2,6DIP H H 460 H H CD3 H 2,6DMB H H 461 H H CD3 H CD3 HH 462 H H CD3 H CH3 H H 463 H H CD3 H H 2,6DIP H 464 H H CD3 H H 2,6DMBH 465 H H CD3 H H CD3 H 466 H H CD3 H H CH3 H 467 H H CD3 H H H 2,6DIP468 H H CD3 H H H 2,6DMB 469 H H CD3 H H H CD3 470 H H CD3 H H H CH3 471H H CD3 H H H H 472 H H CD3 H H H i-Pr 473 H H CD3 H H i-Pr H 474 H HCD3 H i-Pr H H 475 H H CD3 i-Pr H H H 476 H H CH3 CD3 H H H 477 H H CH3CH3 H H H 478 H H CH3 H 2,6DIP H H 479 H H CH3 H 2,6DMB H H 480 H H CH3H CD3 H H 481 H H CH3 H CH3 H H 482 H H CH3 H H 2,6DIP H 483 H H CH3 H H2,6DMB H 484 H H CH3 H H CD3 H 485 H H CH3 H H CH3 H 486 H H CH3 H H H2,6DIP 487 H H CH3 H H H 2,6DMB 488 H H CH3 H H H CD3 489 H H CH3 H H HCH3 490 H H CH3 H H H H 491 H H CH3 H H H i-Pr 492 H H CH3 H H i-Pr H493 H H CH3 H i-Pr H H 494 H H CH3 i-Pr H H H 495 H H H 2,6DIP H CD3 H496 H H H 2,6DIP H CH3 H 497 H H H 2,6DIP H H CD3 498 H H H 2,6DIP H HCH3 499 H H H 2,6DIP H H H 500 H H H 2,6DMB H CD3 H 501 H H H 2,6DMB HCH3 H 502 H H H 2,6DMB H H CD3 503 H H H 2,6DMB H H CH3 504 H H H 2,6DMBH H H 505 H H H CD3 CD3 H H 506 H H H CD3 CH3 H H 507 H H H CD3 H 2,6DIPH 508 H H H CD3 H 2,6DMB H 509 H H H CD3 H CD3 H 510 H H H CD3 H CH3 H511 H H H CD3 H H 2,6DIP 512 H H H CD3 H H 2,6DMB 513 H H H CD3 H H CD3514 H H H CD3 H H CH3 515 H H H CD3 H H H 516 H H H CD3 H H i-Pr 517 H HH CD3 H i-Pr H 518 H H H CD3 i-Pr H H 519 H H H CH3 CD3 H H 520 H H HCH3 CH3 H H 521 H H H CH3 H 2,6DIP H 522 H H H CH3 H 2,6DMB H 523 H H HCH3 H CD3 H 524 H H H CH3 H CH3 H 525 H H H CH3 H H 2,6DIP 526 H H H CH3H H 2,6DMB 527 H H H CH3 H H CD3 528 H H H CH3 H H CH3 529 H H H CH3 H HH 530 H H H CH3 H H i-Pr 531 H H H CH3 H i-Pr H 532 H H H CH3 i-Pr H H533 H H H H 2,6DIP H CD3 534 H H H H 2,6DIP H CH3 535 H H H H 2,6DIP H H536 H H H H 2,6DMB H CD3 537 H H H H 2,6DMB H CH3 538 H H H H 2,6DMB H H539 H H H H CD3 CD3 H 540 H H H H CD3 CH3 H 541 H H H H CD3 H 2,6DIP 542H H H H CD3 H 2,6DMB 543 H H H H CD3 H CD3 544 H H H H CD3 H CH3 545 H HH H CD3 H H 546 H H H H CD3 H i-Pr 547 H H H H CD3 i-Pr H 548 H H H HCH3 CD3 H 549 H H H H CH3 CH3 H 550 H H H H CH3 H 2,6DIP 551 H H H H CH3H 2,6DMB 552 H H H H CH3 H CD3 553 H H H H CH3 H CH3 554 H H H H CH3 H H555 H H H H CH3 H i-Pr 556 H H H H CH3 i-Pr H 557 H H H H H 2,6DIP CD3558 H H H H H 2,6DIP CH3 559 H H H H H 2,6DIP H 560 H H H H H 2,6DMB CD3561 H H H H H 2,6DMB CH3 562 H H H H H 2,6DMB H 563 H H H H H CD3 2,6DIP564 H H H H H CD3 2,6DMB 565 H H H H H CD3 CD3 566 H H H H H CD3 CH3 567H H H H H CD3 H 568 H H H H H CD3 i-Pr 569 H H H H H CH3 2,6DIP 570 H HH H H CH3 2,6DMB 571 H H H H H CH3 CD3 572 H H H H H CH3 CH3 573 H H H HH CH3 H 574 H H H H H CH3 i-Pr 575 H H H H H H 2,6DIP 576 H H H H H H2,6DMB 577 H H H H H H CD3 578 H H H H H H CH3 579 H H H H H H H 580 H HH H H H i-Pr 581 H H H H H i-Pr CD3 582 H H H H H i-Pr CH3 583 H H H H Hi-Pr H 584 H H H H i-Pr CD3 H 585 H H H H i-Pr CH3 H 586 H H H H i-Pr HCD3 587 H H H H i-Pr H CH3 588 H H H H i-Pr H H 589 H H H i-Pr CD3 H H590 H H H i-Pr CH3 H H 591 H H H i-Pr H CD3 H 592 H H H i-Pr H CH3 H 593H H H i-Pr H H CD3 594 H H H i-Pr H H CH3 595 H H H i-Pr H H H 596 H Hi-Pr CD3 H H H 597 H H i-Pr CH3 H H H 598 H H i-Pr H CD3 H H 599 H Hi-Pr H CH3 H H 600 H H i-Pr H H CD3 H 601 H H i-Pr H H CH3 H 602 H Hi-Pr H H H CD3 603 H H i-Pr H H H CH3 604 H H i-Pr H H H H 605 H i-PrCD3 H H H H 606 H i-Pr CH3 H H H H 607 H i-Pr H CD3 H H H 608 H i-Pr HCH3 H H H 609 H i-Pr H H CD3 H H 610 H i-Pr H H CH3 H H 611 H i-Pr H H HCD3 H 612 H i-Pr H H H CH3 H 613 H i-Pr H H H H CD3 614 H i-Pr H H H HCH3 615 H i-Pr H H H H H 616 i-Pr CD3 H H H H H 617 i-Pr CH3 H H H H H618 i-Pr H CD3 H H H H 619 i-Pr H CH3 H H H H 620 i-Pr H H CD3 H H H 621i-Pr H H CH3 H H H 622 i-Pr H H H CD3 H H 623 i-Pr H H H CH3 H H 624i-Pr H H H H CD3 H 625 i-Pr H H H H CH3 H 626 i-Pr H H H H H CD3 627i-Pr H H H H H CH3 628 i-Pr H H H H H HLA629 to LA938 based on the structure:

LA # R11 R12 R13 R14 R31 R33 R34 629 CD3 CD3 H H H H H 630 CD3 CH3 H H HH H 631 CD3 H 2,6DIP H H H H 632 CD3 H 2,6DMB H H H H 633 CD3 H CD3 H HH H 634 CD3 H CH3 H H H H 635 CD3 H H 2,6DIP H H H 636 CD3 H H 2,6DMB HH H 637 CD3 H H CD3 H H H 638 CD3 H H CH3 H H H 639 CD3 H H H 2,6DIP H H640 CD3 H H H 2,6DMB H H 641 CD3 H H H CD3 H H 642 CD3 H H H CH3 H H 643CD3 H H H H 2,6DIP H 644 CD3 H H H H 2,6DMB H 645 CD3 H H H H CD3 H 646CD3 H H H H CH3 H 647 CD3 H H H H H 2,6DIP 648 CD3 H H H H H 2,6DMB 649CD3 H H H H H CD3 650 CD3 H H H H H CH3 651 CD3 H H H H H H 652 CD3 H HH H H i-Pr 653 CD3 H H H H i-Pr H 654 CD3 H H H i-Pr H H 655 CD3 H Hi-Pr H H H 656 CD3 H i-Pr H H H H 657 CD3 i-Pr H H H H H 658 CH3 CD3 H HH H H 659 CH3 CH3 H H H H H 660 CH3 H 2,6DIP H H H H 661 CH3 H 2,6DMB HH H H 662 CH3 H CD3 H H H H 663 CH3 H CH3 H H H H 664 CH3 H H 2,6DIP H HH 665 CH3 H H 2,6DMB H H H 666 CH3 H H CD3 H H H 667 CH3 H H CH3 H H H668 CH3 H H H 2,6DIP H H 669 CH3 H H H 2,6DMB H H 670 CH3 H H H CD3 H H671 CH3 H H H CH3 H H 672 CH3 H H H H 2,6DIP H 673 CH3 H H H H 2,6DMB H674 CH3 H H H H CD3 H 675 CH3 H H H H CH3 H 676 CH3 H H H H H 2,6DIP 677CH3 H H H H H 2,6DMB 678 CH3 H H H H H CD3 679 CH3 H H H H H CH3 680 CH3H H H H H H 681 CH3 H H H H H i-Pr 682 CH3 H H H H i-Pr H 683 CH3 H H Hi-Pr H H 684 CH3 H H i-Pr H H H 685 CH3 H i-Pr H H H H 686 CH3 i-Pr H HH H H 687 H 2,6DIP H CD3 H H H 688 H 2,6DIP H CH3 H H H 689 H 2,6DIP H HCD3 H H 690 H 2,6DIP H H CH3 H H 691 H 2,6DIP H H H CD3 H 692 H 2,6DIP HH H CH3 H 693 H 2,6DIP H H H H CD3 694 H 2,6DIP H H H H CH3 695 H 2,6DIPH H H H H 696 H 2,6DMB H CD3 H H H 697 H 2,6DMB H CH3 H H H 698 H 2,6DMBH H CD3 H H 699 H 2,6DMB H H CH3 H H 700 H 2,6DMB H H H CD3 H 701 H2,6DMB H H H CH3 H 702 H 2,6DMB H H H H CD3 703 H 2,6DMB H H H H CH3 704H 2,6DMB H H H H H 705 H CD3 CD3 H H H H 706 H CD3 CH3 H H H H 707 H CD3H 2,6DIP H H H 708 H CD3 H 2,6DMB H H H 709 H CD3 H CD3 H H H 710 H CD3H CH3 H H H 711 H CD3 H H 2,6DIP H H 712 H CD3 H H 2,6DMB H H 713 H CD3H H CD3 H H 714 H CD3 H H CH3 H H 715 H CD3 H H H 2,6DIP H 716 H CD3 H HH 2,6DMB H 717 H CD3 H H H CD3 H 718 H CD3 H H H CH3 H 719 H CD3 H H H H2,6DIP 720 H CD3 H H H H 2,6DMB 721 H CD3 H H H H CD3 722 H CD3 H H H HCH3 723 H CD3 H H H H H 724 H CD3 H H H H i-Pr 725 H CD3 H H H i-Pr H726 H CD3 H H i-Pr H H 727 H CD3 H i-Pr H H H 728 H CD3 i-Pr H H H H 729H CH3 CD3 H H H H 730 H CH3 CH3 H H H H 731 H CH3 H 2,6DIP H H H 732 HCH3 H 2,6DMB H H H 733 H CH3 H CD3 H H H 734 H CH3 H CH3 H H H 735 H CH3H H 2,6DIP H H 736 H CH3 H H 2,6DMB H H 737 H CH3 H H CD3 H H 738 H CH3H H CH3 H H 739 H CH3 H H H 2,6DIP H 740 H CH3 H H H 2,6DMB H 741 H CH3H H H CD3 H 742 H CH3 H H H CH3 H 743 H CH3 H H H H 2,6DIP 744 H CH3 H HH H 2,6DMB 745 H CH3 H H H H CD3 746 H CH3 H H H H CH3 747 H CH3 H H H HH 748 H CH3 H H H H i-Pr 749 H CH3 H H H i-Pr H 750 H CH3 H H i-Pr H H751 H CH3 H i-Pr H H H 752 H CH3 i-Pr H H H H 753 H H 2,6DIP H CD3 H H754 H H 2,6DIP H CH3 H H 755 H H 2,6DIP H H CD3 H 756 H H 2,6DIP H H CH3H 757 H H 2,6DIP H H H CD3 758 H H 2,6DIP H H H CH3 759 H H 2,6DIP H H HH 760 H H 2,6DMB H CD3 H H 761 H H 2,6DMB H CH3 H H 762 H H 2,6DMB H HCD3 H 763 H H 2,6DMB H H CH3 H 764 H H 2,6DMB H H H CD3 765 H H 2,6DMB HH H CH3 766 H H 2,6DMB H H H H 767 H H CD3 CD3 H H H 768 H H CD3 CH3 H HH 769 H H CD3 H 2,6DIP H H 770 H H CD3 H 2,6DMB H H 771 H H CD3 H CD3 HH 772 H H CD3 H CH3 H H 773 H H CD3 H H 2,6DIP H 774 H H CD3 H H 2,6DMBH 775 H H CD3 H H CD3 H 776 H H CD3 H H CH3 H 777 H H CD3 H H H 2,6DIP778 H H CD3 H H H 2,6DMB 779 H H CD3 H H H CD3 780 H H CD3 H H H CH3 781H H CD3 H H H H 782 H H CD3 H H H i-Pr 783 H H CD3 H H i-Pr H 784 H HCD3 H i-Pr H H 785 H H CD3 i-Pr H H H 786 H H CH3 CD3 H H H 787 H H CH3CH3 H H H 788 H H CH3 H 2,6DIP H H 789 H H CH3 H 2,6DMB H H 790 H H CH3H CD3 H H 791 H H CH3 H CH3 H H 792 H H CH3 H H 2,6DIP H 793 H H CH3 H H2,6DMB H 794 H H CH3 H H CD3 H 795 H H CH3 H H CH3 H 796 H H CH3 H H H2,6DIP 797 H H CH3 H H H 2,6DMB 798 H H CH3 H H H CD3 799 H H CH3 H H HCH3 800 H H CH3 H H H H 801 H H CH3 H H H i-Pr 802 H H CH3 H H i-Pr H803 H H CH3 H i-Pr H H 804 H H CH3 i-Pr H H H 805 H H H 2,6DIP H CD3 H806 H H H 2,6DIP H CH3 H 807 H H H 2,6DIP H H CD3 808 H H H 2,6DIP H HCH3 809 H H H 2,6DIP H H H 810 H H H 2,6DMB H CD3 H 811 H H H 2,6DMB HCH3 H 812 H H H 2,6DMB H H CD3 813 H H H 2,6DMB H H CH3 814 H H H 2,6DMBH H H 815 H H H CD3 CD3 H H 816 H H H CD3 CH3 H H 817 H H H CD3 H 2,6DIPH 818 H H H CD3 H 2,6DMB H 819 H H H CD3 H CD3 H 820 H H H CD3 H CH3 H821 H H H CD3 H H 2,6DIP 822 H H H CD3 H H 2,6DMB 823 H H H CD3 H H CD3824 H H H CD3 H H CH3 825 H H H CD3 H H H 826 H H H CD3 H H i-Pr 827 H HH CD3 H i-Pr H 828 H H H CD3 i-Pr H H 829 H H H CH3 CD3 H H 830 H H HCH3 CH3 H H 831 H H H CH3 H 2,6DIP H 832 H H H CH3 H 2,6DMB H 833 H H HCH3 H CD3 H 834 H H H CH3 H CH3 H 835 H H H CH3 H H 2,6DIP 836 H H H CH3H H 2,6DMB 837 H H H CH3 H H CD3 838 H H H CH3 H H CH3 839 H H H CH3 H HH 840 H H H CH3 H H i-Pr 841 H H H CH3 H i-Pr H 842 H H H CH3 i-Pr H H843 H H H H 2,6DIP CD3 H 844 H H H H 2,6DIP CH3 H 845 H H H H 2,6DIP HCD3 846 H H H H 2,6DIP H CH3 847 H H H H 2,6DIP H H 848 H H H H 2,6DMBCD3 H 849 H H H H 2,6DMB CH3 H 850 H H H H 2,6DMB H CD3 851 H H H H2,6DMB H CH3 852 H H H H 2,6DMB H H 853 H H H H CD3 2,6DIP H 854 H H H HCD3 2,6DMB H 855 H H H H CD3 CD3 H 856 H H H H CD3 CH3 H 857 H H H H CD3H 2,6DIP 858 H H H H CD3 H 2,6DMB 859 H H H H CD3 H CD3 860 H H H H CD3H CH3 861 H H H H CD3 H H 862 H H H H CD3 H i-Pr 863 H H H H CD3 i-Pr H864 H H H H CH3 2,6DIP H 865 H H H H CH3 2,6DMB H 866 H H H H CH3 CD3 H867 H H H H CH3 CH3 H 868 H H H H CH3 H 2,6DIP 869 H H H H CH3 H 2,6DMB870 H H H H CH3 H CD3 871 H H H H CH3 H CH3 872 H H H H CH3 H H 873 H HH H CH3 H i-Pr 874 H H H H CH3 i-Pr H 875 H H H H H 2,6DIP H 876 H H H HH 2,6DMB H 877 H H H H H CD3 CD3 878 H H H H H CD3 CH3 879 H H H H H CD3H 880 H H H H H CD3 i-Pr 881 H H H H H CH3 CD3 882 H H H H H CH3 CH3 883H H H H H CH3 H 884 H H H H H CH3 i-Pr 885 H H H H H H 2,6DIP 886 H H HH H H 2,6DMB 887 H H H H H H CD3 888 H H H H H H CH3 889 H H H H H H H890 H H H H H H i-Pr 891 H H H H H i-Pr CD3 892 H H H H H i-Pr CH3 893 HH H H H i-Pr H 894 H H H H i-Pr CD3 H 895 H H H H i-Pr CH3 H 896 H H H Hi-Pr H CD3 897 H H H H i-Pr H CH3 898 H H H H i-Pr H H 899 H H H i-PrCD3 H H 900 H H H i-Pr CH3 H H 901 H H H i-Pr H CD3 H 902 H H H i-Pr HCH3 H 903 H H H i-Pr H H CD3 904 H H H i-Pr H H CH3 905 H H H i-Pr H H H906 H H i-Pr CD3 H H H 907 H H i-Pr CH3 H H H 908 H H i-Pr H CD3 H H 909H H i-Pr H CH3 H H 910 H H i-Pr H H CD3 H 911 H H i-Pr H H CH3 H 912 H Hi-Pr H H H CD3 913 H H i-Pr H H H CH3 914 H H i-Pr H H H H 915 H i-PrCD3 H H H H 916 H i-Pr CH3 H H H H 917 H i-Pr H CD3 H H H 918 H i-Pr HCH3 H H H 919 H i-Pr H H CD3 H H 920 H i-Pr H H CH3 H H 921 H i-Pr H H HCD3 H 922 H i-Pr H H H CH3 H 923 H i-Pr H H H H CD3 924 H i-Pr H H H HCH3 925 H i-Pr H H H H H 926 i-Pr CD3 H H H H H 927 i-Pr CH3 H H H H H928 i-Pr H CD3 H H H H 929 i-Pr H CH3 H H H H 930 i-Pr H H CD3 H H H 931i-Pr H H CH3 H H H 932 i-Pr H H H CD3 H H 933 i-Pr H H H CH3 H H 934i-Pr H H H H CD3 H 935 i-Pr H H H H CH3 H 936 i-Pr H H H H H CD3 937i-Pr H H H H H CH3 938 i-Pr H H H H H HLA939 to LA1248 based on the structure:

LA # R11 R12 R13 R14 R32 R33 R34 939 CD3 CD3 H H H H H 940 CD3 CH3 H H HH H 941 CD3 H 2,6DIP H H H H 942 CD3 H 2,6DMB H H H H 943 CD3 H CD3 H HH H 944 CD3 H CH3 H H H H 945 CD3 H H 2,6DIP H H H 946 CD3 H H 2,6DMB HH H 947 CD3 H H CD3 H H H 948 CD3 H H CH3 H H H 949 CD3 H H H 2,6DIP H H950 CD3 H H H 2,6DMB H H 951 CD3 H H H CD3 H H 952 CD3 H H H CH3 H H 953CD3 H H H H 2,6DIP H 954 CD3 H H H H 2,6DMB H 955 CD3 H H H H CD3 H 956CD3 H H H H CH3 H 957 CD3 H H H H H 2,6DIP 958 CD3 H H H H H 2,6DMB 959CD3 H H H H H CD3 960 CD3 H H H H H CH3 961 CD3 H H H H H H 962 CD3 H HH H H i-Pr 963 CD3 H H H H i-Pr H 964 CD3 H H H i-Pr H H 965 CD3 H Hi-Pr H H H 966 CD3 H i-Pr H H H H 967 CD3 i-Pr H H H H H 968 CH3 CD3 H HH H H 969 CH3 CH3 H H H H H 970 CH3 H 2,6DIP H H H H 971 CH3 H 2,6DMB HH H H 972 CH3 H CD3 H H H H 973 CH3 H CH3 H H H H 974 CH3 H H 2,6DIP H HH 975 CH3 H H 2,6DMB H H H 976 CH3 H H CD3 H H H 977 CH3 H H CH3 H H H978 CH3 H H H 2,6DIP H H 979 CH3 H H H 2,6DMB H H 980 CH3 H H H CD3 H H981 CH3 H H H CH3 H H 982 CH3 H H H H 2,6DIP H 983 CH3 H H H H 2,6DMB H984 CH3 H H H H CD3 H 985 CH3 H H H H CH3 H 986 CH3 H H H H H 2,6DIP 987CH3 H H H H H 2,6DMB 988 CH3 H H H H H CD3 989 CH3 H H H H H CH3 990 CH3H H H H H H 991 CH3 H H H H H i-Pr 992 CH3 H H H H i-Pr H 993 CH3 H H Hi-Pr H H 994 CH3 H H i-Pr H H H 995 CH3 H i-Pr H H H H 996 CH3 i-Pr H HH H H 997 H 2,6DIP H CD3 H H H 998 H 2,6DIP H CH3 H H H 999 H 2,6DIP H HCD3 H H 1000 H 2,6DIP H H CH3 H H 1001 H 2,6DIP H H H CD3 H 1002 H2,6DIP H H H CH3 H 1003 H 2,6DIP H H H H CD3 1004 H 2,6DIP H H H H CH31005 H 2,6DIP H H H H H 1006 H 2,6DMB H CD3 H H H 1007 H 2,6DMB H CH3 HH H 1008 H 2,6DMB H H CD3 H H 1009 H 2,6DMB H H CH3 H H 1010 H 2,6DMB HH H CD3 H 1011 H 2,6DMB H H H CH3 H 1012 H 2,6DMB H H H H CD3 1013 H2,6DMB H H H H CH3 1014 H 2,6DMB H H H H H 1015 H CD3 CD3 H H H H 1016 HCD3 CH3 H H H H 1017 H CD3 H 2,6DIP H H H 1018 H CD3 H 2,6DMB H H H 1019H CD3 H CD3 H H H 1020 H CD3 H CH3 H H H 1021 H CD3 H H 2,6DIP H H 1022H CD3 H H 2,6DMB H H 1023 H CD3 H H CD3 H H 1024 H CD3 H H CH3 H H 1025H CD3 H H H 2,6DIP H 1026 H CD3 H H H 2,6DMB H 1027 H CD3 H H H CD3 H1028 H CD3 H H H CH3 H 1029 H CD3 H H H H 2,6DIP 1030 H CD3 H H H H2,6DMB 1031 H CD3 H H H H CD3 1032 H CD3 H H H H CH3 1033 H CD3 H H H HH 1034 H CD3 H H H H i-Pr 1035 H CD3 H H H i-Pr H 1036 H CD3 H H i-Pr HH 1037 H CD3 H i-Pr H H H 1038 H CD3 i-Pr H H H H 1039 H CH3 CD3 H H H H1040 H CH3 CH3 H H H H 1041 H CH3 H 2,6DIP H H H 1042 H CH3 H 2,6DMB H HH 1043 H CH3 H CD3 H H H 1044 H CH3 H CH3 H H H 1045 H CH3 H H 2,6DIP HH 1046 H CH3 H H 2,6DMB H H 1047 H CH3 H H CD3 H H 1048 H CH3 H H CH3 HH 1049 H CH3 H H H 2,6DIP H 1050 H CH3 H H H 2,6DMB H 1051 H CH3 H H HCD3 H 1052 H CH3 H H H CH3 H 1053 H CH3 H H H H 2,6DIP 1054 H CH3 H H HH 2,6DMB 1055 H CH3 H H H H CD3 1056 H CH3 H H H H CH3 1057 H CH3 H H HH H 1058 H CH3 H H H H i-Pr 1059 H CH3 H H H i-Pr H 1060 H CH3 H H i-PrH H 1061 H CH3 H i-Pr H H H 1062 H CH3 i-Pr H H H H 1063 H H 2,6DIP HCD3 H H 1064 H H 2,6DIP H CH3 H H 1065 H H 2,6DIP H H CD3 H 1066 H H2,6DIP H H CH3 H 1067 H H 2,6DIP H H H CD3 1068 H H 2,6DIP H H H CH31069 H H 2,6DIP H H H H 1070 H H 2,6DMB H CD3 H H 1071 H H 2,6DMB H CH3H H 1072 H H 2,6DMB H H CD3 H 1073 H H 2,6DMB H H CH3 H 1074 H H 2,6DMBH H H CD3 1075 H H 2,6DMB H H H CH3 1076 H H 2,6DMB H H H H 1077 H H CD3CD3 H H H 1078 H H CD3 CH3 H H H 1079 H H CD3 H 2,6DIP H H 1080 H H CD3H 2,6DMB H H 1081 H H CD3 H CD3 H H 1082 H H CD3 H CH3 H H 1083 H H CD3H H 2,6DIP H 1084 H H CD3 H H 2,6DMB H 1085 H H CD3 H H CD3 H 1086 H HCD3 H H CH3 H 1087 H H CD3 H H H 2,6DIP 1088 H H CD3 H H H 2,6DMB 1089 HH CD3 H H H CD3 1090 H H CD3 H H H CH3 1091 H H CD3 H H H H 1092 H H CD3H H H i-Pr 1093 H H CD3 H H i-Pr H 1094 H H CD3 H i-Pr H H 1095 H H CD3i-Pr H H H 1096 H H CH3 CD3 H H H 1097 H H CH3 CH3 H H H 1098 H H CH3 H2,6DIP H H 1099 H H CH3 H 2,6DMB H H 1100 H H CH3 H CD3 H H 1101 H H CH3H CH3 H H 1102 H H CH3 H H 2,6DIP H 1103 H H CH3 H H 2,6DMB H 1104 H HCH3 H H CD3 H 1105 H H CH3 H H CH3 H 1106 H H CH3 H H H 2,6DIP 1107 H HCH3 H H H 2,6DMB 1108 H H CH3 H H H CD3 1109 H H CH3 H H H CH3 1110 H HCH3 H H H H 1111 H H CH3 H H H i-Pr 1112 H H CH3 H H i-Pr H 1113 H H CH3H i-Pr H H 1114 H H CH3 i-Pr H H H 1115 H H H 2,6DIP CD3 H H 1116 H H H2,6DIP CH3 H H 1117 H H H 2,6DIP H CD3 H 1118 H H H 2,6DIP H CH3 H 1119H H H 2,6DIP H H CD3 1120 H H H 2,6DIP H H CH3 1121 H H H 2,6DIP H H H1122 H H H 2,6DMB CD3 H H 1123 H H H 2,6DMB CH3 H H 1124 H H H 2,6DMB HCD3 H 1125 H H H 2,6DMB H CH3 H 1126 H H H 2,6DMB H H CD3 1127 H H H2,6DMB H H CH3 1128 H H H 2,6DMB H H H 1129 H H H CD3 2,6DIP H H 1130 HH H CD3 2,6DMB H H 1131 H H H CD3 CD3 H H 1132 H H H CD3 CH3 H H 1133 HH H CD3 H 2,6DIP H 1134 H H H CD3 H 2,6DMB H 1135 H H H CD3 H CD3 H 1136H H H CD3 H CH3 H 1137 H H H CD3 H H 2,6DIP 1138 H H H CD3 H H 2,6DMB1139 H H H CD3 H H CD3 1140 H H H CD3 H H CH3 1141 H H H CD3 H H H 1142H H H CD3 H H i-Pr 1143 H H H CD3 H i-Pr H 1144 H H H CD3 i-Pr H H 1145H H H CH3 2,6DIP H H 1146 H H H CH3 2,6DMB H H 1147 H H H CH3 CD3 H H1148 H H H CH3 CH3 H H 1149 H H H CH3 H 2,6DIP H 1150 H H H CH3 H 2,6DMBH 1151 H H H CH3 H CD3 H 1152 H H H CH3 H CH3 H 1153 H H H CH3 H H2,6DIP 1154 H H H CH3 H H 2,6DMB 1155 H H H CH3 H H CD3 1156 H H H CH3 HH CH3 1157 H H H CH3 H H H 1158 H H H CH3 H H i-Pr 1159 H H H CH3 H i-PrH 1160 H H H CH3 i-Pr H H 1161 H H H H 2,6DIP H CD3 1162 H H H H 2,6DIPH CH3 1163 H H H H 2,6DIP H H 1164 H H H H 2,6DMB H CD3 1165 H H H H2,6DMB H CH3 1166 H H H H 2,6DMB H H 1167 H H H H CD3 CD3 H 1168 H H H HCD3 CH3 H 1169 H H H H CD3 H 2,6DIP 1170 H H H H CD3 H 2,6DMB 1171 H H HH CD3 H CD3 1172 H H H H CD3 H CH3 1173 H H H H CD3 H H 1174 H H H H CD3H i-Pr 1175 H H H H CD3 i-Pr H 1176 H H H H CH3 CD3 H 1177 H H H H CH3CH3 H 1178 H H H H CH3 H 2,6DIP 1179 H H H H CH3 H 2,6DMB 1180 H H H HCH3 H CD3 1181 H H H H CH3 H CH3 1182 H H H H CH3 H H 1183 H H H H CH3 Hi-Pr 1184 H H H H CH3 i-Pr H 1185 H H H H H 2,6DIP H 1186 H H H H H2,6DMB H 1187 H H H H H CD3 CD3 1188 H H H H H CD3 CH3 1189 H H H H HCD3 H 1190 H H H H H CD3 i-Pr 1191 H H H H H CH3 CD3 1192 H H H H H CH3CH3 1193 H H H H H CH3 H 1194 H H H H H CH3 i-Pr 1195 H H H H H H 2,6DIP1196 H H H H H H 2,6DMB 1197 H H H H H H CD3 1198 H H H H H H CH3 1199 HH H H H H H 1200 H H H H H H i-Pr 1201 H H H H H i-Pr CD3 1202 H H H H Hi-Pr CH3 1203 H H H H H i-Pr H 1204 H H H H i-Pr CD3 H 1205 H H H H i-PrCH3 H 1206 H H H H i-Pr H CD3 1207 H H H H i-Pr H CH3 1208 H H H H i-PrH H 1209 H H H i-Pr CD3 H H 1210 H H H i-Pr CH3 H H 1211 H H H i-Pr HCD3 H 1212 H H H i-Pr H CH3 H 1213 H H H i-Pr H H CD3 1214 H H H i-Pr HH CH3 1215 H H H i-Pr H H H 1216 H H i-Pr CD3 H H H 1217 H H i-Pr CH3 HH H 1218 H H i-Pr H CD3 H H 1219 H H i-Pr H CH3 H H 1220 H H i-Pr H HCD3 H 1221 H H i-Pr H H CH3 H 1222 H H i-Pr H H H CD3 1223 H H i-Pr H HH CH3 1224 H H i-Pr H H H H 1225 H i-Pr CD3 H H H H 1226 H i-Pr CH3 H HH H 1227 H i-Pr H CD3 H H H 1228 H i-Pr H CH3 H H H 1229 H i-Pr H H CD3H H 1230 H i-Pr H H CH3 H H 1231 H i-Pr H H H CD3 H 1232 H i-Pr H H HCH3 H 1233 H i-Pr H H H H CD3 1234 H i-Pr H H H H CH3 1235 H i-Pr H H HH H 1236 i-Pr CD3 H H H H H 1237 i-Pr CH3 H H H H H 1238 i-Pr H CD3 H HH H 1239 i-Pr H CH3 H H H H 1240 i-Pr H H CD3 H H H 1241 i-Pr H H CH3 HH H 1242 i-Pr H H H CD3 H H 1243 i-Pr H H H CH3 H H 1244 i-Pr H H H HCD3 H 1245 i-Pr H H H H CH3 H 1246 i-Pr H H H H H CD3 1247 i-Pr H H H HH CH3 1248 i-Pr H H H H H HLA1249 to LA1720 based on structure:

LA # R11 R12 R2 R31 R32 R33 1249 CD3 CD3 2,6DIP H H H 1250 CD3 H 2,6DIPBH H H 1251 CD3 CD3 2,6DMB H H H 1252 CD3 CD3 CD3 H H H 1253 CD3 CD3 CH3H H H 1254 CD3 CD3 H H H H 1255 CD3 CD3 ph H H H 1256 CD3 CH3 2,6DIP H HH 1257 CD3 CH3 2,6DIPB H H H 1258 CD3 CH3 2,6DMB H H H 1259 CD3 CH3 CD3H H H 1260 CD3 CH3 CH3 H H H 1261 CD3 CH3 H H H H 1262 CD3 CH3 ph H H H1263 CD3 H 2,6DIP CD3 H H 1264 CD3 H 2,6DIP CH3 H H 1265 CD3 H 2,6DIP HCD3 H 1266 CD3 H 2,6DIP H CH3 H 1267 CD3 H 2,6DIP H H CD3 1268 CD3 H2,6DIP H H CH3 1269 CD3 H 2,6DIP H H H 1270 CD3 H 2,6DIPB CD3 H H 1271CD3 H 2,6DIPB CH3 H H 1272 CD3 H 2,6DIPB H CD3 H 1273 CD3 H 2,6DIPB HCH3 H 1274 CD3 H 2,6DIPB H H CD3 1275 CD3 H 2,6DIPB H H CH3 1276 CD3 H2,6DIPB H H H 1277 CD3 H 2,6DMB CD3 H H 1278 CD3 H 2,6DMB CH3 H H 1279CD3 H 2,6DMB H CD3 H 1280 CD3 H 2,6DMB H CH3 H 1281 CD3 H 2,6DMB H H CD31282 CD3 H 2,6DMB H H CH3 1283 CD3 H 2,6DMB H H H 1284 CD3 H CD3 CD3 H H1285 CD3 H CD3 CH3 H H 1286 CD3 H CD3 H CD3 H 1287 CD3 H CD3 H CH3 H1288 CD3 H CD3 H H CD3 1289 CD3 H CD3 H H CH3 1290 CD3 H CD3 H H H 1291CD3 H CH3 CD3 H H 1292 CD3 H CH3 CH3 H H 1293 CD3 H CH3 H CD3 H 1294 CD3H CH3 H CH3 H 1295 CD3 H CH3 H H CD3 1296 CD3 H CH3 H H CH3 1297 CD3 HCH3 H H H 1298 CD3 H H 2,6DIP H H 1299 CD3 H H 2,6DMB H H 1300 CD3 H HCD3 H H 1301 CD3 H H CH3 H H 1302 CD3 H H H 2,6DIP H 1303 CD3 H H H2,6DMB H 1304 CD3 H H H CD3 H 1305 CD3 H H H CH3 H 1306 CD3 H H H H2,6DIP 1307 CD3 H H H H 2,6DMB 1308 CD3 H H H H CD3 1309 CD3 H H H H CH31310 CD3 H H H H H 1311 CD3 H H H H iPr 1312 CD3 H H H iPr H 1313 CD3 HH iPr H H 1314 CD3 H ph CD3 H H 1315 CD3 H ph CH3 H H 1316 CD3 H ph HCD3 H 1317 CD3 H ph H CH3 H 1318 CD3 H ph H H CD3 1319 CD3 H ph H H CH31320 CD3 H ph H H H 1321 CD3 iPr H H H H 1322 CH3 CD3 2,6DIP H H H 1323CH3 CD3 2,6DIPB H H H 1324 CH3 CD3 2,6DMB H H H 1325 CH3 CD3 CD3 H H H1326 CH3 CD3 CH3 H H H 1327 CH3 CD3 H H H H 1328 CH3 CD3 ph H H H 1329CH3 CH3 2,6DIP H H H 1330 CH3 CH3 2,6DIPB H H H 1331 CH3 CH3 2,6DMB H HH 1332 CH3 CH3 CD3 H H H 1333 CH3 CH3 CH3 H H H 1334 CH3 CH3 H H H H1335 CH3 CH3 ph H H H 1336 CH3 H 2,6DIP CD3 H H 1337 CH3 H 2,6DIP CH3 HH 1338 CH3 H 2,6DIP H CD3 H 1339 CH3 H 2,6DIP H CH3 H 1340 CH3 H 2,6DIPH H CD3 1341 CH3 H 2,6DIP H H CH3 1342 CH3 H 2,6DIP H H H 1343 CH3 H2,6DIPB CD3 H H 1344 CH3 H 2,6DIPB CH3 H H 1345 CH3 H 2,6DIPB H CD3 H1346 CH3 H 2,6DIPB H CH3 H 1347 CH3 H 2,6DIPB H H CD3 1348 CH3 H 2,6DIPBH H CH3 1349 CH3 H 2,6DIPB H H H 1350 CH3 H 2,6DMB CD3 H H 1351 CH3 H2,6DMB CH3 H H 1352 CH3 H 2,6DMB H CD3 H 1353 CH3 H 2,6DMB H CH3 H 1354CH3 H 2,6DMB H H CD3 1355 CH3 H 2,6DMB H H CH3 1356 CH3 H 2,6DMB H H H1357 CH3 H CD3 CD3 H H 1358 CH3 H CD3 CH3 H H 1359 CH3 H CD3 H CD3 H1360 CH3 H CD3 H CH3 H 1361 CH3 H CD3 H H CD3 1362 CH3 H CD3 H H CH31363 CH3 H CD3 H H H 1364 CH3 H CH3 CD3 H H 1365 CH3 H CH3 CH3 H H 1366CH3 H CH3 H CD3 H 1367 CH3 H CH3 H CH3 H 1368 CH3 H CH3 H H CD3 1369 CH3H CH3 H H CH3 1370 CH3 H CH3 H H H 1371 CH3 H H 2,6DIP H H 1372 CH3 H H2,6DMB H H 1373 CH3 H H CD3 H H 1374 CH3 H H CH3 H H 1375 CH3 H H H2,6DIP H 1376 CH3 H H H 2,6DMB H 1377 CH3 H H H CD3 H 1378 CH3 H H H CH3H 1379 CH3 H H H H 2,6DIP 1380 CH3 H H H H 2,6DMB 1381 CH3 H H H H CD31382 CH3 H H H H CH3 1383 CH3 H H H H H 1384 CH3 H H H H iPr 1385 CH3 HH H iPr H 1386 CH3 H H iPr H H 1387 CH3 H ph CD3 H H 1388 CH3 H ph CH3 HH 1389 CH3 H ph H CD3 H 1390 CH3 H ph H CH3 H 1391 CH3 H ph H H CD3 1392CH3 H ph H H CH3 1393 CH3 H ph H H H 1394 CH3 iPr H H H H 1395 H 2,6DIPH CD3 H H 1396 H 2,6DIP H CH3 H H 1397 H 2,6DIP H H CD3 H 1398 H 2,6DIPH H CH3 H 1399 H 2,6DIP H H H CD3 1400 H 2,6DIP H H H CH3 1401 H 2,6DIPH H H H 1402 H 2,6DMB H CD3 H H 1403 H 2,6DMB H CH3 H H 1404 H 2,6DMB HH CD3 H 1405 H 2,6DMB H H CH3 H 1406 H 2,6DMB H H H CD3 1407 H 2,6DMB HH H CH3 1408 H 2,6DMB H H H H 1409 H CD3 2,6DIP CD3 H H 1410 H CD32,6DIP CH3 H H 1411 H CD3 2,6DIP H CD3 H 1412 H CD3 2,6DIP H CH3 H 1413H CD3 2,6DIP H H CD3 1414 H CD3 2,6DIP H H CH3 1415 H CD3 2,6DIP H H H1416 H CD3 2,6DIPB CD3 H H 1417 H CD3 2,6DIPB CH3 H H 1418 H CD3 2,6DIPBH CD3 H 1419 H CD3 2,6DIPB H CH3 H 1420 H CD3 2,6DIPB H H CD3 1421 H CD32,6DIPB H H CH3 1422 H CD3 2,6DIPB H H H 1423 H CD3 2,6DMB CD3 H H 1424H CD3 2,6DMB CH3 H H 1425 H CD3 2,6DMB H CD3 H 1426 H CD3 2,6DMB H CH3 H1427 H CD3 2,6DMB H H CD3 1428 H CD3 2,6DMB H H CH3 1429 H CD3 2,6DMB HH H 1430 H CD3 CD3 CD3 H H 1431 H CD3 CD3 CH3 H H 1432 H CD3 CD3 H CD3 H1433 H CD3 CD3 H CH3 H 1434 H CD3 CD3 H H CD3 1435 H CD3 CD3 H H CH31436 H CD3 CD3 H H H 1437 H CD3 CH3 CD3 H H 1438 H CD3 CH3 CH3 H H 1439H CD3 CH3 H CD3 H 1440 H CD3 CH3 H CH3 H 1441 H CD3 CH3 H H CD3 1442 HCD3 CH3 H H CH3 1443 H CD3 CH3 H H H 1444 H CD3 H 2,6DIP H H 1445 H CD3H 2,6DMB H H 1446 H CD3 H CD3 H H 1447 H CD3 H CH3 H H 1448 H CD3 H H2,6DIP H 1449 H CD3 H H 2,6DMB H 1450 H CD3 H H CD3 H 1451 H CD3 H H CH3H 1452 H CD3 H H H 2,6DIP 1453 H CD3 H H H 2,6DMB 1454 H CD3 H H H CD31455 H CD3 H H H CH3 1456 H CD3 H H H H 1457 H CD3 H H H iPr 1458 H CD3H H iPr H 1459 H CD3 H iPr H H 1460 H CD3 ph CD3 H H 1461 H CD3 ph CH3 HH 1462 H CD3 ph H CD3 H 1463 H CD3 ph H CH3 H 1464 H CD3 ph H H CD3 1465H CD3 ph H H CH3 1466 H CD3 ph H H H 1467 H CH3 2,6DIP CD3 H H 1468 HCH3 2,6DIP CH3 H H 1469 H CH3 2,6DIP H CD3 H 1470 H CH3 2,6DIP H CH3 H1471 H CH3 2,6DIP H H CD3 1472 H CH3 2,6DIP H H CH3 1473 H CH3 2,6DIP HH H 1474 H CH3 2,6DIPB CD3 H H 1475 H CH3 2,6DIPB CH3 H H 1476 H CH32,6DIPB H CD3 H 1477 H CH3 2,6DIPB H CH3 H 1478 H CH3 2,6DIPB H H CD31479 H CH3 2,6DIPB H H CH3 1480 H CH3 2,6DIPB H H H 1481 H CH3 2,6DMBCD3 H H 1482 H CH3 2,6DMB CH3 H H 1483 H CH3 2,6DMB H CD3 H 1484 H CH32,6DMB H CH3 H 1485 H CH3 2,6DMB H H CD3 1486 H CH3 2,6DMB H H CH3 1487H CH3 2,6DMB H H H 1488 H CH3 CD3 CD3 H H 1489 H CH3 CD3 CH3 H H 1490 HCH3 CD3 H CD3 H 1491 H CH3 CD3 H CH3 H 1492 H CH3 CD3 H H CD3 1493 H CH3CD3 H H CH3 1494 H CH3 CD3 H H H 1495 H CH3 CH3 CD3 H H 1496 H CH3 CH3CH3 H H 1497 H CH3 CH3 H CD3 H 1498 H CH3 CH3 H CH3 H 1499 H CH3 CH3 H HCD3 1500 H CH3 CH3 H H CH3 1501 H CH3 CH3 H H H 1502 H CH3 H 2,6DIP H H1503 H CH3 H 2,6DMB H H 1504 H CH3 H CD3 H H 1505 H CH3 H CH3 H H 1506 HCH3 H H 2,6DIP H 1507 H CH3 H H 2,6DMB H 1508 H CH3 H H CD3 H 1509 H CH3H H CH3 H 1510 H CH3 H H H 2,6DIP 1511 H CH3 H H H 2,6DMB 1512 H CH3 H HH CD3 1513 H CH3 H H H CH3 1514 H CH3 H H H H 1515 H CH3 H H H iPr 1516H CH3 H H iPr H 1517 H CH3 H iPr H H 1518 H CH3 ph CD3 H H 1519 H CH3 phCH3 H H 1520 H CH3 ph H CD3 H 1521 H CH3 ph H CH3 H 1522 H CH3 ph H HCD3 1523 H CH3 ph H H CH3 1524 H CH3 ph H H H 1525 H H 2,6DIP CD3 CD3 H1526 H H 2,6DIP CD3 CH3 H 1527 H H 2,6DIP CD3 H CD3 1528 H H 2,6DIP CD3H CH3 1529 H H 2,6DIP CD3 H H 1530 H H 2,6DIP CH3 CD3 H 1531 H H 2,6DIPCH3 CH3 H 1532 H H 2,6DIP CH3 H CD3 1533 H H 2,6DIP CH3 H CH3 1534 H H2,6DIP CH3 H H 1535 H H 2,6DIP H CD3 CD3 1536 H H 2,6DIP H CD3 CH3 1537H H 2,6DIP H CD3 H 1538 H H 2,6DIP H CH3 CD3 1539 H H 2,6DIP H CH3 CH31540 H H 2,6DIP H CH3 H 1541 H H 2,6DIP H H CD3 1542 H H 2,6DIP H H CH31543 H H 2,6DIP H H H 1544 H H 2,6DIPB CD3 CD3 H 1545 H H 2,6DIPB CD3CH3 H 1546 H H 2,6DIPB CD3 H CD3 1547 H H 2,6DIPB CD3 H CH3 1548 H H2,6DIPB CD3 H H 1549 H H 2,6DIPB CH3 CD3 H 1550 H H 2,6DIPB CH3 CH3 H1551 H H 2,6DIPB CH3 H CD3 1552 H H 2,6DIPB CH3 H CH3 1553 H H 2,6DIPBCH3 H H 1554 H H 2,6DIPB H CD3 CD3 1555 H H 2,6DIPB H CD3 CH3 1556 H H2,6DIPB H CD3 H 1557 H H 2,6DIPB H CH3 CD3 1558 H H 2,6DIPB H CH3 CH31559 H H 2,6DIPB H CH3 H 1560 H H 2,6DIPB H H CD3 1561 H H 2,6DIPB H HCH3 1562 H H 2,6DIPB H H H 1563 H H 2,6DMB CD3 CD3 H 1564 H H 2,6DMB CD3CH3 H 1565 H H 2,6DMB CD3 H CD3 1566 H H 2,6DMB CD3 H CH3 1567 H H2,6DMB CD3 H H 1568 H H 2,6DMB CH3 CD3 H 1569 H H 2,6DMB CH3 CH3 H 1570H H 2,6DMB CH3 H CD3 1571 H H 2,6DMB CH3 H CH3 1572 H H 2,6DMB CH3 H H1573 H H 2,6DMB H CD3 CD3 1574 H H 2,6DMB H CD3 CH3 1575 H H 2,6DMB HCD3 H 1576 H H 2,6DMB H CH3 CD3 1577 H H 2,6DMB H CH3 CH3 1578 H H2,6DMB H CH3 H 1579 H H 2,6DMB H H CD3 1580 H H 2,6DMB H H CH3 1581 H H2,6DMB H H H 1582 H H CD3 CD3 CD3 H 1583 H H CD3 CD3 CH3 H 1584 H H CD3CD3 H CD3 1585 H H CD3 CD3 H CH3 1586 H H CD3 CD3 H H 1587 H H CD3 CH3CD3 H 1588 H H CD3 CH3 CH3 H 1589 H H CD3 CH3 H CD3 1590 H H CD3 CH3 HCH3 1591 H H CD3 CH3 H H 1592 H H CD3 H 2,6DIP H 1593 H H CD3 H 2,6DMB H1594 H H CD3 H CD3 CD3 1595 H H CD3 H CD3 CH3 1596 H H CD3 H CD3 H 1597H H CD3 H CH3 CD3 1598 H H CD3 H CH3 CH3 1599 H H CD3 H CH3 H 1600 H HCD3 H H 2,6DIP 1601 H H CD3 H H 2,6DMB 1602 H H CD3 H H CD3 1603 H H CD3H H CH3 1604 H H CD3 H H H 1605 H H CD3 H H iPr 1606 H H CD3 H iPr H1607 H H CD3 iPr H H 1608 H H CH3 CD3 CD3 H 1609 H H CH3 CD3 CH3 H 1610H H CH3 CD3 H CD3 1611 H H CH3 CD3 H CH3 1612 H H CH3 CD3 H H 1613 H HCH3 CH3 CD3 H 1614 H H CH3 CH3 CH3 H 1615 H H CH3 CH3 H CD3 1616 H H CH3CH3 H CH3 1617 H H CH3 CH3 H H 1618 H H CH3 H 2,6DIP H 1619 H H CH3 H2,6DMB H 1620 H H CH3 H CD3 CD3 1621 H H CH3 H CD3 CH3 1622 H H CH3 HCD3 H 1623 H H CH3 H CH3 CD3 1624 H H CH3 H CH3 CH3 1625 H H CH3 H CH3 H1626 H H CH3 H H 2,6DIP 1627 H H CH3 H H 2,6DMB 1628 H H CH3 H H CD31629 H H CH3 H H CH3 1630 H H CH3 H H H 1631 H H CH3 H H iPr 1632 H HCH3 H iPr H 1633 H H CH3 iPr H H 1634 H H H 2,6DIP H CD3 1635 H H H2,6DIP H CH3 1636 H H H 2,6DIP H H 1637 H H H 2,6DMB H CD3 1638 H H H2,6DMB H CH3 1639 H H H 2,6DMB H H 1640 H H H CD3 CD3 H 1641 H H H CD3CH3 H 1642 H H H CD3 H 2,6DIP 1643 H H H CD3 H 2,6DMB 1644 H H H CD3 HCD3 1645 H H H CD3 H CH3 1646 H H H CD3 H H 1647 H H H CD3 H iPr 1648 HH H CD3 iPr H 1649 H H H CH3 CD3 H 1650 H H H CH3 CH3 H 1651 H H H CH3 H2,6DIP 1652 H H H CH3 H 2,6DMB 1653 H H H CH3 H CD3 1654 H H H CH3 H CH31655 H H H CH3 H H 1656 H H H CH3 H iPr 1657 H H H CH3 iPr H 1658 H H HH 2,6DIP H 1659 H H H H 2,6DMB H 1660 H H H H CD3 CD3 1661 H H H H CD3CH3 1662 H H H H CD3 H 1663 H H H H CD3 iPr 1664 H H H H CH3 CD3 1665 HH H H CH3 CH3 1666 H H H H CH3 H 1667 H H H H CH3 iPr 1668 H H H H H2,6DIP 1669 H H H H H 2,6DMB 1670 H H H H H CD3 1671 H H H H H CH3 1672H H H H H H 1673 H H H H H iPr 1674 H H H H iPr CD3 1675 H H H H iPr CH31676 H H H H iPr H 1677 H H H iPr CD3 H 1678 H H H iPr CH3 H 1679 H H HiPr H CD3 1680 H H H iPr H CH3 1681 H H H iPr H H 1682 H H ph CD3 CD3 H1683 H H ph CD3 CH3 H 1684 H H ph CD3 H CD3 1685 H H ph CD3 H CH3 1686 HH ph CD3 H H 1687 H H ph CH3 CD3 H 1688 H H ph CH3 CH3 H 1689 H H ph CH3H CD3 1690 H H ph CH3 H CH3 1691 H H ph CH3 H H 1692 H H ph H CD3 CD31693 H H ph H CD3 CH3 1694 H H ph H CD3 H 1695 H H ph H CH3 CD3 1696 H Hph H CH3 CH3 1697 H H ph H CH3 H 1698 H H ph H H CD3 1699 H H ph H H CH31700 H H ph H H H 1701 H iPr CD3 H H H 1702 H iPr CH3 H H H 1703 H iPr HCD3 H H 1704 H iPr H CH3 H H 1705 H iPr H H CD3 H 1706 H iPr H H CH3 H1707 H iPr H H H CD3 1708 H iPr H H H CH3 1709 H iPr H H H H 1710 iPrCD3 H H H H 1711 iPr CH3 H H H H 1712 iPr H CD3 H H H 1713 iPr H CH3 H HH 1714 iPr H H CD3 H H 1715 iPr H H CH3 H H 1716 iPr H H H CD3 H 1717iPr H H H CH3 H 1718 iPr H H H H CD3 1719 iPr H H H H CH3 1720 iPr H H HH HLA1721 to LA2200 based on structure:

LA # R11 R12 R2 R31 R32 R34 1721 CD3 CD3 2,6DIP H H H 1722 CD3 CD32,6DIPB H H H 1723 CD3 CD3 2,6DMB H H H 1724 CD3 CD3 CD3 H H H 1725 CD3CD3 CH3 H H H 1726 CD3 CD3 H H H H 1727 CD3 CD3 ph H H H 1728 CD3 CH32,6DIP H H H 1729 CD3 CH3 2,6DIPB H H H 1730 CD3 CH3 2,6DMB H H H 1731CD3 CH3 CD3 H H H 1732 CD3 CH3 CH3 H H H 1733 CD3 CH3 H H H H 1734 CD3CH3 ph H H H 1735 CD3 H 2,6DIP CD3 H H 1736 CD3 H 2,6DIP CH3 H H 1737CD3 H 2,6DIP H CD3 H 1738 CD3 H 2,6DIP H CH3 H 1739 CD3 H 2,6DIP H H CD31740 CD3 H 2,6DIP H H CH3 1741 CD3 H 2,6DIP H H H 1742 CD3 H 2,6DIPB CD3H H 1743 CD3 H 2,6DIPB CH3 H H 1744 CD3 H 2,6DIPB H CD3 H 1745 CD3 H2,6DIPB H CH3 H 1746 CD3 H 2,6DIPB H H CD3 1747 CD3 H 2,6DIPB H H CH31748 CD3 H 2,6DIPB H H H 1749 CD3 H 2,6DMB CD3 H H 1750 CD3 H 2,6DMB CH3H H 1751 CD3 H 2,6DMB H CD3 H 1752 CD3 H 2,6DMB H CH3 H 1753 CD3 H2,6DMB H H CD3 1754 CD3 H 2,6DMB H H CH3 1755 CD3 H 2,6DMB H H H 1756CD3 H CD3 CD3 H H 1757 CD3 H CD3 CH3 H H 1758 CD3 H CD3 H CD3 H 1759 CD3H CD3 H CH3 H 1760 CD3 H CD3 H H CD3 1761 CD3 H CD3 H H CH3 1762 CD3 HCD3 H H H 1763 CD3 H CH3 CD3 H H 1764 CD3 H CH3 CH3 H H 1765 CD3 H CH3 HCD3 H 1766 CD3 H CH3 H CH3 H 1767 CD3 H CH3 H H CD3 1768 CD3 H CH3 H HCH3 1769 CD3 H CH3 H H H 1770 CD3 H H 2,6DIP H H 1771 CD3 H H 2,6DMB H H1772 CD3 H H CD3 H H 1773 CD3 H H CH3 H H 1774 CD3 H H H 2,6DIP H 1775CD3 H H H 2,6DMB H 1776 CD3 H H H CD3 H 1777 CD3 H H H CH3 H 1778 CD3 HH H H 2,6DIP 1779 CD3 H H H H 2,6DMB 1780 CD3 H H H H CD3 1781 CD3 H H HH CH3 1782 CD3 H H H H H 1783 CD3 H H H H iPr 1784 CD3 H H H iPr H 1785CD3 H H iPr H H 1786 CD3 H ph CD3 H H 1787 CD3 H ph CH3 H H 1788 CD3 Hph H CD3 H 1789 CD3 H ph H CH3 H 1790 CD3 H ph H H CD3 1791 CD3 H ph H HCH3 1792 CD3 H ph H H H 1793 CD3 iPr H H H H 1794 CH3 CD3 2,6DIP H H H1795 CH3 CD3 2,6DIPB H H H 1796 CH3 CD3 2,6DMB H H H 1797 CH3 CD3 CD3 HH H 1798 CH3 CD3 CH3 H H H 1799 CH3 CD3 H H H H 1800 CH3 CD3 ph H H H1801 CH3 CH3 2,6DIP H H H 1802 CH3 CH3 2,6DIPB H H H 1803 CH3 CH3 2,6DMBH H H 1804 CH3 CH3 CD3 H H H 1805 CH3 CH3 CH3 H H H 1806 CH3 CH3 H H H H1807 CH3 CH3 ph H H H 1808 CH3 H 2,6DIP CD3 H H 1809 CH3 H 2,6DIP CH3 HH 1810 CH3 H 2,6DIP H CD3 H 1811 CH3 H 2,6DIP H CH3 H 1812 CH3 H 2,6DIPH H CD3 1813 CH3 H 2,6DIP H H CH3 1814 CH3 H 2,6DIP H H H 1815 CH3 H2,6DIPB CD3 H H 1816 CH3 H 2,6DIPB CH3 H H 1817 CH3 H 2,6DIPB H CD3 H1818 CH3 H 2,6DIPB H CH3 H 1819 CH3 H 2,6DIPB H H CD3 1820 CH3 H 2,6DIPBH H CH3 1821 CH3 H 2,6DIPB H H H 1822 CH3 H 2,6DMB CD3 H H 1823 CH3 H2,6DMB CH3 H H 1824 CH3 H 2,6DMB H CD3 H 1825 CH3 H 2,6DMB H CH3 H 1826CH3 H 2,6DMB H H CD3 1827 CH3 H 2,6DMB H H CH3 1828 CH3 H 2,6DMB H H H1829 CH3 H CD3 CD3 H H 1830 CH3 H CD3 CH3 H H 1831 CH3 H CD3 H CD3 H1832 CH3 H CD3 H CH3 H 1833 CH3 H CD3 H H CD3 1834 CH3 H CD3 H H CH31835 CH3 H CD3 H H H 1836 CH3 H CH3 CD3 H H 1837 CH3 H CH3 CH3 H H 1838CH3 H CH3 H CD3 H 1839 CH3 H CH3 H CH3 H 1840 CH3 H CH3 H H CD3 1841 CH3H CH3 H H CH3 1842 CH3 H CH3 H H H 1843 CH3 H H 2,6DIP H H 1844 CH3 H H2,6DMB H H 1845 CH3 H H CD3 H H 1846 CH3 H H CH3 H H 1847 CH3 H H H2,6DIP H 1848 CH3 H H H 2,6DMB H 1849 CH3 H H H CD3 H 1850 CH3 H H H CH3H 1851 CH3 H H H H 2,6DIP 1852 CH3 H H H H 2,6DMB 1853 CH3 H H H H CD31854 CH3 H H H H CH3 1855 CH3 H H H H H 1856 CH3 H H H H iPr 1857 CH3 HH H iPr H 1858 CH3 H H iPr H H 1859 CH3 H ph CD3 H H 1860 CH3 H ph CH3 HH 1861 CH3 H ph H CD3 H 1862 CH3 H ph H CH3 H 1863 CH3 H ph H H CD3 1864CH3 H ph H H CH3 1865 CH3 H ph H H H 1866 CH3 iPr H H H H 1867 H 2,6DIPH CD3 H H 1868 H 2,6DIP H CH3 H H 1869 H 2,6DIP H H CD3 H 1870 H 2,6DIPH H CH3 H 1871 H 2,6DIP H H H CD3 1872 H 2,6DIP H H H CH3 1873 H 2,6DIPH H H H 1874 H 2,6DMB H CD3 H H 1875 H 2,6DMB H CH3 H H 1876 H 2,6DMB HH CD3 H 1877 H 2,6DMB H H CH3 H 1878 H 2,6DMB H H H CD3 1879 H 2,6DMB HH H CH3 1880 H 2,6DMB H H H H 1881 H CD3 2,6DIP CD3 H H 1882 H CD32,6DIP CH3 H H 1883 H CD3 2,6DIP H CD3 H 1884 H CD3 2,6DIP H CH3 H 1885H CD3 2,6DIP H H CD3 1886 H CD3 2,6DIP H H CH3 1887 H CD3 2,6DIP H H H1888 H CD3 2,6DIPB CD3 H H 1889 H CD3 2,6DIPB CH3 H H 1890 H CD3 2,6DIPBH CD3 H 1891 H CD3 2,6DIPB H CH3 H 1892 H CD3 2,6DIPB H H CD3 1893 H CD32,6DIPB H H CH3 1894 H CD3 2,6DIPB H H H 1895 H CD3 2,6DMB CD3 H H 1896H CD3 2,6DMB CH3 H H 1897 H CD3 2,6DMB H CD3 H 1898 H CD3 2,6DMB H CH3 H1899 H CD3 2,6DMB H H CD3 1900 H CD3 2,6DMB H H CH3 1901 H CD3 2,6DMB HH H 1902 H CD3 CD3 CD3 H H 1903 H CD3 CD3 CH3 H H 1904 H CD3 CD3 H CD3 H1905 H CD3 CD3 H CH3 H 1906 H CD3 CD3 H H CD3 1907 H CD3 CD3 H H CH31908 H CD3 CD3 H H H 1909 H CD3 CH3 CD3 H H 1910 H CD3 CH3 CH3 H H 1911H CD3 CH3 H CD3 H 1912 H CD3 CH3 H CH3 H 1913 H CD3 CH3 H H CD3 1914 HCD3 CH3 H H CH3 1915 H CD3 CH3 H H H 1916 H CD3 H 2,6DIP H H 1917 H CD3H 2,6DMB H H 1918 H CD3 H CD3 H H 1919 H CD3 H CH3 H H 1920 H CD3 H H2,6DIP H 1921 H CD3 H H 2,6DMB H 1922 H CD3 H H CD3 H 1923 H CD3 H H CH3H 1924 H CD3 H H H 2,6DIP 1925 H CD3 H H H 2,6DMB 1926 H CD3 H H H CD31927 H CD3 H H H CH3 1928 H CD3 H H H H 1929 H CD3 H H H iPr 1930 H CD3H H iPr H 1931 H CD3 H iPr H H 1932 H CD3 ph CD3 H H 1933 H CD3 ph CH3 HH 1934 H CD3 ph H CD3 H 1935 H CD3 ph H CH3 H 1936 H CD3 ph H H CD3 1937H CD3 ph H H CH3 1938 H CD3 ph H H H 1939 H CH3 2,6DIP CD3 H H 1940 HCH3 2,6DIP CH3 H H 1941 H CH3 2,6DIP H CD3 H 1942 H CH3 2,6DIP H CH3 H1943 H CH3 2,6DIP H H CD3 1944 H CH3 2,6DIP H H CH3 1945 H CH3 2,6DIP HH H 1946 H CH3 2,6DIPB CD3 H H 1947 H CH3 2,6DIPB CH3 H H 1948 H CH32,6DIPB H CD3 H 1949 H CH3 2,6DIPB H CH3 H 1950 H CH3 2,6DIPB H H CD31951 H CH3 2,6DIPB H H CH3 1952 H CH3 2,6DIPB H H H 1953 H CH3 2,6DMBCD3 H H 1954 H CH3 2,6DMB CH3 H H 1955 H CH3 2,6DMB H CD3 H 1956 H CH32,6DMB H CH3 H 1957 H CH3 2,6DMB H H CD3 1958 H CH3 2,6DMB H H CH3 1959H CH3 2,6DMB H H H 1960 H CH3 CD3 CD3 H H 1961 H CH3 CD3 CH3 H H 1962 HCH3 CD3 H CD3 H 1963 H CH3 CD3 H CH3 H 1964 H CH3 CD3 H H CD3 1965 H CH3CD3 H H CH3 1966 H CH3 CD3 H H H 1967 H CH3 CH3 CD3 H H 1968 H CH3 CH3CH3 H H 1969 H CH3 CH3 H CD3 H 1970 H CH3 CH3 H CH3 H 1971 H CH3 CH3 H HCD3 1972 H CH3 CH3 H H CH3 1973 H CH3 CH3 H H H 1974 H CH3 H 2,6DIP H H1975 H CH3 H 2,6DMB H H 1976 H CH3 H CD3 H H 1977 H CH3 H CH3 H H 1978 HCH3 H H 2,6DIP H 1979 H CH3 H H 2,6DMB H 1980 H CH3 H H CD3 H 1981 H CH3H H CH3 H 1982 H CH3 H H H 2,6DIP 1983 H CH3 H H H 2,6DMB 1984 H CH3 H HH CD3 1985 H CH3 H H H CH3 1986 H CH3 H H H H 1987 H CH3 H H H iPr 1988H CH3 H H iPr H 1989 H CH3 H iPr H H 1990 H CH3 ph CD3 H H 1991 H CH3 phCH3 H H 1992 H CH3 ph H CD3 H 1993 H CH3 ph H CH3 H 1994 H CH3 ph H HCD3 1995 H CH3 ph H H CH3 1996 H CH3 ph H H H 1997 H H 2,6DIP CD3 CD3 H1998 H H 2,6DIP CD3 CH3 H 1999 H H 2,6DIP CD3 H CD3 2000 H H 2,6DIP CD3H CH3 2001 H H 2,6DIP CD3 H H 2002 H H 2,6DIP CH3 CD3 H 2003 H H 2,6DIPCH3 CH3 H 2004 H H 2,6DIP CH3 H CD3 2005 H H 2,6DIP CH3 H CH3 2006 H H2,6DIP CH3 H H 2007 H H 2,6DIP H CD3 CD3 2008 H H 2,6DIP H CD3 CH3 2009H H 2,6DIP H CD3 H 2010 H H 2,6DIP H CH3 CD3 2011 H H 2,6DIP H CH3 CH32012 H H 2,6DIP H CH3 H 2013 H H 2,6DIP H H CD3 2014 H H 2,6DIP H H CH32015 H H 2,6DIP H H H 2016 H H 2,6DIPB CD3 CD3 H 2017 H H 2,6DIPB CD3CH3 H 2018 H H 2,6DIPB CD3 H CD3 2019 H H 2,6DIPB CD3 H CH3 2020 H H2,6DIPB CD3 H H 2021 H H 2,6DIPB CH3 CD3 H 2022 H H 2,6DIPB CH3 CH3 H2023 H H 2,6DIPB CH3 H CD3 2024 H H 2,6DIPB CH3 H CH3 2025 H H 2,6DIPBCH3 H H 2026 H H 2,6DIPB H CD3 CD3 2027 H H 2,6DIPB H CD3 CH3 2028 H H2,6DIPB H CD3 H 2029 H H 2,6DIPB H CH3 CD3 2030 H H 2,6DIPB H CH3 CH32031 H H 2,6DIPB H CH3 H 2032 H H 2,6DIPB H H CD3 2033 H H 2,6DIPB H HCH3 2034 H H 2,6DIPB H H H 2035 H H 2,6DMB CD3 CD3 H 2036 H H 2,6DMB CD3CH3 H 2037 H H 2,6DMB CD3 H CD3 2038 H H 2,6DMB CD3 H CH3 2039 H H2,6DMB CD3 H H 2040 H H 2,6DMB CH3 CD3 H 2041 H H 2,6DMB CH3 CH3 H 2042H H 2,6DMB CH3 H CD3 2043 H H 2,6DMB CH3 H CH3 2044 H H 2,6DMB CH3 H H2045 H H 2,6DMB H CD3 CD3 2046 H H 2,6DMB H CD3 CH3 2047 H H 2,6DMB HCD3 H 2048 H H 2,6DMB H CH3 CD3 2049 H H 2,6DMB H CH3 CH3 2050 H H2,6DMB H CH3 H 2051 H H 2,6DMB H H CD3 2052 H H 2,6DMB H H CH3 2053 H H2,6DMB H H H 2054 H H CD3 CD3 CD3 H 2055 H H CD3 CD3 CH3 H 2056 H H CD3CD3 H CD3 2057 H H CD3 CD3 H CH3 2058 H H CD3 CD3 H H 2059 H H CD3 CH3CD3 H 2060 H H CD3 CH3 CH3 H 2061 H H CD3 CH3 H CD3 2062 H H CD3 CH3 HCH3 2063 H H CD3 CH3 H H 2064 H H CD3 H 2,6DIP H 2065 H H CD3 H 2,6DMB H2066 H H CD3 H CD3 CD3 2067 H H CD3 H CD3 CH3 2068 H H CD3 H CD3 H 2069H H CD3 H CH3 CD3 2070 H H CD3 H CH3 CH3 2071 H H CD3 H CH3 H 2072 H HCD3 H H 2,6DIP 2073 H H CD3 H H 2,6DMB 2074 H H CD3 H H CD3 2075 H H CD3H H CH3 2076 H H CD3 H H H 2077 H H CD3 H H iPr 2078 H H CD3 H iPr H2079 H H CD3 iPr H H 2080 H H CH3 CD3 CD3 H 2081 H H CH3 CD3 CH3 H 2082H H CH3 CD3 H CD3 2083 H H CH3 CD3 H CH3 2084 H H CH3 CD3 H H 2085 H HCH3 CH3 CD3 H 2086 H H CH3 CH3 CH3 H 2087 H H CH3 CH3 H CD3 2088 H H CH3CH3 H CH3 2089 H H CH3 CH3 H H 2090 H H CH3 H 2,6DIP H 2091 H H CH3 H2,6DMB H 2092 H H CH3 H CD3 CD3 2093 H H CH3 H CD3 CH3 2094 H H CH3 HCD3 H 2095 H H CH3 H CH3 CD3 2096 H H CH3 H CH3 CH3 2097 H H CH3 H CH3 H2098 H H CH3 H H 2,6DIP 2099 H H CH3 H H 2,6DMB 2100 H H CH3 H H CD32101 H H CH3 H H CH3 2102 H H CH3 H H H 2103 H H CH3 H H iPr 2104 H HCH3 H iPr H 2105 H H CH3 iPr H H 2106 H H H 2,6DIP H CD3 2107 H H H2,6DIP H CH3 2108 H H H 2,6DIP H H 2109 H H H 2,6DMB H CD3 2110 H H H2,6DMB H CH3 2111 H H H 2,6DMB H H 2112 H H H CD3 CD3 H 2113 H H H CD3CH3 H 2114 H H H CD3 H 2,6DIP 2115 H H H CD3 H 2,6DMB 2116 H H H CD3 HCD3 2117 H H H CD3 H CH3 2118 H H H CD3 H H 2119 H H H CD3 H iPr 2120 HH H CD3 iPr H 2121 H H H CH3 CD3 H 2122 H H H CH3 CH3 H 2123 H H H CH3 H2,6DIP 2124 H H H CH3 H 2,6DMB 2125 H H H CH3 H CD3 2126 H H H CH3 H CH32127 H H H CH3 H H 2128 H H H CH3 H iPr 2129 H H H CH3 iPr H 2130 H H HH 2,6DIP CD3 2131 H H H H 2,6DIP CH3 2132 H H H H 2,6DIP H 2133 H H H H2,6DMB CD3 2134 H H H H 2,6DMB CH3 2135 H H H H 2,6DMB H 2136 H H H HCD3 2,6DIP 2137 H H H H CD3 2,6DMB 2138 H H H H CD3 CD3 2139 H H H H CD3CH3 2140 H H H H CD3 H 2141 H H H H CD3 iPr 2142 H H H H CH3 2,6DIP 2143H H H H CH3 2,6DMB 2144 H H H H CH3 CD3 2145 H H H H CH3 CH3 2146 H H HH CH3 H 2147 H H H H CH3 iPr 2148 H H H H H 2,6DIP 2149 H H H H H 2,6DMB2150 H H H H H CD3 2151 H H H H H CH3 2152 H H H H H H 2153 H H H H HiPr 2154 H H H H iPr CD3 2155 H H H H iPr CH3 2156 H H H H iPr H 2157 HH H iPr CD3 H 2158 H H H iPr CH3 H 2159 H H H iPr H CD3 2160 H H H iPr HCH3 2161 H H H iPr H H 2162 H H ph CD3 CD3 H 2163 H H ph CD3 CH3 H 2164H H ph CD3 H CD3 2165 H H ph CD3 H CH3 2166 H H ph CD3 H H 2167 H H phCH3 CD3 H 2168 H H ph CH3 CH3 H 2169 H H ph CH3 H CD3 2170 H H ph CH3 HCH3 2171 H H ph CH3 H H 2172 H H ph H CD3 CD3 2173 H H ph H CD3 CH3 2174H H ph H CD3 H 2175 H H ph H CH3 CD3 2176 H H ph H CH3 CH3 2177 H H ph HCH3 H 2178 H H ph H H CD3 2179 H H ph H H CH3 2180 H H ph H H H 2181 HiPr CD3 H H H 2182 H iPr CH3 H H H 2183 H iPr H CD3 H H 2184 H iPr H CH3H H 2185 H iPr H H CD3 H 2186 H iPr H H CH3 H 2187 H iPr H H H CD3 2188H iPr H H H CH3 2189 H iPr H H H H 2190 iPr CD3 H H H H 2191 iPr CH3 H HH H 2192 iPr H CD3 H H H 2193 iPr H CH3 H H H 2194 iPr H H CD3 H H 2195iPr H H CH3 H H 2196 iPr H H H CD3 H 2197 iPr H H H CH3 H 2198 iPr H H HH CD3 2199 iPr H H H H CH3 2200 iPr H H H H HLA2201 to LA2680 based on structure:

LA # R11 R12 R2 R31 R33 R34 2201 CD3 CD3 2,6DIP H H H 2202 CD3 CD32,6DIPB H H H 2203 CD3 CD3 2,6DMB H H H 2204 CD3 CD3 CD3 H H H 2205 CD3CD3 CH3 H H H 2206 CD3 CD3 H H H H 2207 CD3 CD3 ph H H H 2208 CD3 CH32,6DIP H H H 2209 CD3 CH3 2,6DIPB H H H 2210 CD3 CH3 2,6DMB H H H 2211CD3 CH3 CD3 H H H 2212 CD3 CH3 CH3 H H H 2213 CD3 CH3 H H H H 2214 CD3CH3 ph H H H 2215 CD3 H 2,6DIP CD3 H H 2216 CD3 H 2,6DIP CH3 H H 2217CD3 H 2,6DIP H CD3 H 2218 CD3 H 2,6DIP H CH3 H 2219 CD3 H 2,6DIP H H CD32220 CD3 H 2,6DIP H H CH3 2221 CD3 H 2,6DIP H H H 2222 CD3 H 2,6DIPB CD3H H 2223 CD3 H 2,6DIPB CH3 H H 2224 CD3 H 2,6DIPB H CD3 H 2225 CD3 H2,6DIPB H CH3 H 2226 CD3 H 2,6DIPB H H CD3 2227 CD3 H 2,6DIPB H H CH32228 CD3 H 2,6DIPB H H H 2229 CD3 H 2,6DMB CD3 H H 2230 CD3 H 2,6DMB CH3H H 2231 CD3 H 2,6DMB H CD3 H 2232 CD3 H 2,6DMB H CH3 H 2233 CD3 H2,6DMB H H CD3 2234 CD3 H 2,6DMB H H CH3 2235 CD3 H 2,6DMB H H H 2236CD3 H CD3 CD3 H H 2237 CD3 H CD3 CH3 H H 2238 CD3 H CD3 H CD3 H 2239 CD3H CD3 H CH3 H 2240 CD3 H CD3 H H CD3 2241 CD3 H CD3 H H CH3 2242 CD3 HCD3 H H H 2243 CD3 H CH3 CD3 H H 2244 CD3 H CH3 CH3 H H 2245 CD3 H CH3 HCD3 H 2246 CD3 H CH3 H CH3 H 2247 CD3 H CH3 H H CD3 2248 CD3 H CH3 H HCH3 2249 CD3 H CH3 H H H 2250 CD3 H H 2,6DIP H H 2251 CD3 H H 2,6DMB H H2252 CD3 H H CD3 H H 2253 CD3 H H CH3 H H 2254 CD3 H H H 2,6DIP H 2255CD3 H H H 2,6DMB H 2256 CD3 H H H CD3 H 2257 CD3 H H H CH3 H 2258 CD3 HH H H 2,6DIP 2259 CD3 H H H H 2,6DMB 2260 CD3 H H H H CD3 2261 CD3 H H HH CH3 2262 CD3 H H H H H 2263 CD3 H H H H iPr 2264 CD3 H H H iPr H 2265CD3 H H iPr H H 2266 CD3 H ph CD3 H H 2267 CD3 H ph CH3 H H 2268 CD3 Hph H CD3 H 2269 CD3 H ph H CH3 H 2270 CD3 H ph H H CD3 2271 CD3 H ph H HCH3 2272 CD3 H ph H H H 2273 CD3 iPr H H H H 2274 CH3 CD3 2,6DIP H H H2275 CH3 CD3 2,6DIPB H H H 2276 CH3 CD3 2,6DMB H H H 2277 CH3 CD3 CD3 HH H 2278 CH3 CD3 CH3 H H H 2279 CH3 CD3 H H H H 2280 CH3 CD3 ph H H H2281 CH3 CH3 2,6DIP H H H 2282 CH3 CH3 2,6DIPB H H H 2283 CH3 CH3 2,6DMBH H H 2284 CH3 CH3 CD3 H H H 2285 CH3 CH3 CH3 H H H 2286 CH3 CH3 H H H H2287 CH3 CH3 ph H H H 2288 CH3 H 2,6DIP CD3 H H 2289 CH3 H 2,6DIP CH3 HH 2290 CH3 H 2,6DIP H CD3 H 2291 CH3 H 2,6DIP H CH3 H 2292 CH3 H 2,6DIPH H CD3 2293 CH3 H 2,6DIP H H CH3 2294 CH3 H 2,6DIP H H H 2295 CH3 H2,6DIPB CD3 H H 2296 CH3 H 2,6DIPB CH3 H H 2297 CH3 H 2,6DIPB H CD3 H2298 CH3 H 2,6DIPB H CH3 H 2299 CH3 H 2,6DIPB H H CD3 2300 CH3 H 2,6DIPBH H CH3 2301 CH3 H 2,6DIPB H H H 2302 CH3 H 2,6DMB CD3 H H 2303 CH3 H2,6DMB CH3 H H 2304 CH3 H 2,6DMB H CD3 H 2305 CH3 H 2,6DMB H CH3 H 2306CH3 H 2,6DMB H H CD3 2307 CH3 H 2,6DMB H H CH3 2308 CH3 H 2,6DMB H H H2309 CH3 H CD3 CD3 H H 2310 CH3 H CD3 CH3 H H 2311 CH3 H CD3 H CD3 H2312 CH3 H CD3 H CH3 H 2313 CH3 H CD3 H H CD3 2314 CH3 H CD3 H H CH32315 CH3 H CD3 H H H 2316 CH3 H CH3 CD3 H H 2317 CH3 H CH3 CH3 H H 2318CH3 H CH3 H CD3 H 2319 CH3 H CH3 H CH3 H 2320 CH3 H CH3 H H CD3 2321 CH3H CH3 H H CH3 2322 CH3 H CH3 H H H 2323 CH3 H H 2,6DIP H H 2324 CH3 H H2,6DMB H H 2325 CH3 H H CD3 H H 2326 CH3 H H CH3 H H 2327 CH3 H H H2,6DIP H 2328 CH3 H H H 2,6DMB H 2329 CH3 H H H CD3 H 2330 CH3 H H H CH3H 2331 CH3 H H H H 2,6DIP 2332 CH3 H H H H 2,6DMB 2333 CH3 H H H H CD32334 CH3 H H H H CH3 2335 CH3 H H H H H 2336 CH3 H H H H iPr 2337 CH3 HH H iPr H 2338 CH3 H H iPr H H 2339 CH3 H ph CD3 H H 2340 CH3 H ph CH3 HH 2341 CH3 H ph H CD3 H 2342 CH3 H ph H CH3 H 2343 CH3 H ph H H CD3 2344CH3 H ph H H CH3 2345 CH3 H ph H H H 2346 CH3 iPr H H H H 2347 H 2,6DIPH CD3 H H 2348 H 2,6DIP H CH3 H H 2349 H 2,6DIP H H CD3 H 2350 H 2,6DIPH H CH3 H 2351 H 2,6DIP H H H CD3 2352 H 2,6DIP H H H CH3 2353 H 2,6DIPH H H H 2354 H 2,6DMB H CD3 H H 2355 H 2,6DMB H CH3 H H 2356 H 2,6DMB HH CD3 H 2357 H 2,6DMB H H CH3 H 2358 H 2,6DMB H H H CD3 2359 H 2,6DMB HH H CH3 2360 H 2,6DMB H H H H 2361 H CD3 2,6DIP CD3 H H 2362 H CD32,6DIP CH3 H H 2363 H CD3 2,6DIP H CD3 H 2364 H CD3 2,6DIP H CH3 H 2365H CD3 2,6DIP H H CD3 2366 H CD3 2,6DIP H H CH3 2367 H CD3 2,6DIP H H H2368 H CD3 2,6DIPB CD3 H H 2369 H CD3 2,6DIPB CH3 H H 2370 H CD3 2,6DIPBH CD3 H 2371 H CD3 2,6DIPB H CH3 H 2372 H CD3 2,6DIPB H H CD3 2373 H CD32,6DIPB H H CH3 2374 H CD3 2,6DIPB H H H 2375 H CD3 2,6DMB CD3 H H 2376H CD3 2,6DMB CH3 H H 2377 H CD3 2,6DMB H CD3 H 2378 H CD3 2,6DMB H CH3 H2379 H CD3 2,6DMB H H CD3 2380 H CD3 2,6DMB H H CH3 2381 H CD3 2,6DMB HH H 2382 H CD3 CD3 CD3 H H 2383 H CD3 CD3 CH3 H H 2384 H CD3 CD3 H CD3 H2385 H CD3 CD3 H CH3 H 2386 H CD3 CD3 H H CD3 2387 H CD3 CD3 H H CH32388 H CD3 CD3 H H H 2389 H CD3 CH3 CD3 H H 2390 H CD3 CH3 CH3 H H 2391H CD3 CH3 H CD3 H 2392 H CD3 CH3 H CH3 H 2393 H CD3 CH3 H H CD3 2394 HCD3 CH3 H H CH3 2395 H CD3 CH3 H H H 2396 H CD3 H 2,6DIP H H 2397 H CD3H 2,6DMB H H 2398 H CD3 H CD3 H H 2399 H CD3 H CH3 H H 2400 H CD3 H H2,6DIP H 2401 H CD3 H H 2,6DMB H 2402 H CD3 H H CD3 H 2403 H CD3 H H CH3H 2404 H CD3 H H H 2,6DIP 2405 H CD3 H H H 2,6DMB 2406 H CD3 H H H CD32407 H CD3 H H H CH3 2408 H CD3 H H H H 2409 H CD3 H H H iPr 2410 H CD3H H iPr H 2411 H CD3 H iPr H H 2412 H CD3 ph CD3 H H 2413 H CD3 ph CH3 HH 2414 H CD3 ph H CD3 H 2415 H CD3 ph H CH3 H 2416 H CD3 ph H H CD3 2417H CD3 ph H H CH3 2418 H CD3 ph H H H 2419 H CH3 2,6DIP CD3 H H 2420 HCH3 2,6DIP CH3 H H 2421 H CH3 2,6DIP H CD3 H 2422 H CH3 2,6DIP H CH3 H2423 H CH3 2,6DIP H H CD3 2424 H CH3 2,6DIP H H CH3 2425 H CH3 2,6DIP HH H 2426 H CH3 2,6DIPB CD3 H H 2427 H CH3 2,6DIPB CH3 H H 2428 H CH32,6DIPB H CD3 H 2429 H CH3 2,6DIPB H CH3 H 2430 H CH3 2,6DIPB H H CD32431 H CH3 2,6DIPB H H CH3 2432 H CH3 2,6DIPB H H H 2433 H CH3 2,6DMBCD3 H H 2434 H CH3 2,6DMB CH3 H H 2435 H CH3 2,6DMB H CD3 H 2436 H CH32,6DMB H CH3 H 2437 H CH3 2,6DMB H H CD3 2438 H CH3 2,6DMB H H CH3 2439H CH3 2,6DMB H H H 2440 H CH3 CD3 CD3 H H 2441 H CH3 CD3 CH3 H H 2442 HCH3 CD3 H CD3 H 2443 H CH3 CD3 H CH3 H 2444 H CH3 CD3 H H CD3 2445 H CH3CD3 H H CH3 2446 H CH3 CD3 H H H 2447 H CH3 CH3 CD3 H H 2448 H CH3 CH3CH3 H H 2449 H CH3 CH3 H CD3 H 2450 H CH3 CH3 H CH3 H 2451 H CH3 CH3 H HCD3 2452 H CH3 CH3 H H CH3 2453 H CH3 CH3 H H H 2454 H CH3 H 2,6DIP H H2455 H CH3 H 2,6DMB H H 2456 H CH3 H CD3 H H 2457 H CH3 H CH3 H H 2458 HCH3 H H 2,6DIP H 2459 H CH3 H H 2,6DMB H 2460 H CH3 H H CD3 H 2461 H CH3H H CH3 H 2462 H CH3 H H H 2,6DIP 2463 H CH3 H H H 2,6DMB 2464 H CH3 H HH CD3 2465 H CH3 H H H CH3 2466 H CH3 H H H H 2467 H CH3 H H H iPr 2468H CH3 H H iPr H 2469 H CH3 H iPr H H 2470 H CH3 ph CD3 H H 2471 H CH3 phCH3 H H 2472 H CH3 ph H CD3 H 2473 H CH3 ph H CH3 H 2474 H CH3 ph H HCD3 2475 H CH3 ph H H CH3 2476 H CH3 ph H H H 2477 H H 2,6DIP CD3 CD3 H2478 H H 2,6DIP CD3 CH3 H 2479 H H 2,6DIP CD3 H CD3 2480 H H 2,6DIP CD3H CH3 2481 H H 2,6DIP CD3 H H 2482 H H 2,6DIP CH3 CD3 H 2483 H H 2,6DIPCH3 CH3 H 2484 H H 2,6DIP CH3 H CD3 2485 H H 2,6DIP CH3 H CH3 2486 H H2,6DIP CH3 H H 2487 H H 2,6DIP H CD3 CD3 2488 H H 2,6DIP H CD3 CH3 2489H H 2,6DIP H CD3 H 2490 H H 2,6DIP H CH3 CD3 2491 H H 2,6DIP H CH3 CH32492 H H 2,6DIP H CH3 H 2493 H H 2,6DIP H H CD3 2494 H H 2,6DIP H H CH32495 H H 2,6DIP H H H 2496 H H 2,6DIPB CD3 CD3 H 2497 H H 2,6DIPB CD3CH3 H 2498 H H 2,6DIPB CD3 H CD3 2499 H H 2,6DIPB CD3 H CH3 2500 H H2,6DIPB CD3 H H 2501 H H 2,6DIPB CH3 CD3 H 2502 H H 2,6DIPB CH3 CH3 H2503 H H 2,6DIPB CH3 H CD3 2504 H H 2,6DIPB CH3 H CH3 2505 H H 2,6DIPBCH3 H H 2506 H H 2,6DIPB H CD3 CD3 2507 H H 2,6DIPB H CD3 CH3 2508 H H2,6DIPB H CD3 H 2509 H H 2,6DIPB H CH3 CD3 2510 H H 2,6DIPB H CH3 CH32511 H H 2,6DIPB H CH3 H 2512 H H 2,6DIPB H H CD3 2513 H H 2,6DIPB H HCH3 2514 H H 2,6DIPB H H H 2515 H H 2,6DMB CD3 CD3 H 2516 H H 2,6DMB CD3CH3 H 2517 H H 2,6DMB CD3 H CD3 2518 H H 2,6DMB CD3 H CH3 2519 H H2,6DMB CD3 H H 2520 H H 2,6DMB CH3 CD3 H 2521 H H 2,6DMB CH3 CH3 H 2522H H 2,6DMB CH3 H CD3 2523 H H 2,6DMB CH3 H CH3 2524 H H 2,6DMB CH3 H H2525 H H 2,6DMB H CD3 CD3 2526 H H 2,6DMB H CD3 CH3 2527 H H 2,6DMB HCD3 H 2528 H H 2,6DMB H CH3 CD3 2529 H H 2,6DMB H CH3 CH3 2530 H H2,6DMB H CH3 H 2531 H H 2,6DMB H H CD3 2532 H H 2,6DMB H H CH3 2533 H H2,6DMB H H H 2534 H H CD3 CD3 CD3 H 2535 H H CD3 CD3 CH3 H 2536 H H CD3CD3 H CD3 2537 H H CD3 CD3 H CH3 2538 H H CD3 CD3 H H 2539 H H CD3 CH3CD3 H 2540 H H CD3 CH3 CH3 H 2541 H H CD3 CH3 H CD3 2542 H H CD3 CH3 HCH3 2543 H H CD3 CH3 H H 2544 H H CD3 H 2,6DIP H 2545 H H CD3 H 2,6DMB H2546 H H CD3 H CD3 CD3 2547 H H CD3 H CD3 CH3 2548 H H CD3 H CD3 H 2549H H CD3 H CH3 CD3 2550 H H CD3 H CH3 CH3 2551 H H CD3 H CH3 H 2552 H HCD3 H H 2,6DIP 2553 H H CD3 H H 2,6DMB 2554 H H CD3 H H CD3 2555 H H CD3H H CH3 2556 H H CD3 H H H 2557 H H CD3 H H iPr 2558 H H CD3 H iPr H2559 H H CD3 iPr H H 2560 H H CH3 CD3 CD3 H 2561 H H CH3 CD3 CH3 H 2562H H CH3 CD3 H CD3 2563 H H CH3 CD3 H CH3 2564 H H CH3 CD3 H H 2565 H HCH3 CH3 CD3 H 2566 H H CH3 CH3 CH3 H 2567 H H CH3 CH3 H CD3 2568 H H CH3CH3 H CH3 2569 H H CH3 CH3 H H 2570 H H CH3 H 2,6DIP H 2571 H H CH3 H2,6DMB H 2572 H H CH3 H CD3 CD3 2573 H H CH3 H CD3 CH3 2574 H H CH3 HCD3 H 2575 H H CH3 H CH3 CD3 2576 H H CH3 H CH3 CH3 2577 H H CH3 H CH3 H2578 H H CH3 H H 2,6DIP 2579 H H CH3 H H 2,6DMB 2580 H H CH3 H H CD32581 H H CH3 H H CH3 2582 H H CH3 H H H 2583 H H CH3 H H iPr 2584 H HCH3 H iPr H 2585 H H CH3 iPr H H 2586 H H H 2,6DIP CD3 H 2587 H H H2,6DIP CH3 H 2588 H H H 2,6DIP H CD3 2589 H H H 2,6DIP H CH3 2590 H H H2,6DIP H H 2591 H H H 2,6DMB CD3 H 2592 H H H 2,6DMB CH3 H 2593 H H H2,6DMB H CD3 2594 H H H 2,6DMB H CH3 2595 H H H 2,6DMB H H 2596 H H HCD3 2,6DIP H 2597 H H H CD3 2,6DMB H 2598 H H H CD3 CD3 H 2599 H H H CD3CH3 H 2600 H H H CD3 H 2,6DIP 2601 H H H CD3 H 2,6DMB 2602 H H H CD3 HCD3 2603 H H H CD3 H CH3 2604 H H H CD3 H H 2605 H H H CD3 H iPr 2606 HH H CD3 iPr H 2607 H H H CH3 2,6DIP H 2608 H H H CH3 2,6DMB H 2609 H H HCH3 CD3 H 2610 H H H CH3 CH3 H 2611 H H H CH3 H 2,6DIP 2612 H H H CH3 H2,6DMB 2613 H H H CH3 H CD3 2614 H H H CH3 H CH3 2615 H H H CH3 H H 2616H H H CH3 H iPr 2617 H H H CH3 iPr H 2618 H H H H 2,6DIP H 2619 H H H H2,6DMB H 2620 H H H H CD3 CD3 2621 H H H H CD3 CH3 2622 H H H H CD3 H2623 H H H H CD3 iPr 2624 H H H H CH3 CD3 2625 H H H H CH3 CH3 2626 H HH H CH3 H 2627 H H H H CH3 iPr 2628 H H H H H 2,6DIP 2629 H H H H H2,6DMB 2630 H H H H H CD3 2631 H H H H H CH3 2632 H H H H H H 2633 H H HH H iPr 2634 H H H H iPr CD3 2635 H H H H iPr CH3 2636 H H H H iPr H2637 H H H iPr CD3 H 2638 H H H iPr CH3 H 2639 H H H iPr H CD3 2640 H HH iPr H CH3 2641 H H H iPr H H 2642 H H ph CD3 CD3 H 2643 H H ph CD3 CH3H 2644 H H ph CD3 H CD3 2645 H H ph CD3 H CH3 2646 H H ph CD3 H H 2647 HH ph CH3 CD3 H 2648 H H ph CH3 CH3 H 2649 H H ph CH3 H CD3 2650 H H phCH3 H CH3 2651 H H ph CH3 H H 2652 H H ph H CD3 CD3 2653 H H ph H CD3CH3 2654 H H ph H CD3 H 2655 H H ph H CH3 CD3 2656 H H ph H CH3 CH3 2657H H ph H CH3 H 2658 H H ph H H CD3 2659 H H ph H H CH3 2660 H H ph H H H2661 H iPr CD3 H H H 2662 H iPr CH3 H H H 2663 H iPr H CD3 H H 2664 HiPr H CH3 H H 2665 H iPr H H CD3 H 2666 H iPr H H CH3 H 2667 H iPr H H HCD3 2668 H iPr H H H CH3 2669 H iPr H H H H 2670 iPr CD3 H H H H 2671iPr CH3 H H H H 2672 iPr H CD3 H H H 2673 iPr H CH3 H H H 2674 iPr H HCD3 H H 2675 iPr H H CH3 H H 2676 iPr H H H CD3 H 2677 iPr H H H CH3 H2678 iPr H H H H CD3 2679 iPr H H H H CH3 2680 iPr H H H H HLA2681 to LA3156 based on structure:

LA # R11 R12 R2 R32 R33 R34 2681 CD3 CD3 2,6DIP H H H 2682 CD3 CD32,6DIPB H H H 2683 CD3 CD3 2,6DMB H H H 2684 CD3 CD3 CD3 H H H 2685 CD3CD3 CH3 H H H 2686 CD3 CD3 H H H H 2687 CD3 CD3 ph H H H 2688 CD3 CH32,6DIP H H H 2689 CD3 CH3 2,6DIPB H H H 2690 CD3 CH3 2,6DMB H H H 2691CD3 CH3 CD3 H H H 2692 CD3 CH3 CH3 H H H 2693 CD3 CH3 H H H H 2694 CD3CH3 ph H H H 2695 CD3 H 2,6DIP CD3 H H 2696 CD3 H 2,6DIP CH3 H H 2697CD3 H 2,6DIP H CD3 H 2698 CD3 H 2,6DIP H CH3 H 2699 CD3 H 2,6DIP H H CD32700 CD3 H 2,6DIP H H CH3 2701 CD3 H 2,6DIP H H H 2702 CD3 H 2,6DIPB CD3H H 2703 CD3 H 2,6DIPB CH3 H H 2704 CD3 H 2,6DIPB H CD3 H 2705 CD3 H2,6DIPB H CH3 H 2706 CD3 H 2,6DIPB H H CD3 2707 CD3 H 2,6DIPB H H CH32708 CD3 H 2,6DIPB H H H 2709 CD3 H 2,6DMB CD3 H H 2710 CD3 H 2,6DMB CH3H H 2711 CD3 H 2,6DMB H CD3 H 2712 CD3 H 2,6DMB H CH3 H 2713 CD3 H2,6DMB H H CD3 2714 CD3 H 2,6DMB H H CH3 2715 CD3 H 2,6DMB H H H 2716CD3 H CD3 CD3 H H 2717 CD3 H CD3 CH3 H H 2718 CD3 H CD3 H CD3 H 2719 CD3H CD3 H CH3 H 2720 CD3 H CD3 H H CD3 2721 CD3 H CD3 H H CH3 2722 CD3 HCD3 H H H 2723 CD3 H CH3 CD3 H H 2724 CD3 H CH3 CH3 H H 2725 CD3 H CH3 HCD3 H 2726 CD3 H CH3 H CH3 H 2727 CD3 H CH3 H H CD3 2728 CD3 H CH3 H HCH3 2729 CD3 H CH3 H H H 2730 CD3 H H 2,6DIP H H 2731 CD3 H H 2,6DMB H H2732 CD3 H H CD3 H H 2733 CD3 H H CH3 H H 2734 CD3 H H H 2,6DIP H 2735CD3 H H H 2,6DMB H 2736 CD3 H H H CD3 H 2737 CD3 H H H CH3 H 2738 CD3 HH H H 2,6DIP 2739 CD3 H H H H 2,6DMB 2740 CD3 H H H H CD3 2741 CD3 H H HH CH3 2742 CD3 H H H H H 2743 CD3 H H H H iPr 2744 CD3 H H H iPr H 2745CD3 H H iPr H H 2746 CD3 H ph CD3 H H 2747 CD3 H ph CH3 H H 2748 CD3 Hph H CD3 H 2749 CD3 H ph H CH3 H 2750 CD3 H ph H H CD3 2751 CD3 H ph H HCH3 2752 CD3 H ph H H H 2753 CD3 iPr H H H H 2754 CH3 CD3 2,6DIP H H H2755 CH3 CD3 2,6DIPB H H H 2756 CH3 CD3 2,6DMB H H H 2757 CH3 CD3 CD3 HH H 2758 CH3 CD3 CH3 H H H 2759 CH3 CD3 H H H H 2760 CH3 CD3 ph H H H2761 CH3 CH3 2,6DIP H H H 2762 CH3 CH3 2,6DIPB H H H 2763 CH3 CH3 2,6DMBH H H 2764 CH3 CH3 CD3 H H H 2765 CH3 CH3 CH3 H H H 2766 CH3 CH3 H H H H2767 CH3 CH3 ph H H H 2768 CH3 H 2,6DIP CD3 H H 2769 CH3 H 2,6DIP CH3 HH 2770 CH3 H 2,6DIP H CD3 H 2771 CH3 H 2,6DIP H CH3 H 2772 CH3 H 2,6DIPH H CD3 2773 CH3 H 2,6DIP H H CH3 2774 CH3 H 2,6DIP H H H 2775 CH3 H2,6DIPB CD3 H H 2776 CH3 H 2,6DIPB CH3 H H 2777 CH3 H 2,6DIPB H CD3 H2778 CH3 H 2,6DIPB H CH3 H 2779 CH3 H 2,6DIPB H H CD3 2780 CH3 H 2,6DIPBH H CH3 2781 CH3 H 2,6DIPB H H H 2782 CH3 H 2,6DMB CD3 H H 2783 CH3 H2,6DMB CH3 H H 2784 CH3 H 2,6DMB H CD3 H 2785 CH3 H 2,6DMB H CH3 H 2786CH3 H 2,6DMB H H CD3 2787 CH3 H 2,6DMB H H CH3 2788 CH3 H 2,6DMB H H H2789 CH3 H CD3 CD3 H H 2790 CH3 H CD3 CH3 H H 2791 CH3 H CD3 H CD3 H2792 CH3 H CD3 H CH3 H 2793 CH3 H CD3 H H CD3 2794 CH3 H CD3 H H CH32795 CH3 H CD3 H H H 2796 CH3 H CH3 CD3 H H 2797 CH3 H CH3 CH3 H H 2798CH3 H CH3 H CD3 H 2799 CH3 H CH3 H CH3 H 2800 CH3 H CH3 H H CD3 2801 CH3H CH3 H H CH3 2802 CH3 H CH3 H H H 2803 CH3 H H 2,6DIP H H 2804 CH3 H H2,6DMB H H 2805 CH3 H H CD3 H H 2806 CH3 H H CH3 H H 2807 CH3 H H H2,6DIP H 2808 CH3 H H H 2,6DMB H 2809 CH3 H H H CD3 H 2810 CH3 H H H CH3H 2811 CH3 H H H H 2,6DIP 2812 CH3 H H H H 2,6DMB 2813 CH3 H H H H CD32814 CH3 H H H H CH3 2815 CH3 H H H H H 2816 CH3 H H H H iPr 2817 CH3 HH H iPr H 2818 CH3 H H iPr H H 2819 CH3 H ph CD3 H H 2820 CH3 H ph CH3 HH 2821 CH3 H ph H CD3 H 2822 CH3 H ph H CH3 H 2823 CH3 H ph H H CD3 2824CH3 H ph H H CH3 2825 CH3 H ph H H H 2826 CH3 iPr H H H H 2827 H 2,6DIPH CD3 H H 2828 H 2,6DIP H CH3 H H 2829 H 2,6DIP H H CD3 H 2830 H 2,6DIPH H CH3 H 2831 H 2,6DIP H H H CD3 2832 H 2,6DIP H H H CH3 2833 H 2,6DIPH H H H 2834 H 2,6DMB H CD3 H H 2835 H 2,6DMB H CH3 H H 2836 H 2,6DMB HH CD3 H 2837 H 2,6DMB H H CH3 H 2838 H 2,6DMB H H H CD3 2839 H 2,6DMB HH H CH3 2840 H 2,6DMB H H H H 2841 H CD3 2,6DIP CD3 H H 2842 H CD32,6DIP CH3 H H 2843 H CD3 2,6DIP H CD3 H 2844 H CD3 2,6DIP H CH3 H 2845H CD3 2,6DIP H H CD3 2846 H CD3 2,6DIP H H CH3 2847 H CD3 2,6DIP H H H2848 H CD3 2,6DIPB CD3 H H 2849 H CD3 2,6DIPB CH3 H H 2850 H CD3 2,6DIPBH CD3 H 2851 H CD3 2,6DIPB H CH3 H 2852 H CD3 2,6DIPB H H CD3 2853 H CD32,6DIPB H H CH3 2854 H CD3 2,6DIPB H H H 2855 H CD3 2,6DMB CD3 H H 2856H CD3 2,6DMB CH3 H H 2857 H CD3 2,6DMB H CD3 H 2858 H CD3 2,6DMB H CH3 H2859 H CD3 2,6DMB H H CD3 2860 H CD3 2,6DMB H H CH3 2861 H CD3 2,6DMB HH H 2862 H CD3 CD3 CD3 H H 2863 H CD3 CD3 CH3 H H 2864 H CD3 CD3 H CD3 H2865 H CD3 CD3 H CH3 H 2866 H CD3 CD3 H H CD3 2867 H CD3 CD3 H H CH32868 H CD3 CD3 H H H 2869 H CD3 CH3 CD3 H H 2870 H CD3 CH3 CH3 H H 2871H CD3 CH3 H CD3 H 2872 H CD3 CH3 H CH3 H 2873 H CD3 CH3 H H CD3 2874 HCD3 CH3 H H CH3 2875 H CD3 CH3 H H H 2876 H CD3 H 2,6DIP H H 2877 H CD3H 2,6DMB H H 2878 H CD3 H CD3 H H 2879 H CD3 H CH3 H H 2880 H CD3 H H2,6DIP H 2881 H CD3 H H 2,6DMB H 2882 H CD3 H H CD3 H 2883 H CD3 H H CH3H 2884 H CD3 H H H 2,6DIP 2885 H CD3 H H H 2,6DMB 2886 H CD3 H H H CD32887 H CD3 H H H CH3 2888 H CD3 H H H H 2889 H CD3 H H H iPr 2890 H CD3H H iPr H 2891 H CD3 H iPr H H 2892 H CD3 ph CD3 H H 2893 H CD3 ph CH3 HH 2894 H CD3 ph H CD3 H 2895 H CD3 ph H CH3 H 2896 H CD3 ph H H CD3 2897H CD3 ph H H CH3 2898 H CD3 ph H H H 2899 H CH3 2,6DIP CD3 H H 2900 HCH3 2,6DIP CH3 H H 2901 H CH3 2,6DIP H CD3 H 2902 H CH3 2,6DIP H CH3 H2903 H CH3 2,6DIP H H CD3 2904 H CH3 2,6DIP H H CH3 2905 H CH3 2,6DIP HH H 2906 H CH3 2,6DIPB CD3 H H 2907 H CH3 2,6DIPB CH3 H H 2908 H CH32,6DIPB H CD3 H 2909 H CH3 2,6DIPB H CH3 H 2910 H CH3 2,6DIPB H H CD32911 H CH3 2,6DIPB H H CH3 2912 H CH3 2,6DIPB H H H 2913 H CH3 2,6DMBCD3 H H 2914 H CH3 2,6DMB CH3 H H 2915 H CH3 2,6DMB H CD3 H 2916 H CH32,6DMB H CH3 H 2917 H CH3 2,6DMB H H CD3 2918 H CH3 2,6DMB H H CH3 2919H CH3 2,6DMB H H H 2920 H CH3 CD3 CD3 H H 2921 H CH3 CD3 CH3 H H 2922 HCH3 CD3 H CD3 H 2923 H CH3 CD3 H CH3 H 2924 H CH3 CD3 H H CD3 2925 H CH3CD3 H H CH3 2926 H CH3 CD3 H H H 2927 H CH3 CH3 CD3 H H 2928 H CH3 CH3CH3 H H 2929 H CH3 CH3 H CD3 H 2930 H CH3 CH3 H CH3 H 2931 H CH3 CH3 H HCD3 2932 H CH3 CH3 H H CH3 2933 H CH3 CH3 H H H 2934 H CH3 H 2,6DIP H H2935 H CH3 H 2,6DMB H H 2936 H CH3 H CD3 H H 2937 H CH3 H CH3 H H 2938 HCH3 H H 2,6DIP H 2939 H CH3 H H 2,6DMB H 2940 H CH3 H H CD3 H 2941 H CH3H H CH3 H 2942 H CH3 H H H 2,6DIP 2943 H CH3 H H H 2,6DMB 2944 H CH3 H HH CD3 2945 H CH3 H H H CH3 2946 H CH3 H H H H 2947 H CH3 H H H iPr 2948H CH3 H H iPr H 2949 H CH3 H iPr H H 2950 H CH3 ph CD3 H H 2951 H CH3 phCH3 H H 2952 H CH3 ph H CD3 H 2953 H CH3 ph H CH3 H 2954 H CH3 ph H HCD3 2955 H CH3 ph H H CH3 2956 H CH3 ph H H H 2957 H H 2,6DIP CD3 CD3 H2958 H H 2,6DIP CD3 CH3 H 2959 H H 2,6DIP CD3 H CD3 2960 H H 2,6DIP CD3H CH3 2961 H H 2,6DIP CD3 H H 2962 H H 2,6DIP CH3 CD3 H 2963 H H 2,6DIPCH3 CH3 H 2964 H H 2,6DIP CH3 H CD3 2965 H H 2,6DIP CH3 H CH3 2966 H H2,6DIP CH3 H H 2967 H H 2,6DIP H CD3 CD3 2968 H H 2,6DIP H CD3 CH3 2969H H 2,6DIP H CD3 H 2970 H H 2,6DIP H CH3 CD3 2971 H H 2,6DIP H CH3 CH32972 H H 2,6DIP H CH3 H 2973 H H 2,6DIP H H CD3 2974 H H 2,6DIP H H CH32975 H H 2,6DIP H H H 2976 H H 2,6DIPB CD3 CD3 H 2977 H H 2,6DIPB CD3CH3 H 2978 H H 2,6DIPB CD3 H CD3 2979 H H 2,6DIPB CD3 H CH3 2980 H H2,6DIPB CD3 H H 2981 H H 2,6DIPB CH3 CD3 H 2982 H H 2,6DIPB CH3 CH3 H2983 H H 2,6DIPB CH3 H CD3 2984 H H 2,6DIPB CH3 H CH3 2985 H H 2,6DIPBCH3 H H 2986 H H 2,6DIPB H CD3 CD3 2987 H H 2,6DIPB H CD3 CH3 2988 H H2,6DIPB H CD3 H 2989 H H 2,6DIPB H CH3 CD3 2990 H H 2,6DIPB H CH3 CH32991 H H 2,6DIPB H CH3 H 2992 H H 2,6DIPB H H CD3 2993 H H 2,6DIPB H HCH3 2994 H H 2,6DIPB H H H 2995 H H 2,6DMB CD3 CD3 H 2996 H H 2,6DMB CD3CH3 H 2997 H H 2,6DMB CD3 H CD3 2998 H H 2,6DMB CD3 H CH3 2999 H H2,6DMB CD3 H H 3000 H H 2,6DMB CH3 CD3 H 3001 H H 2,6DMB CH3 CH3 H 3002H H 2,6DMB CH3 H CD3 3003 H H 2,6DMB CH3 H CH3 3004 H H 2,6DMB CH3 H H3005 H H 2,6DMB H CD3 CD3 3006 H H 2,6DMB H CD3 CH3 3007 H H 2,6DMB HCD3 H 3008 H H 2,6DMB H CH3 CD3 3009 H H 2,6DMB H CH3 CH3 3010 H H2,6DMB H CH3 H 3011 H H 2,6DMB H H CD3 3012 H H 2,6DMB H H CH3 3013 H H2,6DMB H H H 3014 H H CD3 2,6DIP H H 3015 H H CD3 2,6DMB H H 3016 H HCD3 CD3 CD3 H 3017 H H CD3 CD3 CH3 H 3018 H H CD3 CD3 H CD3 3019 H H CD3CD3 H CH3 3020 H H CD3 CD3 H H 3021 H H CD3 CH3 CD3 H 3022 H H CD3 CH3CH3 H 3023 H H CD3 CH3 H CD3 3024 H H CD3 CH3 H CH3 3025 H H CD3 CH3 H H3026 H H CD3 H 2,6DIP H 3027 H H CD3 H 2,6DMB H 3028 H H CD3 H CD3 CD33029 H H CD3 H CD3 CH3 3030 H H CD3 H CD3 H 3031 H H CD3 H CH3 CD3 3032H H CD3 H CH3 CH3 3033 H H CD3 H CH3 H 3034 H H CD3 H H 2,6DIP 3035 H HCD3 H H 2,6DMB 3036 H H CD3 H H CD3 3037 H H CD3 H H CH3 3038 H H CD3 HH H 3039 H H CD3 H H iPr 3040 H H CD3 H iPr H 3041 H H CD3 iPr H H 3042H H CH3 2,6DIP H H 3043 H H CH3 2,6DMB H H 3044 H H CH3 CD3 CD3 H 3045 HH CH3 CD3 CH3 H 3046 H H CH3 CD3 H CD3 3047 H H CH3 CD3 H CH3 3048 H HCH3 CD3 H H 3049 H H CH3 CH3 CD3 H 3050 H H CH3 CH3 CH3 H 3051 H H CH3CH3 H CD3 3052 H H CH3 CH3 H CH3 3053 H H CH3 CH3 H H 3054 H H CH3 H2,6DIP H 3055 H H CH3 H 2,6DMB H 3056 H H CH3 H CD3 CD3 3057 H H CH3 HCD3 CH3 3058 H H CH3 H CD3 H 3059 H H CH3 H CH3 CD3 3060 H H CH3 H CH3CH3 3061 H H CH3 H CH3 H 3062 H H CH3 H H 2,6DIP 3063 H H CH3 H H 2,6DMB3064 H H CH3 H H CD3 3065 H H CH3 H H CH3 3066 H H CH3 H H H 3067 H HCH3 H H iPr 3068 H H CH3 H iPr H 3069 H H CH3 iPr H H 3070 H H H 2,6DIPH CD3 3071 H H H 2,6DIP H CH3 3072 H H H 2,6DIP H H 3073 H H H 2,6DMB HCD3 3074 H H H 2,6DMB H CH3 3075 H H H 2,6DMB H H 3076 H H H CD3 CD3 H3077 H H H CD3 CH3 H 3078 H H H CD3 H 2,6DIP 3079 H H H CD3 H 2,6DMB3080 H H H CD3 H CD3 3081 H H H CD3 H CH3 3082 H H H CD3 H H 3083 H H HCD3 H iPr 3084 H H H CD3 iPr H 3085 H H H CH3 CD3 H 3086 H H H CH3 CH3 H3087 H H H CH3 H 2,6DIP 3088 H H H CH3 H 2,6DMB 3089 H H H CH3 H CD33090 H H H CH3 H CH3 3091 H H H CH3 H H 3092 H H H CH3 H iPr 3093 H H HCH3 iPr H 3094 H H H H 2,6DIP H 3095 H H H H 2,6DMB H 3096 H H H H CD3CD3 3097 H H H H CD3 CH3 3098 H H H H CD3 H 3099 H H H H CD3 iPr 3100 HH H H CH3 CD3 3101 H H H H CH3 CH3 3102 H H H H CH3 H 3103 H H H H CH3iPr 3104 H H H H H 2,6DIP 3105 H H H H H 2,6DMB 3106 H H H H H CD3 3107H H H H H CH3 3108 H H H H H H 3109 H H H H H iPr 3110 H H H H iPr CD33111 H H H H iPr CH3 3112 H H H H iPr H 3113 H H H iPr CD3 H 3114 H H HiPr CH3 H 3115 H H H iPr H CD3 3116 H H H iPr H CH3 3117 H H H iPr H H3118 H H ph CD3 CD3 H 3119 H H ph CD3 CH3 H 3120 H H ph CD3 H CD3 3121 HH ph CD3 H CH3 3122 H H ph CD3 H H 3123 H H ph CH3 CD3 H 3124 H H ph CH3CH3 H 3125 H H ph CH3 H CD3 3126 H H ph CH3 H CH3 3127 H H ph CH3 H H3128 H H ph H CD3 CD3 3130 H H ph H CD3 H 3131 H H ph H CH3 CD3 3132 H Hph H CH3 CH3 3133 H H ph H CH3 H 3134 H H ph H H CD3 3135 H H ph H H CH33136 H H ph H H H 3137 H iPr CD3 H H H 3138 H iPr CH3 H H H 3139 H iPr HCD3 H H 3140 H iPr H CH3 H H 3141 H iPr H H CD3 H 3142 H iPr H H CH3 H3143 H iPr H H H CD3 3144 H iPr H H H CH3 3145 H iPr H H H H 3146 iPrCD3 H H H H 3147 iPr CH3 H H H H 3148 iPr H CD3 H H H 3149 iPr H CH3 H HH 3150 iPr H H CD3 H H 3151 iPr H H CH3 H H 3152 iPr H H H CD3 H 3153iPr H H H CH3 H 3154 iPr H H H H CD3 3155 iPr H H H H CH3 3156 iPr H H HH HLA3157 to LA3580 based on structure:

LA # R11 R2 R12 R31 R32 R33 3157 CD3 CD3 2,6DIP H H H 3158 CD3 CD32,6DMB H H H 3159 CD3 CD3 CD3 H H H 3160 CD3 CD3 CH3 H H H 3161 CD3 CD3H H H H 3162 CD3 CD3 iPr H H H 3163 CD3 CH3 2,6DIP H H H 3164 CD3 CH32,6DMB H H H 3165 CD3 CH3 CD3 H H H 3166 CD3 CH3 CH3 H H H 3167 CD3 CH3H H H H 3168 CD3 CH3 iPr H H H 3169 CD3 H 2,6DIP CD3 H H 3170 CD3 H2,6DIP CH3 H H 3171 CD3 H 2,6DIP H CD3 H 3172 CD3 H 2,6DIP H CH3 H 3173CD3 H 2,6DIP H H CD3 3174 CD3 H 2,6DIP H H CH3 3175 CD3 H 2,6DIP H H H3176 CD3 H 2,6DMB CD3 H H 3177 CD3 H 2,6DMB CH3 H H 3178 CD3 H 2,6DMB HCD3 H 3179 CD3 H 2,6DMB H CH3 H 3180 CD3 H 2,6DMB H H CD3 3181 CD3 H2,6DMB H H CH3 3182 CD3 H 2,6DMB H H H 3183 CD3 H CD3 CD3 H H 3184 CD3 HCD3 CH3 H H 3185 CD3 H CD3 H CD3 H 3186 CD3 H CD3 H CH3 H 3187 CD3 H CD3H H CD3 3188 CD3 H CD3 H H CH3 3189 CD3 H CD3 H H H 3190 CD3 H CH3 CD3 HH 3191 CD3 H CH3 CH3 H H 3192 CD3 H CH3 H CD3 H 3193 CD3 H CH3 H CH3 H3194 CD3 H CH3 H H CD3 3195 CD3 H CH3 H H CH3 3196 CD3 H CH3 H H H 3197CD3 H H 2,6DIP H H 3198 CD3 H H 2,6DMB H H 3199 CD3 H H CD3 H H 3200 CD3H H CH3 H H 3201 CD3 H H H 2,6DIP H 3202 CD3 H H H 2,6DMB H 3203 CD3 H HH CD3 H 3204 CD3 H H H CH3 H 3205 CD3 H H H H 2,6DIP 3206 CD3 H H H H2,6DMB 3207 CD3 H H H H CD3 3208 CD3 H H H H CH3 3209 CD3 H H H H H 3210CD3 H H H H iPr 3211 CD3 H H H iPr H 3212 CD3 H H iPr H H 3213 CD3 H iPrCD3 H H 3214 CD3 H iPr CH3 H H 3215 CD3 H iPr H CD3 H 3216 CD3 H iPr HCH3 H 3217 CD3 H iPr H H CD3 3218 CD3 H iPr H H CH3 3219 CD3 H iPr H H H3220 CH3 CD3 2,6DIP H H H 3221 CH3 CD3 2,6DMB H H H 3222 CH3 CD3 CD3 H HH 3223 CH3 CD3 CH3 H H H 3224 CH3 CD3 H H H H 3225 CH3 CD3 iPr H H H3226 CH3 CH3 2,6DIP H H H 3227 CH3 CH3 2,6DMB H H H 3228 CH3 CH3 CD3 H HH 3229 CH3 CH3 CH3 H H H 3230 CH3 CH3 H H H H 3231 CH3 CH3 iPr H H H3232 CH3 H 2,6DIP CD3 H H 3233 CH3 H 2,6DIP CH3 H H 3234 CH3 H 2,6DIP HCD3 H 3235 CH3 H 2,6DIP H CH3 H 3236 CH3 H 2,6DIP H H CD3 3237 CH3 H2,6DIP H H CH3 3238 CH3 H 2,6DIP H H H 3239 CH3 H 2,6DMB CD3 H H 3240CH3 H 2,6DMB CH3 H H 3241 CH3 H 2,6DMB H CD3 H 3242 CH3 H 2,6DMB H CH3 H3243 CH3 H 2,6DMB H H CD3 3244 CH3 H 2,6DMB H H CH3 3245 CH3 H 2,6DMB HH H 3246 CH3 H CD3 CD3 H H 3247 CH3 H CD3 CH3 H H 3248 CH3 H CD3 H CD3 H3249 CH3 H CD3 H CH3 H 3250 CH3 H CD3 H H CD3 3251 CH3 H CD3 H H CH33252 CH3 H CD3 H H H 3253 CH3 H CH3 CD3 H H 3254 CH3 H CH3 CH3 H H 3255CH3 H CH3 H CD3 H 3256 CH3 H CH3 H CH3 H 3257 CH3 H CH3 H H CD3 3258 CH3H CH3 H H CH3 3259 CH3 H CH3 H H H 3260 CH3 H H 2,6DIP H H 3261 CH3 H H2,6DMB H H 3262 CH3 H H CD3 H H 3263 CH3 H H CH3 H H 3264 CH3 H H H2,6DIP H 3265 CH3 H H H 2,6DMB H 3266 CH3 H H H CD3 H 3267 CH3 H H H CH3H 3268 CH3 H H H H 2,6DIP 3269 CH3 H H H H 2,6DMB 3270 CH3 H H H H CD33271 CH3 H H H H CH3 3272 CH3 H H H H H 3273 CH3 H H H H iPr 3274 CH3 HH H iPr H 3275 CH3 H H iPr H H 3276 CH3 H iPr CD3 H H 3277 CH3 H iPr CH3H H 3278 CH3 H iPr H CD3 H 3279 CH3 H iPr H CH3 H 3280 CH3 H iPr H H CD33281 CH3 H iPr H H CH3 3282 CH3 H iPr H H H 3283 H 2,6DIP H CD3 H H 3284H 2,6DIP H CH3 H H 3285 H 2,6DIP H H CD3 H 3286 H 2,6DIP H H CH3 H 3287H 2,6DIP H H H CD3 3288 H 2,6DIP H H H CH3 3289 H 2,6DIP H H H H 3290 H2,6DIPB H CD3 H H 3291 H 2,6DIPB H CH3 H H 3292 H 2,6DIPB H H CD3 H 3293H 2,6DIPB H H CH3 H 3294 H 2,6DIPB H H H CD3 3295 H 2,6DIPB H H H CH33296 H 2,6DIPB H H H H 3297 H 2,6DMB H CD3 H H 3298 H 2,6DMB H CH3 H H3299 H 2,6DMB H H CD3 H 3300 H 2,6DMB H H CH3 H 3301 H 2,6DMB H H H CD33302 H 2,6DMB H H H CH3 3303 H 2,6DMB H H H H 3304 H CD3 2,6DIP CD3 H H3305 H CD3 2,6DIP CH3 H H 3306 H CD3 2,6DIP H CD3 H 3307 H CD3 2,6DIP HCH3 H 3308 H CD3 2,6DIP H H CD3 3309 H CD3 2,6DIP H H CH3 3310 H CD32,6DIP H H H 3311 H CD3 2,6DMB CD3 H H 3312 H CD3 2,6DMB CH3 H H 3313 HCD3 2,6DMB H CD3 H 3314 H CD3 2,6DMB H CH3 H 3315 H CD3 2,6DMB H H CD33316 H CD3 2,6DMB H H CH3 3317 H CD3 2,6DMB H H H 3318 H CD3 CD3 CD3 H H3319 H CD3 CD3 CH3 H H 3320 H CD3 CD3 H CD3 H 3321 H CD3 CD3 H CH3 H3322 H CD3 CD3 H H CD3 3323 H CD3 CD3 H H CH3 3324 H CD3 CD3 H H H 3325H CD3 CH3 CD3 H H 3326 H CD3 CH3 CH3 H H 3327 H CD3 CH3 H CD3 H 3328 HCD3 CH3 H CH3 H 3329 H CD3 CH3 H H CD3 3330 H CD3 CH3 H H CH3 3331 H CD3CH3 H H H 3332 H CD3 H 2,6DIP H H 3333 H CD3 H 2,6DMB H H 3334 H CD3 HCD3 H H 3335 H CD3 H CH3 H H 3336 H CD3 H H 2,6DIP H 3337 H CD3 H H2,6DMB H 3338 H CD3 H H CD3 H 3339 H CD3 H H CH3 H 3340 H CD3 H H H2,6DIP 3341 H CD3 H H H 2,6DMB 3342 H CD3 H H H CD3 3343 H CD3 H H H CH33344 H CD3 H H H H 3345 H CD3 H H H iPr 3346 H CD3 H H iPr H 3347 H CD3H iPr H H 3348 H CD3 iPr CD3 H H 3349 H CD3 iPr CH3 H H 3350 H CD3 iPr HCD3 H 3351 H CD3 iPr H CH3 H 3352 H CD3 iPr H H CD3 3353 H CD3 iPr H HCH3 3354 H CD3 iPr H H H 3355 H CH3 2,6DIP CD3 H H 3356 H CH3 2,6DIP CH3H H 3357 H CH3 2,6DIP H CD3 H 3358 H CH3 2,6DIP H CH3 H 3359 H CH32,6DIP H H CD3 3360 H CH3 2,6DIP H H CH3 3361 H CH3 2,6DIP H H H 3362 HCH3 2,6DMB CD3 H H 3363 H CH3 2,6DMB CH3 H H 3364 H CH3 2,6DMB H CD3 H3365 H CH3 2,6DMB H CH3 H 3366 H CH3 2,6DMB H H CD3 3367 H CH3 2,6DMB HH CH3 3368 H CH3 2,6DMB H H H 3369 H CH3 CD3 CD3 H H 3370 H CH3 CD3 CH3H H 3371 H CH3 CD3 H CD3 H 3372 H CH3 CD3 H CH3 H 3373 H CH3 CD3 H H CD33374 H CH3 CD3 H H CH3 3375 H CH3 CD3 H H H 3376 H CH3 CH3 CD3 H H 3377H CH3 CH3 CH3 H H 3378 H CH3 CH3 H CD3 H 3379 H CH3 CH3 H CH3 H 3380 HCH3 CH3 H H CD3 3381 H CH3 CH3 H H CH3 3382 H CH3 CH3 H H H 3383 H CH3 H2,6DIP H H 3384 H CH3 H 2,6DMB H H 3385 H CH3 H CD3 H H 3386 H CH3 H CH3H H 3387 H CH3 H H 2,6DIP H 3388 H CH3 H H 2,6DMB H 3389 H CH3 H H CD3 H3390 H CH3 H H CH3 H 3391 H CH3 H H H 2,6DIP 3392 H CH3 H H H 2,6DMB3393 H CH3 H H H CD3 3394 H CH3 H H H CH3 3395 H CH3 H H H H 3396 H CH3H H H iPr 3397 H CH3 H H iPr H 3398 H CH3 H iPr H H 3399 H CH3 iPr CD3 HH 3400 H CH3 iPr CH3 H H 3401 H CH3 iPr H CD3 H 3402 H CH3 iPr H CH3 H3403 H CH3 iPr H H CD3 3404 H CH3 iPr H H CH3 3405 H CH3 iPr H H H 3406H H 2,6DIP CD3 CD3 H 3407 H H 2,6DIP CD3 CH3 H 3408 H H 2,6DIP CD3 H CD33409 H H 2,6DIP CD3 H CH3 3410 H H 2,6DIP CD3 H H 3411 H H 2,6DIP CH3CD3 H 3412 H H 2,6DIP CH3 CH3 H 3413 H H 2,6DIP CH3 H CD3 3414 H H2,6DIP CH3 H CH3 3415 H H 2,6DIP CH3 H H 3416 H H 2,6DIP H CD3 CD3 3417H H 2,6DIP H CD3 CH3 3418 H H 2,6DIP H CD3 H 3419 H H 2,6DIP H CH3 CD33420 H H 2,6DIP H CH3 CH3 3421 H H 2,6DIP H CH3 H 3422 H H 2,6DIP H HCD3 3423 H H 2,6DIP H H CH3 3424 H H 2,6DIP H H H 3425 H H 2,6DMB CD3CD3 H 3426 H H 2,6DMB CD3 CH3 H 3427 H H 2,6DMB CD3 H CD3 3428 H H2,6DMB CD3 H CH3 3429 H H 2,6DMB CD3 H H 3430 H H 2,6DMB CH3 CD3 H 3431H H 2,6DMB CH3 CH3 H 3432 H H 2,6DMB CH3 H CD3 3433 H H 2,6DMB CH3 H CH33434 H H 2,6DMB CH3 H H 3435 H H 2,6DMB H CD3 CD3 3436 H H 2,6DMB H CD3CH3 3437 H H 2,6DMB H CD3 H 3438 H H 2,6DMB H CH3 CD3 3439 H H 2,6DMB HCH3 CH3 3440 H H 2,6DMB H CH3 H 3441 H H 2,6DMB H H CD3 3442 H H 2,6DMBH H CH3 3443 H H 2,6DMB H H H 3444 H H CD3 CD3 CD3 H 3445 H H CD3 CD3CH3 H 3446 H H CD3 CD3 H CD3 3447 H H CD3 CD3 H CH3 3448 H H CD3 CD3 H H3449 H H CD3 CH3 CD3 H 3450 H H CD3 CH3 CH3 H 3451 H H CD3 CH3 H CD33452 H H CD3 CH3 H CH3 3453 H H CD3 CH3 H H 3454 H H CD3 H 2,6DIP H 3455H H CD3 H 2,6DMB H 3456 H H CD3 H CD3 CD3 3457 H H CD3 H CD3 CH3 3458 HH CD3 H CD3 H 3459 H H CD3 H CH3 CD3 3460 H H CD3 H CH3 CH3 3461 H H CD3H CH3 H 3462 H H CD3 H H 2,6DIP 3463 H H CD3 H H 2,6DMB 3464 H H CD3 H HCD3 3465 H H CD3 H H CH3 3466 H H CD3 H H H 3467 H H CD3 H H iPr 3468 HH CD3 H iPr H 3469 H H CD3 iPr H H 3470 H H CH3 CD3 CD3 H 3471 H H CH3CD3 CH3 H 3472 H H CH3 CD3 H CD3 3473 H H CH3 CD3 H CH3 3474 H H CH3 CD3H H 3475 H H CH3 CH3 CD3 H 3476 H H CH3 CH3 CH3 H 3477 H H CH3 CH3 H CD33478 H H CH3 CH3 H CH3 3479 H H CH3 CH3 H H 3480 H H CH3 H 2,6DIP H 3481H H CH3 H 2,6DMB H 3482 H H CH3 H CD3 CD3 3483 H H CH3 H CD3 CH3 3484 HH CH3 H CD3 H 3485 H H CH3 H CH3 CD3 3486 H H CH3 H CH3 CH3 3487 H H CH3H CH3 H 3488 H H CH3 H H 2,6DIP 3489 H H CH3 H H 2,6DMB 3490 H H CH3 H HCD3 3491 H H CH3 H H CH3 3492 H H CH3 H H H 3493 H H CH3 H H iPr 3494 HH CH3 H iPr H 3495 H H CH3 iPr H H 3496 H H H 2,6DIP H CD3 3497 H H H2,6DIP H CH3 3498 H H H 2,6DIP H H 3499 H H H 2,6DMB H CD3 3500 H H H2,6DMB H CH3 3501 H H H 2,6DMB H H 3502 H H H CD3 CD3 H 3503 H H H CD3CH3 H 3504 H H H CD3 H 2,6DIP 3505 H H H CD3 H 2,6DMB 3506 H H H CD3 HCD3 3507 H H H CD3 H CH3 3508 H H H CD3 H H 3509 H H H CD3 H iPr 3510 HH H CD3 iPr H 3511 H H H CH3 CD3 H 3512 H H H CH3 CH3 H 3513 H H H CH3 H2,6DIP 3514 H H H CH3 H 2,6DMB 3515 H H H CH3 H CD3 3516 H H H CH3 H CH33517 H H H CH3 H H 3518 H H H CH3 H iPr 3519 H H H CH3 iPr H 3520 H H HH 2,6DIP H 3521 H H H H 2,6DMB H 3522 H H H H CD3 CD3 3523 H H H H CD3CH3 3524 H H H H CD3 H 3525 H H H H CD3 iPr 3526 H H H H CH3 CD3 3527 HH H H CH3 CH3 3528 H H H H CH3 H 3529 H H H H CH3 iPr 3530 H H H H H2,6DIP 3531 H H H H H 2,6DMB 3532 H H H H H CD3 3533 H H H H H CH3 3534H H H H H H 3535 H H H H H iPr 3536 H H H H iPr CD3 3537 H H H H iPr CH33538 H H H H iPr H 3539 H H H iPr CD3 H 3540 H H H iPr CH3 H 3541 H H HiPr H CD3 3542 H H H iPr H CH3 3543 H H H iPr H H 3544 H H iPr CD3 CD3 H3545 H H iPr CD3 CH3 H 3546 H H iPr CD3 H CD3 3547 H H iPr CD3 H CH33548 H H iPr CD3 H H 3549 H H iPr CH3 CD3 H 3550 H H iPr CH3 CH3 H 3551H H iPr CH3 H CD3 3552 H H iPr CH3 H CH3 3553 H H iPr CH3 H H 3554 H HiPr H CD3 CD3 3555 H H iPr H CD3 CH3 3556 H H iPr H CD3 H 3557 H H iPr HCH3 CD3 3558 H H iPr H CH3 CH3 3559 H H iPr H CH3 H 3560 H H iPr H H CD33561 H H iPr H H CH3 3562 H H iPr H H H 3563 H ph H CD3 H H 3564 H ph HCH3 H H 3565 H ph H H CD3 H 3566 H ph H H CH3 H 3567 H ph H H H CD3 3568H ph H H H CH3 3569 H ph H H H H 3570 iPr CD3 H H H H 3571 iPr CH3 H H HH 3572 iPr H CD3 H H H 3573 iPr H CH3 H H H 3574 iPr H H CD3 H H 3575iPr H H CH3 H H 3576 iPr H H H CD3 H 3577 iPr H H H CH3 H 3578 iPr H H HH CD3 3579 iPr H H H H CH3 3580 iPr H H H H HLA3851 to LA4012 based on structure:

LA # R11 R2 R12 R31 R32 R34 3581 CD3 CD3 2,6DIP H H H 3582 CD3 CD32,6DMB H H H 3583 CD3 CD3 CD3 H H H 3584 CD3 CD3 CH3 H H H 3585 CD3 CD3H H H H 3586 CD3 CD3 iPr H H H 3587 CD3 CH3 2,6DIP H H H 3588 CD3 CH32,6DMB H H H 3589 CD3 CH3 CD3 H H H 3590 CD3 CH3 CH3 H H H 3591 CD3 CH3H H H H 3592 CD3 CH3 iPr H H H 3593 CD3 H 2,6DIP CD3 H H 3594 CD3 H2,6DIP CH3 H H 3595 CD3 H 2,6DIP H CD3 H 3596 CD3 H 2,6DIP H CH3 H 3597CD3 H 2,6DIP H H CD3 3598 CD3 H 2,6DIP H H CH3 3599 CD3 H 2,6DIP H H H3600 CD3 H 2,6DMB CD3 H H 3601 CD3 H 2,6DMB CH3 H H 3602 CD3 H 2,6DMB HCD3 H 3603 CD3 H 2,6DMB H CH3 H 3604 CD3 H 2,6DMB H H CD3 3605 CD3 H2,6DMB H H CH3 3606 CD3 H 2,6DMB H H H 3607 CD3 H CD3 CD3 H H 3608 CD3 HCD3 CH3 H H 3609 CD3 H CD3 H CD3 H 3610 CD3 H CD3 H CH3 H 3611 CD3 H CD3H H CD3 3612 CD3 H CD3 H H CH3 3613 CD3 H CD3 H H H 3614 CD3 H CH3 CD3 HH 3615 CD3 H CH3 CH3 H H 3616 CD3 H CH3 H CD3 H 3617 CD3 H CH3 H CH3 H3618 CD3 H CH3 H H CD3 3619 CD3 H CH3 H H CH3 3620 CD3 H CH3 H H H 3621CD3 H H 2,6DIP H H 3622 CD3 H H 2,6DMB H H 3623 CD3 H H CD3 H H 3624 CD3H H CH3 H H 3625 CD3 H H H 2,6DIP H 3626 CD3 H H H 2,6DMB H 3627 CD3 H HH CD3 H 3628 CD3 H H H CH3 H 3629 CD3 H H H H 2,6DIP 3630 CD3 H H H H2,6DMB 3631 CD3 H H H H CD3 3632 CD3 H H H H CH3 3633 CD3 H H H H H 3634CD3 H H H H iPr 3635 CD3 H H H iPr H 3636 CD3 H H iPr H H 3637 CD3 H iPrCD3 H H 3638 CD3 H iPr CH3 H H 3639 CD3 H iPr H CD3 H 3640 CD3 H iPr HCH3 H 3641 CD3 H iPr H H CD3 3642 CD3 H iPr H H CH3 3643 CD3 H iPr H H H3644 CH3 CD3 2,6DIP H H H 3645 CH3 CD3 2,6DMB H H H 3646 CH3 CD3 CD3 H HH 3647 CH3 CD3 CH3 H H H 3648 CH3 CD3 H H H H 3649 CH3 CD3 iPr H H H3650 CH3 CH3 2,6DIP H H H 3651 CH3 CH3 2,6DMB H H H 3652 CH3 CH3 CD3 H HH 3653 CH3 CH3 CH3 H H H 3654 CH3 CH3 H H H H 3655 CH3 CH3 iPr H H H3656 CH3 H 2,6DIP CD3 H H 3657 CH3 H 2,6DIP CH3 H H 3658 CH3 H 2,6DIP HCD3 H 3659 CH3 H 2,6DIP H CH3 H 3660 CH3 H 2,6DIP H H CD3 3661 CH3 H2,6DIP H H CH3 3662 CH3 H 2,6DIP H H H 3663 CH3 H 2,6DMB CD3 H H 3664CH3 H 2,6DMB CH3 H H 3665 CH3 H 2,6DMB H CD3 H 3666 CH3 H 2,6DMB H CH3 H3667 CH3 H 2,6DMB H H CD3 3668 CH3 H 2,6DMB H H CH3 3669 CH3 H 2,6DMB HH H 3670 CH3 H CD3 CD3 H H 3671 CH3 H CD3 CH3 H H 3672 CH3 H CD3 H CD3 H3673 CH3 H CD3 H CH3 H 3674 CH3 H CD3 H H CD3 3675 CH3 H CD3 H H CH33676 CH3 H CD3 H H H 3677 CH3 H CH3 CD3 H H 3678 CH3 H CH3 CH3 H H 3679CH3 H CH3 H CD3 H 3680 CH3 H CH3 H CH3 H 3681 CH3 H CH3 H H CD3 3682 CH3H CH3 H H CH3 3683 CH3 H CH3 H H H 3684 CH3 H H 2,6DIP H H 3685 CH3 H H2,6DMB H H 3686 CH3 H H CD3 H H 3687 CH3 H H CH3 H H 3688 CH3 H H H2,6DIP H 3689 CH3 H H H 2,6DMB H 3690 CH3 H H H CD3 H 3691 CH3 H H H CH3H 3692 CH3 H H H H 2,6DIP 3693 CH3 H H H H 2,6DMB 3694 CH3 H H H H CD33695 CH3 H H H H CH3 3696 CH3 H H H H H 3697 CH3 H H H H iPr 3698 CH3 HH H iPr H 3699 CH3 H H iPr H H 3700 CH3 H iPr CD3 H H 3701 CH3 H iPr CH3H H 3702 CH3 H iPr H CD3 H 3703 CH3 H iPr H CH3 H 3704 CH3 H iPr H H CD33705 CH3 H iPr H H CH3 3706 CH3 H iPr H H H 3707 H 2,6DIP H CD3 H H 3708H 2,6DIP H CH3 H H 3709 H 2,6DIP H H CD3 H 3710 H 2,6DIP H H CH3 H 3711H 2,6DIP H H H CD3 3712 H 2,6DIP H H H CH3 3713 H 2,6DIP H H H H 3714 H2,6DIPB H CD3 H H 3715 H 2,6DIPB H CH3 H H 3716 H 2,6DIPB H H CD3 H 3717H 2,6DIPB H H CH3 H 3718 H 2,6DIPB H H H CD3 3719 H 2,6DIPB H H H CH33720 H 2,6DIPB H H H H 3721 H 2,6DMB H CD3 H H 3722 H 2,6DMB H CH3 H H3723 H 2,6DMB H H CD3 H 3724 H 2,6DMB H H CH3 H 3725 H 2,6DMB H H H CD33726 H 2,6DMB H H H CH3 3727 H 2,6DMB H H H H 3728 H CD3 2,6DIP CD3 H H3729 H CD3 2,6DIP CH3 H H 3730 H CD3 2,6DIP H CD3 H 3731 H CD3 2,6DIP HCH3 H 3732 H CD3 2,6DIP H H CD3 3733 H CD3 2,6DIP H H CH3 3734 H CD32,6DIP H H H 3735 H CD3 2,6DMB CD3 H H 3736 H CD3 2,6DMB CH3 H H 3737 HCD3 2,6DMB H CD3 H 3738 H CD3 2,6DMB H CH3 H 3739 H CD3 2,6DMB H H CD33740 H CD3 2,6DMB H H CH3 3741 H CD3 2,6DMB H H H 3742 H CD3 CD3 CD3 H H3743 H CD3 CD3 CH3 H H 3744 H CD3 CD3 H CD3 H 3745 H CD3 CD3 H CH3 H3746 H CD3 CD3 H H CD3 3747 H CD3 CD3 H H CH3 3748 H CD3 CD3 H H H 3749H CD3 CH3 CD3 H H 3750 H CD3 CH3 CH3 H H 3751 H CD3 CH3 H CD3 H 3752 HCD3 CH3 H CH3 H 3753 H CD3 CH3 H H CD3 3754 H CD3 CH3 H H CH3 3755 H CD3CH3 H H H 3756 H CD3 H 2,6DIP H H 3757 H CD3 H 2,6DMB H H 3758 H CD3 HCD3 H H 3759 H CD3 H CH3 H H 3760 H CD3 H H 2,6DIP H 3761 H CD3 H H2,6DMB H 3762 H CD3 H H CD3 H 3763 H CD3 H H CH3 H 3764 H CD3 H H H2,6DIP 3765 H CD3 H H H 2,6DMB 3766 H CD3 H H H CD3 3767 H CD3 H H H CH33768 H CD3 H H H H 3769 H CD3 H H H iPr 3770 H CD3 H H iPr H 3771 H CD3H iPr H H 3772 H CD3 iPr CD3 H H 3773 H CD3 iPr CH3 H H 3774 H CD3 iPr HCD3 H 3775 H CD3 iPr H CH3 H 3776 H CD3 iPr H H CD3 3777 H CD3 iPr H HCH3 3778 H CD3 iPr H H H 3779 H CH3 2,6DIP CD3 H H 3780 H CH3 2,6DIP CH3H H 3781 H CH3 2,6DIP H CD3 H 3782 H CH3 2,6DIP H CH3 H 3783 H CH32,6DIP H H CD3 3784 H CH3 2,6DIP H H CH3 3785 H CH3 2,6DIP H H H 3786 HCH3 2,6DMB CD3 H H 3787 H CH3 2,6DMB CH3 H H 3788 H CH3 2,6DMB H CD3 H3789 H CH3 2,6DMB H CH3 H 3790 H CH3 2,6DMB H H CD3 3791 H CH3 2,6DMB HH CH3 3792 H CH3 2,6DMB H H H 3793 H CH3 CD3 CD3 H H 3794 H CH3 CD3 CH3H H 3795 H CH3 CD3 H CD3 H 3796 H CH3 CD3 H CH3 H 3797 H CH3 CD3 H H CD33798 H CH3 CD3 H H CH3 3799 H CH3 CD3 H H H 3800 H CH3 CH3 CD3 H H 3801H CH3 CH3 CH3 H H 3802 H CH3 CH3 H CD3 H 3803 H CH3 CH3 H CH3 H 3804 HCH3 CH3 H H CD3 3805 H CH3 CH3 H H CH3 3806 H CH3 CH3 H H H 3807 H CH3 H2,6DIP H H 3808 H CH3 H 2,6DMB H H 3809 H CH3 H CD3 H H 3810 H CH3 H CH3H H 3811 H CH3 H H 2,6DIP H 3812 H CH3 H H 2,6DMB H 3813 H CH3 H H CD3 H3814 H CH3 H H CH3 H 3815 H CH3 H H H 2,6DIP 3816 H CH3 H H H 2,6DMB3817 H CH3 H H H CD3 3818 H CH3 H H H CH3 3819 H CH3 H H H H 3820 H CH3H H H iPr 3821 H CH3 H H iPr H 3822 H CH3 H iPr H H 3823 H CH3 iPr CD3 HH 3824 H CH3 iPr CH3 H H 3825 H CH3 iPr H CD3 H 3826 H CH3 iPr H CH3 H3827 H CH3 iPr H H CD3 3828 H CH3 iPr H H CH3 3829 H CH3 iPr H H H 3830H H 2,6DIP CD3 CD3 H 3831 H H 2,6DIP CD3 CH3 H 3832 H H 2,6DIP CD3 H CD33833 H H 2,6DIP CD3 H CH3 3834 H H 2,6DIP CD3 H H 3835 H H 2,6DIP CH3CD3 H 3836 H H 2,6DIP CH3 CH3 H 3837 H H 2,6DIP CH3 H CD3 3838 H H2,6DIP CH3 H CH3 3839 H H 2,6DIP CH3 H H 3840 H H 2,6DIP H CD3 CD3 3841H H 2,6DIP H CD3 CH3 3842 H H 2,6DIP H CD3 H 3843 H H 2,6DIP H CH3 CD33844 H H 2,6DIP H CH3 CH3 3845 H H 2,6DIP H CH3 H 3846 H H 2,6DIP H HCD3 3847 H H 2,6DIP H H CH3 3848 H H 2,6DIP H H H 3849 H H 2,6DMB CD3CD3 H 3850 H H 2,6DMB CD3 CH3 H 3851 H H 2,6DMB CD3 H CD3 3852 H H2,6DMB CD3 H CH3 3853 H H 2,6DMB CD3 H H 3854 H H 2,6DMB CH3 CD3 H 3855H H 2,6DMB CH3 CH3 H 3856 H H 2,6DMB CH3 H CD3 3857 H H 2,6DMB CH3 H CH33858 H H 2,6DMB CH3 H H 3859 H H 2,6DMB H CD3 CD3 3860 H H 2,6DMB H CD3CH3 3861 H H 2,6DMB H CD3 H 3862 H H 2,6DMB H CH3 CD3 3863 H H 2,6DMB HCH3 CH3 3864 H H 2,6DMB H CH3 H 3865 H H 2,6DMB H H CD3 3866 H H 2,6DMBH H CH3 3867 H H 2,6DMB H H H 3868 H H CD3 CD3 CD3 H 3869 H H CD3 CD3CH3 H 3870 H H CD3 CD3 H CD3 3871 H H CD3 CD3 H CH3 3872 H H CD3 CD3 H H3873 H H CD3 CH3 CD3 H 3874 H H CD3 CH3 CH3 H 3875 H H CD3 CH3 H CD33876 H H CD3 CH3 H CH3 3877 H H CD3 CH3 H H 3878 H H CD3 H 2,6DIP H 3879H H CD3 H 2,6DMB H 3880 H H CD3 H CD3 CD3 3881 H H CD3 H CD3 CH3 3882 HH CD3 H CD3 H 3883 H H CD3 H CH3 CD3 3884 H H CD3 H CH3 CH3 3885 H H CD3H CH3 H 3886 H H CD3 H H 2,6DIP 3887 H H CD3 H H 2,6DMB 3888 H H CD3 H HCD3 3889 H H CD3 H H CH3 3890 H H CD3 H H H 3891 H H CD3 H H iPr 3892 HH CD3 H iPr H 3893 H H CD3 iPr H H 3894 H H CH3 CD3 CD3 H 3895 H H CH3CD3 CH3 H 3896 H H CH3 CD3 H CD3 3897 H H CH3 CD3 H CH3 3898 H H CH3 CD3H H 3899 H H CH3 CH3 CD3 H 3900 H H CH3 CH3 CH3 H 3901 H H CH3 CH3 H CD33902 H H CH3 CH3 H CH3 3903 H H CH3 CH3 H H 3904 H H CH3 H 2,6DIP H 3905H H CH3 H 2,6DMB H 3906 H H CH3 H CD3 CD3 3907 H H CH3 H CD3 CH3 3908 HH CH3 H CD3 H 3909 H H CH3 H CH3 CD3 3910 H H CH3 H CH3 CH3 3911 H H CH3H CH3 H 3912 H H CH3 H H 2,6DIP 3913 H H CH3 H H 2,6DMB 3914 H H CH3 H HCD3 3915 H H CH3 H H CH3 3916 H H CH3 H H H 3917 H H CH3 H H iPr 3918 HH CH3 H iPr H 3919 H H CH3 iPr H H 3920 H H H 2,6DIP H CD3 3921 H H H2,6DIP H CH3 3922 H H H 2,6DIP H H 3923 H H H 2,6DMB H CD3 3924 H H H2,6DMB H CH3 3925 H H H 2,6DMB H H 3926 H H H CD3 CD3 H 3927 H H H CD3CH3 H 3928 H H H CD3 H 2,6DIP 3929 H H H CD3 H 2,6DMB 3930 H H H CD3 HCD3 3931 H H H CD3 H CH3 3932 H H H CD3 H H 3933 H H H CD3 H iPr 3934 HH H CD3 iPr H 3935 H H H CH3 CD3 H 3936 H H H CH3 CH3 H 3937 H H H CH3 H2,6DIP 3938 H H H CH3 H 2,6DMB 3939 H H H CH3 H CD3 3940 H H H CH3 H CH33941 H H H CH3 H H 3942 H H H CH3 H iPr 3943 H H H CH3 iPr H 3944 H H HH 2,6DIP CD3 3945 H H H H 2,6DIP CH3 3946 H H H H 2,6DIP H 3947 H H H H2,6DMB CD3 3948 H H H H 2,6DMB CH3 3949 H H H H 2,6DMB H 3950 H H H HCD3 2,6DIP 3951 H H H H CD3 2,6DMB 3952 H H H H CD3 CD3 3953 H H H H CD3CH3 3954 H H H H CD3 H 3955 H H H H CD3 iPr 3956 H H H H CH3 2,6DIP 3957H H H H CH3 2,6DMB 3958 H H H H CH3 CD3 3959 H H H H CH3 CH3 3960 H H HH CH3 H 3961 H H H H CH3 iPr 3962 H H H H H 2,6DIP 3963 H H H H H 2,6DMB3964 H H H H H CD3 3965 H H H H H CH3 3966 H H H H H H 3967 H H H H HiPr 3968 H H H H iPr CD3 3969 H H H H iPr CH3 3970 H H H H iPr H 3971 HH H iPr CD3 H 3972 H H H iPr CH3 H 3973 H H H iPr H CD3 3974 H H H iPr HCH3 3975 H H H iPr H H 3976 H H iPr CD3 CD3 H 3977 H H iPr CD3 CH3 H3978 H H iPr CD3 H CD3 3979 H H iPr CD3 H CH3 3980 H H iPr CD3 H H 3981H H iPr CH3 CD3 H 3982 H H iPr CH3 CH3 H 3983 H H iPr CH3 H CD3 3984 H HiPr CH3 H CH3 3985 H H iPr CH3 H H 3986 H H iPr H CD3 CD3 3987 H H iPr HCD3 CH3 3988 H H iPr H CD3 H 3989 H H iPr H CH3 CD3 3990 H H iPr H CH3CH3 3991 H H iPr H CH3 H 3992 H H iPr H H CD3 3993 H H iPr H H CH3 3994H H iPr H H H 3995 H ph H CD3 H H 3996 H ph H CH3 H H 3997 H ph H H CD3H 3998 H ph H H CH3 H 3999 H ph H H H CD3 4000 H ph H H H CH3 4001 H phH H H H 4002 iPr CD3 H H H H 4003 iPr CH3 H H H H 4004 iPr H CD3 H H H4005 iPr H CH3 H H H 4006 iPr H H CD3 H H 4007 iPr H H CH3 H H 4008 iPrH H H CD3 H 4009 iPr H H H CH3 H 4010 iPr H H H H CD3 4011 iPr H H H HCH3 4012 iPr H H H H HLA4013 to LA4444 based on structure:

LA # R11 R2 R12 R31 R33 R34 4013 CD3 CD3 2,6DIP H H H 4014 CD3 CD32,6DMB H H H 4015 CD3 CD3 CD3 H H H 4016 CD3 CD3 CH3 H H H 4017 CD3 CD3H H H H 4018 CD3 CD3 iPr H H H 4019 CD3 CH3 2,6DIP H H H 4020 CD3 CH32,6DMB H H H 4021 CD3 CH3 CD3 H H H 4022 CD3 CH3 CH3 H H H 4023 CD3 CH3H H H H 4024 CD3 CH3 iPr H H H 4025 CD3 H 2,6DIP CD3 H H 4026 CD3 H2,6DIP CH3 H H 4027 CD3 H 2,6DIP H CD3 H 4028 CD3 H 2,6DIP H CH3 H 4029CD3 H 2,6DIP H H CD3 4030 CD3 H 2,6DIP H H CH3 4031 CD3 H 2,6DIP H H H4032 CD3 H 2,6DMB CD3 H H 4033 CD3 H 2,6DMB CH3 H H 4034 CD3 H 2,6DMB HCD3 H 4035 CD3 H 2,6DMB H CH3 H 4036 CD3 H 2,6DMB H H CD3 4037 CD3 H2,6DMB H H CH3 4038 CD3 H 2,6DMB H H H 4039 CD3 H CD3 CD3 H H 4040 CD3 HCD3 CH3 H H 4041 CD3 H CD3 H CD3 H 4042 CD3 H CD3 H CH3 H 4043 CD3 H CD3H H CD3 4044 CD3 H CD3 H H CH3 4045 CD3 H CD3 H H H 4046 CD3 H CH3 CD3 HH 4047 CD3 H CH3 CH3 H H 4048 CD3 H CH3 H CD3 H 4049 CD3 H CH3 H CH3 H4050 CD3 H CH3 H H CD3 4051 CD3 H CH3 H H CH3 4052 CD3 H CH3 H H H 4053CD3 H H 2,6DIP H H 4054 CD3 H H 2,6DMB H H 4055 CD3 H H CD3 H H 4056 CD3H H CH3 H H 4057 CD3 H H H 2,6DIP H 4058 CD3 H H H 2,6DMB H 4059 CD3 H HH CD3 H 4060 CD3 H H H CH3 H 4061 CD3 H H H H 2,6DIP 4062 CD3 H H H H2,6DMB 4063 CD3 H H H H CD3 4064 CD3 H H H H CH3 4065 CD3 H H H H H 4066CD3 H H H H iPr 4067 CD3 H H H iPr H 4068 CD3 H H iPr H H 4069 CD3 H iPrCD3 H H 4070 CD3 H iPr CH3 H H 4071 CD3 H iPr H CD3 H 4072 CD3 H iPr HCH3 H 4073 CD3 H iPr H H CD3 4074 CD3 H iPr H H CH3 4075 CD3 H iPr H H H4076 CH3 CD3 2,6DIP H H H 4077 CH3 CD3 2,6DMB H H H 4078 CH3 CD3 CD3 H HH 4079 CH3 CD3 CH3 H H H 4080 CH3 CD3 H H H H 4081 CH3 CD3 iPr H H H4082 CH3 CH3 2,6DIP H H H 4083 CH3 CH3 2,6DMB H H H 4084 CH3 CH3 CD3 H HH 4085 CH3 CH3 CH3 H H H 4086 CH3 CH3 H H H H 4087 CH3 CH3 iPr H H H4088 CH3 H 2,6DIP CD3 H H 4089 CH3 H 2,6DIP CH3 H H 4090 CH3 H 2,6DIP HCD3 H 4091 CH3 H 2,6DIP H CH3 H 4092 CH3 H 2,6DIP H H CD3 4093 CH3 H2,6DIP H H CH3 4094 CH3 H 2,6DIP H H H 4095 CH3 H 2,6DMB CD3 H H 4096CH3 H 2,6DMB CH3 H H 4097 CH3 H 2,6DMB H CD3 H 4098 CH3 H 2,6DMB H CH3 H4099 CH3 H 2,6DMB H H CD3 4100 CH3 H 2,6DMB H H CH3 4101 CH3 H 2,6DMB HH H 4102 CH3 H CD3 CD3 H H 4103 CH3 H CD3 CH3 H H 4104 CH3 H CD3 H CD3 H4105 CH3 H CD3 H CH3 H 4106 CH3 H CD3 H H CD3 4107 CH3 H CD3 H H CH34108 CH3 H CD3 H H H 4109 CH3 H CH3 CD3 H H 4110 CH3 H CH3 CH3 H H 4111CH3 H CH3 H CD3 H 4112 CH3 H CH3 H CH3 H 4113 CH3 H CH3 H H CD3 4114 CH3H CH3 H H CH3 4115 CH3 H CH3 H H H 4116 CH3 H H 2,6DIP H H 4117 CH3 H H2,6DMB H H 4118 CH3 H H CD3 H H 4119 CH3 H H CH3 H H 4120 CH3 H H H2,6DIP H 4121 CH3 H H H 2,6DMB H 4122 CH3 H H H CD3 H 4123 CH3 H H H CH3H 4124 CH3 H H H H 2,6DIP 4125 CH3 H H H H 2,6DMB 4126 CH3 H H H H CD34127 CH3 H H H H CH3 4128 CH3 H H H H H 4129 CH3 H H H H iPr 4130 CH3 HH H iPr H 4131 CH3 H H iPr H H 4132 CH3 H iPr CD3 H H 4133 CH3 H iPr CH3H H 4134 CH3 H iPr H CD3 H 4135 CH3 H iPr H CH3 H 4136 CH3 H iPr H H CD34137 CH3 H iPr H H CH3 4138 CH3 H iPr H H H 4139 H 2,6DIP H CD3 H H 4140H 2,6DIP H CH3 H H 4141 H 2,6DIP H H CD3 H 4142 H 2,6DIP H H CH3 H 4143H 2,6DIP H H H CD3 4144 H 2,6DIP H H H CH3 4145 H 2,6DIP H H H H 4146 H2,6DIPB H CD3 H H 4147 H 2,6DIPB H CH3 H H 4148 H 2,6DIPB H H CD3 H 4149H 2,6DIPB H H CH3 H 4150 H 2,6DIPB H H H CD3 4151 H 2,6DIPB H H H CH34152 H 2,6DIPB H H H H 4153 H 2,6DMB H CD3 H H 4154 H 2,6DMB H CH3 H H4155 H 2,6DMB H H CD3 H 4156 H 2,6DMB H H CH3 H 4157 H 2,6DMB H H H CD34158 H 2,6DMB H H H CH3 4159 H 2,6DMB H H H H 4160 H CD3 2,6DIP CD3 H H4161 H CD3 2,6DIP CH3 H H 4162 H CD3 2,6DIP H CD3 H 4163 H CD3 2,6DIP HCH3 H 4164 H CD3 2,6DIP H H CD3 4165 H CD3 2,6DIP H H CH3 4166 H CD32,6DIP H H H 4167 H CD3 2,6DMB CD3 H H 4168 H CD3 2,6DMB CH3 H H 4169 HCD3 2,6DMB H CD3 H 4170 H CD3 2,6DMB H CH3 H 4171 H CD3 2,6DMB H H CD34172 H CD3 2,6DMB H H CH3 4173 H CD3 2,6DMB H H H 4174 H CD3 CD3 CD3 H H4175 H CD3 CD3 CH3 H H 4176 H CD3 CD3 H CD3 H 4177 H CD3 CD3 H CH3 H4178 H CD3 CD3 H H CD3 4179 H CD3 CD3 H H CH3 4180 H CD3 CD3 H H H 4181H CD3 CH3 CD3 H H 4182 H CD3 CH3 CH3 H H 4183 H CD3 CH3 H CD3 H 4184 HCD3 CH3 H CH3 H 4185 H CD3 CH3 H H CD3 4186 H CD3 CH3 H H CH3 4187 H CD3CH3 H H H 4188 H CD3 H 2,6DIP H H 4189 H CD3 H 2,6DMB H H 4190 H CD3 HCD3 H H 4191 H CD3 H CH3 H H 4192 H CD3 H H 2,6DIP H 4193 H CD3 H H2,6DMB H 4194 H CD3 H H CD3 H 4195 H CD3 H H CH3 H 4196 H CD3 H H H2,6DIP 4197 H CD3 H H H 2,6DMB 4198 H CD3 H H H CD3 4199 H CD3 H H H CH34200 H CD3 H H H H 4201 H CD3 H H H iPr 4202 H CD3 H H iPr H 4203 H CD3H iPr H H 4204 H CD3 iPr CD3 H H 4205 H CD3 iPr CH3 H H 4206 H CD3 iPr HCD3 H 4207 H CD3 iPr H CH3 H 4208 H CD3 iPr H H CD3 4209 H CD3 iPr H HCH3 4210 H CD3 iPr H H H 4211 H CH3 2,6DIP CD3 H H 4212 H CH3 2,6DIP CH3H H 4213 H CH3 2,6DIP H CD3 H 4214 H CH3 2,6DIP H CH3 H 4215 H CH32,6DIP H H CD3 4216 H CH3 2,6DIP H H CH3 4217 H CH3 2,6DIP H H H 4218 HCH3 2,6DMB CD3 H H 4219 H CH3 2,6DMB CH3 H H 4220 H CH3 2,6DMB H CD3 H4221 H CH3 2,6DMB H CH3 H 4222 H CH3 2,6DMB H H CD3 4223 H CH3 2,6DMB HH CH3 4224 H CH3 2,6DMB H H H 4225 H CH3 CD3 CD3 H H 4226 H CH3 CD3 CH3H H 4227 H CH3 CD3 H CD3 H 4228 H CH3 CD3 H CH3 H 4229 H CH3 CD3 H H CD34230 H CH3 CD3 H H CH3 4231 H CH3 CD3 H H H 4232 H CH3 CH3 CD3 H H 4233H CH3 CH3 CH3 H H 4234 H CH3 CH3 H CD3 H 4235 H CH3 CH3 H CH3 H 4236 HCH3 CH3 H H CD3 4237 H CH3 CH3 H H CH3 4238 H CH3 CH3 H H H 4239 H CH3 H2,6DIP H H 4240 H CH3 H 2,6DMB H H 4241 H CH3 H CD3 H H 4242 H CH3 H CH3H H 4243 H CH3 H H 2,6DIP H 4244 H CH3 H H 2,6DMB H 4245 H CH3 H H CD3 H4246 H CH3 H H CH3 H 4247 H CH3 H H H 2,6DIP 4248 H CH3 H H H 2,6DMB4249 H CH3 H H H CD3 4250 H CH3 H H H CH3 4251 H CH3 H H H H 4252 H CH3H H H iPr 4253 H CH3 H H iPr H 4254 H CH3 H iPr H H 4255 H CH3 iPr CD3 HH 4256 H CH3 iPr CH3 H H 4257 H CH3 iPr H CD3 H 4258 H CH3 iPr H CH3 H4259 H CH3 iPr H H CD3 4260 H CH3 iPr H H CH3 4261 H CH3 iPr H H H 4262H H 2,6DIP CD3 CD3 H 4263 H H 2,6DIP CD3 CH3 H 4264 H H 2,6DIP CD3 H CD34265 H H 2,6DIP CD3 H CH3 4266 H H 2,6DIP CD3 H H 4267 H H 2,6DIP CH3CD3 H 4268 H H 2,6DIP CH3 CH3 H 4269 H H 2,6DIP CH3 H CD3 4270 H H2,6DIP CH3 H CH3 4271 H H 2,6DIP CH3 H H 4272 H H 2,6DIP H CD3 CD3 4273H H 2,6DIP H CD3 CH3 4274 H H 2,6DIP H CD3 H 4275 H H 2,6DIP H CH3 CD34276 H H 2,6DIP H CH3 CH3 4277 H H 2,6DIP H CH3 H 4278 H H 2,6DIP H HCD3 4279 H H 2,6DIP H H CH3 4280 H H 2,6DIP H H H 4281 H H 2,6DMB CD3CD3 H 4282 H H 2,6DMB CD3 CH3 H 4283 H H 2,6DMB CD3 H CD3 4284 H H2,6DMB CD3 H CH3 4285 H H 2,6DMB CD3 H H 4286 H H 2,6DMB CH3 CD3 H 4287H H 2,6DMB CH3 CH3 H 4288 H H 2,6DMB CH3 H CD3 4289 H H 2,6DMB CH3 H CH34290 H H 2,6DMB CH3 H H 4291 H H 2,6DMB H CD3 CD3 4292 H H 2,6DMB H CD3CH3 4293 H H 2,6DMB H CD3 H 4294 H H 2,6DMB H CH3 CD3 4295 H H 2,6DMB HCH3 CH3 4296 H H 2,6DMB H CH3 H 4297 H H 2,6DMB H H CD3 4298 H H 2,6DMBH H CH3 4299 H H 2,6DMB H H H 4300 H H CD3 CD3 CD3 H 4301 H H CD3 CD3CH3 H 4302 H H CD3 CD3 H CD3 4303 H H CD3 CD3 H CH3 4304 H H CD3 CD3 H H4305 H H CD3 CH3 CD3 H 4306 H H CD3 CH3 CH3 H 4307 H H CD3 CH3 H CD34308 H H CD3 CH3 H CH3 4309 H H CD3 CH3 H H 4310 H H CD3 H 2,6DIP H 4311H H CD3 H 2,6DMB H 4312 H H CD3 H CD3 CD3 4313 H H CD3 H CD3 CH3 4314 HH CD3 H CD3 H 4315 H H CD3 H CH3 CD3 4316 H H CD3 H CH3 CH3 4317 H H CD3H CH3 H 4318 H H CD3 H H 2,6DIP 4319 H H CD3 H H 2,6DMB 4320 H H CD3 H HCD3 4321 H H CD3 H H CH3 4322 H H CD3 H H H 4323 H H CD3 H H iPr 4324 HH CD3 H iPr H 4325 H H CD3 iPr H H 4326 H H CH3 CD3 CD3 H 4327 H H CH3CD3 CH3 H 4328 H H CH3 CD3 H CD3 4329 H H CH3 CD3 H CH3 4330 H H CH3 CD3H H 4331 H H CH3 CH3 CD3 H 4332 H H CH3 CH3 CH3 H 4333 H H CH3 CH3 H CD34334 H H CH3 CH3 H CH3 4335 H H CH3 CH3 H H 4336 H H CH3 H 2,6DIP H 4337H H CH3 H 2,6DMB H 4338 H H CH3 H CD3 CD3 4339 H H CH3 H CD3 CH3 4340 HH CH3 H CD3 H 4341 H H CH3 H CH3 CD3 4342 H H CH3 H CH3 CH3 4343 H H CH3H CH3 H 4344 H H CH3 H H 2,6DIP 4345 H H CH3 H H 2,6DMB 4346 H H CH3 H HCD3 4347 H H CH3 H H CH3 4348 H H CH3 H H H 4349 H H CH3 H H iPr 4350 HH CH3 H iPr H 4351 H H CH3 iPr H H 4352 H H H 2,6DIP CD3 H 4353 H H H2,6DIP CH3 H 4354 H H H 2,6DIP H CD3 4355 H H H 2,6DIP H CH3 4356 H H H2,6DIP H H 4357 H H H 2,6DMB CD3 H 4358 H H H 2,6DMB CH3 H 4359 H H H2,6DMB H CD3 4360 H H H 2,6DMB H CH3 4361 H H H 2,6DMB H H 4362 H H HCD3 2,6DIP H 4363 H H H CD3 2,6DMB H 4364 H H H CD3 CD3 H 4365 H H H CD3CH3 H 4366 H H H CD3 H 2,6DIP 4367 H H H CD3 H 2,6DMB 4368 H H H CD3 HCD3 4369 H H H CD3 H CH3 4370 H H H CD3 H H 4371 H H H CD3 H iPr 4372 HH H CD3 iPr H 4373 H H H CH3 2,6DIP H 4374 H H H CH3 2,6DMB H 4375 H H HCH3 CD3 H 4376 H H H CH3 CH3 H 4377 H H H CH3 H 2,6DIP 4378 H H H CH3 H2,6DMB 4379 H H H CH3 H CD3 4380 H H H CH3 H CH3 4381 H H H CH3 H H 4382H H H CH3 H iPr 4383 H H H CH3 iPr H 4384 H H H H 2,6DIP H 4385 H H H H2,6DMB H 4386 H H H H CD3 CD3 4387 H H H H CD3 CH3 4388 H H H H CD3 H4389 H H H H CD3 iPr 4390 H H H H CH3 CD3 4391 H H H H CH3 CH3 4392 H HH H CH3 H 4393 H H H H CH3 iPr 4394 H H H H H 2,6DIP 4395 H H H H H2,6DMB 4396 H H H H H CD3 4397 H H H H H CH3 4398 H H H H H H 4399 H H HH H iPr 4400 H H H H iPr CD3 4401 H H H H iPr CH3 4402 H H H H iPr H4403 H H H iPr CD3 H 4404 H H H iPr CH3 H 4405 H H H iPr H CD3 4406 H HH iPr H CH3 4407 H H H iPr H H 4408 H H iPr CD3 CD3 H 4409 H H iPr CD3CH3 H 4410 H H iPr CD3 H CD3 4411 H H iPr CD3 H CH3 4412 H H iPr CD3 H H4413 H H iPr CH3 CD3 H 4414 H H iPr CH3 CH3 H 4415 H H iPr CH3 H CD34416 H H iPr CH3 H CH3 4417 H H iPr CH3 H H 4418 H H iPr H CD3 CD3 4419H H iPr H CD3 CH3 4420 H H iPr H CD3 H 4421 H H iPr H CH3 CD3 4422 H HiPr H CH3 CH3 4423 H H iPr H CH3 H 4424 H H iPr H H CD3 4425 H H iPr H HCH3 4426 H H iPr H H H 4427 H ph H CD3 H H 4428 H ph H CH3 H H 4429 H phH H CD3 H 4430 H ph H H CH3 H 4431 H ph H H H CD3 4432 H ph H H H CH34433 H ph H H H H 4434 iPr CD3 H H H H 4435 iPr CH3 H H H H 4436 iPr HCD3 H H H 4437 iPr H CH3 H H H 4438 iPr H H CD3 H H 4439 iPr H H CH3 H H4440 iPr H H H CD3 H 4441 iPr H H H CH3 H 4442 iPr H H H H CD3 4443 iPrH H H H CH3 4444 iPr H H H H HLA4445 to LA4872 based on structure:

LA # R11 R2 R12 R32 R33 R34 4445 CD3 CD3 2,6DIP H H H 4446 CD3 CD32,6DMB H H H 4447 CD3 CD3 CD3 H H H 4448 CD3 CD3 CH3 H H H 4449 CD3 CD3H H H H 4450 CD3 CD3 iPr H H H 4451 CD3 CH3 2,6DIP H H H 4452 CD3 CH32,6DMB H H H 4453 CD3 CH3 CD3 H H H 4454 CD3 CH3 CH3 H H H 4455 CD3 CH3H H H H 4456 CD3 CH3 iPr H H H 4457 CD3 H 2,6DIP CD3 H H 4458 CD3 H2,6DIP CH3 H H 4459 CD3 H 2,6DIP H CD3 H 4460 CD3 H 2,6DIP H CH3 H 4461CD3 H 2,6DIP H H CD3 4462 CD3 H 2,6DIP H H CH3 4463 CD3 H 2,6DIP H H H4464 CD3 H 2,6DMB CD3 H H 4465 CD3 H 2,6DMB CH3 H H 4466 CD3 H 2,6DMB HCD3 H 4467 CD3 H 2,6DMB H CH3 H 4468 CD3 H 2,6DMB H H CD3 4469 CD3 H2,6DMB H H CH3 4470 CD3 H 2,6DMB H H H 4471 CD3 H CD3 CD3 H H 4472 CD3 HCD3 CH3 H H 4473 CD3 H CD3 H CD3 H 4474 CD3 H CD3 H CH3 H 4475 CD3 H CD3H H CD3 4476 CD3 H CD3 H H CH3 4477 CD3 H CD3 H H H 4478 CD3 H CH3 CD3 HH 4479 CD3 H CH3 CH3 H H 4480 CD3 H CH3 H CD3 H 4481 CD3 H CH3 H CH3 H4482 CD3 H CH3 H H CD3 4483 CD3 H CH3 H H CH3 4484 CD3 H CH3 H H H 4485CD3 H H 2,6DIP H H 4486 CD3 H H 2,6DMB H H 4487 CD3 H H CD3 H H 4488 CD3H H CH3 H H 4489 CD3 H H H 2,6DIP H 4490 CD3 H H H 2,6DMB H 4491 CD3 H HH CD3 H 4492 CD3 H H H CH3 H 4493 CD3 H H H H 2,6DIP 4494 CD3 H H H H2,6DMB 4495 CD3 H H H H CD3 4496 CD3 H H H H CH3 4497 CD3 H H H H H 4498CD3 H H H H iPr 4499 CD3 H H H iPr H 4500 CD3 H H iPr H H 4501 CD3 H iPrCD3 H H 4502 CD3 H iPr CH3 H H 4503 CD3 H iPr H CD3 H 4504 CD3 H iPr HCH3 H 4505 CD3 H iPr H H CD3 4506 CD3 H iPr H H CH3 4507 CD3 H iPr H H H4508 CH3 CD3 2,6DIP H H H 4509 CH3 CD3 2,6DMB H H H 4510 CH3 CD3 CD3 H HH 4511 CH3 CD3 CH3 H H H 4512 CH3 CD3 H H H H 4513 CH3 CD3 iPr H H H4514 CH3 CH3 2,6DIP H H H 4515 CH3 CH3 2,6DMB H H H 4516 CH3 CH3 CD3 H HH 4517 CH3 CH3 CH3 H H H 4518 CH3 CH3 H H H H 4519 CH3 CH3 iPr H H H4520 CH3 H 2,6DIP CD3 H H 4521 CH3 H 2,6DIP CH3 H H 4522 CH3 H 2,6DIP HCD3 H 4523 CH3 H 2,6DIP H CH3 H 4524 CH3 H 2,6DIP H H CD3 4525 CH3 H2,6DIP H H CH3 4526 CH3 H 2,6DIP H H H 4527 CH3 H 2,6DMB CD3 H H 4528CH3 H 2,6DMB CH3 H H 4529 CH3 H 2,6DMB H CD3 H 4530 CH3 H 2,6DMB H CH3 H4531 CH3 H 2,6DMB H H CD3 4532 CH3 H 2,6DMB H H CH3 4533 CH3 H 2,6DMB HH H 4534 CH3 H CD3 CD3 H H 4535 CH3 H CD3 CH3 H H 4536 CH3 H CD3 H CD3 H4537 CH3 H CD3 H CH3 H 4538 CH3 H CD3 H H CD3 4539 CH3 H CD3 H H CH34540 CH3 H CD3 H H H 4541 CH3 H CH3 CD3 H H 4542 CH3 H CH3 CH3 H H 4543CH3 H CH3 H CD3 H 4544 CH3 H CH3 H CH3 H 4545 CH3 H CH3 H H CD3 4546 CH3H CH3 H H CH3 4547 CH3 H CH3 H H H 4548 CH3 H H 2,6DIP H H 4549 CH3 H H2,6DMB H H 4550 CH3 H H CD3 H H 4551 CH3 H H CH3 H H 4552 CH3 H H H2,6DIP H 4553 CH3 H H H 2,6DMB H 4554 CH3 H H H CD3 H 4555 CH3 H H H CH3H 4556 CH3 H H H H 2,6DIP 4557 CH3 H H H H 2,6DMB 4558 CH3 H H H H CD34559 CH3 H H H H CH3 4560 CH3 H H H H H 4561 CH3 H H H H iPr 4562 CH3 HH H iPr H 4563 CH3 H H iPr H H 4564 CH3 H iPr CD3 H H 4565 CH3 H iPr CH3H H 4566 CH3 H iPr H CD3 H 4567 CH3 H iPr H CH3 H 4568 CH3 H iPr H H CD34569 CH3 H iPr H H CH3 4570 CH3 H iPr H H H 4571 H 2,6DIP H CD3 H H 4572H 2,6DIP H CH3 H H 4573 H 2,6DIP H H CD3 H 4574 H 2,6DIP H H CH3 H 4575H 2,6DIP H H H CD3 4576 H 2,6DIP H H H CH3 4577 H 2,6DIP H H H H 4578 H2,6DIPB H CD3 H H 4579 H 2,6DIPB H CH3 H H 4580 H 2,6DIPB H H CD3 H 4581H 2,6DIPB H H CH3 H 4582 H 2,6DIPB H H H CD3 4583 H 2,6DIPB H H H CH34584 H 2,6DIPB H H H H 4585 H 2,6DMB H CD3 H H 4586 H 2,6DMB H CH3 H H4587 H 2,6DMB H H CD3 H 4588 H 2,6DMB H H CH3 H 4589 H 2,6DMB H H H CD34590 H 2,6DMB H H H CH3 4591 H 2,6DMB H H H H 4592 H CD3 2,6DIP CD3 H H4593 H CD3 2,6DIP CH3 H H 4594 H CD3 2,6DIP H CD3 H 4595 H CD3 2,6DIP HCH3 H 4596 H CD3 2,6DIP H H CD3 4597 H CD3 2,6DIP H H CH3 4598 H CD32,6DIP H H H 4599 H CD3 2,6DMB CD3 H H 4600 H CD3 2,6DMB CH3 H H 4601 HCD3 2,6DMB H CD3 H 4602 H CD3 2,6DMB H CH3 H 4603 H CD3 2,6DMB H H CD34604 H CD3 2,6DMB H H CH3 4605 H CD3 2,6DMB H H H 4606 H CD3 CD3 CD3 H H4607 H CD3 CD3 CH3 H H 4608 H CD3 CD3 H CD3 H 4609 H CD3 CD3 H CH3 H4610 H CD3 CD3 H H CD3 4611 H CD3 CD3 H H CH3 4612 H CD3 CD3 H H H 4613H CD3 CH3 CD3 H H 4614 H CD3 CH3 CH3 H H 4615 H CD3 CH3 H CD3 H 4616 HCD3 CH3 H CH3 H 4617 H CD3 CH3 H H CD3 4618 H CD3 CH3 H H CH3 4619 H CD3CH3 H H H 4620 H CD3 H 2,6DIP H H 4621 H CD3 H 2,6DMB H H 4622 H CD3 HCD3 H H 4623 H CD3 H CH3 H H 4624 H CD3 H H 2,6DIP H 4625 H CD3 H H2,6DMB H 4626 H CD3 H H CD3 H 4627 H CD3 H H CH3 H 4628 H CD3 H H H2,6DIP 4629 H CD3 H H H 2,6DMB 4630 H CD3 H H H CD3 4631 H CD3 H H H CH34632 H CD3 H H H H 4633 H CD3 H H H iPr 4634 H CD3 H H iPr H 4635 H CD3H iPr H H 4636 H CD3 iPr CD3 H H 4637 H CD3 iPr CH3 H H 4638 H CD3 iPr HCD3 H 4639 H CD3 iPr H CH3 H 4640 H CD3 iPr H H CD3 4641 H CD3 iPr H HCH3 4642 H CD3 iPr H H H 4643 H CH3 2,6DIP CD3 H H 4644 H CH3 2,6DIP CH3H H 4645 H CH3 2,6DIP H CD3 H 4646 H CH3 2,6DIP H CH3 H 4647 H CH32,6DIP H H CD3 4648 H CH3 2,6DIP H H CH3 4649 H CH3 2,6DIP H H H 4650 HCH3 2,6DMB CD3 H H 4651 H CH3 2,6DMB CH3 H H 4652 H CH3 2,6DMB H CD3 H4653 H CH3 2,6DMB H CH3 H 4654 H CH3 2,6DMB H H CD3 4655 H CH3 2,6DMB HH CH3 4656 H CH3 2,6DMB H H H 4657 H CH3 CD3 CD3 H H 4658 H CH3 CD3 CH3H H 4659 H CH3 CD3 H CD3 H 4660 H CH3 CD3 H CH3 H 4661 H CH3 CD3 H H CD34662 H CH3 CD3 H H CH3 4663 H CH3 CD3 H H H 4664 H CH3 CH3 CD3 H H 4665H CH3 CH3 CH3 H H 4666 H CH3 CH3 H CD3 H 4667 H CH3 CH3 H CH3 H 4668 HCH3 CH3 H H CD3 4669 H CH3 CH3 H H CH3 4670 H CH3 CH3 H H H 4671 H CH3 H2,6DIP H H 4672 H CH3 H 2,6DMB H H 4673 H CH3 H CD3 H H 4674 H CH3 H CH3H H 4675 H CH3 H H 2,6DIP H 4676 H CH3 H H 2,6DMB H 4677 H CH3 H H CD3 H4678 H CH3 H H CH3 H 4679 H CH3 H H H 2,6DIP 4680 H CH3 H H H 2,6DMB4681 H CH3 H H H CD3 4682 H CH3 H H H CH3 4683 H CH3 H H H H 4684 H CH3H H H iPr 4685 H CH3 H H iPr H 4686 H CH3 H iPr H H 4687 H CH3 iPr CD3 HH 4688 H CH3 iPr CH3 H H 4689 H CH3 iPr H CD3 H 4690 H CH3 iPr H CH3 H4691 H CH3 iPr H H CD3 4692 H CH3 iPr H H CH3 4693 H CH3 iPr H H H 4694H H 2,6DIP CD3 CD3 H 4695 H H 2,6DIP CD3 CH3 H 4696 H H 2,6DIP CD3 H CD34697 H H 2,6DIP CD3 H CH3 4698 H H 2,6DIP CD3 H H 4699 H H 2,6DIP CH3CD3 H 4700 H H 2,6DIP CH3 CH3 H 4701 H H 2,6DIP CH3 H CD3 4702 H H2,6DIP CH3 H CH3 4703 H H 2,6DIP CH3 H H 4704 H H 2,6DIP H CD3 CD3 4705H H 2,6DIP H CD3 CH3 4706 H H 2,6DIP H CD3 H 4707 H H 2,6DIP H CH3 CD34708 H H 2,6DIP H CH3 CH3 4709 H H 2,6DIP H CH3 H 4710 H H 2,6DIP H HCD3 4711 H H 2,6DIP H H CH3 4712 H H 2,6DIP H H H 4713 H H 2,6DMB CD3CD3 H 4714 H H 2,6DMB CD3 CH3 H 4715 H H 2,6DMB CD3 H CD3 4716 H H2,6DMB CD3 H CH3 4717 H H 2,6DMB CD3 H H 4718 H H 2,6DMB CH3 CD3 H 4719H H 2,6DMB CH3 CH3 H 4720 H H 2,6DMB CH3 H CD3 4721 H H 2,6DMB CH3 H CH34722 H H 2,6DMB CH3 H H 4723 H H 2,6DMB H CD3 CD3 4724 H H 2,6DMB H CD3CH3 4725 H H 2,6DMB H CD3 H 4726 H H 2,6DMB H CH3 CD3 4727 H H 2,6DMB HCH3 CH3 4728 H H 2,6DMB H CH3 H 4729 H H 2,6DMB H H CD3 4730 H H 2,6DMBH H CH3 4731 H H 2,6DMB H H H 4732 H H CD3 2,6DIP H H 4733 H H CD32,6DMB H H 4734 H H CD3 CD3 CD3 H 4735 H H CD3 CD3 CH3 H 4736 H H CD3CD3 H CD3 4737 H H CD3 CD3 H CH3 4738 H H CD3 CD3 H H 4739 H H CD3 CH3CD3 H 4740 H H CD3 CH3 CH3 H 4741 H H CD3 CH3 H CD3 4742 H H CD3 CH3 HCH3 4743 H H CD3 CH3 H H 4744 H H CD3 H 2,6DIP H 4745 H H CD3 H 2,6DMB H4746 H H CD3 H CD3 CD3 4747 H H CD3 H CD3 CH3 4748 H H CD3 H CD3 H 4749H H CD3 H CH3 CD3 4750 H H CD3 H CH3 CH3 4751 H H CD3 H CH3 H 4752 H HCD3 H H 2,6DIP 4753 H H CD3 H H 2,6DMB 4754 H H CD3 H H CD3 4755 H H CD3H H CH3 4756 H H CD3 H H H 4757 H H CD3 H H iPr 4758 H H CD3 H iPr H4759 H H CD3 iPr H H 4760 H H CH3 2,6DIP H H 4761 H H CH3 2,6DMB H H4762 H H CH3 CD3 CD3 H 4763 H H CH3 CD3 CH3 H 4764 H H CH3 CD3 H CD34765 H H CH3 CD3 H CH3 4766 H H CH3 CD3 H H 4767 H H CH3 CH3 CD3 H 4768H H CH3 CH3 CH3 H 4769 H H CH3 CH3 H CD3 4770 H H CH3 CH3 H CH3 4771 H HCH3 CH3 H H 4772 H H CH3 H 2,6DIP H 4773 H H CH3 H 2,6DMB H 4774 H H CH3H CD3 CD3 4775 H H CH3 H CD3 CH3 4776 H H CH3 H CD3 H 4777 H H CH3 H CH3CD3 4778 H H CH3 H CH3 CH3 4779 H H CH3 H CH3 H 4780 H H CH3 H H 2,6DIP4781 H H CH3 H H 2,6DMB 4782 H H CH3 H H CD3 4783 H H CH3 H H CH3 4784 HH CH3 H H H 4785 H H CH3 H H iPr 4786 H H CH3 H iPr H 4787 H H CH3 iPr HH 4788 H H H 2,6DIP H CD3 4789 H H H 2,6DIP H CH3 4790 H H H 2,6DIP H H4791 H H H 2,6DMB H CD3 4792 H H H 2,6DMB H CH3 4793 H H H 2,6DMB H H4794 H H H CD3 CD3 H 4795 H H H CD3 CH3 H 4796 H H H CD3 H 2,6DIP 4797 HH H CD3 H 2,6DMB 4798 H H H CD3 H CD3 4799 H H H CD3 H CH3 4800 H H HCD3 H H 4801 H H H CD3 H iPr 4802 H H H CD3 iPr H 4803 H H H CH3 CD3 H4804 H H H CH3 CH3 H 4805 H H H CH3 H 2,6DIP 4806 H H H CH3 H 2,6DMB4807 H H H CH3 H CD3 4808 H H H CH3 H CH3 4809 H H H CH3 H H 4810 H H HCH3 H iPr 4811 H H H CH3 iPr H 4812 H H H H 2,6DIP H 4813 H H H H 2,6DMBH 4814 H H H H CD3 CD3 4815 H H H H CD3 CH3 4816 H H H H CD3 H 4817 H HH H CD3 iPr 4818 H H H H CH3 CD3 4819 H H H H CH3 CH3 4820 H H H H CH3 H4821 H H H H CH3 iPr 4822 H H H H H 2,6DIP 4823 H H H H H 2,6DMB 4824 HH H H H CD3 4825 H H H H H CH3 4826 H H H H H H 4827 H H H H H iPr 4828H H H H iPr CD3 4829 H H H H iPr CH3 4830 H H H H iPr H 4831 H H H iPrCD3 H 4832 H H H iPr CH3 H 4833 H H H iPr H CD3 4834 H H H iPr H CH34835 H H H iPr H H 4836 H H iPr CD3 CD3 H 4837 H H iPr CD3 CH3 H 4838 HH iPr CD3 H CD3 4839 H H iPr CD3 H CH3 4840 H H iPr CD3 H H 4841 H H iPrCH3 CD3 H 4842 H H iPr CH3 CH3 H 4843 H H iPr CH3 H CD3 4844 H H iPr CH3H CH3 4845 H H iPr CH3 H H 4846 H H iPr H CD3 CD3 4847 H H iPr H CD3 CH34848 H H iPr H CD3 H 4849 H H iPr H CH3 CD3 4850 H H iPr H CH3 CH3 4851H H iPr H CH3 H 4852 H H iPr H H CD3 4853 H H iPr H H CH3 4854 H H iPr HH H 4855 H ph H CD3 H H 4856 H ph H CH3 H H 4857 H ph H H CD3 H 4858 Hph H H CH3 H 4859 H ph H H H CD3 4860 H ph H H H CH3 4861 H ph H H H H4862 iPr CD3 H H H H 4863 iPr CH3 H H H H 4864 iPr H CD3 H H H 4865 iPrH CH3 H H H 4866 iPr H H CD3 H H 4867 iPr H H CH3 H H 4868 iPr H H H CD3H 4869 iPr H H H CH3 H 4870 iPr H H H H CD3 4871 iPr H H H H CH3 4872iPr H H H H HLA4873 to LA5487 based on structure:

LA # R11 R12 R2 R31 R32 R33 R34 4873 CD3 CD3 2,6DIP H H H H 4874 CD3 CD32,6DMB H H H H 4875 CD3 CD3 CD3 H H H H 4876 CD3 CD3 CH3 H H H H 4877CD3 CD3 H H H H H 4878 CD3 CD3 iPr H H H H 4879 CD3 CH3 2,6DIP H H H H4880 CD3 CH3 2,6DMB H H H H 4881 CD3 CH3 CD3 H H H H 4882 CD3 CH3 CH3 HH H H 4883 CD3 CH3 H H H H H 4884 CD3 CH3 iPr H H H H 4885 CD3 H 2,6DIPCD3 H H H 4886 CD3 H 2,6DIP CH3 H H H 4887 CD3 H 2,6DIP H CD3 H H 4888CD3 H 2,6DIP H CH3 H H 4889 CD3 H 2,6DIP H H CD3 H 4890 CD3 H 2,6DIP H HCH3 H 4891 CD3 H 2,6DIP H H H CD3 4892 CD3 H 2,6DIP H H H CH3 4893 CD3 H2,6DIP H H H H 4894 CD3 H 2,6DMB CD3 H H H 4895 CD3 H 2,6DMB CH3 H H H4896 CD3 H 2,6DMB H CD3 H H 4897 CD3 H 2,6DMB H CH3 H H 4898 CD3 H2,6DMB H H CD3 H 4899 CD3 H 2,6DMB H H CH3 H 4900 CD3 H 2,6DMB H H H CD34901 CD3 H 2,6DMB H H H CH3 4902 CD3 H 2,6DMB H H H H 4903 CD3 H CD3 CD3H H H 4904 CD3 H CD3 CH3 H H H 4905 CD3 H CD3 H CD3 H H 4906 CD3 H CD3 HCH3 H H 4907 CD3 H CD3 H H CD3 H 4908 CD3 H CD3 H H CH3 H 4909 CD3 H CD3H H H CD3 4910 CD3 H CD3 H H H CH3 4911 CD3 H CD3 H H H H 4912 CD3 H CH3CD3 H H H 4913 CD3 H CH3 CH3 H H H 4914 CD3 H CH3 H CD3 H H 4915 CD3 HCH3 H CH3 H H 4916 CD3 H CH3 H H CD3 H 4917 CD3 H CH3 H H CH3 H 4918 CD3H CH3 H H H CD3 4919 CD3 H CH3 H H H CH3 4920 CD3 H CH3 H H H H 4921 CD3H H 2,6DIP H H H 4922 CD3 H H 2,6DMB H H H 4923 CD3 H H CD3 H H H 4924CD3 H H CH3 H H H 4925 CD3 H H H 2,6DIP H H 4926 CD3 H H H 2,6DMB H H4927 CD3 H H H CD3 H H 4928 CD3 H H H CH3 H H 4929 CD3 H H H H 2,6DIP H4930 CD3 H H H H 2,6DMB H 4931 CD3 H H H H CD3 H 4932 CD3 H H H H CH3 H4933 CD3 H H H H H 2,6DIP 4934 CD3 H H H H H 2,6DMB 4935 CD3 H H H H HCD3 4936 CD3 H H H H H CH3 4937 CD3 H H H H H H 4938 CD3 H H H H H iPr4939 CD3 H H H H iPr H 4940 CD3 H H H iPr H H 4941 CD3 H H iPr H H H4942 CD3 H iPr CD3 H H H 4943 CD3 H iPr CH3 H H H 4944 CD3 H iPr H CD3 HH 4945 CD3 H iPr H CH3 H H 4946 CD3 H iPr H H CD3 H 4947 CD3 H iPr H HCH3 H 4948 CD3 H iPr H H H CD3 4949 CD3 H iPr H H H CH3 4950 CD3 H iPr HH H H 4951 CH3 CD3 2,6DIP H H H H 4952 CH3 CD3 2,6DMB H H H H 4953 CH3CD3 CD3 H H H H 4954 CH3 CD3 CH3 H H H H 4955 CH3 CD3 H H H H H 4956 CH3CD3 iPr H H H H 4957 CH3 CH3 2,6DIP H H H H 4958 CH3 CH3 2,6DMB H H H H4959 CH3 CH3 CD3 H H H H 4960 CH3 CH3 CH3 H H H H 4961 CH3 CH3 H H H H H4962 CH3 CH3 iPr H H H H 4963 CH3 H 2,6DIP CD3 H H H 4964 CH3 H 2,6DIPCH3 H H H 4965 CH3 H 2,6DIP H CD3 H H 4966 CH3 H 2,6DIP H CH3 H H 4967CH3 H 2,6DIP H H CD3 H 4968 CH3 H 2,6DIP H H CH3 H 4969 CH3 H 2,6DIP H HH CD3 4970 CH3 H 2,6DIP H H H CH3 4971 CH3 H 2,6DIP H H H H 4972 CH3 H2,6DMB CD3 H H H 4973 CH3 H 2,6DMB CH3 H H H 4974 CH3 H 2,6DMB H CD3 H H4975 CH3 H 2,6DMB H CH3 H H 4976 CH3 H 2,6DMB H H CD3 H 4977 CH3 H2,6DMB H H CH3 H 4978 CH3 H 2,6DMB H H H CD3 4979 CH3 H 2,6DMB H H H CH34980 CH3 H 2,6DMB H H H H 4981 CH3 H CD3 CD3 H H H 4982 CH3 H CD3 CH3 HH H 4983 CH3 H CD3 H CD3 H H 4984 CH3 H CD3 H CH3 H H 4985 CH3 H CD3 H HCD3 H 4986 CH3 H CD3 H H CH3 H 4987 CH3 H CD3 H H H CD3 4988 CH3 H CD3 HH H CH3 4989 CH3 H CD3 H H H H 4990 CH3 H CH3 CD3 H H H 4991 CH3 H CH3CH3 H H H 4992 CH3 H CH3 H CD3 H H 4993 CH3 H CH3 H CH3 H H 4994 CH3 HCH3 H H CD3 H 4995 CH3 H CH3 H H CH3 H 4996 CH3 H CH3 H H H CD3 4997 CH3H CH3 H H H CH3 4998 CH3 H CH3 H H H H 4999 CH3 H H 2,6DIP H H H 5000CH3 H H 2,6DMB H H H 5001 CH3 H H CD3 H H H 5002 CH3 H H CH3 H H H 5003CH3 H H H 2,6DIP H H 5004 CH3 H H H 2,6DMB H H 5005 CH3 H H H CD3 H H5006 CH3 H H H CH3 H H 5007 CH3 H H H H 2,6DIP H 5008 CH3 H H H H 2,6DMBH 5009 CH3 H H H H CD3 H 5010 CH3 H H H H CH3 H 5011 CH3 H H H H H2,6DIP 5012 CH3 H H H H H 2,6DMB 5013 CH3 H H H H H CD3 5014 CH3 H H H HH CH3 5015 CH3 H H H H H H 5016 CH3 H H H H H iPr 5017 CH3 H H H H iPr H5018 CH3 H H H iPr H H 5019 CH3 H H iPr H H H 5020 CH3 H iPr CD3 H H H5021 CH3 H iPr CH3 H H H 5022 CH3 H iPr H CD3 H H 5023 CH3 H iPr H CH3 HH 5024 CH3 H iPr H H CD3 H 5025 CH3 H iPr H H CH3 H 5026 CH3 H iPr H H HCD3 5027 CH3 H iPr H H H CH3 5028 CH3 H iPr H H H H 5029 H 2,6DIP H CD3H H H 5030 H 2,6DIP H CH3 H H H 5031 H 2,6DIP H H CD3 H H 5032 H 2,6DIPH H CH3 H H 5033 H 2,6DIP H H H CD3 H 5034 H 2,6DIP H H H CH3 H 5035 H2,6DIP H H H H CD3 5036 H 2,6DIP H H H H CH3 5037 H 2,6DIP H H H H H5038 H 2,6DIPB H CD3 H H H 5039 H 2,6DIPB H CH3 H H H 5040 H 2,6DIPB H HCD3 H H 5041 H 2,6DIPB H H CH3 H H 5042 H 2,6DIPB H H H CD3 H 5043 H2,6DIPB H H H CH3 H 5044 H 2,6DIPB H H H H CD3 5045 H 2,6DIPB H H H HCH3 5046 H 2,6DIPB H H H H H 5047 H 2,6DMB H CD3 H H H 5048 H 2,6DMB HCH3 H H H 5049 H 2,6DMB H H CD3 H H 5050 H 2,6DMB H H CH3 H H 5051 H2,6DMB H H H CD3 H 5052 H 2,6DMB H H H CH3 H 5053 H 2,6DMB H H H H CD35054 H 2,6DMB H H H H CH3 5055 H 2,6DMB H H H H H 5056 H CD3 2,6DIP CD3H H H 5057 H CD3 2,6DIP CH3 H H H 5058 H CD3 2,6DIP H CD3 H H 5059 H CD32,6DIP H CH3 H H 5060 H CD3 2,6DIP H H CD3 H 5061 H CD3 2,6DIP H H CH3 H5062 H CD3 2,6DIP H H H CD3 5063 H CD3 2,6DIP H H H CH3 5064 H CD32,6DIP H H H H 5065 H CD3 2,6DMB CD3 H H H 5066 H CD3 2,6DMB CH3 H H H5067 H CD3 2,6DMB H CD3 H H 5068 H CD3 2,6DMB H CH3 H H 5069 H CD32,6DMB H H CD3 H 5070 H CD3 2,6DMB H H CH3 H 5071 H CD3 2,6DMB H H H CD35072 H CD3 2,6DMB H H H CH3 5073 H CD3 2,6DMB H H H H 5074 H CD3 CD3 CD3H H H 5075 H CD3 CD3 CH3 H H H 5076 H CD3 CD3 H CD3 H H 5077 H CD3 CD3 HCH3 H H 5078 H CD3 CD3 H H CD3 H 5079 H CD3 CD3 H H CH3 H 5080 H CD3 CD3H H H CD3 5081 H CD3 CD3 H H H CH3 5082 H CD3 CD3 H H H H 5083 H CD3 CH3CD3 H H H 5084 H CD3 CH3 CH3 H H H 5085 H CD3 CH3 H CD3 H H 5086 H CD3CH3 H CH3 H H 5087 H CD3 CH3 H H CD3 H 5088 H CD3 CH3 H H CH3 H 5089 HCD3 CH3 H H H CD3 5090 H CD3 CH3 H H H CH3 5091 H CD3 CH3 H H H H 5092 HCD3 H 2,6DIP H H H 5093 H CD3 H 2,6DMB H H H 5094 H CD3 H CD3 H H H 5095H CD3 H CH3 H H H 5096 H CD3 H H 2,6DIP H H 5097 H CD3 H H 2,6DMB H H5098 H CD3 H H CD3 H H 5099 H CD3 H H CH3 H H 5100 H CD3 H H H 2,6DIP H5101 H CD3 H H H 2,6DMB H 5102 H CD3 H H H CD3 H 5103 H CD3 H H H CH3 H5104 H CD3 H H H H 2,6DIP 5105 H CD3 H H H H 2,6DMB 5106 H CD3 H H H HCD3 5107 H CD3 H H H H CH3 5108 H CD3 H H H H H 5109 H CD3 H H H H iPr5110 H CD3 H H H iPr H 5111 H CD3 H H iPr H H 5112 H CD3 H iPr H H H5113 H CD3 iPr CD3 H H H 5114 H CD3 iPr CH3 H H H 5115 H CD3 iPr H CD3 HH 5116 H CD3 iPr H CH3 H H 5117 H CD3 iPr H H CD3 H 5118 H CD3 iPr H HCH3 H 5119 H CD3 iPr H H H CD3 5120 H CD3 iPr H H H CH3 5121 H CD3 iPr HH H H 5122 H CH3 2,6DIP CD3 H H H 5123 H CH3 2,6DIP CH3 H H H 5124 H CH32,6DIP H CD3 H H 5125 H CH3 2,6DIP H CH3 H H 5126 H CH3 2,6DIP H H CD3 H5127 H CH3 2,6DIP H H CH3 H 5128 H CH3 2,6DIP H H H CD3 5129 H CH32,6DIP H H H CH3 5130 H CH3 2,6DIP H H H H 5131 H CH3 2,6DMB CD3 H H H5132 H CH3 2,6DMB CH3 H H H 5133 H CH3 2,6DMB H CD3 H H 5134 H CH32,6DMB H CH3 H H 5135 H CH3 2,6DMB H H CD3 H 5136 H CH3 2,6DMB H H CH3 H5137 H CH3 2,6DMB H H H CD3 5138 H CH3 2,6DMB H H H CH3 5139 H CH32,6DMB H H H H 5140 H CH3 CD3 CD3 H H H 5141 H CH3 CD3 CH3 H H H 5142 HCH3 CD3 H CD3 H H 5143 H CH3 CD3 H CH3 H H 5144 H CH3 CD3 H H CD3 H 5145H CH3 CD3 H H CH3 H 5146 H CH3 CD3 H H H CD3 5147 H CH3 CD3 H H H CH35148 H CH3 CD3 H H H H 5149 H CH3 CH3 CD3 H H H 5150 H CH3 CH3 CH3 H H H5151 H CH3 CH3 H CD3 H H 5152 H CH3 CH3 H CH3 H H 5153 H CH3 CH3 H H CD3H 5154 H CH3 CH3 H H CH3 H 5155 H CH3 CH3 H H H CD3 5156 H CH3 CH3 H H HCH3 5157 H CH3 CH3 H H H H 5158 H CH3 H 2,6DIP H H H 5159 H CH3 H 2,6DMBH H H 5160 H CH3 H CD3 H H H 5161 H CH3 H CH3 H H H 5162 H CH3 H H2,6DIP H H 5163 H CH3 H H 2,6DMB H H 5164 H CH3 H H CD3 H H 5165 H CH3 HH CH3 H H 5166 H CH3 H H H 2,6DIP H 5167 H CH3 H H H 2,6DMB H 5168 H CH3H H H CD3 H 5169 H CH3 H H H CH3 H 5170 H CH3 H H H H 2,6DIP 5171 H CH3H H H H 2,6DMB 5172 H CH3 H H H H CD3 5173 H CH3 H H H H CH3 5174 H CH3H H H H H 5175 H CH3 H H H H iPr 5176 H CH3 H H H iPr H 5177 H CH3 H HiPr H H 5178 H CH3 H iPr H H H 5179 H CH3 iPr CD3 H H H 5180 H CH3 iPrCH3 H H H 5181 H CH3 iPr H CD3 H H 5182 H CH3 iPr H CH3 H H 5183 H CH3iPr H H CD3 H 5184 H CH3 iPr H H CH3 H 5185 H CH3 iPr H H H CD3 5186 HCH3 iPr H H H CH3 5187 H CH3 iPr H H H H 5188 H H 2,6DIP CD3 CD3 H H5189 H H 2,6DIP CD3 CH3 H H 5190 H H 2,6DIP CD3 H CD3 H 5191 H H 2,6DIPCD3 H CH3 H 5192 H H 2,6DIP CD3 H H CD3 5193 H H 2,6DIP CD3 H H CH3 5194H H 2,6DIP CD3 H H H 5195 H H 2,6DIP CH3 CD3 H H 5196 H H 2,6DIP CH3 CH3H H 5197 H H 2,6DIP CH3 H CD3 H 5198 H H 2,6DIP CH3 H CH3 H 5199 H H2,6DIP CH3 H H CD3 5200 H H 2,6DIP CH3 H H CH3 5201 H H 2,6DIP CH3 H H H5202 H H 2,6DIP H CD3 CD3 H 5203 H H 2,6DIP H CD3 CH3 H 5204 H H 2,6DIPH CD3 H CD3 5205 H H 2,6DIP H CD3 H CH3 5206 H H 2,6DIP H CD3 H H 5207 HH 2,6DIP H CH3 CD3 H 5208 H H 2,6DIP H CH3 CH3 H 5209 H H 2,6DIP H CH3 HCD3 5210 H H 2,6DIP H CH3 H CH3 5211 H H 2,6DIP H CH3 H H 5212 H H2,6DIP H H CD3 CD3 5213 H H 2,6DIP H H CD3 CH3 5214 H H 2,6DIP H H CD3 H5215 H H 2,6DIP H H CH3 CD3 5216 H H 2,6DIP H H CH3 CH3 5217 H H 2,6DIPH H CH3 H 5218 H H 2,6DIP H H H CD3 5219 H H 2,6DIP H H H CH3 5220 H H2,6DIP H H H H 5221 H H 2,6DMB CD3 CD3 H H 5222 H H 2,6DMB CD3 CH3 H H5223 H H 2,6DMB CD3 H CD3 H 5224 H H 2,6DMB CD3 H CH3 H 5225 H H 2,6DMBCD3 H H CD3 5226 H H 2,6DMB CD3 H H CH3 5227 H H 2,6DMB CD3 H H H 5228 HH 2,6DMB CH3 CD3 H H 5229 H H 2,6DMB CH3 CH3 H H 5230 H H 2,6DMB CH3 HCD3 H 5231 H H 2,6DMB CH3 H CH3 H 5232 H H 2,6DMB CH3 H H CD3 5233 H H2,6DMB CH3 H H CH3 5234 H H 2,6DMB CH3 H H H 5235 H H 2,6DMB H CD3 CD3 H5236 H H 2,6DMB H CD3 CH3 H 5237 H H 2,6DMB H CD3 H CD3 5238 H H 2,6DMBH CD3 H CH3 5239 H H 2,6DMB H CD3 H H 5240 H H 2,6DMB H CH3 CD3 H 5241 HH 2,6DMB H CH3 CH3 H 5242 H H 2,6DMB H CH3 H CD3 5243 H H 2,6DMB H CH3 HCH3 5244 H H 2,6DMB H CH3 H H 5245 H H 2,6DMB H H CD3 CD3 5246 H H2,6DMB H H CD3 CH3 5247 H H 2,6DMB H H CD3 H 5248 H H 2,6DMB H H CH3 CD35249 H H 2,6DMB H H CH3 CH3 5250 H H 2,6DMB H H CH3 H 5251 H H 2,6DMB HH H CD3 5252 H H 2,6DMB H H H CH3 5253 H H 2,6DMB H H H H 5254 H H CD3CD3 CD3 H H 5255 H H CD3 CD3 CH3 H H 5256 H H CD3 CD3 H CD3 H 5257 H HCD3 CD3 H CH3 H 5258 H H CD3 CD3 H H CD3 5259 H H CD3 CD3 H H CH3 5260 HH CD3 CD3 H H H 5261 H H CD3 CH3 CD3 H H 5262 H H CD3 CH3 CH3 H H 5263 HH CD3 CH3 H CD3 H 5264 H H CD3 CH3 H CH3 H 5265 H H CD3 CH3 H H CD3 5266H H CD3 CH3 H H CH3 5267 H H CD3 CH3 H H H 5268 H H CD3 H 2,6DIP H H5269 H H CD3 H 2,6DMB H H 5270 H H CD3 H CD3 CD3 H 5271 H H CD3 H CD3CH3 H 5272 H H CD3 H CD3 H CD3 5273 H H CD3 H CD3 H CH3 5274 H H CD3 HCD3 H H 5275 H H CD3 H CH3 CD3 H 5276 H H CD3 H CH3 CH3 H 5277 H H CD3 HCH3 H CD3 5278 H H CD3 H CH3 H CH3 5279 H H CD3 H CH3 H H 5280 H H CD3 HH 2,6DIP H 5281 H H CD3 H H 2,6DMB H 5282 H H CD3 H H CD3 CD3 5283 H HCD3 H H CD3 CH3 5284 H H CD3 H H CD3 H 5285 H H CD3 H H CH3 CD3 5286 H HCD3 H H CH3 CH3 5287 H H CD3 H H CH3 H 5288 H H CD3 H H H 2,6DIP 5289 HH CD3 H H H 2,6DMB 5290 H H CD3 H H H CD3 5291 H H CD3 H H H CH3 5292 HH CD3 H H H H 5293 H H CD3 H H H iPr 5294 H H CD3 H H iPr H 5295 H H CD3H iPr H H 5296 H H CD3 iPr H H H 5297 H H CH3 CD3 CD3 H H 5298 H H CH3CD3 CH3 H H 5299 H H CH3 CD3 H CD3 H 5300 H H CH3 CD3 H CH3 H 5301 H HCH3 CD3 H H CD3 5302 H H CH3 CD3 H H CH3 5303 H H CH3 CD3 H H H 5304 H HCH3 CH3 CD3 H H 5305 H H CH3 CH3 CH3 H H 5306 H H CH3 CH3 H CD3 H 5307 HH CH3 CH3 H CH3 H 5308 H H CH3 CH3 H H CD3 5309 H H CH3 CH3 H H CH3 5310H H CH3 CH3 H H H 5311 H H CH3 H 2,6DIP H H 5312 H H CH3 H 2,6DMB H H5313 H H CH3 H CD3 CD3 H 5314 H H CH3 H CD3 CH3 H 5315 H H CH3 H CD3 HCD3 5316 H H CH3 H CD3 H CH3 5317 H H CH3 H CD3 H H 5318 H H CH3 H CH3CD3 H 5319 H H CH3 H CH3 CH3 H 5320 H H CH3 H CH3 H CD3 5321 H H CH3 HCH3 H CH3 5322 H H CH3 H CH3 H H 5323 H H CH3 H H 2,6DIP H 5324 H H CH3H H 2,6DMB H 5325 H H CH3 H H CD3 CD3 5326 H H CH3 H H CD3 CH3 5327 H HCH3 H H CD3 H 5328 H H CH3 H H CH3 CD3 5329 H H CH3 H H CH3 CH3 5330 H HCH3 H H CH3 H 5331 H H CH3 H H H 2,6DIP 5332 H H CH3 H H H 2,6DMB 5333 HH CH3 H H H CD3 5334 H H CH3 H H H CH3 5335 H H CH3 H H H H 5336 H H CH3H H H iPr 5337 H H CH3 H H iPr H 5338 H H CH3 H iPr H H 5339 H H CH3 iPrH H H 5340 H H H 2,6DIP H CD3 H 5341 H H H 2,6DIP H CH3 H 5342 H H H2,6DIP H H CD3 5343 H H H 2,6DIP H H CH3 5344 H H H 2,6DIP H H H 5345 HH H 2,6DMB H CD3 H 5346 H H H 2,6DMB H CH3 H 5347 H H H 2,6DMB H H CD35348 H H H 2,6DMB H H CH3 5349 H H H 2,6DMB H H H 5350 H H H CD3 CD3 H H5351 H H H CD3 CH3 H H 5352 H H H CD3 H 2,6DIP H 5353 H H H CD3 H 2,6DMBH 5354 H H H CD3 H CD3 H 5355 H H H CD3 H CH3 H 5356 H H H CD3 H H2,6DIP 5357 H H H CD3 H H 2,6DMB 5358 H H H CD3 H H CD3 5359 H H H CD3 HH CH3 5360 H H H CD3 H H H 5361 H H H CD3 H H iPr 5362 H H H CD3 H iPr H5363 H H H CD3 iPr H H 5364 H H H CH3 CD3 H H 5365 H H H CH3 CH3 H H5366 H H H CH3 H 2,6DIP H 5367 H H H CH3 H 2,6DMB H 5368 H H H CH3 H CD3H 5369 H H H CH3 H CH3 H 5370 H H H CH3 H H 2,6DIP 5371 H H H CH3 H H2,6DMB 5372 H H H CH3 H H CD3 5373 H H H CH3 H H CH3 5374 H H H CH3 H HH 5375 H H H CH3 H H iPr 5376 H H H CH3 H iPr H 5377 H H H CH3 iPr H H5378 H H H H 2,6DIP H CD3 5379 H H H H 2,6DIP H CH3 5380 H H H H 2,6DIPH H 5381 H H H H 2,6DMB H CD3 5382 H H H H 2,6DMB H CH3 5383 H H H H2,6DMB H H 5384 H H H H CD3 CD3 H 5385 H H H H CD3 CH3 H 5386 H H H HCD3 H 2,6DIP 5387 H H H H CD3 H 2,6DMB 5388 H H H H CD3 H CD3 5389 H H HH CD3 H CH3 5390 H H H H CD3 H H 5391 H H H H CD3 H iPr 5392 H H H H CD3iPr H 5393 H H H H CH3 CD3 H 5394 H H H H CH3 CH3 H 5395 H H H H CH3 H2,6DIP 5396 H H H H CH3 H 2,6DMB 5397 H H H H CH3 H CD3 5398 H H H H CH3H CH3 5399 H H H H CH3 H H 5400 H H H H CH3 H iPr 5401 H H H H CH3 iPr H5402 H H H H H 2,6DIP H 5403 H H H H H 2,6DMB H 5404 H H H H H CD3 CD35405 H H H H H CD3 CH3 5406 H H H H H CD3 H 5407 H H H H H CD3 iPr 5408H H H H H CH3 CD3 5409 H H H H H CH3 CH3 5410 H H H H H CH3 H 5411 H H HH H CH3 iPr 5412 H H H H H H 2,6DIP 5413 H H H H H H 2,6DMB 5414 H H H HH H CD3 5415 H H H H H H CH3 5416 H H H H H H H 5417 H H H H H H iPr5418 H H H H H iPr CD3 5419 H H H H H iPr CH3 5420 H H H H H iPr H 5421H H H H iPr CD3 H 5422 H H H H iPr CH3 H 5423 H H H H iPr H CD3 5424 H HH H iPr H CH3 5425 H H H H iPr H H 5426 H H H iPr CD3 H H 5427 H H H iPrCH3 H H 5428 H H H iPr H CD3 H 5429 H H H iPr H CH3 H 5430 H H H iPr H HCD3 5431 H H H iPr H H CH3 5432 H H H iPr H H H 5433 H H iPr CD3 CD3 H H5434 H H iPr CD3 CH3 H H 5435 H H iPr CD3 H CD3 H 5436 H H iPr CD3 H CH3H 5437 H H iPr CD3 H H CD3 5438 H H iPr CD3 H H CH3 5439 H H iPr CD3 H HH 5440 H H iPr CH3 CD3 H H 5441 H H iPr CH3 CH3 H H 5442 H H iPr CH3 HCD3 H 5443 H H iPr CH3 H CH3 H 5444 H H iPr CH3 H H CD3 5445 H H iPr CH3H H CH3 5446 H H iPr CH3 H H H 5447 H H iPr H CD3 CD3 H 5448 H H iPr HCD3 CH3 H 5449 H H iPr H CD3 H CD3 5450 H H iPr H CD3 H CH3 5451 H H iPrH CD3 H H 5452 H H iPr H CH3 CD3 H 5453 H H iPr H CH3 CH3 H 5454 H H iPrH CH3 H CD3 5455 H H iPr H CH3 H CH3 5456 H H iPr H CH3 H H 5457 H H iPrH H CD3 CD3 5458 H H iPr H H CD3 CH3 5459 H H iPr H H CD3 H 5460 H H iPrH H CH3 CD3 5461 H H iPr H H CH3 CH3 5462 H H iPr H H CH3 H 5463 H H iPrH H H CD3 5464 H H iPr H H H CH3 5465 H H iPr H H H H 5466 H ph H CD3 HH H 5467 H ph H CH3 H H H 5468 H ph H H CD3 H H 5469 H ph H H CH3 H H5470 H ph H H H CD3 H 5471 H ph H H H CH3 H 5472 H ph H H H H CD3 5473 Hph H H H H CH3 5474 H ph H H H H H 5475 iPr CD3 H H H H H 5476 iPr CH3 HH H H H 5477 iPr H CD3 H H H H 5478 iPr H CH3 H H H H 5479 iPr H H CD3 HH H 5480 iPr H H CH3 H H H 5481 iPr H H H CD3 H H 5482 iPr H H H CH3 H H5483 iPr H H H H CD3 H 5484 iPr H H H H CH3 H 5485 iPr H H H H H CD35486 iPr H H H H H CH3 5487 iPr H H H H H HLA5488 to LA5700 based on structure:

LA # R11 R12 R13 R31 R32 R33 5488 CD3 CD3 H H H H 5489 CD3 CH3 H H H H5490 CD3 H 2,6DIP H H H 5491 CD3 H 2,6DMB H H H 5492 CD3 H CD3 H H H5493 CD3 H CH3 H H H 5494 CD3 H H 2,6DIP H H 5495 CD3 H H 2,6DMB H H5496 CD3 H H CD3 H H 5497 CD3 H H CH3 H H 5498 CD3 H H H 2,6DIP H 5499CD3 H H H 2,6DMB H 5500 CD3 H H H CD3 H 5501 CD3 H H H CH3 H 5502 CD3 HH H H 2,6DIP 5503 CD3 H H H H 2,6DMB 5504 CD3 H H H H CD3 5505 CD3 H H HH CH3 5506 CD3 H H H H H 5507 CD3 H H H H iPr 5508 CD3 H H H iPr H 5509CD3 H H iPr H H 5510 CD3 H iPr H H H 5511 CD3 iPr H H H H 5512 CH3 CD3 HH H H 5513 CH3 CH3 H H H H 5514 CH3 H 2,6DIP H H H 5515 CH3 H 2,6DMB H HH 5516 CH3 H CD3 H H H 5517 CH3 H CH3 H H H 5518 CH3 H H 2,6DIP H H 5519CH3 H H 2,6DMB H H 5520 CH3 H H CD3 H H 5521 CH3 H H CH3 H H 5522 CH3 HH H 2,6DIP H 5523 CH3 H H H 2,6DMB H 5524 CH3 H H H CD3 H 5525 CH3 H H HCH3 H 5526 CH3 H H H H 2,6DIP 5527 CH3 H H H H 2,6DMB 5528 CH3 H H H HCD3 5529 CH3 H H H H CH3 5530 CH3 H H H H H 5531 CH3 H H H H iPr 5532CH3 H H H iPr H 5533 CH3 H H iPr H H 5534 CH3 H iPr H H H 5535 CH3 iPr HH H H 5536 H 2,6DIP H CD3 H H 5537 H 2,6DIP H CH3 H H 5538 H 2,6DIP H HCD3 H 5539 H 2,6DIP H H CH3 H 5540 H 2,6DIP H H H CD3 5541 H 2,6DIP H HH CH3 5542 H 2,6DIP H H H H 5543 H 2,6DMB H CD3 H H 5544 H 2,6DMB H CH3H H 5545 H 2,6DMB H H CD3 H 5546 H 2,6DMB H H CH3 H 5547 H 2,6DMB H H HCD3 5548 H 2,6DMB H H H CH3 5549 H 2,6DMB H H H H 5550 H CD3 CD3 H H H5551 H CD3 CH3 H H H 5552 H CD3 H 2,6DIP H H 5553 H CD3 H 2,6DMB H H5554 H CD3 H CD3 H H 5555 H CD3 H CH3 H H 5556 H CD3 H H 2,6DIP H 5557 HCD3 H H 2,6DMB H 5558 H CD3 H H CD3 H 5559 H CD3 H H CH3 H 5560 H CD3 HH H 2,6DIP 5561 H CD3 H H H 2,6DMB 5562 H CD3 H H H CD3 5563 H CD3 H H HCH3 5564 H CD3 H H H H 5565 H CD3 H H H iPr 5566 H CD3 H H iPr H 5567 HCD3 H iPr H H 5568 H CD3 iPr H H H 5569 H CH3 CD3 H H H 5570 H CH3 CH3 HH H 5571 H CH3 H 2,6DIP H H 5572 H CH3 H 2,6DMB H H 5573 H CH3 H CD3 H H5574 H CH3 H CH3 H H 5575 H CH3 H H 2,6DIP H 5576 H CH3 H H 2,6DMB H5577 H CH3 H H CD3 H 5578 H CH3 H H CH3 H 5579 H CH3 H H H 2,6DIP 5580 HCH3 H H H 2,6DMB 5581 H CH3 H H H CD3 5582 H CH3 H H H CH3 5583 H CH3 HH H H 5584 H CH3 H H H iPr 5585 H CH3 H H iPr H 5586 H CH3 H iPr H H5587 H CH3 iPr H H H 5588 H H 2,6DIP H CD3 H 5589 H H 2,6DIP H CH3 H5590 H H 2,6DIP H H CD3 5591 H H 2,6DIP H H CH3 5592 H H 2,6DIP H H H5593 H H 2,6DMB H CD3 H 5594 H H 2,6DMB H CH3 H 5595 H H 2,6DMB H H CD35596 H H 2,6DMB H H CH3 5597 H H 2,6DMB H H H 5598 H H CD3 CD3 H H 5599H H CD3 CH3 H H 5600 H H CD3 H 2,6DIP H 5601 H H CD3 H 2,6DMB H 5602 H HCD3 H CD3 H 5603 H H CD3 H CH3 H 5604 H H CD3 H H 2,6DIP 5605 H H CD3 HH 2,6DMB 5606 H H CD3 H H CD3 5607 H H CD3 H H CH3 5608 H H CD3 H H H5609 H H CD3 H H iPr 5610 H H CD3 H iPr H 5611 H H CD3 iPr H H 5612 H HCH3 CD3 H H 5613 H H CH3 CH3 H H 5614 H H CH3 H 2,6DIP H 5615 H H CH3 H2,6DMB H 5616 H H CH3 H CD3 H 5617 H H CH3 H CH3 H 5618 H H CH3 H H2,6DIP 5619 H H CH3 H H 2,6DMB 5620 H H CH3 H H CD3 5621 H H CH3 H H CH35622 H H CH3 H H H 5623 H H CH3 H H iPr 5624 H H CH3 H iPr H 5625 H HCH3 iPr H H 5626 H H H 2,6DIP H CD3 5627 H H H 2,6DIP H CH3 5628 H H H2,6DIP H H 5629 H H H 2,6DMB H CD3 5630 H H H 2,6DMB H CH3 5631 H H H2,6DMB H H 5632 H H H CD3 CD3 H 5633 H H H CD3 CH3 H 5634 H H H CD3 H2,6DIP 5635 H H H CD3 H 2,6DMB 5636 H H H CD3 H CD3 5637 H H H CD3 H CH35638 H H H CD3 H H 5639 H H H CD3 H iPr 5640 H H H CD3 iPr H 5641 H H HCH3 CD3 H 5642 H H H CH3 CH3 H 5643 H H H CH3 H 2,6DIP 5644 H H H CH3 H2,6DMB 5645 H H H CH3 H CD3 5646 H H H CH3 H CH3 5647 H H H CH3 H H 5648H H H CH3 H iPr 5649 H H H CH3 iPr H 5650 H H H H 2,6DIP H 5651 H H H H2,6DMB H 5652 H H H H CD3 CD3 5653 H H H H CD3 CH3 5654 H H H H CD3 H5655 H H H H CD3 iPr 5656 H H H H CH3 CD3 5657 H H H H CH3 CH3 5658 H HH H CH3 H 5659 H H H H CH3 iPr 5660 H H H H H 2,6DIP 5661 H H H H H2,6DMB 5662 H H H H H CD3 5663 H H H H H CH3 5664 H H H H H H 5665 H H HH H iPr 5666 H H H H iPr CD3 5667 H H H H iPr CH3 5668 H H H H iPr H5669 H H H iPr CD3 H 5670 H H H iPr CH3 H 5671 H H H iPr H CD3 5672 H HH iPr H CH3 5673 H H H iPr H H 5674 H H iPr CD3 H H 5675 H H iPr CH3 H H5676 H H iPr H CD3 H 5677 H H iPr H CH3 H 5678 H H iPr H H CD3 5679 H HiPr H H CH3 5680 H H iPr H H H 5681 H iPr CD3 H H H 5682 H iPr CH3 H H H5683 H iPr H CD3 H H 5684 H iPr H CH3 H H 5685 H iPr H H CD3 H 5686 HiPr H H CH3 H 5687 H iPr H H H CD3 5688 H iPr H H H CH3 5689 H iPr H H HH 5690 iPr CD3 H H H H 5691 iPr CH3 H H H H 5692 iPr H CD3 H H H 5693iPr H CH3 H H H 5694 iPr H H CD3 H H 5695 iPr H H CH3 H H 5696 iPr H H HCD3 H 5697 iPr H H H CH3 H 5698 iPr H H H H CD3 5699 iPr H H H H CH35700 iPr H H H H HLA5701 to LA5921 based on structure:

LA # R11 R12 R13 R31 R32 R34 5701 CD3 CD3 H H H H 5702 CD3 CH3 H H H H5703 CD3 H 2,6DIP H H H 5704 CD3 H 2,6DMB H H H 5705 CD3 H CD3 H H H5706 CD3 H CH3 H H H 5707 CD3 H H 2,6DIP H H 5708 CD3 H H 2,6DMB H H5709 CD3 H H CD3 H H 5710 CD3 H H CH3 H H 5711 CD3 H H H 2,6DIP H 5712CD3 H H H 2,6DMB H 5713 CD3 H H H CD3 H 5714 CD3 H H H CH3 H 5715 CD3 HH H H 2,6DIP 5716 CD3 H H H H 2,6DMB 5717 CD3 H H H H CD3 5718 CD3 H H HH CH3 5719 CD3 H H H H H 5720 CD3 H H H H iPr 5721 CD3 H H H iPr H 5722CD3 H H iPr H H 5723 CD3 H iPr H H H 5724 CD3 iPr H H H H 5725 CH3 CD3 HH H H 5726 CH3 CH3 H H H H 5727 CH3 H 2,6DIP H H H 5728 CH3 H 2,6DMB H HH 5729 CH3 H CD3 H H H 5730 CH3 H CH3 H H H 5731 CH3 H H 2,6DIP H H 5732CH3 H H 2,6DMB H H 5733 CH3 H H CD3 H H 5734 CH3 H H CH3 H H 5735 CH3 HH H 2,6DIP H 5736 CH3 H H H 2,6DMB H 5737 CH3 H H H CD3 H 5738 CH3 H H HCH3 H 5739 CH3 H H H H 2,6DIP 5740 CH3 H H H H 2,6DMB 5741 CH3 H H H HCD3 5742 CH3 H H H H CH3 5743 CH3 H H H H H 5744 CH3 H H H H iPr 5745CH3 H H H iPr H 5746 CH3 H H iPr H H 5747 CH3 H iPr H H H 5748 CH3 iPr HH H H 5749 H 2,6DIP H CD3 H H 5750 H 2,6DIP H CH3 H H 5751 H 2,6DIP H HCD3 H 5752 H 2,6DIP H H CH3 H 5753 H 2,6DIP H H H CD3 5754 H 2,6DIP H HH CH3 5755 H 2,6DIP H H H H 5756 H 2,6DMB H CD3 H H 5757 H 2,6DMB H CH3H H 5758 H 2,6DMB H H CD3 H 5759 H 2,6DMB H H CH3 H 5760 H 2,6DMB H H HCD3 5761 H 2,6DMB H H H CH3 5762 H 2,6DMB H H H H 5763 H CD3 CD3 H H H5764 H CD3 CH3 H H H 5765 H CD3 H 2,6DIP H H 5766 H CD3 H 2,6DMB H H5767 H CD3 H CD3 H H 5768 H CD3 H CH3 H H 5769 H CD3 H H 2,6DIP H 5770 HCD3 H H 2,6DMB H 5771 H CD3 H H CD3 H 5772 H CD3 H H CH3 H 5773 H CD3 HH H 2,6DIP 5774 H CD3 H H H 2,6DMB 5775 H CD3 H H H CD3 5776 H CD3 H H HCH3 5777 H CD3 H H H H 5778 H CD3 H H H iPr 5779 H CD3 H H iPr H 5780 HCD3 H iPr H H 5781 H CD3 iPr H H H 5782 H CH3 CD3 H H H 5783 H CH3 CH3 HH H 5784 H CH3 H 2,6DIP H H 5785 H CH3 H 2,6DMB H H 5786 H CH3 H CD3 H H5787 H CH3 H CH3 H H 5788 H CH3 H H 2,6DIP H 5789 H CH3 H H 2,6DMB H5790 H CH3 H H CD3 H 5791 H CH3 H H CH3 H 5792 H CH3 H H H 2,6DIP 5793 HCH3 H H H 2,6DMB 5794 H CH3 H H H CD3 5795 H CH3 H H H CH3 5796 H CH3 HH H H 5797 H CH3 H H H iPr 5798 H CH3 H H iPr H 5799 H CH3 H iPr H H5800 H CH3 iPr H H H 5801 H H 2,6DIP H CD3 H 5802 H H 2,6DIP H CH3 H5803 H H 2,6DIP H H CD3 5804 H H 2,6DIP H H CH3 5805 H H 2,6DIP H H H5806 H H 2,6DMB H CD3 H 5807 H H 2,6DMB H CH3 H 5808 H H 2,6DMB H H CD35809 H H 2,6DMB H H CH3 5810 H H 2,6DMB H H H 5811 H H CD3 CD3 H H 5812H H CD3 CH3 H H 5813 H H CD3 H 2,6DIP H 5814 H H CD3 H 2,6DMB H 5815 H HCD3 H CD3 H 5816 H H CD3 H CH3 H 5817 H H CD3 H H 2,6DIP 5818 H H CD3 HH 2,6DMB 5819 H H CD3 H H CD3 5820 H H CD3 H H CH3 5821 H H CD3 H H H5822 H H CD3 H H iPr 5823 H H CD3 H iPr H 5824 H H CD3 iPr H H 5825 H HCH3 CD3 H H 5826 H H CH3 CH3 H H 5827 H H CH3 H 2,6DIP H 5828 H H CH3 H2,6DMB H 5829 H H CH3 H CD3 H 5830 H H CH3 H CH3 H 5831 H H CH3 H H2,6DIP 5832 H H CH3 H H 2,6DMB 5833 H H CH3 H H CD3 5834 H H CH3 H H CH35835 H H CH3 H H H 5836 H H CH3 H H iPr 5837 H H CH3 H iPr H 5838 H HCH3 iPr H H 5839 H H H 2,6DIP H CD3 5840 H H H 2,6DIP H CH3 5841 H H H2,6DIP H H 5842 H H H 2,6DMB H CD3 5843 H H H 2,6DMB H CH3 5844 H H H2,6DMB H H 5845 H H H CD3 CD3 H 5846 H H H CD3 CH3 H 5847 H H H CD3 H2,6DIP 5848 H H H CD3 H 2,6DMB 5849 H H H CD3 H CD3 5850 H H H CD3 H CH35851 H H H CD3 H H 5852 H H H CD3 H iPr 5853 H H H CD3 iPr H 5854 H H HCH3 CD3 H 5855 H H H CH3 CH3 H 5856 H H H CH3 H 2,6DIP 5857 H H H CH3 H2,6DMB 5858 H H H CH3 H CD3 5859 H H H CH3 H CH3 5860 H H H CH3 H H 5861H H H CH3 H iPr 5862 H H H CH3 iPr H 5863 H H H H 2,6DIP CD3 5864 H H HH 2,6DIP CH3 5865 H H H H 2,6DIP H 5866 H H H H 2,6DMB CD3 5867 H H H H2,6DMB CH3 5868 H H H H 2,6DMB H 5869 H H H H CD3 2,6DIP 5870 H H H HCD3 2,6DMB 5871 H H H H CD3 CD3 5872 H H H H CD3 CH3 5873 H H H H CD3 H5874 H H H H CD3 iPr 5875 H H H H CH3 2,6DIP 5876 H H H H CH3 2,6DMB5877 H H H H CH3 CD3 5878 H H H H CH3 CH3 5879 H H H H CH3 H 5880 H H HH CH3 iPr 5881 H H H H H 2,6DIP 5882 H H H H H 2,6DMB 5883 H H H H H CD35884 H H H H H CH3 5885 H H H H H H 5886 H H H H H iPr 5887 H H H H iPrCD3 5888 H H H H iPr CH3 5889 H H H H iPr H 5890 H H H iPr CD3 H 5891 HH H iPr CH3 H 5892 H H H iPr H CD3 5893 H H H iPr H CH3 5894 H H H iPr HH 5895 H H iPr CD3 H H 5896 H H iPr CH3 H H 5897 H H iPr H CD3 H 5898 HH iPr H CH3 H 5899 H H iPr H H CD3 5900 H H iPr H H CH3 5901 H H iPr H HH 5902 H iPr CD3 H H H 5903 H iPr CH3 H H H 5904 H iPr H CD3 H H 5905 HiPr H CH3 H H 5906 H iPr H H CD3 H 5907 H iPr H H CH3 H 5908 H iPr H H HCD3 5909 H iPr H H H CH3 5910 H iPr H H H H 5911 iPr CD3 H H H H 5912iPr CH3 H H H H 5913 iPr H CD3 H H H 5914 iPr H CH3 H H H 5915 iPr H HCD3 H H 5916 iPr H H CH3 H H 5917 iPr H H H CD3 H 5918 iPr H H H CH3 H5919 iPr H H H H CD3 5920 iPr H H H H CH3 5921 iPr H H H H HLA5922 to LA6142 based on structure:

LA # R11 R12 R13 R31 R33 R34 5922 CD3 CD3 H H H H 5923 CD3 CH3 H H H H5924 CD3 H 2,6DIP H H H 5925 CD3 H 2,6DMB H H H 5926 CD3 H CD3 H H H5927 CD3 H CH3 H H H 5928 CD3 H H 2,6DIP H H 5929 CD3 H H 2,6DMB H H5930 CD3 H H CD3 H H 5931 CD3 H H CH3 H H 5932 CD3 H H H 2,6DIP H 5933CD3 H H H 2,6DMB H 5934 CD3 H H H CD3 H 5935 CD3 H H H CH3 H 5936 CD3 HH H H 2,6DIP 5937 CD3 H H H H 2,6DMB 5938 CD3 H H H H CD3 5939 CD3 H H HH CH3 5940 CD3 H H H H H 5941 CD3 H H H H iPr 5942 CD3 H H H iPr H 5943CD3 H H iPr H H 5944 CD3 H iPr H H H 5945 CD3 iPr H H H H 5946 CH3 CD3 HH H H 5947 CH3 CH3 H H H H 5948 CH3 H 2,6DIP H H H 5949 CH3 H 2,6DMB H HH 5950 CH3 H CD3 H H H 5951 CH3 H CH3 H H H 5952 CH3 H H 2,6DIP H H 5953CH3 H H 2,6DMB H H 5954 CH3 H H CD3 H H 5955 CH3 H H CH3 H H 5956 CH3 HH H 2,6DIP H 5957 CH3 H H H 2,6DMB H 5958 CH3 H H H CD3 H 5959 CH3 H H HCH3 H 5960 CH3 H H H H 2,6DIP 5961 CH3 H H H H 2,6DMB 5962 CH3 H H H HCD3 5963 CH3 H H H H CH3 5964 CH3 H H H H H 5965 CH3 H H H H iPr 5966CH3 H H H iPr H 5967 CH3 H H iPr H H 5968 CH3 H iPr H H H 5969 CH3 iPr HH H H 5970 H 2,6DIP H CD3 H H 5971 H 2,6DIP H CH3 H H 5972 H 2,6DIP H HCD3 H 5973 H 2,6DIP H H CH3 H 5974 H 2,6DIP H H H CD3 5975 H 2,6DIP H HH CH3 5976 H 2,6DIP H H H H 5977 H 2,6DMB H CD3 H H 5978 H 2,6DMB H CH3H H 5979 H 2,6DMB H H CD3 H 5980 H 2,6DMB H H CH3 H 5981 H 2,6DMB H H HCD3 5982 H 2,6DMB H H H CH3 5983 H 2,6DMB H H H H 5984 H CD3 CD3 H H H5985 H CD3 CH3 H H H 5986 H CD3 H 2,6DIP H H 5987 H CD3 H 2,6DMB H H5988 H CD3 H CD3 H H 5989 H CD3 H CH3 H H 5990 H CD3 H H 2,6DIP H 5991 HCD3 H H 2,6DMB H 5992 H CD3 H H CD3 H 5993 H CD3 H H CH3 H 5994 H CD3 HH H 2,6DIP 5995 H CD3 H H H 2,6DMB 5996 H CD3 H H H CD3 5997 H CD3 H H HCH3 5998 H CD3 H H H H 5999 H CD3 H H H iPr 6000 H CD3 H H iPr H 6001 HCD3 H iPr H H 6002 H CD3 iPr H H H 6003 H CH3 CD3 H H H 6004 H CH3 CH3 HH H 6005 H CH3 H 2,6DIP H H 6006 H CH3 H 2,6DMB H H 6007 H CH3 H CD3 H H6008 H CH3 H CH3 H H 6009 H CH3 H H 2,6DIP H 6010 H CH3 H H 2,6DMB H6011 H CH3 H H CD3 H 6012 H CH3 H H CH3 H 6013 H CH3 H H H 2,6DIP 6014 HCH3 H H H 2,6DMB 6015 H CH3 H H H CD3 6016 H CH3 H H H CH3 6017 H CH3 HH H H 6018 H CH3 H H H iPr 6019 H CH3 H H iPr H 6020 H CH3 H iPr H H6021 H CH3 iPr H H H 6022 H H 2,6DIP H CD3 H 6023 H H 2,6DIP H CH3 H6024 H H 2,6DIP H H CD3 6025 H H 2,6DIP H H CH3 6026 H H 2,6DIP H H H6027 H H 2,6DMB H CD3 H 6028 H H 2,6DMB H CH3 H 6029 H H 2,6DMB H H CD36030 H H 2,6DMB H H CH3 6031 H H 2,6DMB H H H 6032 H H CD3 CD3 H H 6033H H CD3 CH3 H H 6034 H H CD3 H 2,6DIP H 6035 H H CD3 H 2,6DMB H 6036 H HCD3 H CD3 H 6037 H H CD3 H CH3 H 6038 H H CD3 H H 2,6DIP 6039 H H CD3 HH 2,6DMB 6040 H H CD3 H H CD3 6041 H H CD3 H H CH3 6042 H H CD3 H H H6043 H H CD3 H H iPr 6044 H H CD3 H iPr H 6045 H H CD3 iPr H H 6046 H HCH3 CD3 H H 6047 H H CH3 CH3 H H 6048 H H CH3 H 2,6DIP H 6049 H H CH3 H2,6DMB H 6050 H H CH3 H CD3 H 6051 H H CH3 H CH3 H 6052 H H CH3 H H2,6DIP 6053 H H CH3 H H 2,6DMB 6054 H H CH3 H H CD3 6055 H H CH3 H H CH36056 H H CH3 H H H 6057 H H CH3 H H iPr 6058 H H CH3 H iPr H 6059 H HCH3 iPr H H 6060 H H H 2,6DIP CD3 H 6061 H H H 2,6DIP CH3 H 6062 H H H2,6DIP H CD3 6063 H H H 2,6DIP H CH3 6064 H H H 2,6DIP H H 6065 H H H2,6DMB CD3 H 6066 H H H 2,6DMB CH3 H 6067 H H H 2,6DMB H CD3 6068 H H H2,6DMB H CH3 6069 H H H 2,6DMB H H 6070 H H H CD3 2,6DIP H 6071 H H HCD3 2,6DMB H 6072 H H H CD3 CD3 H 6073 H H H CD3 CH3 H 6074 H H H CD3 H2,6DIP 6075 H H H CD3 H 2,6DMB 6076 H H H CD3 H CD3 6077 H H H CD3 H CH36078 H H H CD3 H H 6079 H H H CD3 H iPr 6080 H H H CD3 iPr H 6081 H H HCH3 2,6DIP H 6082 H H H CH3 2,6DMB H 6083 H H H CH3 CD3 H 6084 H H H CH3CH3 H 6085 H H H CH3 H 2,6DIP 6086 H H H CH3 H 2,6DMB 6087 H H H CH3 HCD3 6088 H H H CH3 H CH3 6089 H H H CH3 H H 6090 H H H CH3 H iPr 6091 HH H CH3 iPr H 6092 H H H H 2,6DIP H 6093 H H H H 2,6DMB H 6094 H H H HCD3 CD3 6095 H H H H CD3 CH3 6096 H H H H CD3 H 6097 H H H H CD3 iPr6098 H H H H CH3 CD3 6099 H H H H CH3 CH3 6100 H H H H CH3 H 6101 H H HH CH3 iPr 6102 H H H H H 2,6DIP 6103 H H H H H 2,6DMB 6104 H H H H H CD36105 H H H H H CH3 6106 H H H H H H 6107 H H H H H iPr 6108 H H H H iPrCD3 6109 H H H H iPr CH3 6110 H H H H iPr H 6111 H H H iPr CD3 H 6112 HH H iPr CH3 H 6113 H H H iPr H CD3 6114 H H H iPr H CH3 6115 H H H iPr HH 6116 H H iPr CD3 H H 6117 H H iPr CH3 H H 6118 H H iPr H CD3 H 6119 HH iPr H CH3 H 6120 H H iPr H H CD3 6121 H H iPr H H CH3 6122 H H iPr H HH 6123 H iPr CD3 H H H 6124 H iPr CH3 H H H 6125 H iPr H CD3 H H 6126 HiPr H CH3 H H 6127 H iPr H H CD3 H 6128 H iPr H H CH3 H 6129 H iPr H H HCD3 6130 H iPr H H H CH3 6131 H iPr H H H H 6132 iPr CD3 H H H H 6133iPr CH3 H H H H 6134 iPr H CD3 H H H 6135 iPr H CH3 H H H 6136 iPr H HCD3 H H 6137 iPr H H CH3 H H 6138 iPr H H H CD3 H 6139 iPr H H H CH3 H6140 iPr H H H H CD3 6141 iPr H H H H CH3 6142 iPr H H H H HLA6143 to LA6363 based on structure:

LA # R11 R12 R13 R32 R33 R34 6143 CD3 C3 H H H H 6144 CD3 CH3 H H H H6145 CD3 H 2,6DIP H H H 6146 CD3 H 2,6DMB H H H 6147 CD3 H CD3 H H H6148 CD3 H CH3 H H H 6149 CD3 H H 2,6DIP H H 6150 CD3 H H 2,6DMB H H6151 CD3 H H CD3 H H 6152 CD3 H H CH3 H H 6153 CD3 H H H 2,6DIP H 6154CD3 H H H 2,6DMB H 6155 CD3 H H H CD3 H 6156 CD3 H H H CH3 H 6157 CD3 HH H H 2,6DIP 6158 CD3 H H H H 2,6DMB 6159 CD3 H H H H CD3 6160 CD3 H H HH CH3 6161 CD3 H H H H H 6162 CD3 H H H H iPr 6163 CD3 H H H iPr H 6164CD3 H H iPr H H 6165 CD3 H iPr H H H 6166 CD3 iPr H H H H 6167 CH3 CD3 HH H H 6168 CH3 CH3 H H H H 6169 CH3 H 2,6DIP H H H 6170 CH3 H 2,6DMB H HH 6171 CH3 H CD3 H H H 6172 CH3 H CH3 H H H 6173 CH3 H H 2,6DIP H H 6174CH3 H H 2,6DMB H H 6175 CH3 H H CD3 H H 6176 CH3 H H CH3 H H 6177 CH3 HH H 2,6DIP H 6178 CH3 H H H 2,6DMB H 6179 CH3 H H H CD3 H 6180 CH3 H H HCH3 H 6181 CH3 H H H H 2,6DIP 6182 CH3 H H H H 2,6DMB 6183 CH3 H H H HCD3 6184 CH3 H H H H CH3 6185 CH3 H H H H H 6186 CH3 H H H H iPr 6187CH3 H H H iPr H 6188 CH3 H H iPr H H 6189 CH3 H iPr H H H 6190 CH3 iPr HH H H 6191 H 2,6DIP H CD3 H H 6192 H 2,6DIP H CH3 H H 6193 H 2,6DIP H HCD3 H 6194 H 2,6DIP H H CH3 H 6195 H 2,6DIP H H H CD3 6196 H 2,6DIP H HH CH3 6197 H 2,6DIP H H H H 6198 H 2,6DMB H CD3 H H 6199 H 2,6DMB H CH3H H 6200 H 2,6DMB H H CD3 H 6201 H 2,6DMB H H CH3 H 6202 H 2,6DMB H H HCD3 6203 H 2,6DMB H H H CH3 6204 H 2,6DMB H H H H 6205 H CD3 CD3 H H H6206 H CD3 CH3 H H H 6207 H CD3 H 2,6DIP H H 6208 H CD3 H 2,6DMB H H6209 H CD3 H CD3 H H 6210 H CD3 H CH3 H H 6211 H CD3 H H 2,6DIP H 6212 HCD3 H H 2,6DMB H 6213 H CD3 H H CD3 H 6214 H CD3 H H CH3 H 6215 H CD3 HH H 2,6DIP 6216 H CD3 H H H 2,6DMB 6217 H CD3 H H H CD3 6218 H CD3 H H HCH3 6219 H CD3 H H H H 6220 H CD3 H H H iPr 6221 H CD3 H H iPr H 6222 HCD3 H iPr H H 6223 H CD3 iPr H H H 6224 H CH3 CD3 H H H 6225 H CH3 CH3 HH H 6226 H CH3 H 2,6DIP H H 6227 H CH3 H 2,6DMB H H 6228 H CH3 H CD3 H H6229 H CH3 H CH3 H H 6230 H CH3 H H 2,6DIP H 6231 H CH3 H H 2,6DMB H6232 H CH3 H H CD3 H 6233 H CH3 H H CH3 H 6234 H CH3 H H H 2,6DIP 6235 HCH3 H H H 2,6DMB 6236 H CH3 H H H CD3 6237 H CH3 H H H CH3 6238 H CH3 HH H H 6239 H CH3 H H H iPr 6240 H CH3 H H iPr H 6241 H CH3 H iPr H H6242 H CH3 iPr H H H 6243 H H 2,6DIP CD3 H H 6244 H H 2,6DIP CH3 H H6245 H H 2,6DIP H CD3 H 6246 H H 2,6DIP H CH3 H 6247 H H 2,6DIP H H CD36248 H H 2,6DIP H H CH3 6249 H H 2,6DIP H H H 6250 H H 2,6DMB CD3 H H6251 H H 2,6DMB CH3 H H 6252 H H 2,6DMB H CD3 H 6253 H H 2,6DMB H CH3 H6254 H H 2,6DMB H H CD3 6255 H H 2,6DMB H H CH3 6256 H H 2,6DMB H H H6257 H H CD3 2,6DIP H H 6258 H H CD3 2,6DMB H H 6259 H H CD3 CD3 H H6260 H H CD3 CH3 H H 6261 H H CD3 H 2,6DIP H 6262 H H CD3 H 2,6DMB H6263 H H CD3 H CD3 H 6264 H H CD3 H CH3 H 6265 H H CD3 H H 2,6DIP 6266 HH CD3 H H 2,6DMB 6267 H H CD3 H H CD3 6268 H H CD3 H H CH3 6269 H H CD3H H H 6270 H H CD3 H H iPr 6271 H H CD3 H iPr H 6272 H H CD3 iPr H H6273 H H CH3 2,6DIP H H 6274 H H CH3 2,6DMB H H 6275 H H CH3 CD3 H H6276 H H CH3 CH3 H H 6277 H H CH3 H 2,6DIP H 6278 H H CH3 H 2,6DMB H6279 H H CH3 H CD3 H 6280 H H CH3 H CH3 H 6281 H H CH3 H H 2,6DIP 6282 HH CH3 H H 2,6DMB 6283 H H CH3 H H CD3 6284 H H CH3 H H CH3 6285 H H CH3H H H 6286 H H CH3 H H iPr 6287 H H CH3 H iPr H 6288 H H CH3 iPr H H6289 H H H 2,6DIP H CD3 6290 H H H 2,6DIP H CH3 6291 H H H 2,6DIP H H6292 H H H 2,6DMB H CD3 6293 H H H 2,6DMB H CH3 6294 H H H 2,6DMB H H6295 H H H CD3 CD3 H 6296 H H H CD3 CH3 H 6297 H H H CD3 H 2,6DIP 6298 HH H CD3 H 2,6DMB 6299 H H H CD3 H CD3 6300 H H H CD3 H CH3 6301 H H HCD3 H H 6302 H H H CD3 H iPr 6303 H H H CD3 iPr H 6304 H H H CH3 CD3 H6305 H H H CH3 CH3 H 6306 H H H CH3 H 2,6DIP 6307 H H H CH3 H 2,6DMB6308 H H H CH3 H CD3 6309 H H H CH3 H CH3 6310 H H H CH3 H H 6311 H H HCH3 H iPr 6312 H H H CH3 iPr H 6313 H H H H 2,6DIP H 6314 H H H H 2,6DMBH 6315 H H H H CD3 CD3 6316 H H H H CD3 CH3 6317 H H H H CD3 H 6318 H HH H CD3 iPr 6319 H H H H CH3 CD3 6320 H H H H CH3 CH3 6321 H H H H CH3 H6322 H H H H CH3 iPr 6323 H H H H H 2,6DIP 6324 H H H H H 2,6DMB 6325 HH H H H CD3 6326 H H H H H CH3 6327 H H H H H H 6328 H H H H H iPr 6329H H H H iPr CD3 6330 H H H H iPr CH3 6331 H H H H iPr H 6332 H H H iPrCD3 H 6333 H H H iPr CH3 H 6334 H H H iPr H CD3 6335 H H H iPr H CH36336 H H H iPr H H 6337 H H iPr CD3 H H 6338 H H iPr CH3 H H 6339 H HiPr H CD3 H 6340 H H iPr H CH3 H 6341 H H iPr H H CD3 6342 H H iPr H HCH3 6343 H H iPr H H H 6344 H iPr CD3 H H H 6345 H iPr CH3 H H H 6346 HiPr H CD3 H H 6347 H iPr H CH3 H H 6348 H iPr H H CD3 H 6349 H iPr H HCH3 H 6350 H iPr H H H CD3 6351 H iPr H H H CH3 6352 H iPr H H H H 6353iPr CD3 H H H H 6354 iPr CH3 H H H H 6355 iPr H CD3 H H H 6356 iPr H CH3H H H 6357 iPr H H CD3 H H 6358 iPr H H CH3 H H 6359 iPr H H H CD3 H6360 iPr H H H CH3 H 6361 iPr H H H H CD3 6362 iPr H H H H CH3 6363 iPrH H H H Hwherein 2,6DIP is 2,6 diisopropyl benzene, 2,6DMB is 2,6 dimethylbenzene, and i-Pr is isopropyl.

In one embodiment, the compound has a formula ofM(L_(A))_(n)(L_(B))_(m-n);

-   -   wherein M is Ir or Pt;    -   L_(B) is a bidentate ligand; and    -   wherein when M is Ir, m is 3, and n is 1, 2, or 3; when M is Pt,        m is 2, and n is 1, or 2.

In one embodiment, the compound has a formula of Ir(L_(A))₃. In anotherembodiment, the compound has a formula of Ir(L_(A))(L_(B))₂; and whereinL_(B) is different from L_(A). In another embodiment, the compound has aformula of Ir(L_(A))₂(L_(B)); and wherein L_(B) is different from L_(A).In another embodiment, the compound has a formula of Pt(L_(A))(L_(B));and wherein L_(A) and L_(B) can be same or different.

In one embodiment, L_(A) and L_(B) are connected to form a tetradentateligand. In another embodiment, L_(A) and L_(B) are connected at twoplaces to form a macrocyclic tetradentate ligand.

In one embodiment, L_(B) is selected from the group consisting of:

wherein each X¹ to X¹³ are independently selected from the groupconsisting of carbon and nitrogen;

wherein X is selected from the group consisting of BR′, NR′, PR′, O, S,Se, C═O, S═O, SO₂, CR′R″, SiR′R″, and GeR′R″;

wherein R′ and R″ are optionally fused or joined to form a ring;

wherein each R_(a), R_(b), R_(c), and R_(d) may represent from monosubstitution to the possible maximum number of substitution, or nosubstitution;

wherein R′, R″, R_(a), R_(b), R_(c), and R_(d) are each independentlyselected from the group consisting of hydrogen, deuterium, halide,alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino,silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl,acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl,sulfinyl, sulfonyl, phosphino, and combinations thereof; and

wherein any two adjacent substituents of R_(a), R_(b), R_(c), and R_(d)are optionally fused or joined to form a ring or form a multidentateligand.

In one embodiment, L_(B) is selected from the group consisting of:

In one embodiment, the compound is Compound Ax having the formulaIr(L_(Ai))₃; and wherein x=i; i is an integer from 1 to 6363.

In one embodiment, the compound is the Compound By having the formulaIr(L_(Ai))(L_(j))₂ or Compound Cz having the formula Ir(L_(Ai))₂(L_(j));

wherein y=39i+j−39; i is an integer from 1 to 6363, and j is an integerfrom 1 to 39;

wherein z=39i+j−39; i is an integer from 1 to 6363, and j is an integerfrom 1 to 39; and

wherein L₁ to L₃₉ have the following structure:

In some embodiments, the compound can be an emissive dopant. In someembodiments, the compound can produce emissions via phosphorescence,fluorescence, thermally activated delayed fluorescence, i.e., TADF (alsoreferred to as E-type delayed fluorescence), triplet-tripletannihilation, or combinations of these processes.

According to another aspect of the present disclosure, an OLED is alsoprovided. The OLED includes an anode, a cathode, and an organic layerdisposed between the anode and the cathode. The organic layer mayinclude a host and a phosphorescent dopant. The organic layer caninclude a compound according to Formula I, and its variations asdescribed herein.

The OLED can be incorporated into one or more of a consumer product, anelectronic component module, and a lighting panel. The organic layer canbe an emissive layer and the compound can be an emissive dopant in someembodiments, while the compound can be a non-emissive dopant in otherembodiments.

The organic layer can also include a host. In some embodiments, two ormore hosts are preferred. In some embodiments, the hosts used maybe a)bipolar, b) electron transporting, c) hole transporting or d) wide bandgap materials that play little role in charge transport. In someembodiments, the host can include a metal complex. The host can be atriphenylene containing benzo-fused thiophene or benzo-fused furan. Anysubstituent in the host can be an unfused substituent independentlyselected from the group consisting of C_(n)H_(2n+1), OC_(n)H_(2n+1),OAr₁, N(C_(n)H_(2n+1))₂, N(Ar₁)(Ar₂), CH═CH—C_(n)H_(2n+1),C≡C—C_(n)H_(2n+i), Ar₁, Ar₁-Ar₂, and C_(n)H_(2n)—Ar₁, or the host has nosubstitution. In the preceding substituents n can range from 1 to 10;and Ar₁ and Ar_(e) can be independently selected from the groupconsisting of benzene, biphenyl, naphthalene, triphenylene, carbazole,and heteroaromatic analogs thereof. The host can be an inorganiccompound. For example a Zn containing inorganic material e.g. ZnS.

The host can be a compound comprising at least one chemical groupselected from the group consisting of triphenylene, carbazole,dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene,azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, andaza-dibenzoselenophene. The host can include a metal complex. The hostcan be, but is not limited to, a specific compound selected from thegroup consisting of:

and combinations thereof.Additional information on possible hosts is provided below.

In yet another aspect of the present disclosure, a formulation thatcomprises a compound comprising a ligand L_(A) selected from the groupconsisting of Formula I and Formula II. The formulation can include oneor more components selected from the group consisting of a solvent, ahost, a hole injection material, hole transport material, and anelectron transport layer material, disclosed herein.

Combination with Other Materials

The materials described herein as useful for a particular layer in anorganic light emitting device may be used in combination with a widevariety of other materials present in the device. For example, emissivedopants disclosed herein may be used in conjunction with a wide varietyof hosts, transport layers, blocking layers, injection layers,electrodes and other layers that may be present. The materials describedor referred to below are non-limiting examples of materials that may beuseful in combination with the compounds disclosed herein, and one ofskill in the art can readily consult the literature to identify othermaterials that may be useful in combination.

Conductivity Dopants:

A charge transport layer can be doped with conductivity dopants tosubstantially alter its density of charge carriers, which will in turnalter its conductivity. The conductivity is increased by generatingcharge carriers in the matrix material, and depending on the type ofdopant, a change in the Fermi level of the semiconductor may also beachieved. Hole-transporting layer can be doped by p-type conductivitydopants and n-type conductivity dopants are used in theelectron-transporting layer.

Non-limiting examples of the conductivity dopants that may be used in anOLED in combination with materials disclosed herein are exemplifiedbelow together with references that disclose those materials:EP01617493, EP01968131, EP2020694, EP2684932, US20050139810,US20070160905, US20090167167, US2010288362, WO06081780, WO2009003455,WO2009008277, WO2009011327, WO2014009310, US2007252140, US2015060804 andUS2012146012.

HIL/HTL:

A hole injecting/transporting material to be used in the presentinvention is not particularly limited, and any compound may be used aslong as the compound is typically used as a hole injecting/transportingmaterial. Examples of the material include, but are not limited to: aphthalocyanine or porphyrin derivative; an aromatic amine derivative; anindolocarbazole derivative; a polymer containing fluorohydrocarbon; apolymer with conductivity dopants; a conducting polymer, such asPEDOT/PSS; a self-assembly monomer derived from compounds such asphosphonic acid and silane derivatives; a metal oxide derivative, suchas MoO_(x); a p-type semiconducting organic compound, such as1,4,5,8,9,12-Hexaazatriphenylenehexacarbonitrile; a metal complex, and across-linkable compounds.

Examples of aromatic amine derivatives used in HIL or HTL include, butnot limit to the following general structures:

Each of Ar¹ to Ar⁹ is selected from the group consisting of aromatichydrocarbon cyclic compounds such as benzene, biphenyl, triphenyl,triphenylene, naphthalene, anthracene, phenalene, phenanthrene,fluorene, pyrene, chrysene, perylene, and azulene; the group consistingof aromatic heterocyclic compounds such as dibenzothiophene,dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran,benzothiophene, benzoselenophene, carbazole, indolocarbazole,pyridylindole, pyrrolodipyridine, pyrazole, imidazole, triazole,oxazole, thiazole, oxadiazole, oxatriazole, dioxazole, thiadiazole,pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine,oxathiazine, oxadiazine, indole, benzimidazole, indazole, indoxazine,benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline,cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine,pteridine, xanthene, acridine, phenazine, phenothiazine, phenoxazine,benzofuropyridine, furodipyridine, benzothienopyridine,thienodipyridine, benzoselenophenopyridine, and selenophenodipyridine;and the group consisting of 2 to 10 cyclic structural units which aregroups of the same type or different types selected from the aromatichydrocarbon cyclic group and the aromatic heterocyclic group and arebonded to each other directly or via at least one of oxygen atom,nitrogen atom, sulfur atom, silicon atom, phosphorus atom, boron atom,chain structural unit and the aliphatic cyclic group. Each Ar may beunsubstituted or may be substituted by a substituent selected from thegroup consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl,arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl,heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylicacids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl,phosphino, and combinations thereof.

In one aspect, Ar¹ to Ar⁹ is independently selected from the groupconsisting of:

wherein k is an integer from 1 to 20; X¹⁰¹ to X¹⁰⁸ is C (including CH)or N; Z¹⁰¹ is NAr¹, O, or S; Ar¹ has the same group defined above.

Examples of metal complexes used in HIL or HTL include, but are notlimited to the following general formula:

wherein Met is a metal, which can have an atomic weight greater than 40;(Y¹⁰¹-Y¹⁰²) is a bidentate ligand, Y¹⁰¹ and Y¹⁰² are independentlyselected from C, N, O, P, and S; L¹⁰¹ is an ancillary ligand; k′ is aninteger value from 1 to the maximum number of ligands that may beattached to the metal; and k′+k″ is the maximum number of ligands thatmay be attached to the metal.

In one aspect, (Y₁₀₁-Y¹⁰²) is a 2-phenylpyridine derivative. In anotheraspect, (Y¹⁰¹-Y¹⁰²) is a carbene ligand. In another aspect, Met isselected from Ir, Pt, Os, and Zn. In a further aspect, the metal complexhas a smallest oxidation potential in solution vs. Fc⁺/Fc couple lessthan about 0.6 V.

Non-limiting examples of the HIL and HTL materials that may be used inan OLED in combination with materials disclosed herein are exemplifiedbelow together with references that disclose those materials:CN102702075, DE102012005215, EP01624500, EP01698613, EP01806334,EP01930964, EP01972613, EP01997799, EP02011790, EP02055700, EP02055701,EP1725079, EP2085382, EP2660300, EP650955, JP07-073529, JP2005112765,JP2007091719, JP2008021687, JP2014-009196, KR20110088898, KR20130077473,TW201139402, U.S. Ser. No. 06/517,957, US20020158242, US20030162053,US20050123751, US20060182993, US20060240279, US20070145888,US20070181874, US20070278938, US20080014464, US20080091025,US20080106190, US20080124572, US20080145707, US20080220265,US20080233434, US20080303417, US2008107919, US20090115320,US20090167161, US2009066235, US2011007385, US20110163302, US2011240968,US2011278551, US2012205642, US2013241401, US20140117329, US2014183517,U.S. Pat. No. 5,061,569, U.S. Pat. No. 5,639,914, WO05075451,WO07125714, WO08023550, WO08023759, WO2009145016, WO2010061824,WO2011075644, WO2012177006, WO2013018530, WO2013039073, WO2013087142,WO2013118812, WO2013120577, WO2013157367, WO2013175747, WO2014002873,WO2014015935, WO2014015937, WO2014030872, WO2014030921, WO2014034791,WO2014104514, WO2014157018.

EBL:

An electron blocking layer (EBL) may be used to reduce the number ofelectrons and/or excitons that leave the emissive layer. The presence ofsuch a blocking layer in a device may result in substantially higherefficiencies, and or longer lifetime, as compared to a similar devicelacking a blocking layer. Also, a blocking layer may be used to confineemission to a desired region of an OLED. In some embodiments, the EBLmaterial has a higher LUMO (closer to the vacuum level) and/or highertriplet energy than the emitter closest to the EBL interface. In someembodiments, the EBL material has a higher LUMO (closer to the vacuumlevel) and or higher triplet energy than one or more of the hostsclosest to the EBL interface. In one aspect, the compound used in EBLcontains the same molecule or the same functional groups used as one ofthe hosts described below.

Host:

The light emitting layer of the organic EL device of the presentinvention preferably contains at least a metal complex as light emittingmaterial, and may contain a host material using the metal complex as adopant material. Examples of the host material are not particularlylimited, and any metal complexes or organic compounds may be used aslong as the triplet energy of the host is larger than that of thedopant. Any host material may be used with any dopant so long as thetriplet criteria is satisfied.

Examples of metal complexes used as host are preferred to have thefollowing general formula:

wherein Met is a metal; (Y₁₀₃-Y¹⁰⁴) is a bidentate ligand, Y₁₀₃ and Y¹⁰⁴are independently selected from C, N, O, P, and S; L¹⁰¹ is an anotherligand; k′ is an integer value from 1 to the maximum number of ligandsthat may be attached to the metal; and k′+k″ is the maximum number ofligands that may be attached to the metal.

In one aspect, the metal complexes are:

wherein (O—N) is a bidentate ligand, having metal coordinated to atoms Oand N.

In another aspect, Met is selected from Ir and Pt. In a further aspect,(Y¹⁰³-Y¹⁰⁴) is a carbene ligand.

Examples of other organic compounds used as host are selected from thegroup consisting of aromatic hydrocarbon cyclic compounds such asbenzene, biphenyl, triphenyl, triphenylene, tetraphenylene, naphthalene,anthracene, phenalene, phenanthrene, fluorene, pyrene, chrysene,perylene, and azulene; the group consisting of aromatic heterocycliccompounds such as dibenzothiophene, dibenzofuran, dibenzoselenophene,furan, thiophene, benzofuran, benzothiophene, benzoselenophene,carbazole, indolocarbazole, pyridylindole, pyrrolodipyridine, pyrazole,imidazole, triazole, oxazole, thiazole, oxadiazole, oxatriazole,dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine,triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole,indazole, indoxazine, benzoxazole, benzisoxazole, benzothiazole,quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline,naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine,phenothiazine, phenoxazine, benzofuropyridine, furodipyridine,benzothienopyridine, thienodipyridine, benzoselenophenopyridine, andselenophenodipyridine; and the group consisting of 2 to 10 cyclicstructural units which are groups of the same type or different typesselected from the aromatic hydrocarbon cyclic group and the aromaticheterocyclic group and are bonded to each other directly or via at leastone of oxygen atom, nitrogen atom, sulfur atom, silicon atom, phosphorusatom, boron atom, chain structural unit and the aliphatic cyclic group.Each option within each group may be unsubstituted or may be substitutedby a substituent selected from the group consisting of deuterium,halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl,heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof.

In one aspect, the host compound contains at least one of the followinggroups in the molecule:

wherein each of R¹⁰¹ to R¹⁰⁷ is independently selected from the groupconsisting of hydrogen, deuterium, halide, alkyl, cycloalkyl,heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl,cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl,carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl,sulfonyl, phosphino, and combinations thereof, and when it is aryl orheteroaryl, it has the similar definition as Ar's mentioned above. k isan integer from 0 to 20 or 1 to 20; k′″ is an integer from 0 to 20. X¹⁰¹to X¹⁰⁸ is selected from C (including CH) or N.Z¹⁰¹ and Z¹⁰² is selected from NR¹⁰¹, O, or S.

Non-limiting examples of the host materials that may be used in an OLEDin combination with materials disclosed herein are exemplified belowtogether with references that disclose those materials: EP2034538,EP2034538A, EP2757608, JP2007254297, KR20100079458, KR20120088644,KR20120129733, KR20130115564, TW201329200, US20030175553, US20050238919,US20060280965, US20090017330, US20090030202, US20090167162,US20090302743, US20090309488, US20100012931, US20100084966,US20100187984, US2010187984, US2012075273, US2012126221, US2013009543,US2013105787, US2013175519, US2014001446, US20140183503, US20140225088,US2014034914, U.S. Pat. No. 7,154,114, WO2001039234, WO2004093207,WO2005014551, WO2005089025, WO2006072002, WO2006114966, WO2007063754,WO2008056746, WO2009003898, WO2009021126, WO2009063833, WO2009066778,WO2009066779, WO2009086028, WO2010056066, WO2010107244, WO2011081423,WO2011081431, WO2011086863, WO2012128298, WO2012133644, WO2012133649,WO2013024872, WO2013035275, WO2013081315, WO2013191404, WO2014142472,

Additional Emitters:

One or more additional emitter dopants may be used in conjunction withthe compound of the present disclosure. Examples of the additionalemitter dopants are not particularly limited, and any compounds may beused as long as the compounds are typically used as emitter materials.Examples of suitable emitter materials include, but are not limited to,compounds which can produce emissions via phosphorescence, fluorescence,thermally activated delayed fluorescence, i.e., TADF (also referred toas E-type delayed fluorescence), triplet-triplet annihilation, orcombinations of these processes.

Non-limiting examples of the emitter materials that may be used in anOLED in combination with materials disclosed herein are exemplifiedbelow together with references that disclose those materials:CN103694277, CN1696137, EB01238981, EP01239526, EP01961743, EP1239526,EP1244155, EP1642951, EP1647554, EP1841834, EP1841834B, EP2062907,EP2730583, JP2012074444, JP2013110263, JP4478555, KR1020090133652,KR20120032054, KR20130043460, TW201332980, U.S. Ser. No. 06/699,599,U.S. Ser. No. 06/916,554, US20010019782, US20020034656, US20030068526,US20030072964, US20030138657, US20050123788, US20050244673,US2005123791, US2005260449, US20060008670, US20060065890, US20060127696,US20060134459, US20060134462, US20060202194, US20060251923,US20070034863, US20070087321, US20070103060, US20070111026,US20070190359, US20070231600, US2007034863, US2007104979, US2007104980,US2007138437, US2007224450, US2007278936, US20080020237, US20080233410,US20080261076, US20080297033, US200805851, US2008161567, US2008210930,US20090039776, US20090108737, US20090115322, US20090179555,US2009085476, US2009104472, US20100090591, US20100148663, US20100244004,US20100295032, US2010102716, US2010105902, US2010244004, US2010270916,US20110057559, US20110108822, US20110204333, US2011215710, US2011227049,US2011285275, US2012292601, US20130146848, US2013033172, US2013165653,US2013181190, US2013334521, US20140246656, US2014103305, U.S. Pat. No.6,303,238, U.S. Pat. No. 6,413,656, U.S. Pat. No. 6,653,654, U.S. Pat.No. 6,670,645, U.S. Pat. No. 6,687,266, U.S. Pat. No. 6,835,469, U.S.Pat. No. 6,921,915, U.S. Pat. No. 7,279,704, U.S. Pat. No. 7,332,232,U.S. Pat. No. 7,378,162, U.S. Pat. No. 7,534,505, U.S. Pat. No.7,675,228, U.S. Pat. No. 7,728,137, U.S. Pat. No. 7,740,957, U.S. Pat.No. 7,759,489, U.S. Pat. No. 7,951,947, U.S. Pat. No. 8,067,099, U.S.Pat. No. 8,592,586, U.S. Pat. No. 8,871,361, WO06081973, WO06121811,WO07018067, WO07108362, WO07115970, WO07115981, WO08035571,WO2002015645, WO2003040257, WO2005019373, WO2006056418, WO2008054584,WO2008078800, WO2008096609, WO2008101842, WO2009000673, WO2009050281,WO2009100991, WO2010028151, WO2010054731, WO2010086089, WO2010118029,WO2011044988, WO2011051404, WO2011107491, WO2012020327, WO2012163471,WO2013094620, WO2013107487, WO2013174471, WO2014007565, WO2014008982,WO2014023377, WO2014024131, WO2014031977, WO2014038456, WO2014112450.

HBL:

A hole blocking layer (HBL) may be used to reduce the number of holesand/or excitons that leave the emissive layer. The presence of such ablocking layer in a device may result in substantially higherefficiencies and/or longer lifetime as compared to a similar devicelacking a blocking layer. Also, a blocking layer may be used to confineemission to a desired region of an OLED. In some embodiments, the HBLmaterial has a lower HOMO (further from the vacuum level) and or highertriplet energy than the emitter closest to the HBL interface. In someembodiments, the HBL material has a lower HOMO (further from the vacuumlevel) and or higher triplet energy than one or more of the hostsclosest to the HBL interface.

In one aspect, compound used in HBL contains the same molecule or thesame functional groups used as host described above.

In another aspect, compound used in HBL contains at least one of thefollowing groups in the molecule:

wherein k is an integer from 1 to 20; L¹⁰¹ is an another ligand, k′ isan integer from 1 to 3.

ETL:

Electron transport layer (ETL) may include a material capable oftransporting electrons. Electron transport layer may be intrinsic(undoped), or doped. Doping may be used to enhance conductivity.Examples of the ETL material are not particularly limited, and any metalcomplexes or organic compounds may be used as long as they are typicallyused to transport electrons.

In one aspect, compound used in ETL contains at least one of thefollowing groups in the molecule:

wherein R¹⁰¹ is selected from the group consisting of hydrogen,deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy,aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl,aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof, when it is aryl or heteroaryl, it has the similar definition asAr's mentioned above. Ar¹ to Ar³ has the similar definition as Ar'smentioned above. k is an integer from 1 to 20. X¹⁰¹ to X¹⁰⁸ is selectedfrom C (including CH) or N.

In another aspect, the metal complexes used in ETL contains, but notlimit to the following general formula:

wherein (O—N) or (N—N) is a bidentate ligand, having metal coordinatedto atoms O, N or N, N; L¹⁰¹ is another ligand; k′ is an integer valuefrom 1 to the maximum number of ligands that may be attached to themetal.

Non-limiting examples of the ETL materials that may be used in an OLEDin combination with materials disclosed herein are exemplified belowtogether with references that disclose those materials: CN103508940,EP01602648, EP01734038, EP01956007, JP2004-022334, JP2005149918,JP2005-268199, KR0117693, KR20130108183, US20040036077, US20070104977,US2007018155, US20090101870, US20090115316, US20090140637,US20090179554, US2009218940, US2010108990, US2011156017, US2011210320,US2012193612, US2012214993, US2014014925, US2014014927, US20140284580,U.S. Pat. No. 6,656,612, U.S. Pat. No. 8,415,031, WO2003060956,WO2007111263, WO2009148269, WO2010067894, WO2010072300, WO2011074770,WO2011105373, WO2013079217, WO2013145667, WO2013180376, WO2014104499,WO2014104535,

Charge Generation Layer (CGL)

In tandem or stacked OLEDs, the CGL plays an essential role in theperformance, which is composed of an n-doped layer and a p-doped layerfor injection of electrons and holes, respectively. Electrons and holesare supplied from the CGL and electrodes. The consumed electrons andholes in the CGL are refilled by the electrons and holes injected fromthe cathode and anode, respectively; then, the bipolar currents reach asteady state gradually. Typical CGL materials include n and pconductivity dopants used in the transport layers.

In any above-mentioned compounds used in each layer of the OLED device,the hydrogen atoms can be partially or fully deuterated. Thus, anyspecifically listed substituent, such as, without limitation, methyl,phenyl, pyridyl, etc. may be undeuterated, partially deuterated, andfully deuterated versions thereof. Similarly, classes of substituentssuch as, without limitation, alkyl, aryl, cycloalkyl, heteroaryl, etc.also may be undeuterated, partially deuterated, and fully deuteratedversions thereof.

It is understood that the various embodiments described herein are byway of example only, and are not intended to limit the scope of theinvention. For example, many of the materials and structures describedherein may be substituted with other materials and structures withoutdeviating from the spirit of the invention. The present invention asclaimed may therefore include variations from the particular examplesand preferred embodiments described herein, as will be apparent to oneof skill in the art. It is understood that various theories as to whythe invention works are not intended to be limiting.

1. A compound comprising a ligand L_(A) selected from the groupconsisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclicring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each representfrom mono-substitution to the possible maximum number of substitution,or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independentlyselected from the group consisting of N and CR; wherein at least one ofZ¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the groupconsisting of O, S, and Se; wherein each R, R¹ R², and R³ areindependently selected from the group consisting of hydrogen, deuterium,halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl,heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof; wherein any adjacent substituents of R, R¹ R², and R³ areoptionally joined or fused into a ring; wherein the ligand L_(A) iscoordinated to a metal M; and wherein the ligand L_(A) is optionallylinked with other ligands to comprise a tridentate, tetradentate,pentadentate or hexadentate ligand.
 2. The compound of claim 1, whereinM is selected from the group consisting of Ir, Rh, Re, Ru, Os, Pt, Au,and Cu.
 3. The compound of claim 1, wherein M is Ir or Pt. 4.-5.(canceled)
 6. The compound of claim 1, wherein X is
 0. 7. (canceled) 8.The compound of claim 1, wherein one of Z¹, Z², Z³, and Z⁴ is nitrogen,and three of Z¹, Z², Z³, and Z⁴ is CR.
 9. The compound of claim 1,wherein ring A is selected from the group consisting of pyridine,imidazole, isoimidazole, and pyrazole.
 10. The compound of claim 1,wherein ligand L_(A) is selected from the group consisting of:


11. The compound of claim 1, wherein ligand L_(A) is selected from thegroup consisting of: LA1 to LA318 based on the chemical structure:

LA # R11 R12 R13 R14 R31 R32 R33 1 CD3 CD3 H H H H H 2 CD3 CH3 H H H H H3 CD3 H 2,6DIP H H H H 4 CD3 H 2,6DMB H H H H 5 CD3 H CD3 H H H H 6 CD3H CH3 H H H H 7 CD3 H H 2,6DIP H H H 8 CD3 H H 2,6DMB H H H 9 CD3 H HCD3 H H H 10 CD3 H H CH3 H H H 11 CD3 H H H 2,6DIP H H 12 CD3 H H H2,6DMB H H 13 CD3 H H H CD3 H H 14 CD3 H H H CH3 H H 15 CD3 H H H H2,6DIP H 16 CD3 H H H H 2,6DMB H 17 CD3 H H H H CD3 H 18 CD3 H H H H CH3H 19 CD3 H H H H H 2,6DIP 20 CD3 H H H H H 2,6DMB 21 CD3 H H H H H CD322 CD3 H H H H H CH3 23 CD3 H H H H H H 24 CD3 H H H H H i-Pr 25 CD3 H HH H i-Pr H 26 CD3 H H H i-Pr H H 27 CD3 H H i-Pr H H H 28 CD3 H i-Pr H HH H 29 CD3 i-Pr H H H H H 30 CH3 CD3 H H H H H 31 CH3 CH3 H H H H H 32CH3 H 2,6DIP H H H H 33 CH3 H 2,6DMB H H H H 34 CH3 H CD3 H H H H 35 CH3H CH3 H H H H 36 CH3 H H 2,6DIP H H H 37 CH3 H H 2,6DMB H H H 38 CH3 H HCD3 H H H 39 CH3 H H CH3 H H H 40 CH3 H H H 2,6DIP H H 41 CH3 H H H2,6DMB H H 42 CH3 H H H CD3 H H 43 CH3 H H H CH3 H H 44 CH3 H H H H2,6DIP H 45 CH3 H H H H 2,6DMB H 46 CH3 H H H H CD3 H 47 CH3 H H H H CH3H 48 CH3 H H H H H 2,6DIP 49 CH3 H H H H H 2,6DMB 50 CH3 H H H H H CD351 CH3 H H H H H CH3 52 CH3 H H H H H H 53 CH3 H H H H H i-Pr 54 CH3 H HH H i-Pr H 55 CH3 H H H i-Pr H H 56 CH3 H H i-Pr H H H 57 CH3 H i-Pr H HH H 58 CH3 i-Pr H H H H H 59 H 2,6DIP H CD3 H H H 60 H 2,6DIP H CH3 H HH 61 H 2,6DIP H H CD3 H H 62 H 2,6DIP H H CH3 H H 63 H 2,6DIP H H H CD3H 64 H 2,6DIP H H H CH3 H 65 H 2,6DIP H H H H CD3 66 H 2,6DIP H H H HCH3 67 H 2,6DIP H H H H H 68 H 2,6DMB H CD3 H H H 69 H 2,6DMB H CH3 H HH 70 H 2,6DMB H H CD3 H H 71 H 2,6DMB H H CH3 H H 72 H 2,6DMB H H H CD3H 73 H 2,6DMB H H H CH3 H 74 H 2,6DMB H H H H CD3 75 H 2,6DMB H H H HCH3 76 H 2,6DMB H H H H H 77 H CD3 CD3 H H H H 78 H CD3 CH3 H H H H 79 HCD3 H 2,6DIP H H H 80 H CD3 H 2,6DMB H H H 81 H CD3 H CD3 H H H 82 H CD3H CH3 H H H 83 H CD3 H H 2,6DIP H H 84 H CD3 H H 2,6DMB H H 85 H CD3 H HCD3 H H 86 H CD3 H H CH3 H H 87 H CD3 H H H 2,6DIP H 88 H CD3 H H H2,6DMB H 89 H CD3 H H H CD3 H 90 H CD3 H H H CH3 H 91 H CD3 H H H H2,6DIP 92 H CD3 H H H H 2,6DMB 93 H CD3 H H H H CD3 94 H CD3 H H H H CH395 H CD3 H H H H H 96 H CD3 H H H H i-Pr 97 H CD3 H H H i-Pr H 98 H CD3H H i-Pr H H 99 H CD3 H i-Pr H H H 100 H CD3 i-Pr H H H H 101 H CH3 CD3H H H H 102 H CH3 CH3 H H H H 103 H CH3 H 2,6DIP H H H 104 H CH3 H2,6DMB H H H 105 H CH3 H CD3 H H H 106 H CH3 H CH3 H H H 107 H CH3 H H2,6DIP H H 108 H CH3 H H 2,6DMB H H 109 H CH3 H H CD3 H H 110 H CH3 H HCH3 H H 111 H CH3 H H H 2,6DIP H 112 H CH3 H H H 2,6DMB H 113 H CH3 H HH CD3 H 114 H CH3 H H H CH3 H 115 H CH3 H H H H 2,6DIP 116 H CH3 H H H H2,6DMB 117 H CH3 H H H H CD3 118 H CH3 H H H H CH3 119 H CH3 H H H H H120 H CH3 H H H H i-Pr 121 H CH3 H H H i-Pr H 122 H CH3 H H i-Pr H H 123H CH3 H i-Pr H H H 124 H CH3 i-Pr H H H H 125 H H 2,6DIP H CD3 H H 126 HH 2,6DIP H CH3 H H 127 H H 2,6DIP H H CD3 H 128 H H 2,6DIP H H CH3 H 129H H 2,6DIP H H H CD3 130 H H 2,6DIP H H H CH3 131 H H 2,6DIP H H H H 132H H 2,6DMB H CD3 H H 133 H H 2,6DMB H CH3 H H 134 H H 2,6DMB H H CD3 H135 H H 2,6DMB H H CH3 H 136 H H 2,6DMB H H H CD3 137 H H 2,6DMB H H HCH3 138 H H 2,6DMB H H H H 139 H H CD3 CD3 H H H 140 H H CD3 CH3 H H H141 H H CD3 H 2,6DIP H H 142 H H CD3 H 2,6DMB H H 143 H H CD3 H CD3 H H144 H H CD3 H CH3 H H 145 H H CD3 H H 2,6DIP H 146 H H CD3 H H 2,6DMB H147 H H CD3 H H CD3 H 148 H H CD3 H H CH3 H 149 H H CD3 H H H 2,6DIP 150H H CD3 H H H 2,6DMB 151 H H CD3 H H H CD3 152 H H CD3 H H H CH3 153 H HCD3 H H H H 154 H H CD3 H H H i-Pr 155 H H CD3 H H i-Pr H 156 H H CD3 Hi-Pr H H 157 H H CD3 i-Pr H H H 158 H H CH3 CD3 H H H 159 H H CH3 CH3 HH H 160 H H CH3 H 2,6DIP H H 161 H H CH3 H 2,6DMB H H 162 H H CH3 H CD3H H 163 H H CH3 H CH3 H H 164 H H CH3 H H 2,6DIP H 165 H H CH3 H H2,6DMB H 166 H H CH3 H H CD3 H 167 H H CH3 H H CH3 H 168 H H CH3 H H H2,6DIP 169 H H CH3 H H H 2,6DMB 170 H H CH3 H H H CD3 171 H H CH3 H H HCH3 172 H H CH3 H H H H 173 H H CH3 H H H i-Pr 174 H H CH3 H H i-Pr H175 H H CH3 H i-Pr H H 176 H H CH3 i-Pr H H H 177 H H H 2,6DIP CD3 H H178 H H H 2,6DIP CH3 H H 179 H H H 2,6DIP H CD3 H 180 H H H 2,6DIP H CH3H 181 H H H 2,6DIP H H CD3 182 H H H 2,6DIP H H CH3 183 H H H 2,6DIP H HH 184 H H H 2,6DMB CD3 H H 185 H H H 2,6DMB CH3 H H 186 H H H 2,6DMB HCD3 H 187 H H H 2,6DMB H CH3 H 188 H H H 2,6DMB H H CD3 189 H H H 2,6DMBH H CH3 190 H H H 2,6DMB H H H 191 H H H CD3 2,6DIP H H 192 H H H CD32,6DMB H H 193 H H H CD3 CD3 H H 194 H H H CD3 CH3 H H 195 H H H CD3 H2,6DIP H 196 H H H CD3 H 2,6DMB H 197 H H H CD3 H CD3 H 198 H H H CD3 HCH3 H 199 H H H CD3 H H 2,6DIP 200 H H H CD3 H H 2,6DMB 201 H H H CD3 HH CD3 202 H H H CD3 H H CH3 203 H H H CD3 H H H 204 H H H CD3 H H i-Pr205 H H H CD3 H i-Pr H 206 H H H CD3 i-Pr H H 207 H H H CH3 2,6DIP H H208 H H H CH3 2,6DMB H H 209 H H H CH3 CD3 H H 210 H H H CH3 CH3 H H 211H H H CH3 H 2,6DIP H 212 H H H CH3 H 2,6DMB H 213 H H H CH3 H CD3 H 214H H H CH3 H CH3 H 215 H H H CH3 H H 2,6DIP 216 H H H CH3 H H 2,6DMB 217H H H CH3 H H CD3 218 H H H CH3 H H CH3 219 H H H CH3 H H H 220 H H HCH3 H H i-Pr 221 H H H CH3 H i-Pr H 222 H H H CH3 i-Pr H H 223 H H H H2,6DIP H CD3 224 H H H H 2,6DIP H CH3 225 H H H H 2,6DIP H H 226 H H H H2,6DMB H CD3 227 H H H H 2,6DMB H CH3 228 H H H H 2,6DMB H H 229 H H H HCD3 CD3 H 230 H H H H CD3 CH3 H 231 H H H H CD3 H 2,6DIP 232 H H H H CD3H 2,6DMB 233 H H H H CD3 H CD3 234 H H H H CD3 H CH3 235 H H H H CD3 H H236 H H H H CD3 H i-Pr 237 H H H H CD3 i-Pr H 238 H H H H CH3 CD3 H 239H H H H CH3 CH3 H 240 H H H H CH3 H 2,6DIP 241 H H H H CH3 H 2,6DMB 242H H H H CH3 H CD3 243 H H H H CH3 H CH3 244 H H H H CH3 H H 245 H H H HCH3 H i-Pr 246 H H H H CH3 i-Pr H 247 H H H H H 2,6DIP CD3 248 H H H H H2,6DIP CH3 249 H H H H H 2,6DIP H 250 H H H H H 2,6DMB CD3 251 H H H H H2,6DMB CH3 252 H H H H H 2,6DMB H 253 H H H H H CD3 2,6DIP 254 H H H H HCD3 2,6DMB 255 H H H H H CD3 CD3 256 H H H H H CD3 CH3 257 H H H H H CD3H 258 H H H H H CD3 i-Pr 259 H H H H H CH3 2,6DIP 260 H H H H H CH32,6DMB 261 H H H H H CH3 CD3 262 H H H H H CH3 CH3 263 H H H H H CH3 H264 H H H H H CH3 i-Pr 265 H H H H H H 2,6DIP 266 H H H H H H 2,6DMB 267H H H H H H CD3 268 H H H H H H CH3 269 H H H H H H H 270 H H H H H Hi-Pr 271 H H H H H i-Pr CD3 272 H H H H H i-Pr CH3 273 H H H H H i-Pr H274 H H H H i-Pr CD3 H 275 H H H H i-Pr CH3 H 276 H H H H i-Pr H CD3 277H H H H i-Pr H CH3 278 H H H H i-Pr H H 279 H H H i-Pr CD3 H H 280 H H Hi-Pr CH3 H H 281 H H H i-Pr H CD3 H 282 H H H i-Pr H CH3 H 283 H H Hi-Pr H H CD3 284 H H H i-Pr H H CH3 285 H H H i-Pr H H H 286 H H i-PrCD3 H H H 287 H H i-Pr CH3 H H H 288 H H i-Pr H CD3 H H 289 H H i-Pr HCH3 H H 290 H H i-Pr H H CD3 H 291 H H i-Pr H H CH3 H 292 H H i-Pr H H HCD3 293 H H i-Pr H H H CH3 294 H H i-Pr H H H H 295 H i-Pr CD3 H H H H296 H i-Pr CH3 H H H H 297 H i-Pr H CD3 H H H 298 H i-Pr H CH3 H H H 299H i-Pr H H CD3 H H 300 H i-Pr H H CH3 H H 301 H i-Pr H H H CD3 H 302 Hi-Pr H H H CH3 H 303 H i-Pr H H H H CD3 304 H i-Pr H H H H CH3 305 Hi-Pr H H H H H 306 i-Pr CD3 H H H H H 307 i-Pr CH3 H H H H H 308 i-Pr HCD3 H H H H 309 i-Pr H CH3 H H H H 310 i-Pr H H CD3 H H H 311 i-Pr H HCH3 H H H 312 i-Pr H H H CD3 H H 313 i-Pr H H H CH3 H H 314 i-Pr H H H HCD3 H 315 i-Pr H H H H CH3 H 316 i-Pr H H H H H CD3 317 i-Pr H H H H HCH3 318 i-Pr H H H H H H

LA319 to LA628 based on the structure:

LA # R11 R12 R13 R14 R31 R32 R34 319 CD3 CD3 H H H H H 320 CD3 CH3 H H HH H 321 CD3 H 2,6DIP H H H H 322 CD3 H 2,6DMB H H H H 323 CD3 H CD3 H HH H 324 CD3 H CH3 H H H H 325 CD3 H H 2,6DIP H H H 326 CD3 H H 2,6DMB HH H 327 CD3 H H CD3 H H H 328 CD3 H H CH3 H H H 329 CD3 H H H 2,6DIP H H330 CD3 H H H 2,6DMB H H 331 CD3 H H H CD3 H H 332 CD3 H H H CH3 H H 333CD3 H H H H 2,6DIP H 334 CD3 H H H H 2.6DMB H 335 CD3 H H H H CD3 H 336CD3 H H H H CH3 H 337 CD3 H H H H H 2,6DIP 338 CD3 H H H H H 2,6DMB 339CD3 H H H H H CD3 340 CD3 H H H H H CH3 341 CD3 H H H H H H 342 CD3 H HH H H i-Pr 343 CD3 H H H H i-Pr H 344 CD3 H H H i-Pr H H 345 CD3 H Hi-Pr H H H 346 CD3 H i-Pr H H H H 347 CD3 i-Pr H H H H H 348 CH3 CD3 H HH H H 349 CH3 CH3 H H H H H 350 CH3 H 2,6DIP H H H H 351 CH3 H 2,6DMB HH H H 352 CH3 H CD3 H H H H 353 CH3 H CH3 H H H H 354 CH3 H H 2,6DIP H HH 355 CH3 H H 2,6DMB H H H 356 CH3 H H CD3 H H H 357 CH3 H H CH3 H H H358 CH3 H H H 2,6DIP H H 359 CH3 H H H 2,6DMB H H 360 CH3 H H H CD3 H H361 CH3 H H H CH3 H H 362 CH3 H H H H 2,6DIP H 363 CH3 H H H H 2,6DMB H364 CH3 H H H H CD3 H 365 CH3 H H H H CH3 H 366 CH3 H H H H H 2,6DIP 367CH3 H H H H H 2,6DMB 368 CH3 H H H H H CD3 369 CH3 H H H H H CH3 370 CH3H H H H H H 371 CH3 H H H H H i-Pr 372 CH3 H H H H i-Pr H 373 CH3 H H Hi-Pr H H 374 CH3 H H i-Pr H H H 375 CH3 H i-Pr H H H H 376 CH3 i-Pr H HH H H 377 H 2,6DIP H CD3 H H H 378 H 2,6DIP H CH3 H H H 379 H 2,6DIP H HCD3 H H 380 H 2,6DIP H H CH3 H H 381 H 2,6DIP H H H CD3 H 382 H 2,6DIP HH H CH3 H 383 H 2,6DIP H H H H CD3 384 H 2,6DIP H H H H CH3 385 H 2,6DIPH H H H H 386 H 2,6DMB H CD3 H H H 387 H 2,6DMB H CH3 H H H 388 H 2,6DMBH H CD3 H H 389 H 2,6DMB H H CH3 H H 390 H 2,6DMB H H H CD3 H 391 H2,6DMB H H H CH3 H 392 H 2,6DMB H H H H CD3 393 H 2,6DMB H H H H CH3 394H 2,6DMB H H H H H 395 H CD3 CD3 H H H H 396 H CD3 CH3 H H H H 397 H CD3H 2,6DIP H H H 398 H CD3 H 2,6DMB H H H 399 H CD3 H CD3 H H H 400 H CD3H CH3 H H H 401 H CD3 H H 2,6DIP H H 402 H CD3 H H 2,6DMB H H 403 H CD3H H CD3 H H 404 H CD3 H H CH3 H H 405 H CD3 H H H 2,6DIP H 406 H CD3 H HH 2,6DMB H 407 H CD3 H H H CD3 H 408 H CD3 H H H CH3 H 409 H CD3 H H H H2,6DIP 410 H CD3 H H H H 2,6DMB 411 H CD3 H H H H CD3 412 H CD3 H H H HCH3 413 H CD3 H H H H H 414 H CD3 H H H H i-Pr 415 H CD3 H H H i-Pr H416 H CD3 H H i-Pr H H 417 H CD3 H i-Pr H H H 418 H CD3 i-Pr H H H H 419H CH3 CD3 H H H H 420 H CH3 CH3 H H H H 421 H CH3 H 2,6DIP H H H 422 HCH3 H 2,6DMB H H H 423 H CH3 H CD3 H H H 424 H CH3 H CH3 H H H 425 H CH3H H 2,6DIP H H 426 H CH3 H H 2,6DMB H H 427 H CH3 H H CD3 H H 428 H CH3H H CH3 H H 429 H CH3 H H H 2,6DIP H 430 H CH3 H H H 2,6DMB H 431 H CH3H H H CD3 H 432 H CH3 H H H CH3 H 433 H CH3 H H H H 2,6DIP 434 H CH3 H HH H 2,6DMB 435 H CH3 H H H H CD3 436 H CH3 H H H H CH3 437 H CH3 H H H HH 438 H CH3 H H H H i-Pr 439 H CH3 H H H i-Pr H 440 H CH3 H H i-Pr H H441 H CH3 H i-Pr H H H 442 H CH3 i-Pr H H H H 443 H H 2,6DIP H CD3 H H444 H H 2,6DIP H CH3 H H 445 H H 2,6DIP H H CD3 H 446 H H 2,6DIP H H CH3H 447 H H 2,6DIP H H H CD3 448 H H 2,6DIP H H H CH3 449 H H 2,6DIP H H HH 450 H H 2,6DMB H CD3 H H 451 H H 2,6DMB H CH3 H H 452 H H 2,6DMB H HCD3 H 453 H H 2,6DMB H H CH3 H 454 H H 2,6DMB H H H CD3 455 H H 2,6DMB HH H CH3 456 H H 2,6DMB H H H H 457 H H CD3 CD3 H H H 458 H H CD3 CH3 H HH 459 H H CD3 H 2,6DIP H H 460 H H CD3 H 2,6DMB H H 461 H H CD3 H CD3 HH 462 H H CD3 H CH3 H H 463 H H CD3 H H 2,6DIP H 464 H H CD3 H H 2,6DMBH 465 H H CD3 H H CD3 H 466 H H CD3 H H CH3 H 467 H H CD3 H H H 2,6DIP468 H H CD3 H H H 2,6DMB 469 H H CD3 H H H CD3 470 H H CD3 H H H CH3 471H H CD3 H H H H 472 H H CD3 H H H i-Pr 473 H H CD3 H H i-Pr H 474 H HCD3 H i-Pr H H 475 H H CD3 i-Pr H H H 476 H H CH3 CD3 H H H 477 H H CH3CH3 H H H 478 H H CH3 H 2,6DIP H H 479 H H CH3 H 2,6DMB H H 480 H H CH3H CD3 H H 481 H H CH3 H CH3 H H 482 H H CH3 H H 2,6DIP H 483 H H CH3 H H2,6DMB H 484 H H CH3 H H CD3 H 485 H H CH3 H H CH3 H 486 H H CH3 H H H2,6DIP 487 H H CH3 H H H 2,6DMB 488 H H CH3 H H H CD3 489 H H CH3 H H HCH3 490 H H CH3 H H H H 491 H H CH3 H H H i-Pr 492 H H CH3 H H i-Pr H493 H H CH3 H i-Pr H H 494 H H CH3 i-Pr H H H 495 H H H 2,6DIP H CD3 H496 H H H 2,6DIP H CH3 H 497 H H H 2,6DIP H H CD3 498 H H H 2,6DIP H HCH3 499 H H H 2,6DIP H H H 500 H H H 2,6DMB H CD3 H 501 H H H 2,6DMB HCH3 H 502 H H H 2,6DMB H H CD3 503 H H H 2,6DMB H H CH3 504 H H H 2,6DMBH H H 505 H H H CD3 CD3 H H 506 H H H CD3 CH3 H H 507 H H H CD3 H 2,6DIPH 508 H H H CD3 H 2,6DMB H 509 H H H CD3 H CD3 H 510 H H H CD3 H CH3 H511 H H H CD3 H H 2,6DIP 512 H H H CD3 H H 2,6DMB 513 H H H CD3 H H CD3514 H H H CD3 H H CH3 515 H H H CD3 H H H 516 H H H CD3 H H i-Pr 517 H HH CD3 H i-Pr H 518 H H H CD3 i-Pr H H 519 H H H CH3 CD3 H H 520 H H HCH3 CH3 H H 521 H H H CH3 H 2,6DIP H 522 H H H CH3 H 2,6DMB H 523 H H HCH3 H CD3 H 524 H H H CH3 H CH3 H 525 H H H CH3 H H 2,6DIP 526 H H H CH3H H 2,6DMB 527 H H H CH3 H H CD3 528 H H H CH3 H H CH3 529 H H H CH3 H HH 530 H H H CH3 H H i-Pr 531 H H H CH3 H i-Pr H 532 H H H CH3 i-Pr H H533 H H H H 2,6DIP H CD3 534 H H H H 2,6DIP H CH3 535 H H H H 2,6DIP H H536 H H H H 2,6DMB H CD3 537 H H H H 2,6DMB H CH3 538 H H H H 2,6DMB H H539 H H H H CD3 CD3 H 540 H H H H CD3 CH3 H 541 H H H H CD3 H 2,6DIP 542H H H H CD3 H 2,6DMB 543 H H H H CD3 H CD3 544 H H H H CD3 H CH3 545 H HH H CD3 H H 546 H H H H CD3 H i-Pr 547 H H H H CD3 i-Pr H 548 H H H HCH3 CD3 H 549 H H H H CH3 CH3 H 550 H H H H CH3 H 2,6DIP 551 H H H H CH3H 2,6DMB 552 H H H H CH3 H CD3 553 H H H H CH3 H CH3 554 H H H H CH3 H H555 H H H H CH3 H i-Pr 556 H H H H CH3 i-Pr H 557 H H H H H 2,6DIP CD3558 H H H H H 2,6DIP CH3 559 H H H H H 2,6DIP H 560 H H H H H 2,6DMB CD3561 H H H H H 2,6DMB CH3 562 H H H H H 2,6DMB H 563 H H H H H CD3 2,6DIP564 H H H H H CD3 2,6DMB 565 H H H H H CD3 CD3 566 H H H H H CD3 CH3 567H H H H H CD3 H 568 H H H H H CD3 i-Pr 569 H H H H H CH3 2,6DIP 570 H HH H H CH3 2,6DMB 571 H H H H H CH3 CD3 572 H H H H H CH3 CH3 573 H H H HH CH3 H 574 H H H H H CH3 i-Pr 575 H H H H H H 2,6DIP 576 H H H H H H2,6DMB 577 H H H H H H CD3 578 H H H H H H CH3 579 H H H H H H H 580 H HH H H H i-Pr 581 H H H H H i-Pr CD3 582 H H H H H i-Pr CH3 583 H H H H Hi-Pr H 584 H H H H i-Pr CD3 H 585 H H H H i-Pr CH3 H 586 H H H H i-Pr HCD3 587 H H H H i-Pr H CH3 588 H H H H i-Pr H H 589 H H H i-Pr CD3 H H590 H H H i-Pr CH3 H H 591 H H H i-Pr H CD3 H 592 H H H i-Pr H CH3 H 593H H H i-Pr H H CD3 594 H H H i-Pr H H CH3 595 H H H i-Pr H H H 596 H Hi-Pr CD3 H H H 597 H H i-Pr CH3 H H H 598 H H i-Pr H CD3 H H 599 H Hi-Pr H CH3 H H 600 H H i-Pr H H CD3 H 601 H H i-Pr H H CH3 H 602 H Hi-Pr H H H CD3 603 H H i-Pr H H H CH3 604 H H i-Pr H H H H 605 H i-PrCD3 H H H H 606 H i-Pr CH3 H H H H 607 H i-Pr H CD3 H H H 608 H i-Pr HCH3 H H H 609 H i-Pr H H CD3 H H 610 H i-Pr H H CH3 H H 611 H i-Pr H H HCD3 H 612 H i-Pr H H H CH3 H 613 H i-Pr H H H H CD3 614 H i-Pr H H H HCH3 615 H i-Pr H H H H H 616 i-Pr CD3 H H H H H 617 i-Pr CH3 H H H H H618 i-Pr H CD3 H H H H 619 i-Pr H CH3 H H H H 620 i-Pr H H CD3 H H H 621i-Pr H H CH3 H H H 622 i-Pr H H H CD3 H H 623 i-Pr H H H CH3 H H 624i-Pr H H H H CD3 H 625 i-Pr H H H H CH3 H 626 i-Pr H H H H H CD3 627i-Pr H H H H H CH3 628 i-Pr H H H H H H

LA629 to LA938 based on the structure:

LA # R11 R12 R13 R14 R31 R33 R34 629 CD3 CD3 H H H H H 630 CD3 CH3 H H HH H 631 CD3 H 2,6DIP H H H H 632 CD3 H 2,6DMB H H H H 633 CD3 H CD3 H HH H 634 CD3 H CH3 H H H H 635 CD3 H H 2,6DIP H H H 636 CD3 H H 2,6DMB HH H 637 CD3 H H CD3 H H H 638 CD3 H H CH3 H H H 639 CD3 H H H 2,6DIP H H640 CD3 H H H 2,6DMB H H 641 CD3 H H H CD3 H H 642 CD3 H H H CH3 H H 643CD3 H H H H 2,6DIP H 644 CD3 H H H H 2,6DMB H 645 CD3 H H H H CD3 H 646CD3 H H H H CH3 H 647 CD3 H H H H H 2,6DIP 648 CD3 H H H H H 2,6DMB 649CD3 H H H H H CD3 650 CD3 H H H H H CH3 651 CD3 H H H H H H 652 CD3 H HH H H i-Pr 653 CD3 H H H H i-Pr H 654 CD3 H H H i-Pr H H 655 CD3 H Hi-Pr H H H 656 CD3 H i-Pr H H H H 657 CD3 i-Pr H H H H H 658 CH3 CD3 H HH H H 659 CH3 CH3 H H H H H 660 CH3 H 2,6DIP H H H H 661 CH3 H 2,6DMB HH H H 662 CH3 H CD3 H H H H 663 CH3 H CH3 H H H H 664 CH3 H H 2,6DIP H HH 665 CH3 H H 2,6DMB H H H 666 CH3 H H CD3 H H H 667 CH3 H H CH3 H H H668 CH3 H H H 2,6DIP H H 669 CH3 H H H 2,6DMB H H 670 CH3 H H H CD3 H H671 CH3 H H H CH3 H H 672 CH3 H H H H 2,6DIP H 673 CH3 H H H H 2,6DMB H674 CH3 H H H H CD3 H 675 CH3 H H H H CH3 H 676 CH3 H H H H H 2,6DIP 677CH3 H H H H H 2,6DMB 678 CH3 H H H H H CD3 679 CH3 H H H H H CH3 680 CH3H H H H H H 681 CH3 H H H H H i-Pr 682 CH3 H H H H i-Pr H 683 CH3 H H Hi-Pr H H 684 CH3 H H i-Pr H H H 685 CH3 H i-Pr H H H H 686 CH3 i-Pr H HH H H 687 H 2,6DIP H CD3 H H H 688 H 2,6DIP H CH3 H H H 689 H 2,6DIP H HCD3 H H 690 H 2,6DIP H H CH3 H H 691 H 2,6DIP H H H CD3 H 692 H 2,6DIP HH H CH3 H 693 H 2,6DIP H H H H CD3 694 H 2,6DIP H H H H CH3 695 H 2,6DIPH H H H H 696 H 2,6DMB H CD3 H H H 697 H 2,6DMB H CH3 H H H 698 H 2,6DMBH H CD3 H H 699 H 2,6DMB H H CH3 H H 700 H 2,6DMB H H H CD3 H 701 H2,6DMB H H H CH3 H 702 H 2,6DMB H H H H CD3 703 H 2,6DMB H H H H CH3 704H 2,6DMB H H H H H 705 H CD3 CD3 H H H H 706 H CD3 CH3 H H H H 707 H CD3H 2,6DIP H H H 708 H CD3 H 2,6DMB H H H 709 H CD3 H CD3 H H H 710 H CD3H CH3 H H H 711 H CD3 H H 2,6DIP H H 712 H CD3 H H 2,6DMB H H 713 H CD3H H CD3 H H 714 H CD3 H H CH3 H H 715 H CD3 H H H 2,6DIP H 716 H CD3 H HH 2,6DMB H 717 H CD3 H H H CD3 H 718 H CD3 H H H CH3 H 719 H CD3 H H H H2,6DIP 720 H CD3 H H H H 2,6DMB 721 H CD3 H H H H CD3 722 H CD3 H H H HCH3 723 H CD3 H H H H H 724 H CD3 H H H H i-Pr 725 H CD3 H H H i-Pr H726 H CD3 H H i-Pr H H 727 H CD3 H i-Pr H H H 728 H CD3 i-Pr H H H H 729H CH3 CD3 H H H H 730 H CH3 CH3 H H H H 731 H CH3 H 2,6DIP H H H 732 HCH3 H 2,6DMB H H H 733 H CH3 H CD3 H H H 734 H CH3 H CH3 H H H 735 H CH3H H 2,6DIP H H 736 H CH3 H H 2,6DMB H H 737 H CH3 H H CD3 H H 738 H CH3H H CH3 H H 739 H CH3 H H H 2,6DIP H 740 H CH3 H H H 2,6DMB H 741 H CH3H H H CD3 H 742 H CH3 H H H CH3 H 743 H CH3 H H H H 2,6DIP 744 H CH3 H HH H 2,6DMB 745 H CH3 H H H H CD3 746 H CH3 H H H H CH3 747 H CH3 H H H HH 748 H CH3 H H H H i-Pr 749 H CH3 H H H i-Pr H 750 H CH3 H H i-Pr H H751 H CH3 H i-Pr H H H 752 H CH3 i-Pr H H H H 753 H H 2,6DIP H CD3 H H754 H H 2,6DIP H CH3 H H 755 H H 2,6DIP H H CD3 H 756 H H 2,6DIP H H CH3H 757 H H 2,6DIP H H H CD3 758 H H 2,6DIP H H H CH3 759 H H 2,6DIP H H HH 760 H H 2,6DMB H CD3 H H 761 H H 2,6DMB H CH3 H H 762 H H 2,6DMB H HCD3 H 763 H H 2,6DMB H H CH3 H 764 H H 2,6DMB H H H CD3 765 H H 2,6DMB HH H CH3 766 H H 2,6DMB H H H H 767 H H CD3 CD3 H H H 768 H H CD3 CH3 H HH 769 H H CD3 H 2,6DIP H H 770 H H CD3 H 2,6DMB H H 771 H H CD3 H CD3 HH 772 H H CD3 H CH3 H H 773 H H CD3 H H 2,6DIP H 774 H H CD3 H H 2,6DMBH 775 H H CD3 H H CD3 H 776 H H CD3 H H CH3 H 777 H H CD3 H H H 2,6DIP778 H H CD3 H H H 2,6DMB 779 H H CD3 H H H CD3 780 H H CD3 H H H CH3 781H H CD3 H H H H 782 H H CD3 H H H i-Pr 783 H H CD3 H H i-Pr H 784 H HCD3 H i-Pr H H 785 H H CD3 i-Pr H H H 786 H H CH3 CD3 H H H 787 H H CH3CH3 H H H 788 H H CH3 H 2,6DIP H H 789 H H CH3 H 2,6DMB H H 790 H H CH3H CD3 H H 791 H H CH3 H CH3 H H 792 H H CH3 H H 2,6DIP H 793 H H CH3 H H2,6DMB H 794 H H CH3 H H CD3 H 795 H H CH3 H H CH3 H 796 H H CH3 H H H2,6DIP 797 H H CH3 H H H 2,6DMB 798 H H CH3 H H H CD3 799 H H CH3 H H HCH3 800 H H CH3 H H H H 801 H H CH3 H H H i-Pr 802 H H CH3 H H i-Pr H803 H H CH3 H i-Pr H H 804 H H CH3 i-Pr H H H 805 H H H 2,6DIP H CD3 H806 H H H 2,6DIP H CH3 H 807 H H H 2,6DIP H H CD3 808 H H H 2,6DIP H HCH3 809 H H H 2,6DIP H H H 810 H H H 2,6DMB H CD3 H 811 H H H 2,6DMB HCH3 H 812 H H H 2,6DMB H H CD3 813 H H H 2,6DMB H H CH3 814 H H H 2,6DMBH H H 815 H H H CD3 CD3 H H 816 H H H CD3 CH3 H H 817 H H H CD3 H 2,6DIPH 818 H H H CD3 H 2,6DMB H 819 H H H CD3 H CD3 H 820 H H H CD3 H CH3 H821 H H H CD3 H H 2,6DIP 822 H H H CD3 H H 2,6DMB 823 H H H CD3 H H CD3824 H H H CD3 H H CH3 825 H H H CD3 H H H 826 H H H CD3 H H i-Pr 827 H HH CD3 H i-Pr H 828 H H H CD3 i-Pr H H 829 H H H CH3 CD3 H H 830 H H HCH3 CH3 H H 831 H H H CH3 H 2,6DIP H 832 H H H CH3 H 2,6DMB H 833 H H HCH3 H CD3 H 834 H H H CH3 H CH3 H 835 H H H CH3 H H 2,6DIP 836 H H H CH3H H 2,6DMB 837 H H H CH3 H H CD3 838 H H H CH3 H H CH3 839 H H H CH3 H HH 840 H H H CH3 H H i-Pr 841 H H H CH3 H i-Pr H 842 H H H CH3 i-Pr H H843 H H H H 2,6DIP CD3 H 844 H H H H 2,6DIP CH3 H 845 H H H H 2,6DIP HCD3 846 H H H H 2,6DIP H CH3 847 H H H H 2,6DIP H H 848 H H H H 2,6DMBCD3 H 849 H H H H 2,6DMB CH3 H 850 H H H H 2,6DMB H CD3 851 H H H H2,6DMB H CH3 852 H H H H 2,6DMB H H 853 H H H H CD3 2,6DIP H 854 H H H HCD3 2,6DMB H 855 H H H H CD3 CD3 H 856 H H H H CD3 CH3 H 857 H H H H CD3H 2,6DIP 858 H H H H CD3 H 2,6DMB 859 H H H H CD3 H CD3 860 H H H H CD3H CH3 861 H H H H CD3 H H 862 H H H H CD3 H i-Pr 863 H H H H CD3 i-Pr H864 H H H H CH3 2,6DIP H 865 H H H H CH3 2,6DMB H 866 H H H H CH3 CD3 H867 H H H H CH3 CH3 H 868 H H H H CH3 H 2,6DIP 869 H H H H CH3 H 2,6DMB870 H H H H CH3 H CD3 871 H H H H CH3 H CH3 872 H H H H CH3 H H 873 H HH H CH3 H i-Pr 874 H H H H CH3 i-Pr H 875 H H H H H 2,6DIP H 876 H H H HH 2,6DMB H 877 H H H H H CD3 CD3 878 H H H H H CD3 CH3 879 H H H H H CD3H 880 H H H H H CD3 i-Pr 881 H H H H H CH3 CD3 882 H H H H H CH3 CH3 883H H H H H CH3 H 884 H H H H H CH3 i-Pr 885 H H H H H H 2,6DIP 886 H H HH H H 2,6DMB 887 H H H H H H CD3 888 H H H H H H CH3 889 H H H H H H H890 H H H H H H i-Pr 891 H H H H H i-Pr CD3 892 H H H H H i-Pr CH3 893 HH H H H i-Pr H 894 H H H H i-Pr CD3 H 895 H H H H i-Pr CH3 H 896 H H H Hi-Pr H CD3 897 H H H H i-Pr H CH3 898 H H H H i-Pr H H 899 H H H i-PrCD3 H H 900 H H H i-Pr CH3 H H 901 H H H i-Pr H CD3 H 902 H H H i-Pr HCH3 H 903 H H H i-Pr H H CD3 904 H H H i-Pr H H CH3 905 H H H i-Pr H H H906 H H i-Pr CD3 H H H 907 H H i-Pr CH3 H H H 908 H H i-Pr H CD3 H H 909H H i-Pr H CH3 H H 910 H H i-Pr H H CD3 H 911 H H i-Pr H H CH3 H 912 H Hi-Pr H H H CD3 913 H H i-Pr H H H CH3 914 H H i-Pr H H H H 915 H i-PrCD3 H H H H 916 H i-Pr CH3 H H H H 917 H i-Pr H CD3 H H H 918 H i-Pr HCH3 H H H 919 H i-Pr H H CD3 H H 920 H i-Pr H H CH3 H H 921 H i-Pr H H HCD3 H 922 H i-Pr H H H CH3 H 923 H i-Pr H H H H CD3 924 H i-Pr H H H HCH3 925 H i-Pr H H H H H 926 i-Pr CD3 H H H H H 927 i-Pr CH3 H H H H H928 i-Pr H CD3 H H H H 929 i-Pr H CH3 H H H H 930 i-Pr H H CD3 H H H 931i-Pr H H CH3 H H H 932 i-Pr H H H CD3 H H 933 i-Pr H H H CH3 H H 934i-Pr H H H H CD3 H 935 i-Pr H H H H CH3 H 936 i-Pr H H H H H CD3 937i-Pr H H H H H CH3 938 i-Pr H H H H H H

LA939 to LA1248 based on the structure:

LA # R11 R12 R13 R14 R32 R33 R34 939 CD3 CD3 H H H H H 940 CD3 CH3 H H HH H 941 CD3 H 2,6DIP H H H H 942 CD3 H 2,6DMB H H H H 943 CD3 H CD3 H HH H 944 CD3 H CH3 H H H H 945 CD3 H H 2,6DIP H H H 946 CD3 H H 2,6DMB HH H 947 CD3 H H CD3 H H H 948 CD3 H H CH3 H H H 949 CD3 H H H 2,6DIP H H950 CD3 H H H 2,6DMB H H 951 CD3 H H H CD3 H H 952 CD3 H H H CH3 H H 953CD3 H H H H 2,6DIP H 954 CD3 H H H H 2,6DMB H 955 CD3 H H H H CD3 H 956CD3 H H H H CH3 H 957 CD3 H H H H H 2,6DIP 958 CD3 H H H H H 2,6DMB 959CD3 H H H H H CD3 960 CD3 H H H H H CH3 961 CD3 H H H H H H 962 CD3 H HH H H i-Pr 963 CD3 H H H H i-Pr H 964 CD3 H H H i-Pr H H 965 CD3 H Hi-Pr H H H 966 CD3 H i-Pr H H H H 967 CD3 i-Pr H H H H H 968 CH3 CD3 H HH H H 969 CH3 CH3 H H H H H 970 CH3 H 2,6DIP H H H H 971 CH3 H 2,6DMB HH H H 972 CH3 H CD3 H H H H 973 CH3 H CH3 H H H H 974 CH3 H H 2,6DIP H HH 975 CH3 H H 2,6DMB H H H 976 CH3 H H CD3 H H H 977 CH3 H H CH3 H H H978 CH3 H H H 2,6DIP H H 979 CH3 H H H 2,6DMB H H 980 CH3 H H H CD3 H H981 CH3 H H H CH3 H H 982 CH3 H H H H 2,6DIP H 983 CH3 H H H H 2,6DMB H984 CH3 H H H H CD3 H 985 CH3 H H H H CH3 H 986 CH3 H H H H H 2,6DIP 987CH3 H H H H H 2,6DMB 988 CH3 H H H H H CD3 989 CH3 H H H H H CH3 990 CH3H H H H H H 991 CH3 H H H H H i-Pr 992 CH3 H H H H i-Pr H 993 CH3 H H Hi-Pr H H 994 CH3 H H i-Pr H H H 995 CH3 H i-Pr H H H H 996 CH3 i-Pr H HH H H 997 H 2,6DIP H CD3 H H H 998 H 2,6DIP H CH3 H H H 999 H 2,6DIP H HCD3 H H 1000 H 2,6DIP H H CH3 H H 1001 H 2,6DIP H H H CD3 H 1002 H2,6DIP H H H CH3 H 1003 H 2,6DIP H H H H CD3 1004 H 2,6DIP H H H H CH31005 H 2,6DIP H H H H H 1006 H 2,6DMB H CD3 H H H 1007 H 2,6DMB H CH3 HH H 1008 H 2,6DMB H H CD3 H H 1009 H 2,6DMB H H CH3 H H 1010 H 2,6DMB HH H CD3 H 1011 H 2,6DMB H H H CH3 H 1012 H 2,6DMB H H H H CD3 1013 H2,6DMB H H H H CH3 1014 H 2,6DMB H H H H H 1015 H CD3 CD3 H H H H 1016 HCD3 CH3 H H H H 1017 H CD3 H 2,6DIP H H H 1018 H CD3 H 2,6DMB H H H 1019H CD3 H CD3 H H H 1020 H CD3 H CH3 H H H 1021 H CD3 H H 2,6DIP H H 1022H CD3 H H 2,6DMB H H 1023 H CD3 H H CD3 H H 1024 H CD3 H H CH3 H H 1025H CD3 H H H 2,6DIP H 1026 H CD3 H H H 2,6DMB H 1027 H CD3 H H H CD3 H1028 H CD3 H H H CH3 H 1029 H CD3 H H H H 2,6DIP 1030 H CD3 H H H H2,6DMB 1031 H CD3 H H H H CD3 1032 H CD3 H H H H CH3 1033 H CD3 H H H HH 1034 H CD3 H H H H i-Pr 1035 H CD3 H H H i-Pr H 1036 H CD3 H H i-Pr HH 1037 H CD3 H i-Pr H H H 1038 H CD3 i-Pr H H H H 1039 H CH3 CD3 H H H H1040 H CH3 CH3 H H H H 1041 H CH3 H 2,6DIP H H H 1042 H CH3 H 2,6DMB H HH 1043 H CH3 H CD3 H H H 1044 H CH3 H CH3 H H H 1045 H CH3 H H 2,6DIP HH 1046 H CH3 H H 2,6DMB H H 1047 H CH3 H H CD3 H H 1048 H CH3 H H CH3 HH 1049 H CH3 H H H 2,6DIP H 1050 H CH3 H H H 2,6DMB H 1051 H CH3 H H HCD3 H 1052 H CH3 H H H CH3 H 1053 H CH3 H H H H 2,6DIP 1054 H CH3 H H HH 2,6DMB 1055 H CH3 H H H H CD3 1056 H CH3 H H H H CH3 1057 H CH3 H H HH H 1058 H CH3 H H H H i-Pr 1059 H CH3 H H H i-Pr H 1060 H CH3 H H i-PrH H 1061 H CH3 H i-Pr H H H 1062 H CH3 i-Pr H H H H 1063 H H 2,6DIP HCD3 H H 1064 H H 2,6DIP H CH3 H H 1065 H H 2,6DIP H H CD3 H 1066 H H2,6DIP H H CH3 H 1067 H H 2,6DIP H H H CD3 1068 H H 2,6DIP H H H CH31069 H H 2,6DIP H H H H 1070 H H 2,6DMB H CD3 H H 1071 H H 2,6DMB H CH3H H 1072 H H 2,6DMB H H CD3 H 1073 H H 2,6DMB H H CH3 H 1074 H H 2,6DMBH H H CD3 1075 H H 2,6DMB H H H CH3 1076 H H 2,6DMB H H H H 1077 H H CD3CD3 H H H 1078 H H CD3 CH3 H H H 1079 H H CD3 H 2,6DIP H H 1080 H H CD3H 2,6DMB H H 1081 H H CD3 H CD3 H H 1082 H H CD3 H CH3 H H 1083 H H CD3H H 2,6DIP H 1084 H H CD3 H H 2,6DMB H 1085 H H CD3 H H CD3 H 1086 H HCD3 H H CH3 H 1087 H H CD3 H H H 2,6DIP 1088 H H CD3 H H H 2,6DMB 1089 HH CD3 H H H CD3 1090 H H CD3 H H H CH3 1091 H H CD3 H H H H 1092 H H CD3H H H i-Pr 1093 H H CD3 H H i-Pr H 1094 H H CD3 H i-Pr H H 1095 H H CD3i-Pr H H H 1096 H H CH3 CD3 H H H 1097 H H CH3 CH3 H H H 1098 H H CH3 H2,6DIP H H 1099 H H CH3 H 2,6DMB H H 1100 H H CH3 H CD3 H H 1101 H H CH3H CH3 H H 1102 H H CH3 H H 2,6DIP H 1103 H H CH3 H H 2,6DMB H 1104 H HCH3 H H CD3 H 1105 H H CH3 H H CH3 H 1106 H H CH3 H H H 2,6DIP 1107 H HCH3 H H H 2,6DMB 1108 H H CH3 H H H CD3 1109 H H CH3 H H H CH3 1110 H HCH3 H H H H 1111 H H CH3 H H H i-Pr 1112 H H CH3 H H i-Pr H 1113 H H CH3H i-Pr H H 1114 H H CH3 i-Pr H H H 1115 H H H 2,6DIP CD3 H H 1116 H H H2,6DIP CH3 H H 1117 H H H 2,6DIP H CD3 H 1118 H H H 2,6DIP H CH3 H 1119H H H 2,6DIP H H CD3 1120 H H H 2,6DIP H H CH3 1121 H H H 2,6DIP H H H1122 H H H 2,6DMB CD3 H H 1123 H H H 2,6DMB CH3 H H 1124 H H H 2,6DMB HCD3 H 1125 H H H 2,6DMB H CH3 H 1126 H H H 2,6DMB H H CD3 1127 H H H2,6DMB H H CH3 1128 H H H 2,6DMB H H H 1129 H H H CD3 2,6DIP H H 1130 HH H CD3 2,6DMB H H 1131 H H H CD3 CD3 H H 1132 H H H CD3 CH3 H H 1133 HH H CD3 H 2,6DIP H 1134 H H H CD3 H 2,6DMB H 1135 H H H CD3 H CD3 H 1136H H H CD3 H CH3 H 1137 H H H CD3 H H 2,6DIP 1138 H H H CD3 H H 2,6DMB1139 H H H CD3 H H CD3 1140 H H H CD3 H H CH3 1141 H H H CD3 H H H 1142H H H CD3 H H i-Pr 1143 H H H CD3 H i-Pr H 1144 H H H CD3 i-Pr H H 1145H H H CH3 2,6DIP H H 1146 H H H CH3 2,6DMB H H 1147 H H H CH3 CD3 H H1148 H H H CH3 CH3 H H 1149 H H H CH3 H 2,6DIP H 1150 H H H CH3 H 2,6DMBH 1151 H H H CH3 H CD3 H 1152 H H H CH3 H CH3 H 1153 H H H CH3 H H2,6DIP 1154 H H H CH3 H H 2,6DMB 1155 H H H CH3 H H CD3 1156 H H H CH3 HH CH3 1157 H H H CH3 H H H 1158 H H H CH3 H H i-Pr 1159 H H H CH3 H i-PrH 1160 H H H CH3 i-Pr H H 1161 H H H H 2,6DIP H CD3 1162 H H H H 2,6DIPH CH3 1163 H H H H 2,6DIP H H 1164 H H H H 2,6DMB H CD3 1165 H H H H2,6DMB H CH3 1166 H H H H 2,6DMB H H 1167 H H H H CD3 CD3 H 1168 H H H HCD3 CH3 H 1169 H H H H CD3 H 2,6DIP 1170 H H H H CD3 H 2,6DMB 1171 H H HH CD3 H CD3 1172 H H H H CD3 H CH3 1173 H H H H CD3 H H 1174 H H H H CD3H i-Pr 1175 H H H H CD3 i-Pr H 1176 H H H H CH3 CD3 H 1177 H H H H CH3CH3 H 1178 H H H H CH3 H 2,6DIP 1179 H H H H CH3 H 2,6DMB 1180 H H H HCH3 H CD3 1181 H H H H CH3 H CH3 1182 H H H H CH3 H H 1183 H H H H CH3 Hi-Pr 1184 H H H H CH3 i-Pr H 1185 H H H H H 2,6DIP H 1186 H H H H H2,6DMB H 1187 H H H H H CD3 CD3 1188 H H H H H CD3 CH3 1189 H H H H HCD3 H 1190 H H H H H CD3 i-Pr 1191 H H H H H CH3 CD3 1192 H H H H H CH3CH3 1193 H H H H H CH3 H 1194 H H H H H CH3 i-Pr 1195 H H H H H H 2,6DIP1196 H H H H H H 2,6DMB 1197 H H H H H H CD3 1198 H H H H H H CH3 1199 HH H H H H H 1200 H H H H H H i-Pr 1201 H H H H H i-Pr CD3 1202 H H H H Hi-Pr CH3 1203 H H H H H i-Pr H 1204 H H H H i-Pr CD3 H 1205 H H H H i-PrCH3 H 1206 H H H H i-Pr H CD3 1207 H H H H i-Pr H CH3 1208 H H H H i-PrH H 1209 H H H i-Pr CD3 H H 1210 H H H i-Pr CH3 H H 1211 H H H i-Pr HCD3 H 1212 H H H i-Pr H CH3 H 1213 H H H i-Pr H H CD3 1214 H H H i-Pr HH CH3 1215 H H H i-Pr H H H 1216 H H i-Pr CD3 H H H 1217 H H i-Pr CH3 HH H 1218 H H i-Pr H CD3 H H 1219 H H i-Pr H CH3 H H 1220 H H i-Pr H HCD3 H 1221 H H i-Pr H H CH3 H 1222 H H i-Pr H H H CD3 1223 H H i-Pr H HH CH3 1224 H H i-Pr H H H H 1225 H i-Pr CD3 H H H H 1226 H i-Pr CH3 H HH H 1227 H i-Pr H CD3 H H H 1228 H i-Pr H CH3 H H H 1229 H i-Pr H H CD3H H 1230 H i-Pr H H CH3 H H 1231 H i-Pr H H H CD3 H 1232 H i-Pr H H HCH3 H 1233 H i-Pr H H H H CD3 1234 H i-Pr H H H H CH3 1235 H i-Pr H H HH H 1236 i-Pr CD3 H H H H H 1237 i-Pr CH3 H H H H H 1238 i-Pr H CD3 H HH H 1239 i-Pr H CH3 H H H H 1240 i-Pr H H CD3 H H H 1241 i-Pr H H CH3 HH H 1242 i-Pr H H H CD3 H H 1243 i-Pr H H H CH3 H H 1244 i-Pr H H H HCD3 H 1245 i-Pr H H H H CH3 H 1246 i-Pr H H H H H CD3 1247 i-Pr H H H HH CH3 1248 i-Pr H H H H H H

LA1249 to LA1720 based on structure:

LA # R11 R12 R2 R31 R32 R33 1249 CD3 CD3 2,6DIP H H H 1250 CD3 H 2,6DIPBH H H 1251 CD3 CD3 2,6DMB H H H 1252 CD3 CD3 CD3 H H H 1253 CD3 CD3 CH3H H H 1254 CD3 CD3 H H H H 1255 CD3 CD3 ph H H H 1256 CD3 CH3 2,6DIP H HH 1257 CD3 CH3 2,6DIPB H H H 1258 CD3 CH3 2,6DMB H H H 1259 CD3 CH3 CD3H H H 1260 CD3 CH3 CH3 H H H 1261 CD3 CH3 H H H H 1262 CD3 CH3 ph H H H1263 CD3 H 2,6DIP CD3 H H 1264 CD3 H 2,6DIP CH3 H H 1265 CD3 H 2,6DIP HCD3 H 1266 CD3 H 2,6DIP H CH3 H 1267 CD3 H 2,6DIP H H CD3 1268 CD3 H2,6DIP H H CH3 1269 CD3 H 2,6DIP H H H 1270 CD3 H 2,6DIPB CD3 H H 1271CD3 H 2,6DIPB CH3 H H 1272 CD3 H 2,6DIPB H CD3 H 1273 CD3 H 2,6DIPB HCH3 H 1274 CD3 H 2,6DIPB H H CD3 1275 CD3 H 2,6DIPB H H CH3 1276 CD3 H2,6DIPB H H H 1277 CD3 H 2,6DMB CD3 H H 1278 CD3 H 2,6DMB CH3 H H 1279CD3 H 2,6DMB H CD3 H 1280 CD3 H 2,6DMB H CH3 H 1281 CD3 H 2,6DMB H H CD31282 CD3 H 2,6DMB H H CH3 1283 CD3 H 2,6DMB H H H 1284 CD3 H CD3 CD3 H H1285 CD3 H CD3 CH3 H H 1286 CD3 H CD3 H CD3 H 1287 CD3 H CD3 H CH3 H1288 CD3 H CD3 H H CD3 1289 CD3 H CD3 H H CH3 1290 CD3 H CD3 H H H 1291CD3 H CH3 CD3 H H 1292 CD3 H CH3 CH3 H H 1293 CD3 H CH3 H CD3 H 1294 CD3H CH3 H CH3 H 1295 CD3 H CH3 H H CD3 1296 CD3 H CH3 H H CH3 1297 CD3 HCH3 H H H 1298 CD3 H H 2,6DIP H H 1299 CD3 H H 2,6DMB H H 1300 CD3 H HCD3 H H 1301 CD3 H H CH3 H H 1302 CD3 H H H 2,6DIP H 1303 CD3 H H H2,6DMB H 1304 CD3 H H H CD3 H 1305 CD3 H H H CH3 H 1306 CD3 H H H H2,6DIP 1307 CD3 H H H H 2,6DMB 1308 CD3 H H H H CD3 1309 CD3 H H H H CH31310 CD3 H H H H H 1311 CD3 H H H H iPr 1312 CD3 H H H iPr H 1313 CD3 HH iPr H H 1314 CD3 H ph CD3 H H 1315 CD3 H ph CH3 H H 1316 CD3 H ph HCD3 H 1317 CD3 H ph H CH3 H 1318 CD3 H ph H H CD3 1319 CD3 H ph H H CH31320 CD3 H ph H H H 1321 CD3 iPr H H H H 1322 CH3 CD3 2,6DIP H H H 1323CH3 CD3 2,6DIPB H H H 1324 CH3 CD3 2,6DMB H H H 1325 CH3 CD3 CD3 H H H1326 CH3 CD3 CH3 H H H 1327 CH3 CD3 H H H H 1328 CH3 CD3 ph H H H 1329CH3 CH3 2,6DIP H H H 1330 CH3 CH3 2,6DIPB H H H 1331 CH3 CH3 2,6DMB H HH 1332 CH3 CH3 CD3 H H H 1333 CH3 CH3 CH3 H H H 1334 CH3 CH3 H H H H1335 CH3 CH3 ph H H H 1336 CH3 H 2,6DIP CD3 H H 1337 CH3 H 2,6DIP CH3 HH 1338 CH3 H 2,6DIP H CD3 H 1339 CH3 H 2,6DIP H CH3 H 1340 CH3 H 2,6DIPH H CD3 1341 CH3 H 2,6DIP H H CH3 1342 CH3 H 2,6DIP H H H 1343 CH3 H2,6DIPB CD3 H H 1344 CH3 H 2,6DIPB CH3 H H 1345 CH3 H 2,6DIPB H CD3 H1346 CH3 H 2,6DIPB H CH3 H 1347 CH3 H 2,6DIPB H H CD3 1348 CH3 H 2,6DIPBH H CH3 1349 CH3 H 2,6DIPB H H H 1350 CH3 H 2,6DMB CD3 H H 1351 CH3 H2,6DMB CH3 H H 1352 CH3 H 2,6DMB H CD3 H 1353 CH3 H 2,6DMB H CH3 H 1354CH3 H 2,6DMB H H CD3 1355 CH3 H 2,6DMB H H CH3 1356 CH3 H 2,6DMB H H H1357 CH3 H CD3 CD3 H H 1358 CH3 H CD3 CH3 H H 1359 CH3 H CD3 H CD3 H1360 CH3 H CD3 H CH3 H 1361 CH3 H CD3 H H CD3 1362 CH3 H CD3 H H CH31363 CH3 H CD3 H H H 1364 CH3 H CH3 CD3 H H 1365 CH3 H CH3 CH3 H H 1366CH3 H CH3 H CD3 H 1367 CH3 H CH3 H CH3 H 1368 CH3 H CH3 H H CD3 1369 CH3H CH3 H H CH3 1370 CH3 H CH3 H H H 1371 CH3 H H 2,6DIP H H 1372 CH3 H H2,6DMB H H 1373 CH3 H H CD3 H H 1374 CH3 H H CH3 H H 1375 CH3 H H H2,6DIP H 1376 CH3 H H H 2,6DMB H 1377 CH3 H H H CD3 H 1378 CH3 H H H CH3H 1379 CH3 H H H H 2,6DIP 1380 CH3 H H H H 2,6DMB 1381 CH3 H H H H CD31382 CH3 H H H H CH3 1383 CH3 H H H H H 1384 CH3 H H H H iPr 1385 CH3 HH H iPr H 1386 CH3 H H iPr H H 1387 CH3 H ph CD3 H H 1388 CH3 H ph CH3 HH 1389 CH3 H ph H CD3 H 1390 CH3 H ph H CH3 H 1391 CH3 H ph H H CD3 1392CH3 H ph H H CH3 1393 CH3 H ph H H H 1394 CH3 iPr H H H H 1395 H 2,6DIPH CD3 H H 1396 H 2,6DIP H CH3 H H 1397 H 2,6DIP H H CD3 H 1398 H 2,6DIPH H CH3 H 1399 H 2,6DIP H H H CD3 1400 H 2,6DIP H H H CH3 1401 H 2,6DIPH H H H 1402 H 2,6DMB H CD3 H H 1403 H 2,6DMB H CH3 H H 1404 H 2,6DMB HH CD3 H 1405 H 2,6DMB H H CH3 H 1406 H 2,6DMB H H H CD3 1407 H 2,6DMB HH H CH3 1408 H 2,6DMB H H H H 1409 H CD3 2,6DIP CD3 H H 1410 H CD32,6DIP CH3 H H 1411 H CD3 2,6DIP H CD3 H 1412 H CD3 2,6DIP H CH3 H 1413H CD3 2,6DIP H H CD3 1414 H CD3 2,6DIP H H CH3 1415 H CD3 2,6DIP H H H1416 H CD3 2,6DIPB CD3 H H 1417 H CD3 2,6DIPB CH3 H H 1418 H CD3 2,6DIPBH CD3 H 1419 H CD3 2,6DIPB H CH3 H 1420 H CD3 2,6DIPB H H CD3 1421 H CD32,6DIPB H H CH3 1422 H CD3 2,6DIPB H H H 1423 H CD3 2,6DMB CD3 H H 1424H CD3 2,6DMB CH3 H H 1425 H CD3 2,6DMB H CD3 H 1426 H CD3 2,6DMB H CH3 H1427 H CD3 2,6DMB H H CD3 1428 H CD3 2,6DMB H H CH3 1429 H CD3 2,6DMB HH H 1430 H CD3 CD3 CD3 H H 1431 H CD3 CD3 CH3 H H 1432 H CD3 CD3 H CD3 H1433 H CD3 CD3 H CH3 H 1434 H CD3 CD3 H H CD3 1435 H CD3 CD3 H H CH31436 H CD3 CD3 H H H 1437 H CD3 CH3 CD3 H H 1438 H CD3 CH3 CH3 H H 1439H CD3 CH3 H CD3 H 1440 H CD3 CH3 H CH3 H 1441 H CD3 CH3 H H CD3 1442 HCD3 CH3 H H CH3 1443 H CD3 CH3 H H H 1444 H CD3 H 2,6DIP H H 1445 H CD3H 2,6DMB H H 1446 H CD3 H CD3 H H 1447 H CD3 H CH3 H H 1448 H CD3 H H2,6DIP H 1449 H CD3 H H 2,6DMB H 1450 H CD3 H H CD3 H 1451 H CD3 H H CH3H 1452 H CD3 H H H 2,6DIP 1453 H CD3 H H H 2,6DMB 1454 H CD3 H H H CD31455 H CD3 H H H CH3 1456 H CD3 H H H H 1457 H CD3 H H H iPr 1458 H CD3H H iPr H 1459 H CD3 H iPr H H 1460 H CD3 ph CD3 H H 1461 H CD3 ph CH3 HH 1462 H CD3 ph H CD3 H 1463 H CD3 ph H CH3 H 1464 H CD3 ph H H CD3 1465H CD3 ph H H CH3 1466 H CD3 ph H H H 1467 H CH3 2,6DIP CD3 H H 1468 HCH3 2,6DIP CH3 H H 1469 H CH3 2,6DIP H CD3 H 1470 H CH3 2,6DIP H CH3 H1471 H CH3 2,6DIP H H CD3 1472 H CH3 2,6DIP H H CH3 1473 H CH3 2,6DIP HH H 1474 H CH3 2,6DIPB CD3 H H 1475 H CH3 2,6DIPB CH3 H H 1476 H CH32,6DIPB H CD3 H 1477 H CH3 2,6DIPB H CH3 H 1478 H CH3 2,6DIPB H H CD31479 H CH3 2,6DIPB H H CH3 1480 H CH3 2,6DIPB H H H 1481 H CH3 2,6DMBCD3 H H 1482 H CH3 2,6DMB CH3 H H 1483 H CH3 2,6DMB H CD3 H 1484 H CH32,6DMB H CH3 H 1485 H CH3 2,6DMB H H CD3 1486 H CH3 2,6DMB H H CH3 1487H CH3 2,6DMB H H H 1488 H CH3 CD3 CD3 H H 1489 H CH3 CD3 CH3 H H 1490 HCH3 CD3 H CD3 H 1491 H CH3 CD3 H CH3 H 1492 H CH3 CD3 H H CD3 1493 H CH3CD3 H H CH3 1494 H CH3 CD3 H H H 1495 H CH3 CH3 CD3 H H 1496 H CH3 CH3CH3 H H 1497 H CH3 CH3 H CD3 H 1498 H CH3 CH3 H CH3 H 1499 H CH3 CH3 H HCD3 1500 H CH3 CH3 H H CH3 1501 H CH3 CH3 H H H 1502 H CH3 H 2,6DIP H H1503 H CH3 H 2,6DMB H H 1504 H CH3 H CD3 H H 1505 H CH3 H CH3 H H 1506 HCH3 H H 2,6DIP H 1507 H CH3 H H 2,6DMB H 1508 H CH3 H H CD3 H 1509 H CH3H H CH3 H 1510 H CH3 H H H 2,6DIP 1511 H CH3 H H H 2,6DMB 1512 H CH3 H HH CD3 1513 H CH3 H H H CH3 1514 H CH3 H H H H 1515 H CH3 H H H iPr 1516H CH3 H H iPr H 1517 H CH3 H iPr H H 1518 H CH3 ph CD3 H H 1519 H CH3 phCH3 H H 1520 H CH3 ph H CD3 H 1521 H CH3 ph H CH3 H 1522 H CH3 ph H HCD3 1523 H CH3 ph H H CH3 1524 H CH3 ph H H H 1525 H H 2,6DIP CD3 CD3 H1526 H H 2,6DIP CD3 CH3 H 1527 H H 2,6DIP CD3 H CD3 1528 H H 2,6DIP CD3H CH3 1529 H H 2,6DIP CD3 H H 1530 H H 2,6DIP CH3 CD3 H 1531 H H 2,6DIPCH3 CH3 H 1532 H H 2,6DIP CH3 H CD3 1533 H H 2,6DIP CH3 H CH3 1534 H H2,6DIP CH3 H H 1535 H H 2,6DIP H CD3 CD3 1536 H H 2,6DIP H CD3 CH3 1537H H 2,6DIP H CD3 H 1538 H H 2,6DIP H CH3 CD3 1539 H H 2,6DIP H CH3 CH31540 H H 2,6DIP H CH3 H 1541 H H 2,6DIP H H CD3 1542 H H 2,6DIP H H CH31543 H H 2,6DIP H H H 1544 H H 2,6DIPB CD3 CD3 H 1545 H H 2,6DIPB CD3CH3 H 1546 H H 2,6DIPB CD3 H CD3 1547 H H 2,6DIPB CD3 H CH3 1548 H H2,6DIPB CD3 H H 1549 H H 2,6DIPB CH3 CD3 H 1550 H H 2,6DIPB CH3 CH3 H1551 H H 2,6DIPB CH3 H CD3 1552 H H 2,6DIPB CH3 H CH3 1553 H H 2,6DIPBCH3 H H 1554 H H 2,6DIPB H CD3 CD3 1555 H H 2,6DIPB H CD3 CH3 1556 H H2,6DIPB H CD3 H 1557 H H 2,6DIPB H CH3 CD3 1558 H H 2,6DIPB H CH3 CH31559 H H 2,6DIPB H CH3 H 1560 H H 2,6DIPB H H CD3 1561 H H 2,6DIPB H HCH3 1562 H H 2,6DIPB H H H 1563 H H 2,6DMB CD3 CD3 H 1564 H H 2,6DMB CD3CH3 H 1565 H H 2,6DMB CD3 H CD3 1566 H H 2,6DMB CD3 H CH3 1567 H H2,6DMB CD3 H H 1568 H H 2,6DMB CH3 CD3 H 1569 H H 2,6DMB CH3 CH3 H 1570H H 2,6DMB CH3 H CD3 1571 H H 2,6DMB CH3 H CH3 1572 H H 2,6DMB CH3 H H1573 H H 2,6DMB H CD3 CD3 1574 H H 2,6DMB H CD3 CH3 1575 H H 2,6DMB HCD3 H 1576 H H 2,6DMB H CH3 CD3 1577 H H 2,6DMB H CH3 CH3 1578 H H2,6DMB H CH3 H 1579 H H 2,6DMB H H CD3 1580 H H 2,6DMB H H CH3 1581 H H2,6DMB H H H 1582 H H CD3 CD3 CD3 H 1583 H H CD3 CD3 CH3 H 1584 H H CD3CD3 H CD3 1585 H H CD3 CD3 H CH3 1586 H H CD3 CD3 H H 1587 H H CD3 CH3CD3 H 1588 H H CD3 CH3 CH3 H 1589 H H CD3 CH3 H CD3 1590 H H CD3 CH3 HCH3 1591 H H CD3 CH3 H H 1592 H H CD3 H 2,6DIP H 1593 H H CD3 H 2,6DMB H1594 H H CD3 H CD3 CD3 1595 H H CD3 H CD3 CH3 1596 H H CD3 H CD3 H 1597H H CD3 H CH3 CD3 1598 H H CD3 H CH3 CH3 1599 H H CD3 H CH3 H 1600 H HCD3 H H 2,6DIP 1601 H H CD3 H H 2,6DMB 1602 H H CD3 H H CD3 1603 H H CD3H H CH3 1604 H H CD3 H H H 1605 H H CD3 H H iPr 1606 H H CD3 H iPr H1607 H H CD3 iPr H H 1608 H H CH3 CD3 CD3 H 1609 H H CH3 CD3 CH3 H 1610H H CH3 CD3 H CD3 1611 H H CH3 CD3 H CH3 1612 H H CH3 CD3 H H 1613 H HCH3 CH3 CD3 H 1614 H H CH3 CH3 CH3 H 1615 H H CH3 CH3 H CD3 1616 H H CH3CH3 H CH3 1617 H H CH3 CH3 H H 1618 H H CH3 H 2,6DIP H 1619 H H CH3 H2,6DMB H 1620 H H CH3 H CD3 CD3 1621 H H CH3 H CD3 CH3 1622 H H CH3 HCD3 H 1623 H H CH3 H CH3 CD3 1624 H H CH3 H CH3 CH3 1625 H H CH3 H CH3 H1626 H H CH3 H H 2,6DIP 1627 H H CH3 H H 2,6DMB 1628 H H CH3 H H CD31629 H H CH3 H H CH3 1630 H H CH3 H H H 1631 H H CH3 H H iPr 1632 H HCH3 H iPr H 1633 H H CH3 iPr H H 1634 H H H 2,6DIP H CD3 1635 H H H2,6DIP H CH3 1636 H H H 2,6DIP H H 1637 H H H 2,6DMB H CD3 1638 H H H2,6DMB H CH3 1639 H H H 2,6DMB H H 1640 H H H CD3 CD3 H 1641 H H H CD3CH3 H 1642 H H H CD3 H 2,6DIP 1643 H H H CD3 H 2,6DMB 1644 H H H CD3 HCD3 1645 H H H CD3 H CH3 1646 H H H CD3 H H 1647 H H H CD3 H iPr 1648 HH H CD3 iPr H 1649 H H H CH3 CD3 H 1650 H H H CH3 CH3 H 1651 H H H CH3 H2,6DIP 1652 H H H CH3 H 2,6DMB 1653 H H H CH3 H CD3 1654 H H H CH3 H CH31655 H H H CH3 H H 1656 H H H CH3 H iPr 1657 H H H CH3 iPr H 1658 H H HH 2,6DIP H 1659 H H H H 2,6DMB H 1660 H H H H CD3 CD3 1661 H H H H CD3CH3 1662 H H H H CD3 H 1663 H H H H CD3 iPr 1664 H H H H CH3 CD3 1665 HH H H CH3 CH3 1666 H H H H CH3 H 1667 H H H H CH3 iPr 1668 H H H H H2,6DIP 1669 H H H H H 2,6DMB 1670 H H H H H CD3 1671 H H H H H CH3 1672H H H H H H 1673 H H H H H iPr 1674 H H H H iPr CD3 1675 H H H H iPr CH31676 H H H H iPr H 1677 H H H iPr CD3 H 1678 H H H iPr CH3 H 1679 H H HiPr H CD3 1680 H H H iPr H CH3 1681 H H H iPr H H 1682 H H ph CD3 CD3 H1683 H H ph CD3 CH3 H 1684 H H ph CD3 H CD3 1685 H H ph CD3 H CH3 1686 HH ph CD3 H H 1687 H H ph CH3 CD3 H 1688 H H ph CH3 CH3 H 1689 H H ph CH3H CD3 1690 H H ph CH3 H CH3 1691 H H ph CH3 H H 1692 H H ph H CD3 CD31693 H H ph H CD3 CH3 1694 H H ph H CD3 H 1695 H H ph H CH3 CD3 1696 H Hph H CH3 CH3 1697 H H ph H CH3 H 1698 H H ph H H CD3 1699 H H ph H H CH31700 H H ph H H H 1701 H iPr CD3 H H H 1702 H iPr CH3 H H H 1703 H iPr HCD3 H H 1704 H iPr H CH3 H H 1705 H iPr H H CD3 H 1706 H iPr H H CH3 H1707 H iPr H H H CD3 1708 H iPr H H H CH3 1709 H iPr H H H H 1710 iPrCD3 H H H H 1711 iPr CH3 H H H H 1712 iPr H CD3 H H H 1713 iPr H CH3 H HH 1714 iPr H H CD3 H H 1715 iPr H H CH3 H H 1716 iPr H H H CD3 H 1717iPr H H H CH3 H 1718 iPr H H H H CD3 1719 iPr H H H H CH3 1720 iPr H H HH H

LA1721 to LA2200 based on structure:

LA # R11 R12 R2 R31 R32 R34 1721 CD3 CD3 2,6DIP H H H 1722 CD3 CD32,6DIPB H H H 1723 CD3 CD3 2,6DMB H H H 1724 CD3 CD3 CD3 H H H 1725 CD3CD3 CH3 H H H 1726 CD3 CD3 H H H H 1727 CD3 CD3 ph H H H 1728 CD3 CH32,6DIP H H H 1729 CD3 CH3 2,6DIPB H H H 1730 CD3 CH3 2,6DMB H H H 1731CD3 CH3 CD3 H H H 1732 CD3 CH3 CH3 H H H 1733 CD3 CH3 H H H H 1734 CD3CH3 ph H H H 1735 CD3 H 2,6DIP CD3 H H 1736 CD3 H 2,6DIP CH3 H H 1737CD3 H 2,6DIP H CD3 H 1738 CD3 H 2,6DIP H CH3 H 1739 CD3 H 2,6DIP H H CD31740 CD3 H 2,6DIP H H CH3 1741 CD3 H 2,6DIP H H H 1742 CD3 H 2,6DIPB CD3H H 1743 CD3 H 2,6DIPB CH3 H H 1744 CD3 H 2,6DIPB H CD3 H 1745 CD3 H2,6DIPB H CH3 H 1746 CD3 H 2,6DIPB H H CD3 1747 CD3 H 2,6DIPB H H CH31748 CD3 H 2,6DIPB H H H 1749 CD3 H 2,6DMB CD3 H H 1750 CD3 H 2,6DMB CH3H H 1751 CD3 H 2,6DMB H CD3 H 1752 CD3 H 2,6DMB H CH3 H 1753 CD3 H2,6DMB H H CD3 1754 CD3 H 2,6DMB H H CH3 1755 CD3 H 2,6DMB H H H 1756CD3 H CD3 CD3 H H 1757 CD3 H CD3 CH3 H H 1758 CD3 H CD3 H CD3 H 1759 CD3H CD3 H CH3 H 1760 CD3 H CD3 H H CD3 1761 CD3 H CD3 H H CH3 1762 CD3 HCD3 H H H 1763 CD3 H CH3 CD3 H H 1764 CD3 H CH3 CH3 H H 1765 CD3 H CH3 HCD3 H 1766 CD3 H CH3 H CH3 H 1767 CD3 H CH3 H H CD3 1768 CD3 H CH3 H HCH3 1769 CD3 H CH3 H H H 1770 CD3 H H 2,6DIP H H 1771 CD3 H H 2,6DMB H H1772 CD3 H H CD3 H H 1773 CD3 H H CH3 H H 1774 CD3 H H H 2,6DIP H 1775CD3 H H H 2,6DMB H 1776 CD3 H H H CD3 H 1777 CD3 H H H CH3 H 1778 CD3 HH H H 2,6DIP 1779 CD3 H H H H 2,6DMB 1780 CD3 H H H H CD3 1781 CD3 H H HH CH3 1782 CD3 H H H H H 1783 CD3 H H H H iPr 1784 CD3 H H H iPr H 1785CD3 H H iPr H H 1786 CD3 H ph CD3 H H 1787 CD3 H ph CH3 H H 1788 CD3 Hph H CD3 H 1789 CD3 H ph H CH3 H 1790 CD3 H ph H H CD3 1791 CD3 H ph H HCH3 1792 CD3 H ph H H H 1793 CD3 iPr H H H H 1794 CH3 CD3 2,6DIP H H H1795 CH3 CD3 2,6DIPB H H H 1796 CH3 CD3 2,6DMB H H H 1797 CH3 CD3 CD3 HH H 1798 CH3 CD3 CH3 H H H 1799 CH3 CD3 H H H H 1800 CH3 CD3 ph H H H1801 CH3 CH3 2,6DIP H H H 1802 CH3 CH3 2,6DIPB H H H 1803 CH3 CH3 2,6DMBH H H 1804 CH3 CH3 CD3 H H H 1805 CH3 CH3 CH3 H H H 1806 CH3 CH3 H H H H1807 CH3 CH3 ph H H H 1808 CH3 H 2,6DIP CD3 H H 1809 CH3 H 2,6DIP CH3 HH 1810 CH3 H 2,6DIP H CD3 H 1811 CH3 H 2,6DIP H CH3 H 1812 CH3 H 2,6DIPH H CD3 1813 CH3 H 2,6DIP H H CH3 1814 CH3 H 2,6DIP H H H 1815 CH3 H2,6DIPB CD3 H H 1816 CH3 H 2,6DIPB CH3 H H 1817 CH3 H 2,6DIPB H CD3 H1818 CH3 H 2,6DIPB H CH3 H 1819 CH3 H 2,6DIPB H H CD3 1820 CH3 H 2,6DIPBH H CH3 1821 CH3 H 2,6DIPB H H H 1822 CH3 H 2,6DMB CD3 H H 1823 CH3 H2,6DMB CH3 H H 1824 CH3 H 2,6DMB H CD3 H 1825 CH3 H 2,6DMB H CH3 H 1826CH3 H 2,6DMB H H CD3 1827 CH3 H 2,6DMB H H CH3 1828 CH3 H 2,6DMB H H H1829 CH3 H CD3 CD3 H H 1830 CH3 H CD3 CH3 H H 1831 CH3 H CD3 H CD3 H1832 CH3 H CD3 H CH3 H 1833 CH3 H CD3 H H CD3 1834 CH3 H CD3 H H CH31835 CH3 H CD3 H H H 1836 CH3 H CH3 CD3 H H 1837 CH3 H CH3 CH3 H H 1838CH3 H CH3 H CD3 H 1839 CH3 H CH3 H CH3 H 1840 CH3 H CH3 H H CD3 1841 CH3H CH3 H H CH3 1842 CH3 H CH3 H H H 1843 CH3 H H 2,6DIP H H 1844 CH3 H H2,6DMB H H 1845 CH3 H H CD3 H H 1846 CH3 H H CH3 H H 1847 CH3 H H H2,6DIP H 1848 CH3 H H H 2,6DMB H 1849 CH3 H H H CD3 H 1850 CH3 H H H CH3H 1851 CH3 H H H H 2,6DIP 1852 CH3 H H H H 2,6DMB 1853 CH3 H H H H CD31854 CH3 H H H H CH3 1855 CH3 H H H H H 1856 CH3 H H H H iPr 1857 CH3 HH H iPr H 1858 CH3 H H iPr H H 1859 CH3 H ph CD3 H H 1860 CH3 H ph CH3 HH 1861 CH3 H ph H CD3 H 1862 CH3 H ph H CH3 H 1863 CH3 H ph H H CD3 1864CH3 H ph H H CH3 1865 CH3 H ph H H H 1866 CH3 iPr H H H H 1867 H 2,6DIPH CD3 H H 1868 H 2,6DIP H CH3 H H 1869 H 2,6DIP H H CD3 H 1870 H 2,6DIPH H CH3 H 1871 H 2,6DIP H H H CD3 1872 H 2,6DIP H H H CH3 1873 H 2,6DIPH H H H 1874 H 2,6DMB H CD3 H H 1875 H 2,6DMB H CH3 H H 1876 H 2,6DMB HH CD3 H 1877 H 2,6DMB H H CH3 H 1878 H 2,6DMB H H H CD3 1879 H 2,6DMB HH H CH3 1880 H 2,6DMB H H H H 1881 H CD3 2,6DIP CD3 H H 1882 H CD32,6DIP CH3 H H 1883 H CD3 2,6DIP H CD3 H 1884 H CD3 2,6DIP H CH3 H 1885H CD3 2,6DIP H H CD3 1886 H CD3 2,6DIP H H CH3 1887 H CD3 2,6DIP H H H1888 H CD3 2,6DIPB CD3 H H 1889 H CD3 2,6DIPB CH3 H H 1890 H CD3 2,6DIPBH CD3 H 1891 H CD3 2,6DIPB H CH3 H 1892 H CD3 2,6DIPB H H CD3 1893 H CD32,6DIPB H H CH3 1894 H CD3 2,6DIPB H H H 1895 H CD3 2,6DMB CD3 H H 1896H CD3 2,6DMB CH3 H H 1897 H CD3 2,6DMB H CD3 H 1898 H CD3 2,6DMB H CH3 H1899 H CD3 2,6DMB H H CD3 1900 H CD3 2,6DMB H H CH3 1901 H CD3 2,6DMB HH H 1902 H CD3 CD3 CD3 H H 1903 H CD3 CD3 CH3 H H 1904 H CD3 CD3 H CD3 H1905 H CD3 CD3 H CH3 H 1906 H CD3 CD3 H H CD3 1907 H CD3 CD3 H H CH31908 H CD3 CD3 H H H 1909 H CD3 CH3 CD3 H H 1910 H CD3 CH3 CH3 H H 1911H CD3 CH3 H CD3 H 1912 H CD3 CH3 H CH3 H 1913 H CD3 CH3 H H CD3 1914 HCD3 CH3 H H CH3 1915 H CD3 CH3 H H H 1916 H CD3 H 2,6DIP H H 1917 H CD3H 2,6DMB H H 1918 H CD3 H CD3 H H 1919 H CD3 H CH3 H H 1920 H CD3 H H2,6DIP H 1921 H CD3 H H 2,6DMB H 1922 H CD3 H H CD3 H 1923 H CD3 H H CH3H 1924 H CD3 H H H 2,6DIP 1925 H CD3 H H H 2,6DMB 1926 H CD3 H H H CD31927 H CD3 H H H CH3 1928 H CD3 H H H H 1929 H CD3 H H H iPr 1930 H CD3H H iPr H 1931 H CD3 H iPr H H 1932 H CD3 ph CD3 H H 1933 H CD3 ph CH3 HH 1934 H CD3 ph H CD3 H 1935 H CD3 ph H CH3 H 1936 H CD3 ph H H CD3 1937H CD3 ph H H CH3 1938 H CD3 ph H H H 1939 H CH3 2,6DIP CD3 H H 1940 HCH3 2,6DIP CH3 H H 1941 H CH3 2,6DIP H CD3 H 1942 H CH3 2,6DIP H CH3 H1943 H CH3 2,6DIP H H CD3 1944 H CH3 2,6DIP H H CH3 1945 H CH3 2,6DIP HH H 1946 H CH3 2,6DIPB CD3 H H 1947 H CH3 2,6DIPB CH3 H H 1948 H CH32,6DIPB H CD3 H 1949 H CH3 2,6DIPB H CH3 H 1950 H CH3 2,6DIPB H H CD31951 H CH3 2,6DIPB H H CH3 1952 H CH3 2,6DIPB H H H 1953 H CH3 2,6DMBCD3 H H 1954 H CH3 2,6DMB CH3 H H 1955 H CH3 2,6DMB H CD3 H 1956 H CH32,6DMB H CH3 H 1957 H CH3 2,6DMB H H CD3 1958 H CH3 2,6DMB H H CH3 1959H CH3 2,6DMB H H H 1960 H CH3 CD3 CD3 H H 1961 H CH3 CD3 CH3 H H 1962 HCH3 CD3 H CD3 H 1963 H CH3 CD3 H CH3 H 1964 H CH3 CD3 H H CD3 1965 H CH3CD3 H H CH3 1966 H CH3 CD3 H H H 1967 H CH3 CH3 CD3 H H 1968 H CH3 CH3CH3 H H 1969 H CH3 CH3 H CD3 H 1970 H CH3 CH3 H CH3 H 1971 H CH3 CH3 H HCD3 1972 H CH3 CH3 H H CH3 1973 H CH3 CH3 H H H 1974 H CH3 H 2,6DIP H H1975 H CH3 H 2,6DMB H H 1976 H CH3 H CD3 H H 1977 H CH3 H CH3 H H 1978 HCH3 H H 2,6DIP H 1979 H CH3 H H 2,6DMB H 1980 H CH3 H H CD3 H 1981 H CH3H H CH3 H 1982 H CH3 H H H 2,6DIP 1983 H CH3 H H H 2,6DMB 1984 H CH3 H HH CD3 1985 H CH3 H H H CH3 1986 H CH3 H H H H 1987 H CH3 H H H iPr 1988H CH3 H H iPr H 1989 H CH3 H iPr H H 1990 H CH3 ph CD3 H H 1991 H CH3 phCH3 H H 1992 H CH3 ph H CD3 H 1993 H CH3 ph H CH3 H 1994 H CH3 ph H HCD3 1995 H CH3 ph H H CH3 1996 H CH3 ph H H H 1997 H H 2,6DIP CD3 CD3 H1998 H H 2,6DIP CD3 CH3 H 1999 H H 2,6DIP CD3 H CD3 2000 H H 2,6DIP CD3H CH3 2001 H H 2,6DIP CD3 H H 2002 H H 2,6DIP CH3 CD3 H 2003 H H 2,6DIPCH3 CH3 H 2004 H H 2,6DIP CH3 H CD3 2005 H H 2,6DIP CH3 H CH3 2006 H H2,6DIP CH3 H H 2007 H H 2,6DIP H CD3 CD3 2008 H H 2,6DIP H CD3 CH3 2009H H 2,6DIP H CD3 H 2010 H H 2,6DIP H CH3 CD3 2011 H H 2,6DIP H CH3 CH32012 H H 2,6DIP H CH3 H 2013 H H 2,6DIP H H CD3 2014 H H 2,6DIP H H CH32015 H H 2,6DIP H H H 2016 H H 2,6DIPB CD3 CD3 H 2017 H H 2,6DIPB CD3CH3 H 2018 H H 2,6DIPB CD3 H CD3 2019 H H 2,6DIPB CD3 H CH3 2020 H H2,6DIPB CD3 H H 2021 H H 2,6DIPB CH3 CD3 H 2022 H H 2,6DIPB CH3 CH3 H2023 H H 2,6DIPB CH3 H CD3 2024 H H 2,6DIPB CH3 H CH3 2025 H H 2,6DIPBCH3 H H 2026 H H 2,6DIPB H CD3 CD3 2027 H H 2,6DIPB H CD3 CH3 2028 H H2,6DIPB H CD3 H 2029 H H 2,6DIPB H CH3 CD3 2030 H H 2,6DIPB H CH3 CH32031 H H 2,6DIPB H CH3 H 2032 H H 2,6DIPB H H CD3 2033 H H 2,6DIPB H HCH3 2034 H H 2,6DIPB H H H 2035 H H 2,6DMB CD3 CD3 H 2036 H H 2,6DMB CD3CH3 H 2037 H H 2,6DMB CD3 H CD3 2038 H H 2,6DMB CD3 H CH3 2039 H H2,6DMB CD3 H H 2040 H H 2,6DMB CH3 CD3 H 2041 H H 2,6DMB CH3 CH3 H 2042H H 2,6DMB CH3 H CD3 2043 H H 2,6DMB CH3 H CH3 2044 H H 2,6DMB CH3 H H2045 H H 2,6DMB H CD3 CD3 2046 H H 2,6DMB H CD3 CH3 2047 H H 2,6DMB HCD3 H 2048 H H 2,6DMB H CH3 CD3 2049 H H 2,6DMB H CH3 CH3 2050 H H2,6DMB H CH3 H 2051 H H 2,6DMB H H CD3 2052 H H 2,6DMB H H CH3 2053 H H2,6DMB H H H 2054 H H CD3 CD3 CD3 H 2055 H H CD3 CD3 CH3 H 2056 H H CD3CD3 H CD3 2057 H H CD3 CD3 H CH3 2058 H H CD3 CD3 H H 2059 H H CD3 CH3CD3 H 2060 H H CD3 CH3 CH3 H 2061 H H CD3 CH3 H CD3 2062 H H CD3 CH3 HCH3 2063 H H CD3 CH3 H H 2064 H H CD3 H 2,6DIP H 2065 H H CD3 H 2,6DMB H2066 H H CD3 H CD3 CD3 2067 H H CD3 H CD3 CH3 2068 H H CD3 H CD3 H 2069H H CD3 H CH3 CD3 2070 H H CD3 H CH3 CH3 2071 H H CD3 H CH3 H 2072 H HCD3 H H 2,6DIP 2073 H H CD3 H H 2,6DMB 2074 H H CD3 H H CD3 2075 H H CD3H H CH3 2076 H H CD3 H H H 2077 H H CD3 H H iPr 2078 H H CD3 H iPr H2079 H H CD3 iPr H H 2080 H H CH3 CD3 CD3 H 2081 H H CH3 CD3 CH3 H 2082H H CH3 CD3 H CD3 2083 H H CH3 CD3 H CH3 2084 H H CH3 CD3 H H 2085 H HCH3 CH3 CD3 H 2086 H H CH3 CH3 CH3 H 2087 H H CH3 CH3 H CD3 2088 H H CH3CH3 H CH3 2089 H H CH3 CH3 H H 2090 H H CH3 H 2,6DIP H 2091 H H CH3 H2,6DMB H 2092 H H CH3 H CD3 CD3 2093 H H CH3 H CD3 CH3 2094 H H CH3 HCD3 H 2095 H H CH3 H CH3 CD3 2096 H H CH3 H CH3 CH3 2097 H H CH3 H CH3 H2098 H H CH3 H H 2,6DIP 2099 H H CH3 H H 2,6DMB 2100 H H CH3 H H CD32101 H H CH3 H H CH3 2102 H H CH3 H H H 2103 H H CH3 H H iPr 2104 H HCH3 H iPr H 2105 H H CH3 iPr H H 2106 H H H 2,6DIP H CD3 2107 H H H2,6DIP H CH3 2108 H H H 2,6DIP H H 2109 H H H 2,6DMB H CD3 2110 H H H2,6DMB H CH3 2111 H H H 2,6DMB H H 2112 H H H CD3 CD3 H 2113 H H H CD3CH3 H 2114 H H H CD3 H 2,6DIP 2115 H H H CD3 H 2,6DMB 2116 H H H CD3 HCD3 2117 H H H CD3 H CH3 2118 H H H CD3 H H 2119 H H H CD3 H iPr 2120 HH H CD3 iPr H 2121 H H H CH3 CD3 H 2122 H H H CH3 CH3 H 2123 H H H CH3 H2,6DIP 2124 H H H CH3 H 2,6DMB 2125 H H H CH3 H CD3 2126 H H H CH3 H CH32127 H H H CH3 H H 2128 H H H CH3 H iPr 2129 H H H CH3 iPr H 2130 H H HH 2,6DIP CD3 2131 H H H H 2,6DIP CH3 2132 H H H H 2,6DIP H 2133 H H H H2,6DMB CD3 2134 H H H H 2,6DMB CH3 2135 H H H H 2,6DMB H 2136 H H H HCD3 2,6DIP 2137 H H H H CD3 2,6DMB 2138 H H H H CD3 CD3 2139 H H H H CD3CH3 2140 H H H H CD3 H 2141 H H H H CD3 iPr 2142 H H H H CH3 2,6DIP 2143H H H H CH3 2,6DMB 2144 H H H H CH3 CD3 2145 H H H H CH3 CH3 2146 H H HH CH3 H 2147 H H H H CH3 iPr 2148 H H H H H 2,6DIP 2149 H H H H H 2,6DMB2150 H H H H H CD3 2151 H H H H H CH3 2152 H H H H H H 2153 H H H H HiPr 2154 H H H H iPr CD3 2155 H H H H iPr CH3 2156 H H H H iPr H 2157 HH H iPr CD3 H 2158 H H H iPr CH3 H 2159 H H H iPr H CD3 2160 H H H iPr HCH3 2161 H H H iPr H H 2162 H H ph CD3 CD3 H 2163 H H ph CD3 CH3 H 2164H H ph CD3 H CD3 2165 H H ph CD3 H CH3 2166 H H ph CD3 H H 2167 H H phCH3 CD3 H 2168 H H ph CH3 CH3 H 2169 H H ph CH3 H CD3 2170 H H ph CH3 HCH3 2171 H H ph CH3 H H 2172 H H ph H CD3 CD3 2173 H H ph H CD3 CH3 2174H H ph H CD3 H 2175 H H ph H CH3 CD3 2176 H H ph H CH3 CH3 2177 H H ph HCH3 H 2178 H H ph H H CD3 2179 H H ph H H CH3 2180 H H ph H H H 2181 HiPr CD3 H H H 2182 H iPr CH3 H H H 2183 H iPr H CD3 H H 2184 H iPr H CH3H H 2185 H iPr H H CD3 H 2186 H iPr H H CH3 H 2187 H iPr H H H CD3 2188H iPr H H H CH3 2189 H iPr H H H H 2190 iPr CD3 H H H H 2191 iPr CH3 H HH H 2192 iPr H CD3 H H H 2193 iPr H CH3 H H H 2194 iPr H H CD3 H H 2195iPr H H CH3 H H 2196 iPr H H H CD3 H 2197 iPr H H H CH3 H 2198 iPr H H HH CD3 2199 iPr H H H H CH3 2200 iPr H H H H H

LA2201 to LA2680 based on structure:

LA # R11 R12 R2 R31 R33 R34 2201 CD3 CD3 2,6DIP H H H 2202 CD3 CD32,6DIPB H H H 2203 CD3 CD3 2,6DMB H H H 2204 CD3 CD3 CD3 H H H 2205 CD3CD3 CH3 H H H 2206 CD3 CD3 H H H H 2207 CD3 CD3 ph H H H 2208 CD3 CH32,6DIP H H H 2209 CD3 CH3 2,6DIPB H H H 2210 CD3 CH3 2,6DMB H H H 2211CD3 CH3 CD3 H H H 2212 CD3 CH3 CH3 H H H 2213 CD3 CH3 H H H H 2214 CD3CH3 ph H H H 2215 CD3 H 2,6DIP CD3 H H 2216 CD3 H 2,6DIP CH3 H H 2217CD3 H 2,6DIP H CD3 H 2218 CD3 H 2,6DIP H CH3 H 2219 CD3 H 2,6DIP H H CD32220 CD3 H 2,6DIP H H CH3 2221 CD3 H 2,6DIP H H H 2222 CD3 H 2,6DIPB CD3H H 2223 CD3 H 2,6DIPB CH3 H H 2224 CD3 H 2,6DIPB H CD3 H 2225 CD3 H2,6DIPB H CH3 H 2226 CD3 H 2,6DIPB H H CD3 2227 CD3 H 2,6DIPB H H CH32228 CD3 H 2,6DIPB H H H 2229 CD3 H 2,6DMB CD3 H H 2230 CD3 H 2,6DMB CH3H H 2231 CD3 H 2,6DMB H CD3 H 2232 CD3 H 2,6DMB H CH3 H 2233 CD3 H2,6DMB H H CD3 2234 CD3 H 2,6DMB H H CH3 2235 CD3 H 2,6DMB H H H 2236CD3 H CD3 CD3 H H 2237 CD3 H CD3 CH3 H H 2238 CD3 H CD3 H CD3 H 2239 CD3H CD3 H CH3 H 2240 CD3 H CD3 H H CD3 2241 CD3 H CD3 H H CH3 2242 CD3 HCD3 H H H 2243 CD3 H CH3 CD3 H H 2244 CD3 H CH3 CH3 H H 2245 CD3 H CH3 HCD3 H 2246 CD3 H CH3 H CH3 H 2247 CD3 H CH3 H H CD3 2248 CD3 H CH3 H HCH3 2249 CD3 H CH3 H H H 2250 CD3 H H 2,6DIP H H 2251 CD3 H H 2,6DMB H H2252 CD3 H H CD3 H H 2253 CD3 H H CH3 H H 2254 CD3 H H H 2,6DIP H 2255CD3 H H H 2,6DMB H 2256 CD3 H H H CD3 H 2257 CD3 H H H CH3 H 2258 CD3 HH H H 2,6DIP 2259 CD3 H H H H 2,6DMB 2260 CD3 H H H H CD3 2261 CD3 H H HH CH3 2262 CD3 H H H H H 2263 CD3 H H H H iPr 2264 CD3 H H H iPr H 2265CD3 H H iPr H H 2266 CD3 H ph CD3 H H 2267 CD3 H ph CH3 H H 2268 CD3 Hph H CD3 H 2269 CD3 H ph H CH3 H 2270 CD3 H ph H H CD3 2271 CD3 H ph H HCH3 2272 CD3 H ph H H H 2273 CD3 iPr H H H H 2274 CH3 CD3 2,6DIP H H H2275 CH3 CD3 2,6DIPB H H H 2276 CH3 CD3 2,6DMB H H H 2277 CH3 CD3 CD3 HH H 2278 CH3 CD3 CH3 H H H 2279 CH3 CD3 H H H H 2280 CH3 CD3 ph H H H2281 CH3 CH3 2,6DIP H H H 2282 CH3 CH3 2,6DIPB H H H 2283 CH3 CH3 2,6DMBH H H 2284 CH3 CH3 CD3 H H H 2285 CH3 CH3 CH3 H H H 2286 CH3 CH3 H H H H2287 CH3 CH3 ph H H H 2288 CH3 H 2,6DIP CD3 H H 2289 CH3 H 2,6DIP CH3 HH 2290 CH3 H 2,6DIP H CD3 H 2291 CH3 H 2,6DIP H CH3 H 2292 CH3 H 2,6DIPH H CD3 2293 CH3 H 2,6DIP H H CH3 2294 CH3 H 2,6DIP H H H 2295 CH3 H2,6DIPB CD3 H H 2296 CH3 H 2,6DIPB CH3 H H 2297 CH3 H 2,6DIPB H CD3 H2298 CH3 H 2,6DIPB H CH3 H 2299 CH3 H 2,6DIPB H H CD3 2300 CH3 H 2,6DIPBH H CH3 2301 CH3 H 2,6DIPB H H H 2302 CH3 H 2,6DMB CD3 H H 2303 CH3 H2,6DMB CH3 H H 2304 CH3 H 2,6DMB H CD3 H 2305 CH3 H 2,6DMB H CH3 H 2306CH3 H 2,6DMB H H CD3 2307 CH3 H 2,6DMB H H CH3 2308 CH3 H 2,6DMB H H H2309 CH3 H CD3 CD3 H H 2310 CH3 H CD3 CH3 H H 2311 CH3 H CD3 H CD3 H2312 CH3 H CD3 H CH3 H 2313 CH3 H CD3 H H CD3 2314 CH3 H CD3 H H CH32315 CH3 H CD3 H H H 2316 CH3 H CH3 CD3 H H 2317 CH3 H CH3 CH3 H H 2318CH3 H CH3 H CD3 H 2319 CH3 H CH3 H CH3 H 2320 CH3 H CH3 H H CD3 2321 CH3H CH3 H H CH3 2322 CH3 H CH3 H H H 2323 CH3 H H 2,6DIP H H 2324 CH3 H H2,6DMB H H 2325 CH3 H H CD3 H H 2326 CH3 H H CH3 H H 2327 CH3 H H H2,6DIP H 2328 CH3 H H H 2,6DMB H 2329 CH3 H H H CD3 H 2330 CH3 H H H CH3H 2331 CH3 H H H H 2,6DIP 2332 CH3 H H H H 2,6DMB 2333 CH3 H H H H CD32334 CH3 H H H H CH3 2335 CH3 H H H H H 2336 CH3 H H H H iPr 2337 CH3 HH H iPr H 2338 CH3 H H iPr H H 2339 CH3 H ph CD3 H H 2340 CH3 H ph CH3 HH 2341 CH3 H ph H CD3 H 2342 CH3 H ph H CH3 H 2343 CH3 H ph H H CD3 2344CH3 H ph H H CH3 2345 CH3 H ph H H H 2346 CH3 iPr H H H H 2347 H 2,6DIPH CD3 H H 2348 H 2,6DIP H CH3 H H 2349 H 2,6DIP H H CD3 H 2350 H 2,6DIPH H CH3 H 2351 H 2,6DIP H H H CD3 2352 H 2,6DIP H H H CH3 2353 H 2,6DIPH H H H 2354 H 2,6DMB H CD3 H H 2355 H 2,6DMB H CH3 H H 2356 H 2,6DMB HH CD3 H 2357 H 2,6DMB H H CH3 H 2358 H 2,6DMB H H H CD3 2359 H 2,6DMB HH H CH3 2360 H 2,6DMB H H H H 2361 H CD3 2,6DIP CD3 H H 2362 H CD32,6DIP CH3 H H 2363 H CD3 2,6DIP H CD3 H 2364 H CD3 2,6DIP H CH3 H 2365H CD3 2,6DIP H H CD3 2366 H CD3 2,6DIP H H CH3 2367 H CD3 2,6DIP H H H2368 H CD3 2,6DIPB CD3 H H 2369 H CD3 2,6DIPB CH3 H H 2370 H CD3 2,6DIPBH CD3 H 2371 H CD3 2,6DIPB H CH3 H 2372 H CD3 2,6DIPB H H CD3 2373 H CD32,6DIPB H H CH3 2374 H CD3 2,6DIPB H H H 2375 H CD3 2,6DMB CD3 H H 2376H CD3 2,6DMB CH3 H H 2377 H CD3 2,6DMB H CD3 H 2378 H CD3 2,6DMB H CH3 H2379 H CD3 2,6DMB H H CD3 2380 H CD3 2,6DMB H H CH3 2381 H CD3 2,6DMB HH H 2382 H CD3 CD3 CD3 H H 2383 H CD3 CD3 CH3 H H 2384 H CD3 CD3 H CD3 H2385 H CD3 CD3 H CH3 H 2386 H CD3 CD3 H H CD3 2387 H CD3 CD3 H H CH32388 H CD3 CD3 H H H 2389 H CD3 CH3 CD3 H H 2390 H CD3 CH3 CH3 H H 2391H CD3 CH3 H CD3 H 2392 H CD3 CH3 H CH3 H 2393 H CD3 CH3 H H CD3 2394 HCD3 CH3 H H CH3 2395 H CD3 CH3 H H H 2396 H CD3 H 2,6DIP H H 2397 H CD3H 2,6DMB H H 2398 H CD3 H CD3 H H 2399 H CD3 H CH3 H H 2400 H CD3 H H2,6DIP H 2401 H CD3 H H 2,6DMB H 2402 H CD3 H H CD3 H 2403 H CD3 H H CH3H 2404 H CD3 H H H 2,6DIP 2405 H CD3 H H H 2,6DMB 2406 H CD3 H H H CD32407 H CD3 H H H CH3 2408 H CD3 H H H H 2409 H CD3 H H H iPr 2410 H CD3H H iPr H 2411 H CD3 H iPr H H 2412 H CD3 ph CD3 H H 2413 H CD3 ph CH3 HH 2414 H CD3 ph H CD3 H 2415 H CD3 ph H CH3 H 2416 H CD3 ph H H CD3 2417H CD3 ph H H CH3 2418 H CD3 ph H H H 2419 H CH3 2,6DIP CD3 H H 2420 HCH3 2,6DIP CH3 H H 2421 H CH3 2,6DIP H CD3 H 2422 H CH3 2,6DIP H CH3 H2423 H CH3 2,6DIP H H CD3 2424 H CH3 2,6DIP H H CH3 2425 H CH3 2,6DIP HH H 2426 H CH3 2,6DIPB CD3 H H 2427 H CH3 2,6DIPB CH3 H H 2428 H CH32,6DIPB H CD3 H 2429 H CH3 2,6DIPB H CH3 H 2430 H CH3 2,6DIPB H H CD32431 H CH3 2,6DIPB H H CH3 2432 H CH3 2,6DIPB H H H 2433 H CH3 2,6DMBCD3 H H 2434 H CH3 2,6DMB CH3 H H 2435 H CH3 2,6DMB H CD3 H 2436 H CH32,6DMB H CH3 H 2437 H CH3 2,6DMB H H CD3 2438 H CH3 2,6DMB H H CH3 2439H CH3 2,6DMB H H H 2440 H CH3 CD3 CD3 H H 2441 H CH3 CD3 CH3 H H 2442 HCH3 CD3 H CD3 H 2443 H CH3 CD3 H CH3 H 2444 H CH3 CD3 H H CD3 2445 H CH3CD3 H H CH3 2446 H CH3 CD3 H H H 2447 H CH3 CH3 CD3 H H 2448 H CH3 CH3CH3 H H 2449 H CH3 CH3 H CD3 H 2450 H CH3 CH3 H CH3 H 2451 H CH3 CH3 H HCD3 2452 H CH3 CH3 H H CH3 2453 H CH3 CH3 H H H 2454 H CH3 H 2,6DIP H H2455 H CH3 H 2,6DMB H H 2456 H CH3 H CD3 H H 2457 H CH3 H CH3 H H 2458 HCH3 H H 2,6DIP H 2459 H CH3 H H 2,6DMB H 2460 H CH3 H H CD3 H 2461 H CH3H H CH3 H 2462 H CH3 H H H 2,6DIP 2463 H CH3 H H H 2,6DMB 2464 H CH3 H HH CD3 2465 H CH3 H H H CH3 2466 H CH3 H H H H 2467 H CH3 H H H iPr 2468H CH3 H H iPr H 2469 H CH3 H iPr H H 2470 H CH3 ph CD3 H H 2471 H CH3 phCH3 H H 2472 H CH3 ph H CD3 H 2473 H CH3 ph H CH3 H 2474 H CH3 ph H HCD3 2475 H CH3 ph H H CH3 2476 H CH3 ph H H H 2477 H H 2,6DIP CD3 CD3 H2478 H H 2,6DIP CD3 CH3 H 2479 H H 2,6DIP CD3 H CD3 2480 H H 2,6DIP CD3H CH3 2481 H H 2,6DIP CD3 H H 2482 H H 2,6DIP CH3 CD3 H 2483 H H 2,6DIPCH3 CH3 H 2484 H H 2,6DIP CH3 H CD3 2485 H H 2,6DIP CH3 H CH3 2486 H H2,6DIP CH3 H H 2487 H H 2,6DIP H CD3 CD3 2488 H H 2,6DIP H CD3 CH3 2489H H 2,6DIP H CD3 H 2490 H H 2,6DIP H CH3 CD3 2491 H H 2,6DIP H CH3 CH32492 H H 2,6DIP H CH3 H 2493 H H 2,6DIP H H CD3 2494 H H 2,6DIP H H CH32495 H H 2,6DIP H H H 2496 H H 2,6DIPB CD3 CD3 H 2497 H H 2,6DIPB CD3CH3 H 2498 H H 2,6DIPB CD3 H CD3 2499 H H 2,6DIPB CD3 H CH3 2500 H H2,6DIPB CD3 H H 2501 H H 2,6DIPB CH3 CD3 H 2502 H H 2,6DIPB CH3 CH3 H2503 H H 2,6DIPB CH3 H CD3 2504 H H 2,6DIPB CH3 H CH3 2505 H H 2,6DIPBCH3 H H 2506 H H 2,6DIPB H CD3 CD3 2507 H H 2,6DIPB H CD3 CH3 2508 H H2,6DIPB H CD3 H 2509 H H 2,6DIPB H CH3 CD3 2510 H H 2,6DIPB H CH3 CH32511 H H 2,6DIPB H CH3 H 2512 H H 2,6DIPB H H CD3 2513 H H 2,6DIPB H HCH3 2514 H H 2,6DIPB H H H 2515 H H 2,6DMB CD3 CD3 H 2516 H H 2,6DMB CD3CH3 H 2517 H H 2,6DMB CD3 H CD3 2518 H H 2,6DMB CD3 H CH3 2519 H H2,6DMB CD3 H H 2520 H H 2,6DMB CH3 CD3 H 2521 H H 2,6DMB CH3 CH3 H 2522H H 2,6DMB CH3 H CD3 2523 H H 2,6DMB CH3 H CH3 2524 H H 2,6DMB CH3 H H2525 H H 2,6DMB H CD3 CD3 2526 H H 2,6DMB H CD3 CH3 2527 H H 2,6DMB HCD3 H 2528 H H 2,6DMB H CH3 CD3 2529 H H 2,6DMB H CH3 CH3 2530 H H2,6DMB H CH3 H 2531 H H 2,6DMB H H CD3 2532 H H 2,6DMB H H CH3 2533 H H2,6DMB H H H 2534 H H CD3 CD3 CD3 H 2535 H H CD3 CD3 CH3 H 2536 H H CD3CD3 H CD3 2537 H H CD3 CD3 H CH3 2538 H H CD3 CD3 H H 2539 H H CD3 CH3CD3 H 2540 H H CD3 CH3 CH3 H 2541 H H CD3 CH3 H CD3 2542 H H CD3 CH3 HCH3 2543 H H CD3 CH3 H H 2544 H H CD3 H 2,6DIP H 2545 H H CD3 H 2,6DMB H2546 H H CD3 H CD3 CD3 2547 H H CD3 H CD3 CH3 2548 H H CD3 H CD3 H 2549H H CD3 H CH3 CD3 2550 H H CD3 H CH3 CH3 2551 H H CD3 H CH3 H 2552 H HCD3 H H 2,6DIP 2553 H H CD3 H H 2,6DMB 2554 H H CD3 H H CD3 2555 H H CD3H H CH3 2556 H H CD3 H H H 2557 H H CD3 H H iPr 2558 H H CD3 H iPr H2559 H H CD3 iPr H H 2560 H H CH3 CD3 CD3 H 2561 H H CH3 CD3 CH3 H 2562H H CH3 CD3 H CD3 2563 H H CH3 CD3 H CH3 2564 H H CH3 CD3 H H 2565 H HCH3 CH3 CD3 H 2566 H H CH3 CH3 CH3 H 2567 H H CH3 CH3 H CD3 2568 H H CH3CH3 H CH3 2569 H H CH3 CH3 H H 2570 H H CH3 H 2,6DIP H 2571 H H CH3 H2,6DMB H 2572 H H CH3 H CD3 CD3 2573 H H CH3 H CD3 CH3 2574 H H CH3 HCD3 H 2575 H H CH3 H CH3 CD3 2576 H H CH3 H CH3 CH3 2577 H H CH3 H CH3 H2578 H H CH3 H H 2,6DIP 2579 H H CH3 H H 2,6DMB 2580 H H CH3 H H CD32581 H H CH3 H H CH3 2582 H H CH3 H H H 2583 H H CH3 H H iPr 2584 H HCH3 H iPr H 2585 H H CH3 iPr H H 2586 H H H 2,6DIP CD3 H 2587 H H H2,6DIP CH3 H 2588 H H H 2,6DIP H CD3 2589 H H H 2,6DIP H CH3 2590 H H H2,6DIP H H 2591 H H H 2,6DMB CD3 H 2592 H H H 2,6DMB CH3 H 2593 H H H2,6DMB H CD3 2594 H H H 2,6DMB H CH3 2595 H H H 2,6DMB H H 2596 H H HCD3 2,6DIP H 2597 H H H CD3 2,6DMB H 2598 H H H CD3 CD3 H 2599 H H H CD3CH3 H 2600 H H H CD3 H 2,6DIP 2601 H H H CD3 H 2,6DMB 2602 H H H CD3 HCD3 2603 H H H CD3 H CH3 2604 H H H CD3 H H 2605 H H H CD3 H iPr 2606 HH H CD3 iPr H 2607 H H H CH3 2,6DIP H 2608 H H H CH3 2,6DMB H 2609 H H HCH3 CD3 H 2610 H H H CH3 CH3 H 2611 H H H CH3 H 2,6DIP 2612 H H H CH3 H2,6DMB 2613 H H H CH3 H CD3 2614 H H H CH3 H CH3 2615 H H H CH3 H H 2616H H H CH3 H iPr 2617 H H H CH3 iPr H 2618 H H H H 2,6DIP H 2619 H H H H2,6DMB H 2620 H H H H CD3 CD3 2621 H H H H CD3 CH3 2622 H H H H CD3 H2623 H H H H CD3 iPr 2624 H H H H CH3 CD3 2625 H H H H CH3 CH3 2626 H HH H CH3 H 2627 H H H H CH3 iPr 2628 H H H H H 2,6DIP 2629 H H H H H2,6DMB 2630 H H H H H CD3 2631 H H H H H CH3 2632 H H H H H H 2633 H H HH H iPr 2634 H H H H iPr CD3 2635 H H H H iPr CH3 2636 H H H H iPr H2637 H H H iPr CD3 H 2638 H H H iPr CH3 H 2639 H H H iPr H CD3 2640 H HH iPr H CH3 2641 H H H iPr H H 2642 H H ph CD3 CD3 H 2643 H H ph CD3 CH3H 2644 H H ph CD3 H CD3 2645 H H ph CD3 H CH3 2646 H H ph CD3 H H 2647 HH ph CH3 CD3 H 2648 H H ph CH3 CH3 H 2649 H H ph CH3 H CD3 2650 H H phCH3 H CH3 2651 H H ph CH3 H H 2652 H H ph H CD3 CD3 2653 H H ph H CD3CH3 2654 H H ph H CD3 H 2655 H H ph H CH3 CD3 2656 H H ph H CH3 CH3 2657H H ph H CH3 H 2658 H H ph H H CD3 2659 H H ph H H CH3 2660 H H ph H H H2661 H iPr CD3 H H H 2662 H iPr CH3 H H H 2663 H iPr H CD3 H H 2664 HiPr H CH3 H H 2665 H iPr H H CD3 H 2666 H iPr H H CH3 H 2667 H iPr H H HCD3 2668 H iPr H H H CH3 2669 H iPr H H H H 2670 iPr CD3 H H H H 2671iPr CH3 H H H H 2672 iPr H CD3 H H H 2673 iPr H CH3 H H H 2674 iPr H HCD3 H H 2675 iPr H H CH3 H H 2676 iPr H H H CD3 H 2677 iPr H H H CH3 H2678 iPr H H H H CD3 2679 iPr H H H H CH3 2680 iPr H H H H H

LA2681 to LA3156 based on structure:

LA # R11 R12 R2 R32 R33 R34 2681 CD3 CD3 2,6DIP H H H 2682 CD3 CD32,6DIPB H H H 2683 CD3 CD3 2,6DMB H H H 2684 CD3 CD3 CD3 H H H 2685 CD3CD3 CH3 H H H 2686 CD3 CD3 H H H H 2687 CD3 CD3 ph H H H 2688 CD3 CH32,6DIP H H H 2689 CD3 CH3 2,6DIPB H H H 2690 CD3 CH3 2,6DMB H H H 2691CD3 CH3 CD3 H H H 2692 CD3 CH3 CH3 H H H 2693 CD3 CH3 H H H H 2694 CD3CH3 ph H H H 2695 CD3 H 2,6DIP CD3 H H 2696 CD3 H 2,6DIP CH3 H H 2697CD3 H 2,6DIP H CD3 H 2698 CD3 H 2,6DIP H CH3 H 2699 CD3 H 2,6DIP H H CD32700 CD3 H 2,6DIP H H CH3 2701 CD3 H 2,6DIP H H H 2702 CD3 H 2,6DIPB CD3H H 2703 CD3 H 2,6DIPB CH3 H H 2704 CD3 H 2,6DIPB H CD3 H 2705 CD3 H2,6DIPB H CH3 H 2706 CD3 H 2,6DIPB H H CD3 2707 CD3 H 2,6DIPB H H CH32708 CD3 H 2,6DIPB H H H 2709 CD3 H 2,6DMB CD3 H H 2710 CD3 H 2,6DMB CH3H H 2711 CD3 H 2,6DMB H CD3 H 2712 CD3 H 2,6DMB H CH3 H 2713 CD3 H2,6DMB H H CD3 2714 CD3 H 2,6DMB H H CH3 2715 CD3 H 2,6DMB H H H 2716CD3 H CD3 CD3 H H 2717 CD3 H CD3 CH3 H H 2718 CD3 H CD3 H CD3 H 2719 CD3H CD3 H CH3 H 2720 CD3 H CD3 H H CD3 2721 CD3 H CD3 H H CH3 2722 CD3 HCD3 H H H 2723 CD3 H CH3 CD3 H H 2724 CD3 H CH3 CH3 H H 2725 CD3 H CH3 HCD3 H 2726 CD3 H CH3 H CH3 H 2727 CD3 H CH3 H H CD3 2728 CD3 H CH3 H HCH3 2729 CD3 H CH3 H H H 2730 CD3 H H 2,6DIP H H 2731 CD3 H H 2,6DMB H H2732 CD3 H H CD3 H H 2733 CD3 H H CH3 H H 2734 CD3 H H H 2,6DIP H 2735CD3 H H H 2,6DMB H 2736 CD3 H H H CD3 H 2737 CD3 H H H CH3 H 2738 CD3 HH H H 2,6DIP 2739 CD3 H H H H 2,6DMB 2740 CD3 H H H H CD3 2741 CD3 H H HH CH3 2742 CD3 H H H H H 2743 CD3 H H H H iPr 2744 CD3 H H H iPr H 2745CD3 H H iPr H H 2746 CD3 H ph CD3 H H 2747 CD3 H ph CH3 H H 2748 CD3 Hph H CD3 H 2749 CD3 H ph H CH3 H 2750 CD3 H ph H H CD3 2751 CD3 H ph H HCH3 2752 CD3 H ph H H H 2753 CD3 iPr H H H H 2754 CH3 CD3 2,6DIP H H H2755 CH3 CD3 2,6DIPB H H H 2756 CH3 CD3 2,6DMB H H H 2757 CH3 CD3 CD3 HH H 2758 CH3 CD3 CH3 H H H 2759 CH3 CD3 H H H H 2760 CH3 CD3 ph H H H2761 CH3 CH3 2,6DIP H H H 2762 CH3 CH3 2,6DIPB H H H 2763 CH3 CH3 2,6DMBH H H 2764 CH3 CH3 CD3 H H H 2765 CH3 CH3 CH3 H H H 2766 CH3 CH3 H H H H2767 CH3 CH3 ph H H H 2768 CH3 H 2,6DIP CD3 H H 2769 CH3 H 2,6DIP CH3 HH 2770 CH3 H 2,6DIP H CD3 H 2771 CH3 H 2,6DIP H CH3 H 2772 CH3 H 2,6DIPH H CD3 2773 CH3 H 2,6DIP H H CH3 2774 CH3 H 2,6DIP H H H 2775 CH3 H2,6DIPB CD3 H H 2776 CH3 H 2,6DIPB CH3 H H 2777 CH3 H 2,6DIPB H CD3 H2778 CH3 H 2,6DIPB H CH3 H 2779 CH3 H 2,6DIPB H H CD3 2780 CH3 H 2,6DIPBH H CH3 2781 CH3 H 2,6DIPB H H H 2782 CH3 H 2,6DMB CD3 H H 2783 CH3 H2,6DMB CH3 H H 2784 CH3 H 2,6DMB H CD3 H 2785 CH3 H 2,6DMB H CH3 H 2786CH3 H 2,6DMB H H CD3 2787 CH3 H 2,6DMB H H CH3 2788 CH3 H 2,6DMB H H H2789 CH3 H CD3 CD3 H H 2790 CH3 H CD3 CH3 H H 2791 CH3 H CD3 H CD3 H2792 CH3 H CD3 H CH3 H 2793 CH3 H CD3 H H CD3 2794 CH3 H CD3 H H CH32795 CH3 H CD3 H H H 2796 CH3 H CH3 CD3 H H 2797 CH3 H CH3 CH3 H H 2798CH3 H CH3 H CD3 H 2799 CH3 H CH3 H CH3 H 2800 CH3 H CH3 H H CD3 2801 CH3H CH3 H H CH3 2802 CH3 H CH3 H H H 2803 CH3 H H 2,6DIP H H 2804 CH3 H H2,6DMB H H 2805 CH3 H H CD3 H H 2806 CH3 H H CH3 H H 2807 CH3 H H H2,6DIP H 2808 CH3 H H H 2,6DMB H 2809 CH3 H H H CD3 H 2810 CH3 H H H CH3H 2811 CH3 H H H H 2,6DIP 2812 CH3 H H H H 2,6DMB 2813 CH3 H H H H CD32814 CH3 H H H H CH3 2815 CH3 H H H H H 2816 CH3 H H H H iPr 2817 CH3 HH H iPr H 2818 CH3 H H iPr H H 2819 CH3 H ph CD3 H H 2820 CH3 H ph CH3 HH 2821 CH3 H ph H CD3 H 2822 CH3 H ph H CH3 H 2823 CH3 H ph H H CD3 2824CH3 H ph H H CH3 2825 CH3 H ph H H H 2826 CH3 iPr H H H H 2827 H 2,6DIPH CD3 H H 2828 H 2,6DIP H CH3 H H 2829 H 2,6DIP H H CD3 H 2830 H 2,6DIPH H CH3 H 2831 H 2,6DIP H H H CD3 2832 H 2,6DIP H H H CH3 2833 H 2,6DIPH H H H 2834 H 2,6DMB H CD3 H H 2835 H 2,6DMB H CH3 H H 2836 H 2,6DMB HH CD3 H 2837 H 2,6DMB H H CH3 H 2838 H 2,6DMB H H H CD3 2839 H 2,6DMB HH H CH3 2840 H 2,6DMB H H H H 2841 H CD3 2,6DIP CD3 H H 2842 H CD32,6DIP CH3 H H 2843 H CD3 2,6DIP H CD3 H 2844 H CD3 2,6DIP H CH3 H 2845H CD3 2,6DIP H H CD3 2846 H CD3 2,6DIP H H CH3 2847 H CD3 2,6DIP H H H2848 H CD3 2,6DIPB CD3 H H 2849 H CD3 2,6DIPB CH3 H H 2850 H CD3 2,6DIPBH CD3 H 2851 H CD3 2,6DIPB H CH3 H 2852 H CD3 2,6DIPB H H CD3 2853 H CD32,6DIPB H H CH3 2854 H CD3 2,6DIPB H H H 2855 H CD3 2,6DMB CD3 H H 2856H CD3 2,6DMB CH3 H H 2857 H CD3 2,6DMB H CD3 H 2858 H CD3 2,6DMB H CH3 H2859 H CD3 2,6DMB H H CD3 2860 H CD3 2,6DMB H H CH3 2861 H CD3 2,6DMB HH H 2862 H CD3 CD3 CD3 H H 2863 H CD3 CD3 CH3 H H 2864 H CD3 CD3 H CD3 H2865 H CD3 CD3 H CH3 H 2866 H CD3 CD3 H H CD3 2867 H CD3 CD3 H H CH32868 H CD3 CD3 H H H 2869 H CD3 CH3 CD3 H H 2870 H CD3 CH3 CH3 H H 2871H CD3 CH3 H CD3 H 2872 H CD3 CH3 H CH3 H 2873 H CD3 CH3 H H CD3 2874 HCD3 CH3 H H CH3 2875 H CD3 CH3 H H H 2876 H CD3 H 2,6DIP H H 2877 H CD3H 2,6DMB H H 2878 H CD3 H CD3 H H 2879 H CD3 H CH3 H H 2880 H CD3 H H2,6DIP H 2881 H CD3 H H 2,6DMB H 2882 H CD3 H H CD3 H 2883 H CD3 H H CH3H 2884 H CD3 H H H 2,6DIP 2885 H CD3 H H H 2,6DMB 2886 H CD3 H H H CD32887 H CD3 H H H CH3 2888 H CD3 H H H H 2889 H CD3 H H H iPr 2890 H CD3H H iPr H 2891 H CD3 H iPr H H 2892 H CD3 ph CD3 H H 2893 H CD3 ph CH3 HH 2894 H CD3 ph H CD3 H 2895 H CD3 ph H CH3 H 2896 H CD3 ph H H CD3 2897H CD3 ph H H CH3 2898 H CD3 ph H H H 2899 H CH3 2,6DIP CD3 H H 2900 HCH3 2,6DIP CH3 H H 2901 H CH3 2,6DIP H CD3 H 2902 H CH3 2,6DIP H CH3 H2903 H CH3 2,6DIP H H CD3 2904 H CH3 2,6DIP H H CH3 2905 H CH3 2,6DIP HH H 2906 H CH3 2,6DIPB CD3 H H 2907 H CH3 2,6DIPB CH3 H H 2908 H CH32,6DIPB H CD3 H 2909 H CH3 2,6DIPB H CH3 H 2910 H CH3 2,6DIPB H H CD32911 H CH3 2,6DIPB H H CH3 2912 H CH3 2,6DIPB H H H 2913 H CH3 2,6DMBCD3 H H 2914 H CH3 2,6DMB CH3 H H 2915 H CH3 2,6DMB H CD3 H 2916 H CH32,6DMB H CH3 H 2917 H CH3 2,6DMB H H CD3 2918 H CH3 2,6DMB H H CH3 2919H CH3 2,6DMB H H H 2920 H CH3 CD3 CD3 H H 2921 H CH3 CD3 CH3 H H 2922 HCH3 CD3 H CD3 H 2923 H CH3 CD3 H CH3 H 2924 H CH3 CD3 H H CD3 2925 H CH3CD3 H H CH3 2926 H CH3 CD3 H H H 2927 H CH3 CH3 CD3 H H 2928 H CH3 CH3CH3 H H 2929 H CH3 CH3 H CD3 H 2930 H CH3 CH3 H CH3 H 2931 H CH3 CH3 H HCD3 2932 H CH3 CH3 H H CH3 2933 H CH3 CH3 H H H 2934 H CH3 H 2,6DIP H H2935 H CH3 H 2,6DMB H H 2936 H CH3 H CD3 H H 2937 H CH3 H CH3 H H 2938 HCH3 H H 2,6DIP H 2939 H CH3 H H 2,6DMB H 2940 H CH3 H H CD3 H 2941 H CH3H H CH3 H 2942 H CH3 H H H 2,6DIP 2943 H CH3 H H H 2,6DMB 2944 H CH3 H HH CD3 2945 H CH3 H H H CH3 2946 H CH3 H H H H 2947 H CH3 H H H iPr 2948H CH3 H H iPr H 2949 H CH3 H iPr H H 2950 H CH3 ph CD3 H H 2951 H CH3 phCH3 H H 2952 H CH3 ph H CD3 H 2953 H CH3 ph H CH3 H 2954 H CH3 ph H HCD3 2955 H CH3 ph H H CH3 2956 H CH3 ph H H H 2957 H H 2,6DIP CD3 CD3 H2958 H H 2,6DIP CD3 CH3 H 2959 H H 2,6DIP CD3 H CD3 2960 H H 2,6DIP CD3H CH3 2961 H H 2,6DIP CD3 H H 2962 H H 2,6DIP CH3 CD3 H 2963 H H 2,6DIPCH3 CH3 H 2964 H H 2,6DIP CH3 H CD3 2965 H H 2,6DIP CH3 H CH3 2966 H H2,6DIP CH3 H H 2967 H H 2,6DIP H CD3 CD3 2968 H H 2,6DIP H CD3 CH3 2969H H 2,6DIP H CD3 H 2970 H H 2,6DIP H CH3 CD3 2971 H H 2,6DIP H CH3 CH32972 H H 2,6DIP H CH3 H 2973 H H 2,6DIP H H CD3 2974 H H 2,6DIP H H CH32975 H H 2,6DIP H H H 2976 H H 2,6DIPB CD3 CD3 H 2977 H H 2,6DIPB CD3CH3 H 2978 H H 2,6DIPB CD3 H CD3 2979 H H 2,6DIPB CD3 H CH3 2980 H H2,6DIPB CD3 H H 2981 H H 2,6DIPB CH3 CD3 H 2982 H H 2,6DIPB CH3 CH3 H2983 H H 2,6DIPB CH3 H CD3 2984 H H 2,6DIPB CH3 H CH3 2985 H H 2,6DIPBCH3 H H 2986 H H 2,6DIPB H CD3 CD3 2987 H H 2,6DIPB H CD3 CH3 2988 H H2,6DIPB H CD3 H 2989 H H 2,6DIPB H CH3 CD3 2990 H H 2,6DIPB H CH3 CH32991 H H 2,6DIPB H CH3 H 2992 H H 2,6DIPB H H CD3 2993 H H 2,6DIPB H HCH3 2994 H H 2,6DIPB H H H 2995 H H 2,6DMB CD3 CD3 H 2996 H H 2,6DMB CD3CH3 H 2997 H H 2,6DMB CD3 H CD3 2998 H H 2,6DMB CD3 H CH3 2999 H H2,6DMB CD3 H H 3000 H H 2,6DMB CH3 CD3 H 3001 H H 2,6DMB CH3 CH3 H 3002H H 2,6DMB CH3 H CD3 3003 H H 2,6DMB CH3 H CH3 3004 H H 2,6DMB CH3 H H3005 H H 2,6DMB H CD3 CD3 3006 H H 2,6DMB H CD3 CH3 3007 H H 2,6DMB HCD3 H 3008 H H 2,6DMB H CH3 CD3 3009 H H 2,6DMB H CH3 CH3 3010 H H2,6DMB H CH3 H 3011 H H 2,6DMB H H CD3 3012 H H 2,6DMB H H CH3 3013 H H2,6DMB H H H 3014 H H CD3 2,6DIP H H 3015 H H CD3 2,6DMB H H 3016 H HCD3 CD3 CD3 H 3017 H H CD3 CD3 CH3 H 3018 H H CD3 CD3 H CD3 3019 H H CD3CD3 H CH3 3020 H H CD3 CD3 H H 3021 H H CD3 CH3 CD3 H 3022 H H CD3 CH3CH3 H 3023 H H CD3 CH3 H CD3 3024 H H CD3 CH3 H CH3 3025 H H CD3 CH3 H H3026 H H CD3 H 2,6DIP H 3027 H H CD3 H 2,6DMB H 3028 H H CD3 H CD3 CD33029 H H CD3 H CD3 CH3 3030 H H CD3 H CD3 H 3031 H H CD3 H CH3 CD3 3032H H CD3 H CH3 CH3 3033 H H CD3 H CH3 H 3034 H H CD3 H H 2,6DIP 3035 H HCD3 H H 2,6DMB 3036 H H CD3 H H CD3 3037 H H CD3 H H CH3 3038 H H CD3 HH H 3039 H H CD3 H H iPr 3040 H H CD3 H iPr H 3041 H H CD3 iPr H H 3042H H CH3 2,6DIP H H 3043 H H CH3 2,6DMB H H 3044 H H CH3 CD3 CD3 H 3045 HH CH3 CD3 CH3 H 3046 H H CH3 CD3 H CD3 3047 H H CH3 CD3 H CH3 3048 H HCH3 CD3 H H 3049 H H CH3 CH3 CD3 H 3050 H H CH3 CH3 CH3 H 3051 H H CH3CH3 H CD3 3052 H H CH3 CH3 H CH3 3053 H H CH3 CH3 H H 3054 H H CH3 H2,6DIP H 3055 H H CH3 H 2,6DMB H 3056 H H CH3 H CD3 CD3 3057 H H CH3 HCD3 CH3 3058 H H CH3 H CD3 H 3059 H H CH3 H CH3 CD3 3060 H H CH3 H CH3CH3 3061 H H CH3 H CH3 H 3062 H H CH3 H H 2,6DIP 3063 H H CH3 H H 2,6DMB3064 H H CH3 H H CD3 3065 H H CH3 H H CH3 3066 H H CH3 H H H 3067 H HCH3 H H iPr 3068 H H CH3 H iPr H 3069 H H CH3 iPr H H 3070 H H H 2,6DIPH CD3 3071 H H H 2,6DIP H CH3 3072 H H H 2,6DIP H H 3073 H H H 2,6DMB HCD3 3074 H H H 2,6DMB H CH3 3075 H H H 2,6DMB H H 3076 H H H CD3 CD3 H3077 H H H CD3 CH3 H 3078 H H H CD3 H 2,6DIP 3079 H H H CD3 H 2,6DMB3080 H H H CD3 H CD3 3081 H H H CD3 H CH3 3082 H H H CD3 H H 3083 H H HCD3 H iPr 3084 H H H CD3 iPr H 3085 H H H CH3 CD3 H 3086 H H H CH3 CH3 H3087 H H H CH3 H 2,6DIP 3088 H H H CH3 H 2,6DMB 3089 H H H CH3 H CD33090 H H H CH3 H CH3 3091 H H H CH3 H H 3092 H H H CH3 H iPr 3093 H H HCH3 iPr H 3094 H H H H 2,6DIP H 3095 H H H H 2,6DMB H 3096 H H H H CD3CD3 3097 H H H H CD3 CH3 3098 H H H H CD3 H 3099 H H H H CD3 iPr 3100 HH H H CH3 CD3 3101 H H H H CH3 CH3 3102 H H H H CH3 H 3103 H H H H CH3iPr 3104 H H H H H 2,6DIP 3105 H H H H H 2,6DMB 3106 H H H H H CD3 3107H H H H H CH3 3108 H H H H H H 3109 H H H H H iPr 3110 H H H H iPr CD33111 H H H H iPr CH3 3112 H H H H iPr H 3113 H H H iPr CD3 H 3114 H H HiPr CH3 H 3115 H H H iPr H CD3 3116 H H H iPr H CH3 3117 H H H iPr H H3118 H H ph CD3 CD3 H 3119 H H ph CD3 CH3 H 3120 H H ph CD3 H CD3 3121 HH ph CD3 H CH3 3122 H H ph CD3 H H 3123 H H ph CH3 CD3 H 3124 H H ph CH3CH3 H 3125 H H ph CH3 H CD3 3126 H H ph CH3 H CH3 3127 H H ph CH3 H H3128 H H ph H CD3 CD3 3129 H H ph H CD3 CH3 3130 H H ph H CD3 H 3131 H Hph H CH3 CD3 3132 H H ph H CH3 CH3 3133 H H ph H CH3 H 3134 H H ph H HCD3 3135 H H ph H H CH3 3136 H H ph H H H 3137 H iPr CD3 H H H 3138 HiPr CH3 H H H 3139 H iPr H CD3 H H 3140 H iPr H CH3 H H 3141 H iPr H HCD3 H 3142 H iPr H H CH3 H 3143 H iPr H H H CD3 3144 H iPr H H H CH33145 H iPr H H H H 3146 iPr CD3 H H H H 3147 iPr CH3 H H H H 3148 iPr HCD3 H H H 3149 iPr H CH3 H H H 3150 iPr H H CD3 H H 3151 iPr H H CH3 H H3152 iPr H H H CD3 H 3153 iPr H H H CH3 H 3154 iPr H H H H CD3 3155 iPrH H H H CH3 3156 iPr H H H H H

LA3157 to LA3580 based on structure:

LA # R11 R2 R12 R31 R32 R33 3157 CD3 CD3 2,6DIP H H H 3158 CD3 CD32,6DMB H H H 3159 CD3 CD3 CD3 H H H 3160 CD3 CD3 CH3 H H H 3161 CD3 CD3H H H H 3162 CD3 CD3 iPr H H H 3163 CD3 CH3 2,6DIP H H H 3164 CD3 CH32,6DMB H H H 3165 CD3 CH3 CD3 H H H 3166 CD3 CH3 CH3 H H H 3167 CD3 CH3H H H H 3168 CD3 CH3 iPr H H H 3169 CD3 H 2,6DIP CD3 H H 3170 CD3 H2,6DIP CH3 H H 3171 CD3 H 2,6DIP H CD3 H 3172 CD3 H 2,6DIP H CH3 H 3173CD3 H 2,6DIP H H CD3 3174 CD3 H 2,6DIP H H CH3 3175 CD3 H 2,6DIP H H H3176 CD3 H 2,6DMB CD3 H H 3177 CD3 H 2,6DMB CH3 H H 3178 CD3 H 2,6DMB HCD3 H 3179 CD3 H 2,6DMB H CH3 H 3180 CD3 H 2,6DMB H H CD3 3181 CD3 H2,6DMB H H CH3 3182 CD3 H 2,6DMB H H H 3183 CD3 H CD3 CD3 H H 3184 CD3 HCD3 CH3 H H 3185 CD3 H CD3 H CD3 H 3186 CD3 H CD3 H CH3 H 3187 CD3 H CD3H H CD3 3188 CD3 H CD3 H H CH3 3189 CD3 H CD3 H H H 3190 CD3 H CH3 CD3 HH 3191 CD3 H CH3 CH3 H H 3192 CD3 H CH3 H CD3 H 3193 CD3 H CH3 H CH3 H3194 CD3 H CH3 H H CD3 3195 CD3 H CH3 H H CH3 3196 CD3 H CH3 H H H 3197CD3 H H 2,6DIP H H 3198 CD3 H H 2,6DMB H H 3199 CD3 H H CD3 H H 3200 CD3H H CH3 H H 3201 CD3 H H H 2,6DIP H 3202 CD3 H H H 2,6DMB H 3203 CD3 H HH CD3 H 3204 CD3 H H H CH3 H 3205 CD3 H H H H 2,6DIP 3206 CD3 H H H H2,6DMB 3207 CD3 H H H H CD3 3208 CD3 H H H H CH3 3209 CD3 H H H H H 3210CD3 H H H H iPr 3211 CD3 H H H iPr H 3212 CD3 H H iPr H H 3213 CD3 H iPrCD3 H H 3214 CD3 H iPr CH3 H H 3215 CD3 H iPr H CD3 H 3216 CD3 H iPr HCH3 H 3217 CD3 H iPr H H CD3 3218 CD3 H iPr H H CH3 3219 CD3 H iPr H H H3220 CH3 CD3 2,6DIP H H H 3221 CH3 CD3 2,6DMB H H H 3222 CH3 CD3 CD3 H HH 3223 CH3 CD3 CH3 H H H 3224 CH3 CD3 H H H H 3225 CH3 CD3 iPr H H H3226 CH3 CH3 2,6DIP H H H 3227 CH3 CH3 2,6DMB H H H 3228 CH3 CH3 CD3 H HH 3229 CH3 CH3 CH3 H H H 3230 CH3 CH3 H H H H 3231 CH3 CH3 iPr H H H3232 CH3 H 2,6DIP CD3 H H 3233 CH3 H 2,6DIP CH3 H H 3234 CH3 H 2,6DIP HCD3 H 3235 CH3 H 2,6DIP H CH3 H 3236 CH3 H 2,6DIP H H CD3 3237 CH3 H2,6DIP H H CH3 3238 CH3 H 2,6DIP H H H 3239 CH3 H 2,6DMB CD3 H H 3240CH3 H 2,6DMB CH3 H H 3241 CH3 H 2,6DMB H CD3 H 3242 CH3 H 2,6DMB H CH3 H3243 CH3 H 2,6DMB H H CD3 3244 CH3 H 2,6DMB H H CH3 3245 CH3 H 2,6DMB HH H 3246 CH3 H CD3 CD3 H H 3247 CH3 H CD3 CH3 H H 3248 CH3 H CD3 H CD3 H3249 CH3 H CD3 H CH3 H 3250 CH3 H CD3 H H CD3 3251 CH3 H CD3 H H CH33252 CH3 H CD3 H H H 3253 CH3 H CH3 CD3 H H 3254 CH3 H CH3 CH3 H H 3255CH3 H CH3 H CD3 H 3256 CH3 H CH3 H CH3 H 3257 CH3 H CH3 H H CD3 3258 CH3H CH3 H H CH3 3259 CH3 H CH3 H H H 3260 CH3 H H 2,6DIP H H 3261 CH3 H H2,6DMB H H 3262 CH3 H H CD3 H H 3263 CH3 H H CH3 H H 3264 CH3 H H H2,6DIP H 3265 CH3 H H H 2,6DMB H 3266 CH3 H H H CD3 H 3267 CH3 H H H CH3H 3268 CH3 H H H H 2,6DIP 3269 CH3 H H H H 2,6DMB 3270 CH3 H H H H CD33271 CH3 H H H H CH3 3272 CH3 H H H H H 3273 CH3 H H H H iPr 3274 CH3 HH H iPr H 3275 CH3 H H iPr H H 3276 CH3 H iPr CD3 H H 3277 CH3 H iPr CH3H H 3278 CH3 H iPr H CD3 H 3279 CH3 H iPr H CH3 H 3280 CH3 H iPr H H CD33281 CH3 H iPr H H CH3 3282 CH3 H iPr H H H 3283 H 2,6DIP H CD3 H H 3284H 2,6DIP H CH3 H H 3285 H 2,6DIP H H CD3 H 3286 H 2,6DIP H H CH3 H 3287H 2,6DIP H H H CD3 3288 H 2,6DIP H H H CH3 3289 H 2,6DIP H H H H 3290 H2,6DIPB H CD3 H H 3291 H 2,6DIPB H CH3 H H 3292 H 2,6DIPB H H CD3 H 3293H 2,6DIPB H H CH3 H 3294 H 2,6DIPB H H H CD3 3295 H 2,6DIPB H H H CH33296 H 2,6DIPB H H H H 3297 H 2,6DMB H CD3 H H 3298 H 2,6DMB H CH3 H H3299 H 2,6DMB H H CD3 H 3300 H 2,6DMB H H CH3 H 3301 H 2,6DMB H H H CD33302 H 2,6DMB H H H CH3 3303 H 2,6DMB H H H H 3304 H CD3 2,6DIP CD3 H H3305 H CD3 2,6DIP CH3 H H 3306 H CD3 2,6DIP H CD3 H 3307 H CD3 2,6DIP HCH3 H 3308 H CD3 2,6DIP H H CD3 3309 H CD3 2,6DIP H H CH3 3310 H CD32,6DIP H H H 3311 H CD3 2,6DMB CD3 H H 3312 H CD3 2,6DMB CH3 H H 3313 HCD3 2,6DMB H CD3 H 3314 H CD3 2,6DMB H CH3 H 3315 H CD3 2,6DMB H H CD33316 H CD3 2,6DMB H H CH3 3317 H CD3 2,6DMB H H H 3318 H CD3 CD3 CD3 H H3319 H CD3 CD3 CH3 H H 3320 H CD3 CD3 H CD3 H 3321 H CD3 CD3 H CH3 H3322 H CD3 CD3 H H CD3 3323 H CD3 CD3 H H CH3 3324 H CD3 CD3 H H H 3325H CD3 CH3 CD3 H H 3326 H CD3 CH3 CH3 H H 3327 H CD3 CH3 H CD3 H 3328 HCD3 CH3 H CH3 H 3329 H CD3 CH3 H H CD3 3330 H CD3 CH3 H H CH3 3331 H CD3CH3 H H H 3332 H CD3 H 2,6DIP H H 3333 H CD3 H 2,6DMB H H 3334 H CD3 HCD3 H H 3335 H CD3 H CH3 H H 3336 H CD3 H H 2,6DIP H 3337 H CD3 H H2,6DMB H 3338 H CD3 H H CD3 H 3339 H CD3 H H CH3 H 3340 H CD3 H H H2,6DIP 3341 H CD3 H H H 2,6DMB 3342 H CD3 H H H CD3 3343 H CD3 H H H CH33344 H CD3 H H H H 3345 H CD3 H H H iPr 3346 H CD3 H H iPr H 3347 H CD3H iPr H H 3348 H CD3 iPr CD3 H H 3349 H CD3 iPr CH3 H H 3350 H CD3 iPr HCD3 H 3351 H CD3 iPr H CH3 H 3352 H CD3 iPr H H CD3 3353 H CD3 iPr H HCH3 3354 H CD3 iPr H H H 3355 H CH3 2,6DIP CD3 H H 3356 H CH3 2,6DIP CH3H H 3357 H CH3 2,6DIP H CD3 H 3358 H CH3 2,6DIP H CH3 H 3359 H CH32,6DIP H H CD3 3360 H CH3 2,6DIP H H CH3 3361 H CH3 2,6DIP H H H 3362 HCH3 2,6DMB CD3 H H 3363 H CH3 2,6DMB CH3 H H 3364 H CH3 2,6DMB H CD3 H3365 H CH3 2,6DMB H CH3 H 3366 H CH3 2,6DMB H H CD3 3367 H CH3 2,6DMB HH CH3 3368 H CH3 2,6DMB H H H 3369 H CH3 CD3 CD3 H H 3370 H CH3 CD3 CH3H H 3371 H CH3 CD3 H CD3 H 3372 H CH3 CD3 H CH3 H 3373 H CH3 CD3 H H CD33374 H CH3 CD3 H H CH3 3375 H CH3 CD3 H H H 3376 H CH3 CH3 CD3 H H 3377H CH3 CH3 CH3 H H 3378 H CH3 CH3 H CD3 H 3379 H CH3 CH3 H CH3 H 3380 HCH3 CH3 H H CD3 3381 H CH3 CH3 H H CH3 3382 H CH3 CH3 H H H 3383 H CH3 H2,6DIP H H 3384 H CH3 H 2,6DMB H H 3385 H CH3 H CD3 H H 3386 H CH3 H CH3H H 3387 H CH3 H H 2,6DIP H 3388 H CH3 H H 2,6DMB H 3389 H CH3 H H CD3 H3390 H CH3 H H CH3 H 3391 H CH3 H H H 2,6DIP 3392 H CH3 H H H 2,6DMB3393 H CH3 H H H CD3 3394 H CH3 H H H CH3 3395 H CH3 H H H H 3396 H CH3H H H iPr 3397 H CH3 H H iPr H 3398 H CH3 H iPr H H 3399 H CH3 iPr CD3 HH 3400 H CH3 iPr CH3 H H 3401 H CH3 iPr H CD3 H 3402 H CH3 iPr H CH3 H3403 H CH3 iPr H H CD3 3404 H CH3 iPr H H CH3 3405 H CH3 iPr H H H 3406H H 2,6DIP CD3 CD3 H 3407 H H 2,6DIP CD3 CH3 H 3408 H H 2,6DIP CD3 H CD33409 H H 2,6DIP CD3 H CH3 3410 H H 2,6DIP CD3 H H 3411 H H 2,6DIP CH3CD3 H 3412 H H 2,6DIP CH3 CH3 H 3413 H H 2,6DIP CH3 H CD3 3414 H H2,6DIP CH3 H CH3 3415 H H 2,6DIP CH3 H H 3416 H H 2,6DIP H CD3 CD3 3417H H 2,6DIP H CD3 CH3 3418 H H 2,6DIP H CD3 H 3419 H H 2,6DIP H CH3 CD33420 H H 2,6DIP H CH3 CH3 3421 H H 2,6DIP H CH3 H 3422 H H 2,6DIP H HCD3 3423 H H 2,6DIP H H CH3 3424 H H 2,6DIP H H H 3425 H H 2,6DMB CD3CD3 H 3426 H H 2,6DMB CD3 CH3 H 3427 H H 2,6DMB CD3 H CD3 3428 H H2,6DMB CD3 H CH3 3429 H H 2,6DMB CD3 H H 3430 H H 2,6DMB CH3 CD3 H 3431H H 2,6DMB CH3 CH3 H 3432 H H 2,6DMB CH3 H CD3 3433 H H 2,6DMB CH3 H CH33434 H H 2,6DMB CH3 H H 3435 H H 2,6DMB H CD3 CD3 3436 H H 2,6DMB H CD3CH3 3437 H H 2,6DMB H CD3 H 3438 H H 2,6DMB H CH3 CD3 3439 H H 2,6DMB HCH3 CH3 3440 H H 2,6DMB H CH3 H 3441 H H 2,6DMB H H CD3 3442 H H 2,6DMBH H CH3 3443 H H 2,6DMB H H H 3444 H H CD3 CD3 CD3 H 3445 H H CD3 CD3CH3 H 3446 H H CD3 CD3 H CD3 3447 H H CD3 CD3 H CH3 3448 H H CD3 CD3 H H3449 H H CD3 CH3 CD3 H 3450 H H CD3 CH3 CH3 H 3451 H H CD3 CH3 H CD33452 H H CD3 CH3 H CH3 3453 H H CD3 CH3 H H 3454 H H CD3 H 2,6DIP H 3455H H CD3 H 2,6DMB H 3456 H H CD3 H CD3 CD3 3457 H H CD3 H CD3 CH3 3458 HH CD3 H CD3 H 3459 H H CD3 H CH3 CD3 3460 H H CD3 H CH3 CH3 3461 H H CD3H CH3 H 3462 H H CD3 H H 2,6DIP 3463 H H CD3 H H 2,6DMB 3464 H H CD3 H HCD3 3465 H H CD3 H H CH3 3466 H H CD3 H H H 3467 H H CD3 H H iPr 3468 HH CD3 H iPr H 3469 H H CD3 iPr H H 3470 H H CH3 CD3 CD3 H 3471 H H CH3CD3 CH3 H 3472 H H CH3 CD3 H CD3 3473 H H CH3 CD3 H CH3 3474 H H CH3 CD3H H 3475 H H CH3 CH3 CD3 H 3476 H H CH3 CH3 CH3 H 3477 H H CH3 CH3 H CD33478 H H CH3 CH3 H CH3 3479 H H CH3 CH3 H H 3480 H H CH3 H 2,6DIP H 3481H H CH3 H 2,6DMB H 3482 H H CH3 H CD3 CD3 3483 H H CH3 H CD3 CH3 3484 HH CH3 H CD3 H 3485 H H CH3 H CH3 CD3 3486 H H CH3 H CH3 CH3 3487 H H CH3H CH3 H 3488 H H CH3 H H 2,6DIP 3489 H H CH3 H H 2,6DMB 3490 H H CH3 H HCD3 3491 H H CH3 H H CH3 3492 H H CH3 H H H 3493 H H CH3 H H iPr 3494 HH CH3 H iPr H 3495 H H CH3 iPr H H 3496 H H H 2,6DIP H CD3 3497 H H H2,6DIP H CH3 3498 H H H 2,6DIP H H 3499 H H H 2,6DMB H CD3 3500 H H H2,6DMB H CH3 3501 H H H 2,6DMB H H 3502 H H H CD3 CD3 H 3503 H H H CD3CH3 H 3504 H H H CD3 H 2,6DIP 3505 H H H CD3 H 2,6DMB 3506 H H H CD3 HCD3 3507 H H H CD3 H CH3 3508 H H H CD3 H H 3509 H H H CD3 H iPr 3510 HH H CD3 iPr H 3511 H H H CH3 CD3 H 3512 H H H CH3 CH3 H 3513 H H H CH3 H2,6DIP 3514 H H H CH3 H 2,6DMB 3515 H H H CH3 H CD3 3516 H H H CH3 H CH33517 H H H CH3 H H 3518 H H H CH3 H iPr 3519 H H H CH3 iPr H 3520 H H HH 2,6DIP H 3521 H H H H 2,6DMB H 3522 H H H H CD3 CD3 3523 H H H H CD3CH3 3524 H H H H CD3 H 3525 H H H H CD3 iPr 3526 H H H H CH3 CD3 3527 HH H H CH3 CH3 3528 H H H H CH3 H 3529 H H H H CH3 iPr 3530 H H H H H2,6DIP 3531 H H H H H 2,6DMB 3532 H H H H H CD3 3533 H H H H H CH3 3534H H H H H H 3535 H H H H H iPr 3536 H H H H iPr CD3 3537 H H H H iPr CH33538 H H H H iPr H 3539 H H H iPr CD3 H 3540 H H H iPr CH3 H 3541 H H HiPr H CD3 3542 H H H iPr H CH3 3543 H H H iPr H H 3544 H H iPr CD3 CD3 H3545 H H iPr CD3 CH3 H 3546 H H iPr CD3 H CD3 3547 H H iPr CD3 H CH33548 H H iPr CD3 H H 3549 H H iPr CH3 CD3 H 3550 H H iPr CH3 CH3 H 3551H H iPr CH3 H CD3 3552 H H iPr CH3 H CH3 3553 H H iPr CH3 H H 3554 H HiPr H CD3 CD3 3555 H H iPr H CD3 CH3 3556 H H iPr H CD3 H 3557 H H iPr HCH3 CD3 3558 H H iPr H CH3 CH3 3559 H H iPr H CH3 H 3560 H H iPr H H CD33561 H H iPr H H CH3 3562 H H iPr H H H 3563 H ph H CD3 H H 3564 H ph HCH3 H H 3565 H ph H H CD3 H 3566 H ph H H CH3 H 3567 H ph H H H CD3 3568H ph H H H CH3 3569 H ph H H H H 3570 iPr CD3 H H H H 3571 iPr CH3 H H HH 3572 iPr H CD3 H H H 3573 iPr H CH3 H H H 3574 iPr H H CD3 H H 3575iPr H H CH3 H H 3576 iPr H H H CD3 H 3577 iPr H H H CH3 H 3578 iPr H H HH CD3 3579 iPr H H H H CH3 3580 iPr H H H H H

LA3851 to LA4012 based on structure:

LA # R11 R2 R12 R31 R32 R34 3581 CD3 CD3 2,6DIP H H H 3582 CD3 CD32,6DMB H H H 3583 CD3 CD3 CD3 H H H 3584 CD3 CD3 CH3 H H H 3585 CD3 CD3H H H H 3586 CD3 CD3 iPr H H H 3587 CD3 CH3 2,6DIP H H H 3588 CD3 CH32,6DMB H H H 3589 CD3 CH3 CD3 H H H 3590 CD3 CH3 CH3 H H H 3591 CD3 CH3H H H H 3592 CD3 CH3 iPr H H H 3593 CD3 H 2,6DIP CD3 H H 3594 CD3 H2,6DIP CH3 H H 3595 CD3 H 2,6DIP H CD3 H 3596 CD3 H 2,6DIP H CH3 H 3597CD3 H 2,6DIP H H CD3 3598 CD3 H 2,6DIP H H CH3 3599 CD3 H 2,6DIP H H H3600 CD3 H 2,6DMB CD3 H H 3601 CD3 H 2,6DMB CH3 H H 3602 CD3 H 2,6DMB HCD3 H 3603 CD3 H 2,6DMB H CH3 H 3604 CD3 H 2,6DMB H H CD3 3605 CD3 H2,6DMB H H CH3 3606 CD3 H 2,6DMB H H H 3607 CD3 H CD3 CD3 H H 3608 CD3 HCD3 CH3 H H 3609 CD3 H CD3 H CD3 H 3610 CD3 H CD3 H CH3 H 3611 CD3 H CD3H H CD3 3612 CD3 H CD3 H H CH3 3613 CD3 H CD3 H H H 3614 CD3 H CH3 CD3 HH 3615 CD3 H CH3 CH3 H H 3616 CD3 H CH3 H CD3 H 3617 CD3 H CH3 H CH3 H3618 CD3 H CH3 H H CD3 3619 CD3 H CH3 H H CH3 3620 CD3 H CH3 H H H 3621CD3 H H 2,6DIP H H 3622 CD3 H H 2,6DMB H H 3623 CD3 H H CD3 H H 3624 CD3H H CH3 H H 3625 CD3 H H H 2,6DIP H 3626 CD3 H H H 2,6DMB H 3627 CD3 H HH CD3 H 3628 CD3 H H H CH3 H 3629 CD3 H H H H 2,6DIP 3630 CD3 H H H H2,6DMB 3631 CD3 H H H H CD3 3632 CD3 H H H H CH3 3633 CD3 H H H H H 3634CD3 H H H H iPr 3635 CD3 H H H iPr H 3636 CD3 H H iPr H H 3637 CD3 H iPrCD3 H H 3638 CD3 H iPr CH3 H H 3639 CD3 H iPr H CD3 H 3640 CD3 H iPr HCH3 H 3641 CD3 H iPr H H CD3 3642 CD3 H iPr H H CH3 3643 CD3 H iPr H H H3644 CH3 CD3 2,6DIP H H H 3645 CH3 CD3 2,6DMB H H H 3646 CH3 CD3 CD3 H HH 3647 CH3 CD3 CH3 H H H 3648 CH3 CD3 H H H H 3649 CH3 CD3 iPr H H H3650 CH3 CH3 2,6DIP H H H 3651 CH3 CH3 2,6DMB H H H 3652 CH3 CH3 CD3 H HH 3653 CH3 CH3 CH3 H H H 3654 CH3 CH3 H H H H 3655 CH3 CH3 iPr H H H3656 CH3 H 2,6DIP CD3 H H 3657 CH3 H 2,6DIP CH3 H H 3658 CH3 H 2,6DIP HCD3 H 3659 CH3 H 2,6DIP H CH3 H 3660 CH3 H 2,6DIP H H CD3 3661 CH3 H2,6DIP H H CH3 3662 CH3 H 2,6DIP H H H 3663 CH3 H 2,6DMB CD3 H H 3664CH3 H 2,6DMB CH3 H H 3665 CH3 H 2,6DMB H CD3 H 3666 CH3 H 2,6DMB H CH3 H3667 CH3 H 2,6DMB H H CD3 3668 CH3 H 2,6DMB H H CH3 3669 CH3 H 2,6DMB HH H 3670 CH3 H CD3 CD3 H H 3671 CH3 H CD3 CH3 H H 3672 CH3 H CD3 H CD3 H3673 CH3 H CD3 H CH3 H 3674 CH3 H CD3 H H CD3 3675 CH3 H CD3 H H CH33676 CH3 H CD3 H H H 3677 CH3 H CH3 CD3 H H 3678 CH3 H CH3 CH3 H H 3679CH3 H CH3 H CD3 H 3680 CH3 H CH3 H CH3 H 3681 CH3 H CH3 H H CD3 3682 CH3H CH3 H H CH3 3683 CH3 H CH3 H H H 3684 CH3 H H 2,6DIP H H 3685 CH3 H H2,6DMB H H 3686 CH3 H H CD3 H H 3687 CH3 H H CH3 H H 3688 CH3 H H H2,6DIP H 3689 CH3 H H H 2,6DMB H 3690 CH3 H H H CD3 H 3691 CH3 H H H CH3H 3692 CH3 H H H H 2,6DIP 3693 CH3 H H H H 2,6DMB 3694 CH3 H H H H CD33695 CH3 H H H H CH3 3696 CH3 H H H H H 3697 CH3 H H H H iPr 3698 CH3 HH H iPr H 3699 CH3 H H iPr H H 3700 CH3 H iPr CD3 H H 3701 CH3 H iPr CH3H H 3702 CH3 H iPr H CD3 H 3703 CH3 H iPr H CH3 H 3704 CH3 H iPr H H CD33705 CH3 H iPr H H CH3 3706 CH3 H iPr H H H 3707 H 2,6DIP H CD3 H H 3708H 2,6DIP H CH3 H H 3709 H 2,6DIP H H CD3 H 3710 H 2,6DIP H H CH3 H 3711H 2,6DIP H H H CD3 3712 H 2,6DIP H H H CH3 3713 H 2,6DIP H H H H 3714 H2,6DIPB H CD3 H H 3715 H 2,6DIPB H CH3 H H 3716 H 2,6DIPB H H CD3 H 3717H 2,6DIPB H H CH3 H 3718 H 2,6DIPB H H H CD3 3719 H 2,6DIPB H H H CH33720 H 2,6DIPB H H H H 3721 H 2,6DMB H CD3 H H 3722 H 2,6DMB H CH3 H H3723 H 2,6DMB H H CD3 H 3724 H 2,6DMB H H CH3 H 3725 H 2,6DMB H H H CD33726 H 2,6DMB H H H CH3 3727 H 2,6DMB H H H H 3728 H CD3 2,6DIP CD3 H H3729 H CD3 2,6DIP CH3 H H 3730 H CD3 2,6DIP H CD3 H 3731 H CD3 2,6DIP HCH3 H 3732 H CD3 2,6DIP H H CD3 3733 H CD3 2,6DIP H H CH3 3734 H CD32,6DIP H H H 3735 H CD3 2,6DMB CD3 H H 3736 H CD3 2,6DMB CH3 H H 3737 HCD3 2,6DMB H CD3 H 3738 H CD3 2,6DMB H CH3 H 3739 H CD3 2,6DMB H H CD33740 H CD3 2,6DMB H H CH3 3741 H CD3 2,6DMB H H H 3742 H CD3 CD3 CD3 H H3743 H CD3 CD3 CH3 H H 3744 H CD3 CD3 H CD3 H 3745 H CD3 CD3 H CH3 H3746 H CD3 CD3 H H CD3 3747 H CD3 CD3 H H CH3 3748 H CD3 CD3 H H H 3749H CD3 CH3 CD3 H H 3750 H CD3 CH3 CH3 H H 3751 H CD3 CH3 H CD3 H 3752 HCD3 CH3 H CH3 H 3753 H CD3 CH3 H H CD3 3754 H CD3 CH3 H H CH3 3755 H CD3CH3 H H H 3756 H CD3 H 2,6DIP H H 3757 H CD3 H 2,6DMB H H 3758 H CD3 HCD3 H H 3759 H CD3 H CH3 H H 3760 H CD3 H H 2,6DIP H 3761 H CD3 H H2,6DMB H 3762 H CD3 H H CD3 H 3763 H CD3 H H CH3 H 3764 H CD3 H H H2,6DIP 3765 H CD3 H H H 2,6DMB 3766 H CD3 H H H CD3 3767 H CD3 H H H CH33768 H CD3 H H H H 3769 H CD3 H H H iPr 3770 H CD3 H H iPr H 3771 H CD3H iPr H H 3772 H CD3 iPr CD3 H H 3773 H CD3 iPr CH3 H H 3774 H CD3 iPr HCD3 H 3775 H CD3 iPr H CH3 H 3776 H CD3 iPr H H CD3 3777 H CD3 iPr H HCH3 3778 H CD3 iPr H H H 3779 H CH3 2,6DIP CD3 H H 3780 H CH3 2,6DIP CH3H H 3781 H CH3 2,6DIP H CD3 H 3782 H CH3 2,6DIP H CH3 H 3783 H CH32,6DIP H H CD3 3784 H CH3 2,6DIP H H CH3 3785 H CH3 2,6DIP H H H 3786 HCH3 2,6DMB CD3 H H 3787 H CH3 2,6DMB CH3 H H 3788 H CH3 2,6DMB H CD3 H3789 H CH3 2,6DMB H CH3 H 3790 H CH3 2,6DMB H H CD3 3791 H CH3 2,6DMB HH CH3 3792 H CH3 2,6DMB H H H 3793 H CH3 CD3 CD3 H H 3794 H CH3 CD3 CH3H H 3795 H CH3 CD3 H CD3 H 3796 H CH3 CD3 H CH3 H 3797 H CH3 CD3 H H CD33798 H CH3 CD3 H H CH3 3799 H CH3 CD3 H H H 3800 H CH3 CH3 CD3 H H 3801H CH3 CH3 CH3 H H 3802 H CH3 CH3 H CD3 H 3803 H CH3 CH3 H CH3 H 3804 HCH3 CH3 H H CD3 3805 H CH3 CH3 H H CH3 3806 H CH3 CH3 H H H 3807 H CH3 H2,6DIP H H 3808 H CH3 H 2,6DMB H H 3809 H CH3 H CD3 H H 3810 H CH3 H CH3H H 3811 H CH3 H H 2,6DIP H 3812 H CH3 H H 2,6DMB H 3813 H CH3 H H CD3 H3814 H CH3 H H CH3 H 3815 H CH3 H H H 2,6DIP 3816 H CH3 H H H 2,6DMB3817 H CH3 H H H CD3 3818 H CH3 H H H CH3 3819 H CH3 H H H H 3820 H CH3H H H iPr 3821 H CH3 H H iPr H 3822 H CH3 H iPr H H 3823 H CH3 iPr CD3 HH 3824 H CH3 iPr CH3 H H 3825 H CH3 iPr H CD3 H 3826 H CH3 iPr H CH3 H3827 H CH3 iPr H H CD3 3828 H CH3 iPr H H CH3 3829 H CH3 iPr H H H 3830H H 2,6DIP CD3 CD3 H 3831 H H 2,6DIP CD3 CH3 H 3832 H H 2,6DIP CD3 H CD33833 H H 2,6DIP CD3 H CH3 3834 H H 2,6DIP CD3 H H 3835 H H 2,6DIP CH3CD3 H 3836 H H 2,6DIP CH3 CH3 H 3837 H H 2,6DIP CH3 H CD3 3838 H H2,6DIP CH3 H CH3 3839 H H 2,6DIP CH3 H H 3840 H H 2,6DIP H CD3 CD3 3841H H 2,6DIP H CD3 CH3 3842 H H 2,6DIP H CD3 H 3843 H H 2,6DIP H CH3 CD33844 H H 2,6DIP H CH3 CH3 3845 H H 2,6DIP H CH3 H 3846 H H 2,6DIP H HCD3 3847 H H 2,6DIP H H CH3 3848 H H 2,6DIP H H H 3849 H H 2,6DMB CD3CD3 H 3850 H H 2,6DMB CD3 CH3 H 3851 H H 2,6DMB CD3 H CD3 3852 H H2,6DMB CD3 H CH3 3853 H H 2,6DMB CD3 H H 3854 H H 2,6DMB CH3 CD3 H 3855H H 2,6DMB CH3 CH3 H 3856 H H 2,6DMB CH3 H CD3 3857 H H 2,6DMB CH3 H CH33858 H H 2,6DMB CH3 H H 3859 H H 2,6DMB H CD3 CD3 3860 H H 2,6DMB H CD3CH3 3861 H H 2,6DMB H CD3 H 3862 H H 2,6DMB H CH3 CD3 3863 H H 2,6DMB HCH3 CH3 3864 H H 2,6DMB H CH3 H 3865 H H 2,6DMB H H CD3 3866 H H 2,6DMBH H CH3 3867 H H 2,6DMB H H H 3868 H H CD3 CD3 CD3 H 3869 H H CD3 CD3CH3 H 3956 H H H H CH3 2,6DIP 3957 H H H H CH3 2,6DMB 3958 H H H H CH3CD3 3959 H H H H CH3 CH3 3960 H H H H CH3 H 3961 H H H H CH3 iPr 3962 HH H H H 2,6DIP 3963 H H H H H 2,6DMB 3964 H H H H H CD3 3965 H H H H HCH3 3966 H H H H H H 3967 H H H H H iPr 3968 H H H H iPr CD3 3969 H H HH iPr CH3 3970 H H H H iPr H 3971 H H H iPr CD3 H 3972 H H H iPr CH3 H3973 H H H iPr H CD3 3974 H H H iPr H CH3 3975 H H H iPr H H 3976 H HiPr CD3 CD3 H 3977 H H iPr CD3 CH3 H 3978 H H iPr CD3 H CD3 3979 H H iPrCD3 H CH3 3980 H H iPr CD3 H H 3981 H H iPr CH3 CD3 H 3982 H H iPr CH3CH3 H 3983 H H iPr CH3 H CD3 3984 H H iPr CH3 H CH3 3985 H H iPr CH3 H H3986 H H iPr H CD3 CD3 3987 H H iPr H CD3 CH3 3988 H H iPr H CD3 H 3989H H iPr H CH3 CD3 3990 H H iPr H CH3 CH3 3991 H H iPr H CH3 H 3992 H HiPr H H CD3 3993 H H iPr H H CH3 3994 H H iPr H H H 3995 H ph H CD3 H H3996 H ph H CH3 H H 3997 H ph H H CD3 H 3998 H ph H H CH3 H 3999 H ph HH H CD3 4000 H ph H H H CH3 4001 H ph H H H H 4002 iPr CD3 H H H H 4003iPr CH3 H H H H 4004 iPr H CD3 H H H 4005 iPr H CH3 H H H 4006 iPr H HCD3 H H 4007 iPr H H CH3 H H 4008 iPr H H H CD3 H 4009 iPr H H H CH3 H4010 iPr H H H H CD3 4011 iPr H H H H CH3 4012 iPr H H H H H

LA4013 to LA4444 based on structure:

LA # R11 R2 R12 R31 R33 R34 4013 CD3 CD3 2,6DIP H H H 4014 CD3 CD32,6DMB H H H 4015 CD3 CD3 CD3 H H H 4016 CD3 CD3 CH3 H H H 4017 CD3 CD3H H H H 4018 CD3 CD3 iPr H H H 4019 CD3 CH3 2,6DIP H H H 4020 CD3 CH32,6DMB H H H 4021 CD3 CH3 CD3 H H H 4022 CD3 CH3 CH3 H H H 4023 CD3 CH3H H H H 4024 CD3 CH3 iPr H H H 4025 CD3 H 2,6DIP CD3 H H 4026 CD3 H2,6DIP CH3 H H 4027 CD3 H 2,6DIP H CD3 H 4028 CD3 H 2,6DIP H CH3 H 4029CD3 H 2,6DIP H H CD3 4030 CD3 H 2,6DIP H H CH3 4031 CD3 H 2,6DIP H H H4032 CD3 H 2,6DMB CD3 H H 4033 CD3 H 2,6DMB CH3 H H 4034 CD3 H 2,6DMB HCD3 H 4035 CD3 H 2,6DMB H CH3 H 4036 CD3 H 2,6DMB H H CD3 4037 CD3 H2,6DMB H H CH3 4038 CD3 H 2,6DMB H H H 4039 CD3 H CD3 CD3 H H 4040 CD3 HCD3 CH3 H H 4041 CD3 H CD3 H CD3 H 4042 CD3 H CD3 H CH3 H 4043 CD3 H CD3H H CD3 4044 CD3 H CD3 H H CH3 4045 CD3 H CD3 H H H 4046 CD3 H CH3 CD3 HH 4047 CD3 H CH3 CH3 H H 4048 CD3 H CH3 H CD3 H 4049 CD3 H CH3 H CH3 H4050 CD3 H CH3 H H CD3 4051 CD3 H CH3 H H CH3 4052 CD3 H CH3 H H H 4053CD3 H H 2,6DIP H H 4054 CD3 H H 2,6DMB H H 4055 CD3 H H CD3 H H 4056 CD3H H CH3 H H 4057 CD3 H H H 2,6DIP H 4058 CD3 H H H 2,6DMB H 4059 CD3 H HH CD3 H 4060 CD3 H H H CH3 H 4061 CD3 H H H H 2,6DIP 4062 CD3 H H H H2,6DMB 4063 CD3 H H H H CD3 4064 CD3 H H H H CH3 4065 CD3 H H H H H 4066CD3 H H H H iPr 4067 CD3 H H H iPr H 4068 CD3 H H iPr H H 4069 CD3 H iPrCD3 H H 4070 CD3 H iPr CH3 H H 4071 CD3 H iPr H CD3 H 4072 CD3 H iPr HCH3 H 4073 CD3 H iPr H H CD3 4074 CD3 H iPr H H CH3 4075 CD3 H iPr H H H4076 CH3 CD3 2,6DIP H H H 4077 CH3 CD3 2,6DMB H H H 4078 CH3 CD3 CD3 H HH 4079 CH3 CD3 CH3 H H H 4080 CH3 CD3 H H H H 4081 CH3 CD3 iPr H H H4082 CH3 CH3 2,6DIP H H H 4083 CH3 CH3 2,6DMB H H H 4084 CH3 CH3 CD3 H HH 4085 CH3 CH3 CH3 H H H 4086 CH3 CH3 H H H H 4087 CH3 CH3 iPr H H H4088 CH3 H 2,6DIP CD3 H H 4089 CH3 H 2,6DIP CH3 H H 4090 CH3 H 2,6DIP HCD3 H 4091 CH3 H 2,6DIP H CH3 H 4092 CH3 H 2,6DIP H H CD3 4093 CH3 H2,6DIP H H CH3 4094 CH3 H 2,6DIP H H H 4095 CH3 H 2,6DMB CD3 H H 4096CH3 H 2,6DMB CH3 H H 4097 CH3 H 2,6DMB H CD3 H 4098 CH3 H 2,6DMB H CH3 H4099 CH3 H 2,6DMB H H CD3 4100 CH3 H 2,6DMB H H CH3 4101 CH3 H 2,6DMB HH H 4102 CH3 H CD3 CD3 H H 4103 CH3 H CD3 CH3 H H 4104 CH3 H CD3 H CD3 H4105 CH3 H CD3 H CH3 H 4106 CH3 H CD3 H H CD3 4107 CH3 H CD3 H H CH34108 CH3 H CD3 H H H 4109 CH3 H CH3 CD3 H H 4110 CH3 H CH3 CH3 H H 4111CH3 H CH3 H CD3 H 4112 CH3 H CH3 H CH3 H 4113 CH3 H CH3 H H CD3 4114 CH3H CH3 H H CH3 4115 CH3 H CH3 H H H 4116 CH3 H H 2,6DIP H H 4117 CH3 H H2,6DMB H H 4118 CH3 H H CD3 H H 4119 CH3 H H CH3 H H 4120 CH3 H H H2,6DIP H 4121 CH3 H H H 2,6DMB H 4122 CH3 H H H CD3 H 4123 CH3 H H H CH3H 4124 CH3 H H H H 2,6DIP 4125 CH3 H H H H 2,6DMB 4126 CH3 H H H H CD34127 CH3 H H H H CH3 4128 CH3 H H H H H 4129 CH3 H H H H iPr 4130 CH3 HH H iPr H 4131 CH3 H H iPr H H 4132 CH3 H iPr CD3 H H 4133 CH3 H iPr CH3H H 4134 CH3 H iPr H CD3 H 4135 CH3 H iPr H CH3 H 4136 CH3 H iPr H H CD34137 CH3 H iPr H H CH3 4138 CH3 H iPr H H H 4139 H 2,6DIP H CD3 H H 4140H 2,6DIP H CH3 H H 4141 H 2,6DIP H H CD3 H 4142 H 2,6DIP H H CH3 H 4143H 2,6DIP H H H CD3 4144 H 2,6DIP H H H CH3 4145 H 2,6DIP H H H H 4146 H2,6DIPB H CD3 H H 4147 H 2,6DIPB H CH3 H H 4148 H 2,6DIPB H H CD3 H 4149H 2,6DIPB H H CH3 H 4150 H 2,6DIPB H H H CD3 4151 H 2,6DIPB H H H CH34152 H 2,6DIPB H H H H 4153 H 2,6DMB H CD3 H H 4154 H 2,6DMB H CH3 H H4155 H 2,6DMB H H CD3 H 4156 H 2,6DMB H H CH3 H 4157 H 2,6DMB H H H CD34158 H 2,6DMB H H H CH3 4159 H 2,6DMB H H H H 4160 H CD3 2,6DIP CD3 H H4161 H CD3 2,6DIP CH3 H H 4162 H CD3 2,6DIP H CD3 H 4163 H CD3 2,6DIP HCH3 H 4164 H CD3 2,6DIP H H CD3 4165 H CD3 2,6DIP H H CH3 4166 H CD32,6DIP H H H 4167 H CD3 2,6DMB CD3 H H 4168 H CD3 2,6DMB CH3 H H 4169 HCD3 2,6DMB H CD3 H 4170 H CD3 2,6DMB H CH3 H 4171 H CD3 2,6DMB H H CD34172 H CD3 2,6DMB H H CH3 4173 H CD3 2,6DMB H H H 4174 H CD3 CD3 CD3 H H4175 H CD3 CD3 CH3 H H 4176 H CD3 CD3 H CD3 H 4177 H CD3 CD3 H CH3 H4178 H CD3 CD3 H H CD3 4179 H CD3 CD3 H H CH3 4180 H CD3 CD3 H H H 4181H CD3 CH3 CD3 H H 4182 H CD3 CH3 CH3 H H 4183 H CD3 CH3 H CD3 H 4184 HCD3 CH3 H CH3 H 4185 H CD3 CH3 H H CD3 4186 H CD3 CH3 H H CH3 4187 H CD3CH3 H H H 4188 H CD3 H 2,6DIP H H 4189 H CD3 H 2,6DMB H H 4190 H CD3 HCD3 H H 4191 H CD3 H CH3 H H 4192 H CD3 H H 2,6DIP H 4193 H CD3 H H2,6DMB H 4194 H CD3 H H CD3 H 4195 H CD3 H H CH3 H 4196 H CD3 H H H2,6DIP 4197 H CD3 H H H 2,6DMB 4198 H CD3 H H H CD3 4199 H CD3 H H H CH34200 H CD3 H H H H 4201 H CD3 H H H iPr 4202 H CD3 H H iPr H 4203 H CD3H iPr H H 4204 H CD3 iPr CD3 H H 4205 H CD3 iPr CH3 H H 4206 H CD3 iPr HCD3 H 4207 H CD3 iPr H CH3 H 4208 H CD3 iPr H H CD3 4209 H CD3 iPr H HCH3 4210 H CD3 iPr H H H 4211 H CH3 2,6DIP CD3 H H 4212 H CH3 2,6DIP CH3H H 4213 H CH3 2,6DIP H CD3 H 4214 H CH3 2,6DIP H CH3 H 4215 H CH32,6DIP H H CD3 4216 H CH3 2,6DIP H H CH3 4217 H CH3 2,6DIP H H H 4218 HCH3 2,6DMB CD3 H H 4219 H CH3 2,6DMB CH3 H H 4220 H CH3 2,6DMB H CD3 H4221 H CH3 2,6DMB H CH3 H 4222 H CH3 2,6DMB H H CD3 4223 H CH3 2,6DMB HH CH3 4224 H CH3 2,6DMB H H H 4225 H CH3 CD3 CD3 H H 4226 H CH3 CD3 CH3H H 4227 H CH3 CD3 H CD3 H 4228 H CH3 CD3 H CH3 H 4229 H CH3 CD3 H H CD34230 H CH3 CD3 H H CH3 4231 H CH3 CD3 H H H 4232 H CH3 CH3 CD3 H H 4233H CH3 CH3 CH3 H H 4234 H CH3 CH3 H CD3 H 4235 H CH3 CH3 H CH3 H 4236 HCH3 CH3 H H CD3 4237 H CH3 CH3 H H CH3 4238 H CH3 CH3 H H H 4239 H CH3 H2,6DIP H H 4240 H CH3 H 2,6DMB H H 4241 H CH3 H CD3 H H 4242 H CH3 H CH3H H 4243 H CH3 H H 2,6DIP H 4244 H CH3 H H 2,6DMB H 4245 H CH3 H H CD3 H4246 H CH3 H H CH3 H 4247 H CH3 H H H 2,6DIP 4248 H CH3 H H H 2,6DMB4249 H CH3 H H H CD3 4250 H CH3 H H H CH3 4251 H CH3 H H H H 4252 H CH3H H H iPr 4253 H CH3 H H iPr H 4254 H CH3 H iPr H H 4255 H CH3 iPr CD3 HH 4256 H CH3 iPr CH3 H H 4257 H CH3 iPr H CD3 H 4258 H CH3 iPr H CH3 H4259 H CH3 iPr H H CD3 4260 H CH3 iPr H H CH3 4261 H CH3 iPr H H H 4262H H 2,6DIP CD3 CD3 H 4263 H H 2,6DIP CD3 CH3 H 4264 H H 2,6DIP CD3 H CD34265 H H 2,6DIP CD3 H CH3 4266 H H 2,6DIP CD3 H H 4267 H H 2,6DIP CH3CD3 H 4268 H H 2,6DIP CH3 CH3 H 4269 H H 2,6DIP CH3 H CD3 4270 H H2,6DIP CH3 H CH3 4271 H H 2,6DIP CH3 H H 4272 H H 2,6DIP H CD3 CD3 4273H H 2,6DIP H CD3 CH3 4274 H H 2,6DIP H CD3 H 4275 H H 2,6DIP H CH3 CD34276 H H 2,6DIP H CH3 CH3 4277 H H 2,6DIP H CH3 H 4278 H H 2,6DIP H HCD3 4279 H H 2,6DIP H H CH3 4280 H H 2,6DIP H H H 4281 H H 2,6DMB CD3CD3 H 4282 H H 2,6DMB CD3 CH3 H 4283 H H 2,6DMB CD3 H CD3 4284 H H2,6DMB CD3 H CH3 4285 H H 2,6DMB CD3 H H 4286 H H 2,6DMB CH3 CD3 H 4287H H 2,6DMB CH3 CH3 H 4288 H H 2,6DMB CH3 H CD3 4289 H H 2,6DMB CH3 H CH34290 H H 2,6DMB CH3 H H 4291 H H 2,6DMB H CD3 CD3 4292 H H 2,6DMB H CD3CH3 4293 H H 2,6DMB H CD3 H 4294 H H 2,6DMB H CH3 CD3 4295 H H 2,6DMB HCH3 CH3 4296 H H 2,6DMB H CH3 H 4297 H H 2,6DMB H H CD3 4298 H H 2,6DMBH H CH3 4299 H H 2,6DMB H H H 4300 H H CD3 CD3 CD3 H 4301 H H CD3 CD3CH3 H 4302 H H CD3 CD3 H CD3 4303 H H CD3 CD3 H CH3 4304 H H CD3 CD3 H H4305 H H CD3 CH3 CD3 H 4306 H H CD3 CH3 CH3 H 4307 H H CD3 CH3 H CD34308 H H CD3 CH3 H CH3 4309 H H CD3 CH3 H H 4310 H H CD3 H 2,6DIP H 4311H H CD3 H 2,6DMB H 4312 H H CD3 H CD3 CD3 4313 H H CD3 H CD3 CH3 4314 HH CD3 H CD3 H 4315 H H CD3 H CH3 CD3 4316 H H CD3 H CH3 CH3 4317 H H CD3H CH3 H 4318 H H CD3 H H 2,6DIP 4319 H H CD3 H H 2,6DMB 4320 H H CD3 H HCD3 4321 H H CD3 H H CH3 4322 H H CD3 H H H 4323 H H CD3 H H iPr 4324 HH CD3 H iPr H 4325 H H CD3 iPr H H 4326 H H CH3 CD3 CD3 H 4327 H H CH3CD3 CH3 H 4328 H H CH3 CD3 H CD3 4329 H H CH3 CD3 H CH3 4330 H H CH3 CD3H H 4331 H H CH3 CH3 CD3 H 4332 H H CH3 CH3 CH3 H 4333 H H CH3 CH3 H CD34334 H H CH3 CH3 H CH3 4335 H H CH3 CH3 H H 4336 H H CH3 H 2,6DIP H 4337H H CH3 H 2,6DMB H 4338 H H CH3 H CD3 CD3 4339 H H CH3 H CD3 CH3 4340 HH CH3 H CD3 H 4341 H H CH3 H CH3 CD3 4342 H H CH3 H CH3 CH3 4343 H H CH3H CH3 H 4344 H H CH3 H H 2,6DIP 4345 H H CH3 H H 2,6DMB 4346 H H CH3 H HCD3 4347 H H CH3 H H CH3 4348 H H CH3 H H H 4349 H H CH3 H H iPr 4350 HH CH3 H iPr H 4351 H H CH3 iPr H H 4352 H H H 2,6DIP CD3 H 4353 H H H2,6DIP CH3 H 4354 H H H 2,6DIP H CD3 4355 H H H 2,6DIP H CH3 4356 H H H2,6DIP H H 4357 H H H 2,6DMB CD3 H 4358 H H H 2,6DMB CH3 H 4359 H H H2,6DMB H CD3 4360 H H H 2,6DMB H CH3 4361 H H H 2,6DMB H H 4362 H H HCD3 2,6DIP H 4363 H H H CD3 2,6DMB H 4364 H H H CD3 CD3 H 4365 H H H CD3CH3 H 4366 H H H CD3 H 2,6DIP 4367 H H H CD3 H 2,6DMB 4368 H H H CD3 HCD3 4369 H H H CD3 H CH3 4370 H H H CD3 H H 4371 H H H CD3 H iPr 4372 HH H CD3 iPr H 4373 H H H CH3 2,6DIP H 4374 H H H CH3 2,6DMB H 4375 H H HCH3 CD3 H 4376 H H H CH3 CH3 H 4377 H H H CH3 H 2,6DIP 4378 H H H CH3 H2,6DMB 4379 H H H CH3 H CD3 4380 H H H CH3 H CH3 4381 H H H CH3 H H 4382H H H CH3 H iPr 4383 H H H CH3 iPr H 4384 H H H H 2,6DIP H 4385 H H H H2,6DMB H 4386 H H H H CD3 CD3 4387 H H H H CD3 CH3 4388 H H H H CD3 H4389 H H H H CD3 iPr 4390 H H H H CH3 CD3 4391 H H H H CH3 CH3 4392 H HH H CH3 H 4393 H H H H CH3 iPr 4394 H H H H H 2,6DIP 4395 H H H H H2,6DMB 4396 H H H H H CD3 4397 H H H H H CH3 4398 H H H H H H 4399 H H HH H iPr 4400 H H H H iPr CD3 4401 H H H H iPr CH3 4402 H H H H iPr H4403 H H H iPr CD3 H 4404 H H H iPr CH3 H 4405 H H H iPr H CD3 4406 H HH iPr H CH3 4407 H H H iPr H H 4408 H H iPr CD3 CD3 H 4409 H H iPr CD3CH3 H 4410 H H iPr CD3 H CD3 4411 H H iPr CD3 H CH3 4412 H H iPr CD3 H H4413 H H iPr CH3 CD3 H 4414 H H iPr CH3 CH3 H 4415 H H iPr CH3 H CD34416 H H iPr CH3 H CH3 4417 H H iPr CH3 H H 4418 H H iPr H CD3 CD3 4419H H iPr H CD3 CH3 4420 H H iPr H CD3 H 4421 H H iPr H CH3 CD3 4422 H HiPr H CH3 CH3 4423 H H iPr H CH3 H 4424 H H iPr H H CD3 4425 H H iPr H HCH3 4426 H H iPr H H H 4427 H ph H CD3 H H 4428 H ph H CH3 H H 4429 H phH H CD3 H 4430 H ph H H CH3 H 4431 H ph H H H CD3 4432 H ph H H H CH34433 H ph H H H H 4434 iPr CD3 H H H H 4435 iPr CH3 H H H H 4436 iPr HCD3 H H H 4437 iPr H CH3 H H H 4438 iPr H H CD3 H H 4439 iPr H H CH3 H H4440 iPr H H H CD3 H 4441 iPr H H H CH3 H 4442 iPr H H H H CD3 4443 iPrH H H H CH3 4444 iPr H H H H H

LA4445 to LA4872 based on structure:

LA # R11 R2 R12 R32 R33 R34 4445 CD3 CD3 2,6DIP H H H 4446 CD3 CD32,6DMB H H H 4447 CD3 CD3 CD3 H H H 4448 CD3 CD3 CH3 H H H 4449 CD3 CD3H H H H 4450 CD3 CD3 iPr H H H 4451 CD3 CH3 2,6DIP H H H 4452 CD3 CH32,6DMB H H H 4453 CD3 CH3 CD3 H H H 4454 CD3 CH3 CH3 H H H 4455 CD3 CH3H H H H 4456 CD3 CH3 iPr H H H 4457 CD3 H 2,6DIP CD3 H H 4458 CD3 H2,6DIP CH3 H H 4459 CD3 H 2,6DIP H CD3 H 4460 CD3 H 2,6DIP H CH3 H 4461CD3 H 2,6DIP H H CD3 4462 CD3 H 2,6DIP H H CH3 4463 CD3 H 2,6DIP H H H4464 CD3 H 2,6DMB CD3 H H 4465 CD3 H 2,6DMB CH3 H H 4466 CD3 H 2,6DMB HCD3 H 4467 CD3 H 2,6DMB H CH3 H 4468 CD3 H 2,6DMB H H CD3 4469 CD3 H2,6DMB H H CH3 4470 CD3 H 2,6DMB H H H 4471 CD3 H CD3 CD3 H H 4472 CD3 HCD3 CH3 H H 4473 CD3 H CD3 H CD3 H 4474 CD3 H CD3 H CH3 H 4475 CD3 H CD3H H CD3 4476 CD3 H CD3 H H CH3 4477 CD3 H CD3 H H H 4478 CD3 H CH3 CD3 HH 4479 CD3 H CH3 CH3 H H 4480 CD3 H CH3 H CD3 H 4481 CD3 H CH3 H CH3 H4482 CD3 H CH3 H H CD3 4483 CD3 H CH3 H H CH3 4484 CD3 H CH3 H H H 4485CD3 H H 2,6DIP H H 4486 CD3 H H 2,6DMB H H 4487 CD3 H H CD3 H H 4488 CD3H H CH3 H H 4489 CD3 H H H 2,6DIP H 4490 CD3 H H H 2,6DMB H 4491 CD3 H HH CD3 H 4492 CD3 H H H CH3 H 4493 CD3 H H H H 2,6DIP 4494 CD3 H H H H2,6DMB 4495 CD3 H H H H CD3 4496 CD3 H H H H CH3 4497 CD3 H H H H H 4498CD3 H H H H iPr 4499 CD3 H H H iPr H 4500 CD3 H H iPr H H 4501 CD3 H iPrCD3 H H 4502 CD3 H iPr CH3 H H 4503 CD3 H iPr H CD3 H 4504 CD3 H iPr HCH3 H 4505 CD3 H iPr H H CD3 4506 CD3 H iPr H H CH3 4507 CD3 H iPr H H H4508 CH3 CD3 2,6DIP H H H 4509 CH3 CD3 2,6DMB H H H 4510 CH3 CD3 CD3 H HH 4511 CH3 CD3 CH3 H H H 4512 CH3 CD3 H H H H 4513 CH3 CD3 iPr H H H4514 CH3 CH3 2,6DIP H H H 4515 CH3 CH3 2,6DMB H H H 4516 CH3 CH3 CD3 H HH 4517 CH3 CH3 CH3 H H H 4518 CH3 CH3 H H H H 4519 CH3 CH3 iPr H H H4520 CH3 H 2,6DIP CD3 H H 4521 CH3 H 2,6DIP CH3 H H 4522 CH3 H 2,6DIP HCD3 H 4523 CH3 H 2,6DIP H CH3 H 4524 CH3 H 2,6DIP H H CD3 4525 CH3 H2,6DIP H H CH3 4526 CH3 H 2,6DIP H H H 4527 CH3 H 2,6DMB CD3 H H 4528CH3 H 2,6DMB CH3 H H 4529 CH3 H 2,6DMB H CD3 H 4530 CH3 H 2,6DMB H CH3 H4531 CH3 H 2,6DMB H H CD3 4532 CH3 H 2,6DMB H H CH3 4533 CH3 H 2,6DMB HH H 4534 CH3 H CD3 CD3 H H 4535 CH3 H CD3 CH3 H H 4536 CH3 H CD3 H CD3 H4537 CH3 H CD3 H CH3 H 4538 CH3 H CD3 H H CD3 4539 CH3 H CD3 H H CH34540 CH3 H CD3 H H H 4541 CH3 H CH3 CD3 H H 4542 CH3 H CH3 CH3 H H 4543CH3 H CH3 H CD3 H 4544 CH3 H CH3 H CH3 H 4545 CH3 H CH3 H H CD3 4546 CH3H CH3 H H CH3 4547 CH3 H CH3 H H H 4548 CH3 H H 2,6DIP H H 4549 CH3 H H2,6DMB H H 4550 CH3 H H CD3 H H 4551 CH3 H H CH3 H H 4552 CH3 H H H2,6DIP H 4553 CH3 H H H 2,6DMB H 4554 CH3 H H H CD3 H 4555 CH3 H H H CH3H 4556 CH3 H H H H 2,6DIP 4557 CH3 H H H H 2,6DMB 4558 CH3 H H H H CD34559 CH3 H H H H CH3 4560 CH3 H H H H H 4561 CH3 H H H H iPr 4562 CH3 HH H iPr H 4563 CH3 H H iPr H H 4564 CH3 H iPr CD3 H H 4565 CH3 H iPr CH3H H 4566 CH3 H iPr H CD3 H 4567 CH3 H iPr H CH3 H 4568 CH3 H iPr H H CD34569 CH3 H iPr H H CH3 4570 CH3 H iPr H H H 4571 H 2,6DIP H CD3 H H 4572H 2,6DIP H CH3 H H 4573 H 2,6DIP H H CD3 H 4574 H 2,6DIP H H CH3 H 4575H 2,6DIP H H H CD3 4576 H 2,6DIP H H H CH3 4577 H 2,6DIP H H H H 4578 H2,6DIPB H CD3 H H 4579 H 2,6DIPB H CH3 H H 4580 H 2,6DIPB H H CD3 H 4581H 2,6DIPB H H CH3 H 4582 H 2,6DIPB H H H CD3 4583 H 2,6DIPB H H H CH34584 H 2,6DIPB H H H H 4585 H 2,6DMB H CD3 H H 4586 H 2,6DMB H CH3 H H4587 H 2,6DMB H H CD3 H 4588 H 2,6DMB H H CH3 H 4589 H 2,6DMB H H H CD34590 H 2,6DMB H H H CH3 4591 H 2,6DMB H H H H 4592 H CD3 2,6DIP CD3 H H4593 H CD3 2,6DIP CH3 H H 4594 H CD3 2,6DIP H CD3 H 4595 H CD3 2,6DIP HCH3 H 4596 H CD3 2,6DIP H H CD3 4597 H CD3 2,6DIP H H CH3 4598 H CD32,6DIP H H H 4599 H CD3 2,6DMB CD3 H H 4600 H CD3 2,6DMB CH3 H H 4601 HCD3 2,6DMB H CD3 H 4602 H CD3 2,6DMB H CH3 H 4603 H CD3 2,6DMB H H CD34604 H CD3 2,6DMB H H CH3 4605 H CD3 2,6DMB H H H 4606 H CD3 CD3 CD3 H H4607 H CD3 CD3 CH3 H H 4608 H CD3 CD3 H CD3 H 4609 H CD3 CD3 H CH3 H4610 H CD3 CD3 H H CD3 4611 H CD3 CD3 H H CH3 4612 H CD3 CD3 H H H 4613H CD3 CH3 CD3 H H 4614 H CD3 CH3 CH3 H H 4615 H CD3 CH3 H CD3 H 4616 HCD3 CH3 H CH3 H 4617 H CD3 CH3 H H CD3 4618 H CD3 CH3 H H CH3 4619 H CD3CH3 H H H 4620 H CD3 H 2,6DIP H H 4621 H CD3 H 2,6DMB H H 4622 H CD3 HCD3 H H 4623 H CD3 H CH3 H H 4624 H CD3 H H 2,6DIP H 4625 H CD3 H H2,6DMB H 4626 H CD3 H H CD3 H 4627 H CD3 H H CH3 H 4628 H CD3 H H H2,6DIP 4629 H CD3 H H H 2,6DMB 4630 H CD3 H H H CD3 4631 H CD3 H H H CH34632 H CD3 H H H H 4633 H CD3 H H H iPr 4634 H CD3 H H iPr H 4635 H CD3H iPr H H 4636 H CD3 iPr CD3 H H 4637 H CD3 iPr CH3 H H 4638 H CD3 iPr HCD3 H 4639 H CD3 iPr H CH3 H 4640 H CD3 iPr H H CD3 4641 H CD3 iPr H HCH3 4642 H CD3 iPr H H H 4643 H CH3 2,6DIP CD3 H H 4644 H CH3 2,6DIP CH3H H 4645 H CH3 2,6DIP H CD3 H 4646 H CH3 2,6DIP H CH3 H 4647 H CH32,6DIP H H CD3 4648 H CH3 2,6DIP H H CH3 4649 H CH3 2,6DIP H H H 4650 HCH3 2,6DMB CD3 H H 4651 H CH3 2,6DMB CH3 H H 4652 H CH3 2,6DMB H CD3 H4653 H CH3 2,6DMB H CH3 H 4654 H CH3 2,6DMB H H CD3 4655 H CH3 2,6DMB HH CH3 4656 H CH3 2,6DMB H H H 4657 H CH3 CD3 CD3 H H 4658 H CH3 CD3 CH3H H 4659 H CH3 CD3 H CD3 H 4660 H CH3 CD3 H CH3 H 4661 H CH3 CD3 H H CD34662 H CH3 CD3 H H CH3 4663 H CH3 CD3 H H H 4664 H CH3 CH3 CD3 H H 4665H CH3 CH3 CH3 H H 4666 H CH3 CH3 H CD3 H 4667 H CH3 CH3 H CH3 H 4668 HCH3 CH3 H H CD3 4669 H CH3 CH3 H H CH3 4670 H CH3 CH3 H H H 4671 H CH3 H2,6DIP H H 4672 H CH3 H 2,6DMB H H 4673 H CH3 H CD3 H H 4674 H CH3 H CH3H H 4675 H CH3 H H 2,6DIP H 4676 H CH3 H H 2,6DMB H 4677 H CH3 H H CD3 H4678 H CH3 H H CH3 H 4679 H CH3 H H H 2,6DIP 4680 H CH3 H H H 2,6DMB4681 H CH3 H H H CD3 4682 H CH3 H H H CH3 4683 H CH3 H H H H 4684 H CH3H H H iPr 4685 H CH3 H H iPr H 4686 H CH3 H iPr H H 4687 H CH3 iPr CD3 HH 4688 H CH3 iPr CH3 H H 4689 H CH3 iPr H CD3 H 4690 H CH3 iPr H CH3 H4691 H CH3 iPr H H CD3 4692 H CH3 iPr H H CH3 4693 H CH3 iPr H H H 4694H H 2,6DIP CD3 CD3 H 4695 H H 2,6DIP CD3 CH3 H 4696 H H 2,6DIP CD3 H CD34697 H H 2,6DIP CD3 H CH3 4698 H H 2,6DIP CD3 H H 4699 H H 2,6DIP CH3CD3 H 4700 H H 2,6DIP CH3 CH3 H 4701 H H 2,6DIP CH3 H CD3 4702 H H2,6DIP CH3 H CH3 4703 H H 2,6DIP CH3 H H 4704 H H 2,6DIP H CD3 CD3 4705H H 2,6DIP H CD3 CH3 4706 H H 2,6DIP H CD3 H 4707 H H 2,6DIP H CH3 CD34708 H H 2,6DIP H CH3 CH3 4709 H H 2,6DIP H CH3 H 4710 H H 2,6DIP H HCD3 4711 H H 2,6DIP H H CH3 4712 H H 2,6DIP H H H 4713 H H 2,6DMB CD3CD3 H 4714 H H 2,6DMB CD3 CH3 H 4715 H H 2,6DMB CD3 H CD3 4716 H H2,6DMB CD3 H CH3 4717 H H 2,6DMB CD3 H H 4718 H H 2,6DMB CH3 CD3 H 4719H H 2,6DMB CH3 CH3 H 4720 H H 2,6DMB CH3 H CD3 4721 H H 2,6DMB CH3 H CH34722 H H 2,6DMB CH3 H H 4723 H H 2,6DMB H CD3 CD3 4724 H H 2,6DMB H CD3CH3 4725 H H 2,6DMB H CD3 H 4726 H H 2,6DMB H CH3 CD3 4727 H H 2,6DMB HCH3 CH3 4728 H H 2,6DMB H CH3 H 4729 H H 2,6DMB H H CD3 4730 H H 2,6DMBH H CH3 4731 H H 2,6DMB H H H 4732 H H CD3 2,6DIP H H 4733 H H CD32,6DMB H H 4734 H H CD3 CD3 CD3 H 4735 H H CD3 CD3 CH3 H 4736 H H CD3CD3 H CD3 4737 H H CD3 CD3 H CH3 4738 H H CD3 CD3 H H 4739 H H CD3 CH3CD3 H 4740 H H CD3 CH3 CH3 H 4741 H H CD3 CH3 H CD3 4742 H H CD3 CH3 HCH3 4743 H H CD3 CH3 H H 4744 H H CD3 H 2,6DIP H 4745 H H CD3 H 2,6DMB H4746 H H CD3 H CD3 CD3 4747 H H CD3 H CD3 CH3 4748 H H CD3 H CD3 H 4749H H CD3 H CH3 CD3 4750 H H CD3 H CH3 CH3 4751 H H CD3 H CH3 H 4752 H HCD3 H H 2,6DIP 4753 H H CD3 H H 2,6DMB 4754 H H CD3 H H CD3 4755 H H CD3H H CH3 4756 H H CD3 H H H 4757 H H CD3 H H iPr 4758 H H CD3 H iPr H4759 H H CD3 iPr H H 4760 H H CH3 2,6DIP H H 4761 H H CH3 2,6DMB H H4762 H H CH3 CD3 CD3 H 4763 H H CH3 CD3 CH3 H 4764 H H CH3 CD3 H CD34765 H H CH3 CD3 H CH3 4766 H H CH3 CD3 H H 4767 H H CH3 CH3 CD3 H 4768H H CH3 CH3 CH3 H 4769 H H CH3 CH3 H CD3 4770 H H CH3 CH3 H CH3 4771 H HCH3 CH3 H H 4772 H H CH3 H 2,6DIP H 4773 H H CH3 H 2,6DMB H 4774 H H CH3H CD3 CD3 4775 H H CH3 H CD3 CH3 4776 H H CH3 H CD3 H 4777 H H CH3 H CH3CD3 4778 H H CH3 H CH3 CH3 4779 H H CH3 H CH3 H 4780 H H CH3 H H 2,6DIP4781 H H CH3 H H 2,6DMB 4782 H H CH3 H H CD3 4783 H H CH3 H H CH3 4784 HH CH3 H H H 4785 H H CH3 H H iPr 4786 H H CH3 H iPr H 4787 H H CH3 iPr HH 4788 H H H 2,6DIP H CD3 4789 H H H 2,6DIP H CH3 4790 H H H 2,6DIP H H4791 H H H 2,6DMB H CD3 4792 H H H 2,6DMB H CH3 4793 H H H 2,6DMB H H4794 H H H CD3 CD3 H 4795 H H H CD3 CH3 H 4796 H H H CD3 H 2,6DIP 4797 HH H CD3 H 2,6DMB 4798 H H H CD3 H CD3 4799 H H H CD3 H CH3 4800 H H HCD3 H H 4801 H H H CD3 H iPr 4802 H H H CD3 iPr H 4803 H H H CH3 CD3 H4804 H H H CH3 CH3 H 4805 H H H CH3 H 2,6DIP 4806 H H H CH3 H 2,6DMB4807 H H H CH3 H CD3 4808 H H H CH3 H CH3 4809 H H H CH3 H H 4810 H H HCH3 H iPr 4811 H H H CH3 iPr H 4812 H H H H 2,6DIP H 4813 H H H H 2,6DMBH 4814 H H H H CD3 CD3 4815 H H H H CD3 CH3 4816 H H H H CD3 H 4817 H HH H CD3 iPr 4818 H H H H CH3 CD3 4819 H H H H CH3 CH3 4820 H H H H CH3 H4821 H H H H CH3 iPr 4822 H H H H H 2,6DIP 4823 H H H H H 2,6DMB 4824 HH H H H CD3 4825 H H H H H CH3 4826 H H H H H H 4827 H H H H H iPr 4828H H H H iPr CD3 4829 H H H H iPr CH3 4830 H H H H iPr H 4831 H H H iPrCD3 H 4832 H H H iPr CH3 H 4833 H H H iPr H CD3 4834 H H H iPr H CH34835 H H H iPr H H 4836 H H iPr CD3 CD3 H 4837 H H iPr CD3 CH3 H 4838 HH iPr CD3 H CD3 4839 H H iPr CD3 H CH3 4840 H H iPr CD3 H H 4841 H H iPrCH3 CD3 H 4842 H H iPr CH3 CH3 H 4843 H H iPr CH3 H CD3 4844 H H iPr CH3H CH3 4845 H H iPr CH3 H H 4846 H H iPr H CD3 CD3 4847 H H iPr H CD3 CH34848 H H iPr H CD3 H 4849 H H iPr H CH3 CD3 4850 H H iPr H CH3 CH3 4851H H iPr H CH3 H 4852 H H iPr H H CD3 4853 H H iPr H H CH3 4854 H H iPr HH H 4855 H ph H CD3 H H 4856 H ph H CH3 H H 4857 H ph H H CD3 H 4858 Hph H H CH3 H 4859 H ph H H H CD3 4860 H ph H H H CH3 4861 H ph H H H H4862 iPr CD3 H H H H 4863 iPr CH3 H H H H 4864 iPr H CD3 H H H 4865 iPrH CH3 H H H 4866 iPr H H CD3 H H 4867 iPr H H CH3 H H 4868 iPr H H H CD3H 4869 iPr H H H CH3 H 4870 iPr H H H H CD3 4871 iPr H H H H CH3 4872iPr H H H H H

LA4873 to LA5487 based on structure:

LA # R11 R12 R2 R31 R32 R33 R34 4873 CD3 CD3 2,6DIP H H H H 4874 CD3 CD32,6DMB H H H H 4875 CD3 CD3 CD3 H H H H 4876 CD3 CD3 CH3 H H H H 4877CD3 CD3 H H H H H 4878 CD3 CD3 iPr H H H H 4879 CD3 CH3 2,6DIP H H H H4880 CD3 CH3 2,6DMB H H H H 4881 CD3 CH3 CD3 H H H H 4882 CD3 CH3 CH3 HH H H 4883 CD3 CH3 H H H H H 4884 CD3 CH3 iPr H H H H 4885 CD3 H 2,6DIPCD3 H H H 4886 CD3 H 2,6DIP CH3 H H H 4887 CD3 H 2,6DIP H CD3 H H 4888CD3 H 2,6DIP H CH3 H H 4889 CD3 H 2,6DIP H H CD3 H 4890 CD3 H 2,6DIP H HCH3 H 4891 CD3 H 2,6DIP H H H CD3 4892 CD3 H 2,6DIP H H H CH3 4893 CD3 H2,6DIP H H H H 4894 CD3 H 2,6DMB CD3 H H H 4895 CD3 H 2,6DMB CH3 H H H4896 CD3 H 2,6DMB H CD3 H H 4897 CD3 H 2,6DMB H CH3 H H 4898 CD3 H2,6DMB H H CD3 H 4899 CD3 H 2,6DMB H H CH3 H 4900 CD3 H 2,6DMB H H H CD34901 CD3 H 2,6DMB H H H CH3 4902 CD3 H 2,6DMB H H H H 4903 CD3 H CD3 CD3H H H 4904 CD3 H CD3 CH3 H H H 4905 CD3 H CD3 H CD3 H H 4906 CD3 H CD3 HCH3 H H 4907 CD3 H CD3 H H CD3 H 4908 CD3 H CD3 H H CH3 H 4909 CD3 H CD3H H H CD3 4910 CD3 H CD3 H H H CH3 4911 CD3 H CD3 H H H H 4912 CD3 H CH3CD3 H H H 4913 CD3 H CH3 CH3 H H H 4914 CD3 H CH3 H CD3 H H 4915 CD3 HCH3 H CH3 H H 4916 CD3 H CH3 H H CD3 H 4917 CD3 H CH3 H H CH3 H 4918 CD3H CH3 H H H CD3 4919 CD3 H CH3 H H H CH3 4920 CD3 H CH3 H H H H 4921 CD3H H 2,6DIP H H H 4922 CD3 H H 2,6DMB H H H 4923 CD3 H H CD3 H H H 4924CD3 H H CH3 H H H 4925 CD3 H H H 2,6DIP H H 4926 CD3 H H H 2,6DMB H H4927 CD3 H H H CD3 H H 4928 CD3 H H H CH3 H H 4929 CD3 H H H H 2,6DIP H4930 CD3 H H H H 2,6DMB H 4931 CD3 H H H H CD3 H 4932 CD3 H H H H CH3 H4933 CD3 H H H H H 2,6DIP 4934 CD3 H H H H H 2,6DMB 4935 CD3 H H H H HCD3 4936 CD3 H H H H H CH3 4937 CD3 H H H H H H 4938 CD3 H H H H H iPr4939 CD3 H H H H iPr H 4940 CD3 H H H iPr H H 4941 CD3 H H iPr H H H4942 CD3 H iPr CD3 H H H 4943 CD3 H iPr CH3 H H H 4944 CD3 H iPr H CD3 HH 4945 CD3 H iPr H CH3 H H 4946 CD3 H iPr H H CD3 H 4947 CD3 H iPr H HCH3 H 4948 CD3 H iPr H H H CD3 4949 CD3 H iPr H H H CH3 4950 CD3 H iPr HH H H 4951 CH3 CD3 2,6DIP H H H H 4952 CH3 CD3 2,6DMB H H H H 4953 CH3CD3 CD3 H H H H 4954 CH3 CD3 CH3 H H H H 4955 CH3 CD3 H H H H H 4956 CH3CD3 iPr H H H H 4957 CH3 CH3 2,6DIP H H H H 4958 CH3 CH3 2,6DMB H H H H4959 CH3 CH3 CD3 H H H H 4960 CH3 CH3 CH3 H H H H 4961 CH3 CH3 H H H H H4962 CH3 CH3 iPr H H H H 4963 CH3 H 2,6DIP CD3 H H H 4964 CH3 H 2,6DIPCH3 H H H 4965 CH3 H 2,6DIP H CD3 H H 4966 CH3 H 2,6DIP H CH3 H H 4967CH3 H 2,6DIP H H CD3 H 4968 CH3 H 2,6DIP H H CH3 H 4969 CH3 H 2,6DIP H HH CD3 4970 CH3 H 2,6DIP H H H CH3 4971 CH3 H 2,6DIP H H H H 4972 CH3 H2,6DMB CD3 H H H 4973 CH3 H 2,6DMB CH3 H H H 4974 CH3 H 2,6DMB H CD3 H H4975 CH3 H 2,6DMB H CH3 H H 4976 CH3 H 2,6DMB H H CD3 H 4977 CH3 H2,6DMB H H CH3 H 4978 CH3 H 2,6DMB H H H CD3 4979 CH3 H 2,6DMB H H H CH34980 CH3 H 2,6DMB H H H H 4981 CH3 H CD3 CD3 H H H 4982 CH3 H CD3 CH3 HH H 4983 CH3 H CD3 H CD3 H H 4984 CH3 H CD3 H CH3 H H 4985 CH3 H CD3 H HCD3 H 4986 CH3 H CD3 H H CH3 H 4987 CH3 H CD3 H H H CD3 4988 CH3 H CD3 HH H CH3 4989 CH3 H CD3 H H H H 4990 CH3 H CH3 CD3 H H H 4991 CH3 H CH3CH3 H H H 4992 CH3 H CH3 H CD3 H H 4993 CH3 H CH3 H CH3 H H 4994 CH3 HCH3 H H CD3 H 4995 CH3 H CH3 H H CH3 H 4996 CH3 H CH3 H H H CD3 4997 CH3H CH3 H H H CH3 4998 CH3 H CH3 H H H H 4999 CH3 H H 2,6DIP H H H 5000CH3 H H 2,6DMB H H H 5001 CH3 H H CD3 H H H 5002 CH3 H H CH3 H H H 5003CH3 H H H 2,6DIP H H 5004 CH3 H H H 2,6DMB H H 5005 CH3 H H H CD3 H H5006 CH3 H H H CH3 H H 5007 CH3 H H H H 2,6DIP H 5008 CH3 H H H H 2,6DMBH 5009 CH3 H H H H CD3 H 5010 CH3 H H H H CH3 H 5011 CH3 H H H H H2,6DIP 5012 CH3 H H H H H 2,6DMB 5013 CH3 H H H H H CD3 5014 CH3 H H H HH CH3 5015 CH3 H H H H H H 5016 CH3 H H H H H iPr 5017 CH3 H H H H iPr H5018 CH3 H H H iPr H H 5019 CH3 H H iPr H H H 5020 CH3 H iPr CD3 H H H5021 CH3 H iPr CH3 H H H 5022 CH3 H iPr H CD3 H H 5023 CH3 H iPr H CH3 HH 5024 CH3 H iPr H H CD3 H 5025 CH3 H iPr H H CH3 H 5026 CH3 H iPr H H HCD3 5027 CH3 H iPr H H H CH3 5028 CH3 H iPr H H H H 5029 H 2,6DIP H CD3H H H 5030 H 2,6DIP H CH3 H H H 5031 H 2,6DIP H H CD3 H H 5032 H 2,6DIPH H CH3 H H 5033 H 2,6DIP H H H CD3 H 5034 H 2,6DIP H H H CH3 H 5035 H2,6DIP H H H H CD3 5036 H 2,6DIP H H H H CH3 5037 H 2,6DIP H H H H H5038 H 2,6DIPB H CD3 H H H 5039 H 2,6DIPB H CH3 H H H 5040 H 2,6DIPB H HCD3 H H 5041 H 2,6DIPB H H CH3 H H 5042 H 2,6DIPB H H H CD3 H 5043 H2,6DIPB H H H CH3 H 5044 H 2,6DIPB H H H H CD3 5045 H 2,6DIPB H H H HCH3 5046 H 2,6DIPB H H H H H 5047 H 2,6DMB H CD3 H H H 5048 H 2,6DMB HCH3 H H H 5049 H 2,6DMB H H CD3 H H 5050 H 2,6DMB H H CH3 H H 5051 H2,6DMB H H H CD3 H 5052 H 2,6DMB H H H CH3 H 5053 H 2,6DMB H H H H CD35054 H 2,6DMB H H H H CH3 5055 H 2,6DMB H H H H H 5056 H CD3 2,6DIP CD3H H H 5057 H CD3 2,6DIP CH3 H H H 5058 H CD3 2,6DIP H CD3 H H 5059 H CD32,6DIP H CH3 H H 5060 H CD3 2,6DIP H H CD3 H 5061 H CD3 2,6DIP H H CH3 H5062 H CD3 2,6DIP H H H CD3 5063 H CD3 2,6DIP H H H CH3 5064 H CD32,6DIP H H H H 5065 H CD3 2,6DMB CD3 H H H 5066 H CD3 2,6DMB CH3 H H H5067 H CD3 2,6DMB H CD3 H H 5068 H CD3 2,6DMB H CH3 H H 5069 H CD32,6DMB H H CD3 H 5070 H CD3 2,6DMB H H CH3 H 5071 H CD3 2,6DMB H H H CD35072 H CD3 2,6DMB H H H CH3 5073 H CD3 2,6DMB H H H H 5074 H CD3 CD3 CD3H H H 5075 H CD3 CD3 CH3 H H H 5076 H CD3 CD3 H CD3 H H 5077 H CD3 CD3 HCH3 H H 5078 H CD3 CD3 H H CD3 H 5079 H CD3 CD3 H H CH3 H 5080 H CD3 CD3H H H CD3 5081 H CD3 CD3 H H H CH3 5082 H CD3 CD3 H H H H 5083 H CD3 CH3CD3 H H H 5084 H CD3 CH3 CH3 H H H 5085 H CD3 CH3 H CD3 H H 5086 H CD3CH3 H CH3 H H 5087 H CD3 CH3 H H CD3 H 5088 H CD3 CH3 H H CH3 H 5089 HCD3 CH3 H H H CD3 5090 H CD3 CH3 H H H CH3 5091 H CD3 CH3 H H H H 5092 HCD3 H 2,6DIP H H H 5093 H CD3 H 2,6DMB H H H 5094 H CD3 H CD3 H H H 5095H CD3 H CH3 H H H 5096 H CD3 H H 2,6DIP H H 5097 H CD3 H H 2,6DMB H H5098 H CD3 H H CD3 H H 5099 H CD3 H H CH3 H H 5100 H CD3 H H H 2,6DIP H5101 H CD3 H H H 2,6DMB H 5102 H CD3 H H H CD3 H 5103 H CD3 H H H CH3 H5104 H CD3 H H H H 2,6DIP 5105 H CD3 H H H H 2,6DMB 5106 H CD3 H H H HCD3 5107 H CD3 H H H H CH3 5108 H CD3 H H H H H 5109 H CD3 H H H H iPr5110 H CD3 H H H iPr H 5111 H CD3 H H iPr H H 5112 H CD3 H iPr H H H5113 H CD3 iPr CD3 H H H 5114 H CD3 iPr CH3 H H H 5115 H CD3 iPr H CD3 HH 5116 H CD3 iPr H CH3 H H 5117 H CD3 iPr H H CD3 H 5118 H CD3 iPr H HCH3 H 5119 H CD3 iPr H H H CD3 5120 H CD3 iPr H H H CH3 5121 H CD3 iPr HH H H 5122 H CH3 2,6DIP CD3 H H H 5123 H CH3 2,6DIP CH3 H H H 5124 H CH32,6DIP H CD3 H H 5125 H CH3 2,6DIP H CH3 H H 5126 H CH3 2,6DIP H H CD3 H5127 H CH3 2,6DIP H H CH3 H 5128 H CH3 2,6DIP H H H CD3 5129 H CH32,6DIP H H H CH3 5130 H CH3 2,6DIP H H H H 5131 H CH3 2,6DMB CD3 H H H5132 H CH3 2,6DMB CH3 H H H 5133 H CH3 2,6DMB H CD3 H H 5134 H CH32,6DMB H CH3 H H 5135 H CH3 2,6DMB H H CD3 H 5136 H CH3 2,6DMB H H CH3 H5137 H CH3 2,6DMB H H H CD3 5138 H CH3 2,6DMB H H H CH3 5139 H CH32,6DMB H H H H 5140 H CH3 CD3 CD3 H H H 5141 H CH3 CD3 CH3 H H H 5142 HCH3 CD3 H CD3 H H 5143 H CH3 CD3 H CH3 H H 5144 H CH3 CD3 H H CD3 H 5145H CH3 CD3 H H CH3 H 5146 H CH3 CD3 H H H CD3 5147 H CH3 CD3 H H H CH35148 H CH3 CD3 H H H H 5149 H CH3 CH3 CD3 H H H 5150 H CH3 CH3 CH3 H H H5151 H CH3 CH3 H CD3 H H 5152 H CH3 CH3 H CH3 H H 5153 H CH3 CH3 H H CD3H 5154 H CH3 CH3 H H CH3 H 5155 H CH3 CH3 H H H CD3 5156 H CH3 CH3 H H HCH3 5157 H CH3 CH3 H H H H 5158 H CH3 H 2,6DIP H H H 5159 H CH3 H 2,6DMBH H H 5160 H CH3 H CD3 H H H 5161 H CH3 H CH3 H H H 5162 H CH3 H H2,6DIP H H 5163 H CH3 H H 2,6DMB H H 5164 H CH3 H H CD3 H H 5165 H CH3 HH CH3 H H 5166 H CH3 H H H 2,6DIP H 5167 H CH3 H H H 2,6DMB H 5168 H CH3H H H CD3 H 5169 H CH3 H H H CH3 H 5170 H CH3 H H H H 2,6DIP 5171 H CH3H H H H 2,6DMB 5172 H CH3 H H H H CD3 5173 H CH3 H H H H CH3 5174 H CH3H H H H H 5175 H CH3 H H H H iPr 5176 H CH3 H H H iPr H 5177 H CH3 H HiPr H H 5178 H CH3 H iPr H H H 5179 H CH3 iPr CD3 H H H 5180 H CH3 iPrCH3 H H H 5181 H CH3 iPr H CD3 H H 5182 H CH3 iPr H CH3 H H 5183 H CH3iPr H H CD3 H 5184 H CH3 iPr H H CH3 H 5185 H CH3 iPr H H H CD3 5186 HCH3 iPr H H H CH3 5187 H CH3 iPr H H H H 5188 H H 2,6DIP CD3 CD3 H H5189 H H 2,6DIP CD3 CH3 H H 5190 H H 2,6DIP CD3 H CD3 H 5191 H H 2,6DIPCD3 H CH3 H 5192 H H 2,6DIP CD3 H H CD3 5193 H H 2,6DIP CD3 H H CH3 5194H H 2,6DIP CD3 H H H 5195 H H 2,6DIP CH3 CD3 H H 5196 H H 2,6DIP CH3 CH3H H 5197 H H 2,6DIP CH3 H CD3 H 5198 H H 2,6DIP CH3 H CH3 H 5199 H H2,6DIP CH3 H H CD3 5200 H H 2,6DIP CH3 H H CH3 5201 H H 2,6DIP CH3 H H H5202 H H 2,6DIP H CD3 CD3 H 5203 H H 2,6DIP H CD3 CH3 H 5204 H H 2,6DIPH CD3 H CD3 5205 H H 2,6DIP H CD3 H CH3 5206 H H 2,6DIP H CD3 H H 5207 HH 2,6DIP H CH3 CD3 H 5208 H H 2,6DIP H CH3 CH3 H 5209 H H 2,6DIP H CH3 HCD3 5210 H H 2,6DIP H CH3 H CH3 5211 H H 2,6DIP H CH3 H H 5212 H H2,6DIP H H CD3 CD3 5213 H H 2,6DIP H H CD3 CH3 5214 H H 2,6DIP H H CD3 H5215 H H 2,6DIP H H CH3 CD3 5216 H H 2,6DIP H H CH3 CH3 5217 H H 2,6DIPH H CH3 H 5218 H H 2,6DIP H H H CD3 5219 H H 2,6DIP H H H CH3 5220 H H2,6DIP H H H H 5221 H H 2,6DMB CD3 CD3 H H 5222 H H 2,6DMB CD3 CH3 H H5223 H H 2,6DMB CD3 H CD3 H 5224 H H 2,6DMB CD3 H CH3 H 5225 H H 2,6DMBCD3 H H CD3 5226 H H 2,6DMB CD3 H H CH3 5227 H H 2,6DMB CD3 H H H 5228 HH 2,6DMB CH3 CD3 H H 5229 H H 2,6DMB CH3 CH3 H H 5230 H H 2,6DMB CH3 HCD3 H 5231 H H 2,6DMB CH3 H CH3 H 5232 H H 2,6DMB CH3 H H CD3 5233 H H2,6DMB CH3 H H CH3 5234 H H 2,6DMB CH3 H H H 5235 H H 2,6DMB H CD3 CD3 H5236 H H 2,6DMB H CD3 CH3 H 5237 H H 2,6DMB H CD3 H CD3 5238 H H 2,6DMBH CD3 H CH3 5239 H H 2,6DMB H CD3 H H 5240 H H 2,6DMB H CH3 CD3 H 5241 HH 2,6DMB H CH3 CH3 H 5242 H H 2,6DMB H CH3 H CD3 5243 H H 2,6DMB H CH3 HCH3 5244 H H 2,6DMB H CH3 H H 5245 H H 2,6DMB H H CD3 CD3 5246 H H2,6DMB H H CD3 CH3 5247 H H 2,6DMB H H CD3 H 5248 H H 2,6DMB H H CH3 CD35249 H H 2,6DMB H H CH3 CH3 5250 H H 2,6DMB H H CH3 H 5251 H H 2,6DMB HH H CD3 5252 H H 2,6DMB H H H CH3 5253 H H 2,6DMB H H H H 5254 H H CD3CD3 CD3 H H 5255 H H CD3 CD3 CH3 H H 5256 H H CD3 CD3 H CD3 H 5257 H HCD3 CD3 H CH3 H 5258 H H CD3 CD3 H H CD3 5259 H H CD3 CD3 H H CH3 5260 HH CD3 CD3 H H H 5261 H H CD3 CH3 CD3 H H 5262 H H CD3 CH3 CH3 H H 5263 HH CD3 CH3 H CD3 H 5264 H H CD3 CH3 H CH3 H 5265 H H CD3 CH3 H H CD3 5266H H CD3 CH3 H H CH3 5267 H H CD3 CH3 H H H 5268 H H CD3 H 2,6DIP H H5269 H H CD3 H 2,6DMB H H 5270 H H CD3 H CD3 CD3 H 5271 H H CD3 H CD3CH3 H 5272 H H CD3 H CD3 H CD3 5273 H H CD3 H CD3 H CH3 5274 H H CD3 HCD3 H H 5275 H H CD3 H CH3 CD3 H 5276 H H CD3 H CH3 CH3 H 5277 H H CD3 HCH3 H CD3 5278 H H CD3 H CH3 H CH3 5279 H H CD3 H CH3 H H 5280 H H CD3 HH 2,6DIP H 5281 H H CD3 H H 2,6DMB H 5282 H H CD3 H H CD3 CD3 5283 H HCD3 H H CD3 CH3 5284 H H CD3 H H CD3 H 5285 H H CD3 H H CH3 CD3 5286 H HCD3 H H CH3 CH3 5287 H H CD3 H H CH3 H 5288 H H CD3 H H H 2,6DIP 5289 HH CD3 H H H 2,6DMB 5290 H H CD3 H H H CD3 5291 H H CD3 H H H CH3 5292 HH CD3 H H H H 5293 H H CD3 H H H iPr 5294 H H CD3 H H iPr H 5295 H H CD3H iPr H H 5296 H H CD3 iPr H H H 5297 H H CH3 CD3 CD3 H H 5298 H H CH3CD3 CH3 H H 5299 H H CH3 CD3 H CD3 H 5300 H H CH3 CD3 H CH3 H 5301 H HCH3 CD3 H H CD3 5302 H H CH3 CD3 H H CH3 5303 H H CH3 CD3 H H H 5304 H HCH3 CH3 CD3 H H 5305 H H CH3 CH3 CH3 H H 5306 H H CH3 CH3 H CD3 H 5307 HH CH3 CH3 H CH3 H 5308 H H CH3 CH3 H H CD3 5309 H H CH3 CH3 H H CH3 5310H H CH3 CH3 H H H 5311 H H CH3 H 2,6DIP H H 5312 H H CH3 H 2,6DMB H H5313 H H CH3 H CD3 CD3 H 5314 H H CH3 H CD3 CH3 H 5315 H H CH3 H CD3 HCD3 5316 H H CH3 H CD3 H CH3 5317 H H CH3 H CD3 H H 5318 H H CH3 H CH3CD3 H 5319 H H CH3 H CH3 CH3 H 5320 H H CH3 H CH3 H CD3 5321 H H CH3 HCH3 H CH3 5322 H H CH3 H CH3 H H 5323 H H CH3 H H 2,6DIP H 5324 H H CH3H H 2,6DMB H 5325 H H CH3 H H CD3 CD3 5326 H H CH3 H H CD3 CH3 5327 H HCH3 H H CD3 H 5328 H H CH3 H H CH3 CD3 5329 H H CH3 H H CH3 CH3 5330 H HCH3 H H CH3 H 5331 H H CH3 H H H 2,6DIP 5332 H H CH3 H H H 2,6DMB 5333 HH CH3 H H H CD3 5334 H H CH3 H H H CH3 5335 H H CH3 H H H H 5336 H H CH3H H H iPr 5337 H H CH3 H H iPr H 5338 H H CH3 H iPr H H 5339 H H CH3 iPrH H H 5340 H H H 2,6DIP H CD3 H 5341 H H H 2,6DIP H CH3 H 5342 H H H2,6DIP H H CD3 5343 H H H 2,6DIP H H CH3 5344 H H H 2,6DIP H H H 5345 HH H 2,6DMB H CD3 H 5346 H H H 2,6DMB H CH3 H 5347 H H H 2,6DMB H H CD35348 H H H 2,6DMB H H CH3 5349 H H H 2,6DMB H H H 5350 H H H CD3 CD3 H H5351 H H H CD3 CH3 H H 5352 H H H CD3 H 2,6DIP H 5353 H H H CD3 H 2,6DMBH 5354 H H H CD3 H CD3 H 5355 H H H CD3 H CH3 H 5356 H H H CD3 H H2,6DIP 5357 H H H CD3 H H 2,6DMB 5358 H H H CD3 H H CD3 5359 H H H CD3 HH CH3 5360 H H H CD3 H H H 5361 H H H CD3 H H iPr 5362 H H H CD3 H iPr H5363 H H H CD3 iPr H H 5364 H H H CH3 CD3 H H 5365 H H H CH3 CH3 H H5366 H H H CH3 H 2,6DIP H 5367 H H H CH3 H 2,6DMB H 5368 H H H CH3 H CD3H 5369 H H H CH3 H CH3 H 5370 H H H CH3 H H 2,6DIP 5371 H H H CH3 H H2,6DMB 5372 H H H CH3 H H CD3 5373 H H H CH3 H H CH3 5374 H H H CH3 H HH 5375 H H H CH3 H H iPr 5376 H H H CH3 H iPr H 5377 H H H CH3 iPr H H5378 H H H H 2,6DIP H CD3 5379 H H H H 2,6DIP H CH3 5380 H H H H 2,6DIPH H 5381 H H H H 2,6DMB H CD3 5382 H H H H 2,6DMB H CH3 5383 H H H H2,6DMB H H 5384 H H H H CD3 CD3 H 5385 H H H H CD3 CH3 H 5386 H H H HCD3 H 2,6DIP 5387 H H H H CD3 H 2,6DMB 5388 H H H H CD3 H CD3 5389 H H HH CD3 H CH3 5390 H H H H CD3 H H 5391 H H H H CD3 H iPr 5392 H H H H CD3iPr H 5393 H H H H CH3 CD3 H 5394 H H H H CH3 CH3 H 5395 H H H H CH3 H2,6DIP 5396 H H H H CH3 H 2,6DMB 5397 H H H H CH3 H CD3 5398 H H H H CH3H CH3 5399 H H H H CH3 H H 5400 H H H H CH3 H iPr 5401 H H H H CH3 iPr H5402 H H H H H 2,6DIP H 5403 H H H H H 2,6DMB H 5404 H H H H H CD3 CD35405 H H H H H CD3 CH3 5406 H H H H H CD3 H 5407 H H H H H CD3 iPr 5408H H H H H CH3 CD3 5409 H H H H H CH3 CH3 5410 H H H H H CH3 H 5411 H H HH H CH3 iPr 5412 H H H H H H 2,6DIP 5413 H H H H H H 2,6DMB 5414 H H H HH H CD3 5415 H H H H H H CH3 5416 H H H H H H H 5417 H H H H H H iPr5418 H H H H H iPr CD3 5419 H H H H H iPr CH3 5420 H H H H H iPr H 5421H H H H iPr CD3 H 5422 H H H H iPr CH3 H 5423 H H H H iPr H CD3 5424 H HH H iPr H CH3 5425 H H H H iPr H H 5426 H H H iPr CD3 H H 5427 H H H iPrCH3 H H 5428 H H H iPr H CD3 H 5429 H H H iPr H CH3 H 5430 H H H iPr H HCD3 5431 H H H iPr H H CH3 5432 H H H iPr H H H 5433 H H iPr CD3 CD3 H H5434 H H iPr CD3 CH3 H H 5435 H H iPr CD3 H CD3 H 5436 H H iPr CD3 H CH3H 5437 H H iPr CD3 H H CD3 5438 H H iPr CD3 H H CH3 5439 H H iPr CD3 H HH 5440 H H iPr CH3 CD3 H H 5441 H H iPr CH3 CH3 H H 5442 H H iPr CH3 HCD3 H 5443 H H iPr CH3 H CH3 H 5444 H H iPr CH3 H H CD3 5445 H H iPr CH3H H CH3 5446 H H iPr CH3 H H H 5447 H H iPr H CD3 CD3 H 5448 H H iPr HCD3 CH3 H 5449 H H iPr H CD3 H CD3 5450 H H iPr H CD3 H CH3 5451 H H iPrH CD3 H H 5452 H H iPr H CH3 CD3 H 5453 H H iPr H CH3 CH3 H 5454 H H iPrH CH3 H CD3 5455 H H iPr H CH3 H CH3 5456 H H iPr H CH3 H H 5457 H H iPrH H CD3 CD3 5458 H H iPr H H CD3 CH3 5459 H H iPr H H CD3 H 5460 H H iPrH H CH3 CD3 5461 H H iPr H H CH3 CH3 5462 H H iPr H H CH3 H 5463 H H iPrH H H CD3 5464 H H iPr H H H CH3 5465 H H iPr H H H H 5466 H ph H CD3 HH H 5467 H ph H CH3 H H H 5468 H ph H H CD3 H H 5469 H ph H H CH3 H H5470 H ph H H H CD3 H 5471 H ph H H H CH3 H 5472 H ph H H H H CD3 5473 Hph H H H H CH3 5474 H ph H H H H H 5475 iPr CD3 H H H H H 5476 iPr CH3 HH H H H 5477 iPr H CD3 H H H H 5478 iPr H CH3 H H H H 5479 iPr H H CD3 HH H 5480 iPr H H CH3 H H H 5481 iPr H H H CD3 H H 5482 iPr H H H CH3 H H5483 iPr H H H H CD3 H 5484 iPr H H H H CH3 H 5485 iPr H H H H H CD35486 iPr H H H H H CH3 5487 iPr H H H H H H

LA5488 to LA5700 based on structure:

LA # R11 R12 R13 R31 R32 R33 5488 CD3 CD3 H H H H 5489 CD3 CH3 H H H H5490 CD3 H 2,6DIP H H H 5491 CD3 H 2,6DMB H H H 5492 CD3 H CD3 H H H5493 CD3 H CH3 H H H 5494 CD3 H H 2,6DIP H H 5495 CD3 H H 2,6DMB H H5496 CD3 H H CD3 H H 5497 CD3 H H CH3 H H 5498 CD3 H H H 2,6DIP H 5499CD3 H H H 2,6DMB H 5500 CD3 H H H CD3 H 5501 CD3 H H H CH3 H 5502 CD3 HH H H 2,6DIP 5503 CD3 H H H H 2,6DMB 5504 CD3 H H H H CD3 5505 CD3 H H HH CH3 5506 CD3 H H H H H 5507 CD3 H H H H iPr 5508 CD3 H H H iPr H 5509CD3 H H iPr H H 5510 CD3 H iPr H H H 5511 CD3 iPr H H H H 5512 CH3 CD3 HH H H 5513 CH3 CH3 H H H H 5514 CH3 H 2,6DIP H H H 5515 CH3 H 2,6DMB H HH 5516 CH3 H CD3 H H H 5517 CH3 H CH3 H H H 5518 CH3 H H 2,6DIP H H 5519CH3 H H 2,6DMB H H 5520 CH3 H H CD3 H H 5521 CH3 H H CH3 H H 5522 CH3 HH H 2,6DIP H 5523 CH3 H H H 2,6DMB H 5524 CH3 H H H CD3 H 5525 CH3 H H HCH3 H 5526 CH3 H H H H 2,6DIP 5527 CH3 H H H H 2,6DMB 5528 CH3 H H H HCD3 5529 CH3 H H H H CH3 5530 CH3 H H H H H 5531 CH3 H H H H iPr 5532CH3 H H H iPr H 5533 CH3 H H iPr H H 5534 CH3 H iPr H H H 5535 CH3 iPr HH H H 5536 H 2,6DIP H CD3 H H 5537 H 2,6DIP H CH3 H H 5538 H 2,6DIP H HCD3 H 5539 H 2,6DIP H H CH3 H 5540 H 2,6DIP H H H CD3 5541 H 2,6DIP H HH CH3 5542 H 2,6DIP H H H H 5543 H 2,6DMB H CD3 H H 5544 H 2,6DMB H CH3H H 5545 H 2,6DMB H H CD3 H 5546 H 2,6DMB H H CH3 H 5547 H 2,6DMB H H HCD3 5548 H 2,6DMB H H H CH3 5549 H 2,6DMB H H H H 5550 H CD3 CD3 H H H5551 H CD3 CH3 H H H 5552 H CD3 H 2,6DIP H H 5553 H CD3 H 2,6DMB H H5554 H CD3 H CD3 H H 5555 H CD3 H CH3 H H 5556 H CD3 H H 2,6DIP H 5557 HCD3 H H 2,6DMB H 5558 H CD3 H H CD3 H 5559 H CD3 H H CH3 H 5560 H CD3 HH H 2,6DIP 5561 H CD3 H H H 2,6DMB 5562 H CD3 H H H CD3 5563 H CD3 H H HCH3 5564 H CD3 H H H H 5565 H CD3 H H H iPr 5566 H CD3 H H iPr H 5567 HCD3 H iPr H H 5568 H CD3 iPr H H H 5569 H CH3 CD3 H H H 5570 H CH3 CH3 HH H 5571 H CH3 H 2,6DIP H H 5572 H CH3 H 2,6DMB H H 5573 H CH3 H CD3 H H5574 H CH3 H CH3 H H 5575 H CH3 H H 2,6DIP H 5576 H CH3 H H 2,6DMB H5577 H CH3 H H CD3 H 5578 H CH3 H H CH3 H 5579 H CH3 H H H 2,6DIP 5580 HCH3 H H H 2,6DMB 5581 H CH3 H H H CD3 5582 H CH3 H H H CH3 5583 H CH3 HH H H 5584 H CH3 H H H iPr 5585 H CH3 H H iPr H 5586 H CH3 H iPr H H5587 H CH3 iPr H H H 5588 H H 2,6DIP H CD3 H 5589 H H 2,6DIP H CH3 H5590 H H 2,6DIP H H CD3 5591 H H 2,6DIP H H CH3 5592 H H 2,6DIP H H H5593 H H 2,6DMB H CD3 H 5594 H H 2,6DMB H CH3 H 5595 H H 2,6DMB H H CD35596 H H 2,6DMB H H CH3 5597 H H 2,6DMB H H H 5598 H H CD3 CD3 H H 5599H H CD3 CH3 H H 5600 H H CD3 H 2,6DIP H 5601 H H CD3 H 2,6DMB H 5602 H HCD3 H CD3 H 5603 H H CD3 H CH3 H 5604 H H CD3 H H 2,6DIP 5605 H H CD3 HH 2,6DMB 5606 H H CD3 H H CD3 5607 H H CD3 H H CH3 5608 H H CD3 H H H5609 H H CD3 H H iPr 5610 H H CD3 H iPr H 5611 H H CD3 iPr H H 5612 H HCH3 CD3 H H 5613 H H CH3 CH3 H H 5614 H H CH3 H 2,6DIP H 5615 H H CH3 H2,6DMB H 5616 H H CH3 H CD3 H 5617 H H CH3 H CH3 H 5618 H H CH3 H H2,6DIP 5619 H H CH3 H H 2,6DMB 5620 H H CH3 H H CD3 5621 H H CH3 H H CH35622 H H CH3 H H H 5623 H H CH3 H H iPr 5624 H H CH3 H iPr H 5625 H HCH3 iPr H H 5626 H H H 2,6DIP H CD3 5627 H H H 2,6DIP H CH3 5628 H H H2,6DIP H H 5629 H H H 2,6DMB H CD3 5630 H H H 2,6DMB H CH3 5631 H H H2,6DMB H H 5632 H H H CD3 CD3 H 5633 H H H CD3 CH3 H 5634 H H H CD3 H2,6DIP 5635 H H H CD3 H 2,6DMB 5636 H H H CD3 H CD3 5637 H H H CD3 H CH35638 H H H CD3 H H 5639 H H H CD3 H iPr 5640 H H H CD3 iPr H 5641 H H HCH3 CD3 H 5642 H H H CH3 CH3 H 5643 H H H CH3 H 2,6DIP 5644 H H H CH3 H2,6DMB 5645 H H H CH3 H CD3 5646 H H H CH3 H CH3 5647 H H H CH3 H H 5648H H H CH3 H iPr 5649 H H H CH3 iPr H 5650 H H H H 2,6DIP H 5651 H H H H2,6DMB H 5652 H H H H CD3 CD3 5653 H H H H CD3 CH3 5654 H H H H CD3 H5655 H H H H CD3 iPr 5656 H H H H CH3 CD3 5657 H H H H CH3 CH3 5658 H HH H CH3 H 5659 H H H H CH3 iPr 5660 H H H H H 2,6DIP 5661 H H H H H2,6DMB 5662 H H H H H CD3 5663 H H H H H CH3 5664 H H H H H H 5665 H H HH H iPr 5666 H H H H iPr CD3 5667 H H H H iPr CH3 5668 H H H H iPr H5669 H H H iPr CD3 H 5670 H H H iPr CH3 H 5671 H H H iPr H CD3 5672 H HH iPr H CH3 5673 H H H iPr H H 5674 H H iPr CD3 H H 5675 H H iPr CH3 H H5676 H H iPr H CD3 H 5677 H H iPr H CH3 H 5678 H H iPr H H CD3 5679 H HiPr H H CH3 5680 H H iPr H H H 5681 H iPr CD3 H H H 5682 H iPr CH3 H H H5683 H iPr H CD3 H H 5684 H iPr H CH3 H H 5685 H iPr H H CD3 H 5686 HiPr H H CH3 H 5687 H iPr H H H CD3 5688 H iPr H H H CH3 5689 H iPr H H HH 5690 iPr CD3 H H H H 5691 iPr CH3 H H H H 5692 iPr H CD3 H H H 5693iPr H CH3 H H H 5694 iPr H H CD3 H H 5695 iPr H H CH3 H H 5696 iPr H H HCD3 H 5697 iPr H H H CH3 H 5698 iPr H H H H CD3 5699 iPr H H H H CH35700 iPr H H H H H

LA5701 to LA5921 based on structure:

LA # R11 R12 R13 R31 R32 R34 5701 CD3 CD3 H H H H 5702 CD3 CH3 H H H H5703 CD3 H 2,6DIP H H H 5704 CD3 H 2,6DMB H H H 5705 CD3 H CD3 H H H5706 CD3 H CH3 H H H 5707 CD3 H H 2,6DIP H H 5708 CD3 H H 2,6DMB H H5709 CD3 H H CD3 H H 5710 CD3 H H CH3 H H 5711 CD3 H H H 2,6DIP H 5712CD3 H H H 2,6DMB H 5713 CD3 H H H CD3 H 5714 CD3 H H H CH3 H 5715 CD3 HH H H 2,6DIP 5716 CD3 H H H H 2,6DMB 5717 CD3 H H H H CD3 5718 CD3 H H HH CH3 5719 CD3 H H H H H 5720 CD3 H H H H iPr 5721 CD3 H H H iPr H 5722CD3 H H iPr H H 5723 CD3 H iPr H H H 5724 CD3 iPr H H H H 5725 CH3 CD3 HH H H 5726 CH3 CH3 H H H H 5727 CH3 H 2,6DIP H H H 5728 CH3 H 2,6DMB H HH 5729 CH3 H CD3 H H H 5730 CH3 H CH3 H H H 5731 CH3 H H 2,6DIP H H 5732CH3 H H 2,6DMB H H 5733 CH3 H H CD3 H H 5734 CH3 H H CH3 H H 5735 CH3 HH H 2,6DIP H 5736 CH3 H H H 2,6DMB H 5737 CH3 H H H CD3 H 5738 CH3 H H HCH3 H 5739 CH3 H H H H 2,6DIP 5740 CH3 H H H H 2,6DMB 5741 CH3 H H H HCD3 5742 CH3 H H H H CH3 5743 CH3 H H H H H 5744 CH3 H H H H iPr 5745CH3 H H H iPr H 5746 CH3 H H iPr H H 5747 CH3 H iPr H H H 5748 CH3 iPr HH H H 5749 H 2,6DIP H CD3 H H 5750 H 2,6DIP H CH3 H H 5751 H 2,6DIP H HCD3 H 5752 H 2,6DIP H H CH3 H 5753 H 2,6DIP H H H CD3 5754 H 2,6DIP H HH CH3 5755 H 2,6DIP H H H H 5756 H 2,6DMB H CD3 H H 5757 H 2,6DMB H CH3H H 5758 H 2,6DMB H H CD3 H 5759 H 2,6DMB H H CH3 H 5760 H 2,6DMB H H HCD3 5761 H 2,6DMB H H H CH3 5762 H 2,6DMB H H H H 5763 H CD3 CD3 H H H5764 H CD3 CH3 H H H 5765 H CD3 H 2,6DIP H H 5766 H CD3 H 2,6DMB H H5767 H CD3 H CD3 H H 5768 H CD3 H CH3 H H 5769 H CD3 H H 2,6DIP H 5770 HCD3 H H 2,6DMB H 5771 H CD3 H H CD3 H 5772 H CD3 H H CH3 H 5773 H CD3 HH H 2,6DIP 5774 H CD3 H H H 2,6DMB 5775 H CD3 H H H CD3 5776 H CD3 H H HCH3 5777 H CD3 H H H H 5778 H CD3 H H H iPr 5779 H CD3 H H iPr H 5780 HCD3 H iPr H H 5781 H CD3 iPr H H H 5782 H CH3 CD3 H H H 5783 H CH3 CH3 HH H 5784 H CH3 H 2,6DIP H H 5785 H CH3 H 2,6DMB H H 5786 H CH3 H CD3 H H5787 H CH3 H CH3 H H 5788 H CH3 H H 2,6DIP H 5789 H CH3 H H 2,6DMB H5790 H CH3 H H CD3 H 5791 H CH3 H H CH3 H 5792 H CH3 H H H 2,6DIP 5793 HCH3 H H H 2,6DMB 5794 H CH3 H H H CD3 5795 H CH3 H H H CH3 5796 H CH3 HH H H 5797 H CH3 H H H iPr 5798 H CH3 H H iPr H 5799 H CH3 H iPr H H5800 H CH3 iPr H H H 5801 H H 2,6DIP H CD3 H 5802 H H 2,6DIP H CH3 H5803 H H 2,6DIP H H CD3 5804 H H 2,6DIP H H CH3 5805 H H 2,6DIP H H H5806 H H 2,6DMB H CD3 H 5807 H H 2,6DMB H CH3 H 5808 H H 2,6DMB H H CD35809 H H 2,6DMB H H CH3 5810 H H 2,6DMB H H H 5811 H H CD3 CD3 H H 5812H H CD3 CH3 H H 5813 H H CD3 H 2,6DIP H 5814 H H CD3 H 2,6DMB H 5815 H HCD3 H CD3 H 5816 H H CD3 H CH3 H 5817 H H CD3 H H 2,6DIP 5818 H H CD3 HH 2,6DMB 5819 H H CD3 H H CD3 5820 H H CD3 H H CH3 5821 H H CD3 H H H5822 H H CD3 H H iPr 5823 H H CD3 H iPr H 5824 H H CD3 iPr H H 5825 H HCH3 CD3 H H 5826 H H CH3 CH3 H H 5827 H H CH3 H 2,6DIP H 5828 H H CH3 H2,6DMB H 5829 H H CH3 H CD3 H 5830 H H CH3 H CH3 H 5831 H H CH3 H H2,6DIP 5832 H H CH3 H H 2,6DMB 5833 H H CH3 H H CD3 5834 H H CH3 H H CH35835 H H CH3 H H H 5836 H H CH3 H H iPr 5837 H H CH3 H iPr H 5838 H HCH3 iPr H H 5839 H H H 2,6DIP H CD3 5840 H H H 2,6DIP H CH3 5841 H H H2,6DIP H H 5842 H H H 2,6DMB H CD3 5843 H H H 2,6DMB H CH3 5844 H H H2,6DMB H H 5845 H H H CD3 CD3 H 5846 H H H CD3 CH3 H 5847 H H H CD3 H2,6DIP 5848 H H H CD3 H 2,6DMB 5849 H H H CD3 H CD3 5850 H H H CD3 H CH35851 H H H CD3 H H 5852 H H H CD3 H iPr 5853 H H H CD3 iPr H 5854 H H HCH3 CD3 H 5855 H H H CH3 CH3 H 5856 H H H CH3 H 2,6DIP 5857 H H H CH3 H2,6DMB 5858 H H H CH3 H CD3 5859 H H H CH3 H CH3 5860 H H H CH3 H H 5861H H H CH3 H iPr 5862 H H H CH3 iPr H 5863 H H H H 2,6DIP CD3 5864 H H HH 2,6DIP CH3 5865 H H H H 2,6DIP H 5866 H H H H 2,6DMB CD3 5867 H H H H2,6DMB CH3 5868 H H H H 2,6DMB H 5869 H H H H CD3 2,6DIP 5870 H H H HCD3 2,6DMB 5871 H H H H CD3 CD3 5872 H H H H CD3 CH3 5873 H H H H CD3 H5874 H H H H CD3 iPr 5875 H H H H CH3 2,6DIP 5876 H H H H CH3 2,6DMB5877 H H H H CH3 CD3 5878 H H H H CH3 CH3 5879 H H H H CH3 H 5880 H H HH CH3 iPr 5881 H H H H H 2,6DIP 5882 H H H H H 2,6DMB 5883 H H H H H CD35884 H H H H H CH3 5885 H H H H H H 5886 H H H H H iPr 5887 H H H H iPrCD3 5888 H H H H iPr CH3 5889 H H H H iPr H 5890 H H H iPr CD3 H 5891 HH H iPr CH3 H 5892 H H H iPr H CD3 5893 H H H iPr H CH3 5894 H H H iPr HH 5895 H H iPr CD3 H H 5896 H H iPr CH3 H H 5897 H H iPr H CD3 H 5898 HH iPr H CH3 H 5899 H H iPr H H CD3 5900 H H iPr H H CH3 5901 H H iPr H HH 5902 H iPr CD3 H H H 5903 H iPr CH3 H H H 5904 H iPr H CD3 H H 5905 HiPr H CH3 H H 5906 H iPr H H CD3 H 5907 H iPr H H CH3 H 5908 H iPr H H HCD3 5909 H iPr H H H CH3 5910 H iPr H H H H 5911 iPr CD3 H H H H 5912iPr CH3 H H H H 5913 iPr H CD3 H H H 5914 iPr H CH3 H H H 5915 iPr H HCD3 H H 5916 iPr H H CH3 H H 5917 iPr H H H CD3 H 5918 iPr H H H CH3 H5919 iPr H H H H CD3 5920 iPr H H H H CH3 5921 iPr H H H H H

LA5922 to LA6142 based on structure:

LA # R11 R12 R13 R31 R33 R34 5922 CD3 CD3 H H H H 5923 CD3 CH3 H H H H5924 CD3 H 2,6DIP H H H 5925 CD3 H 2,6DMB H H H 5926 CD3 H CD3 H H H5927 CD3 H CH3 H H H 5928 CD3 H H 2,6DIP H H 5929 CD3 H H 2,6DMB H H5930 CD3 H H CD3 H H 5931 CD3 H H CH3 H H 5932 CD3 H H H 2,6DIP H 5933CD3 H H H 2,6DMB H 5934 CD3 H H H CD3 H 5935 CD3 H H H CH3 H 5936 CD3 HH H H 2,6DIP 5937 CD3 H H H H 2,6DMB 5938 CD3 H H H H CD3 5939 CD3 H H HH CH3 5940 CD3 H H H H H 5941 CD3 H H H H iPr 5942 CD3 H H H iPr H 5943CD3 H H iPr H H 5944 CD3 H iPr H H H 5945 CD3 iPr H H H H 5946 CH3 CD3 HH H H 5947 CH3 CH3 H H H H 5948 CH3 H 2,6DIP H H H 5949 CH3 H 2,6DMB H HH 5950 CH3 H CD3 H H H 5951 CH3 H CH3 H H H 5952 CH3 H H 2,6DIP H H 5953CH3 H H 2,6DMB H H 5954 CH3 H H CD3 H H 5955 CH3 H H CH3 H H 5956 CH3 HH H 2,6DIP H 5957 CH3 H H H 2,6DMB H 5958 CH3 H H H CD3 H 5959 CH3 H H HCH3 H 5960 CH3 H H H H 2,6DIP 5961 CH3 H H H H 2,6DMB 5962 CH3 H H H HCD3 5963 CH3 H H H H CH3 5964 CH3 H H H H H 5965 CH3 H H H H iPr 5966CH3 H H H iPr H 5967 CH3 H H iPr H H 5968 CH3 H iPr H H H 5969 CH3 iPr HH H H 5970 H 2,6DIP H CD3 H H 5971 H 2,6DIP H CH3 H H 5972 H 2,6DIP H HCD3 H 5973 H 2,6DIP H H CH3 H 5974 H 2,6DIP H H H CD3 5975 H 2,6DIP H HH CH3 5976 H 2,6DIP H H H H 5977 H 2,6DMB H CD3 H H 5978 H 2,6DMB H CH3H H 5979 H 2,6DMB H H CD3 H 5980 H 2,6DMB H H CH3 H 5981 H 2,6DMB H H HCD3 5982 H 2,6DMB H H H CH3 5983 H 2,6DMB H H H H 5984 H CD3 CD3 H H H5985 H CD3 CH3 H H H 5986 H CD3 H 2,6DIP H H 5987 H CD3 H 2,6DMB H H5988 H CD3 H CD3 H H 5989 H CD3 H CH3 H H 5990 H CD3 H H 2,6DIP H 5991 HCD3 H H 2,6DMB H 5992 H CD3 H H CD3 H 5993 H CD3 H H CH3 H 5994 H CD3 HH H 2,6DIP 5995 H CD3 H H H 2,6DMB 5996 H CD3 H H H CD3 5997 H CD3 H H HCH3 5998 H CD3 H H H H 5999 H CD3 H H H iPr 6000 H CD3 H H iPr H 6001 HCD3 H iPr H H 6002 H CD3 iPr H H H 6003 H CH3 CD3 H H H 6004 H CH3 CH3 HH H 6005 H CH3 H 2,6DIP H H 6006 H CH3 H 2,6DMB H H 6007 H CH3 H CD3 H H6008 H CH3 H CH3 H H 6009 H CH3 H H 2,6DIP H 6010 H CH3 H H 2,6DMB H6011 H CH3 H H CD3 H 6012 H CH3 H H CH3 H 6013 H CH3 H H H 2,6DIP 6014 HCH3 H H H 2,6DMB 6015 H CH3 H H H CD3 6016 H CH3 H H H CH3 6017 H CH3 HH H H 6018 H CH3 H H H iPr 6019 H CH3 H H iPr H 6020 H CH3 H iPr H H6021 H CH3 iPr H H H 6022 H H 2,6DIP H CD3 H 6023 H H 2,6DIP H CH3 H6024 H H 2,6DIP H H CD3 6025 H H 2,6DIP H H CH3 6026 H H 2,6DIP H H H6027 H H 2,6DMB H CD3 H 6028 H H 2,6DMB H CH3 H 6029 H H 2,6DMB H H CD36030 H H 2,6DMB H H CH3 6031 H H 2,6DMB H H H 6032 H H CD3 CD3 H H 6033H H CD3 CH3 H H 6034 H H CD3 H 2,6DIP H 6035 H H CD3 H 2,6DMB H 6036 H HCD3 H CD3 H 6037 H H CD3 H CH3 H 6038 H H CD3 H H 2,6DIP 6039 H H CD3 HH 2,6DMB 6040 H H CD3 H H CD3 6041 H H CD3 H H CH3 6042 H H CD3 H H H6043 H H CD3 H H iPr 6044 H H CD3 H iPr H 6045 H H CD3 iPr H H 6046 H HCH3 CD3 H H 6047 H H CH3 CH3 H H 6048 H H CH3 H 2,6DIP H 6049 H H CH3 H2,6DMB H 6050 H H CH3 H CD3 H 6051 H H CH3 H CH3 H 6052 H H CH3 H H2,6DIP 6053 H H CH3 H H 2,6DMB 6054 H H CH3 H H CD3 6055 H H CH3 H H CH36056 H H CH3 H H H 6057 H H CH3 H H iPr 6058 H H CH3 H iPr H 6059 H HCH3 iPr H H 6060 H H H 2,6DIP CD3 H 6061 H H H 2,6DIP CH3 H 6062 H H H2,6DIP H CD3 6063 H H H 2,6DIP H CH3 6064 H H H 2,6DIP H H 6065 H H H2,6DMB CD3 H 6066 H H H 2,6DMB CH3 H 6067 H H H 2,6DMB H CD3 6068 H H H2,6DMB H CH3 6069 H H H 2,6DMB H H 6070 H H H CD3 2,6DIP H 6071 H H HCD3 2,6DMB H 6072 H H H CD3 CD3 H 6073 H H H CD3 CH3 H 6074 H H H CD3 H2,6DIP 6075 H H H CD3 H 2,6DMB 6076 H H H CD3 H CD3 6077 H H H CD3 H CH36078 H H H CD3 H H 6079 H H H CD3 H iPr 6080 H H H CD3 iPr H 6081 H H HCH3 2,6DIP H 6082 H H H CH3 2,6DMB H 6083 H H H CH3 CD3 H 6084 H H H CH3CH3 H 6085 H H H CH3 H 2,6DIP 6086 H H H CH3 H 2,6DMB 6087 H H H CH3 HCD3 6088 H H H CH3 H CH3 6089 H H H CH3 H H 6090 H H H CH3 H iPr 6091 HH H CH3 iPr H 6092 H H H H 2,6DIP H 6093 H H H H 2,6DMB H 6094 H H H HCD3 CD3 6095 H H H H CD3 CH3 6096 H H H H CD3 H 6097 H H H H CD3 iPr6098 H H H H CH3 CD3 6099 H H H H CH3 CH3 6100 H H H H CH3 H 6101 H H HH CH3 iPr 6102 H H H H H 2,6DIP 6103 H H H H H 2,6DMB 6104 H H H H H CD36105 H H H H H CH3 6106 H H H H H H 6107 H H H H H iPr 6108 H H H H iPrCD3 6109 H H H H iPr CH3 6110 H H H H iPr H 6111 H H H iPr CD3 H 6112 HH H iPr CH3 H 6113 H H H iPr H CD3 6114 H H H iPr H CH3 6115 H H H iPr HH 6116 H H iPr CD3 H H 6117 H H iPr CH3 H H 6118 H H iPr H CD3 H 6119 HH iPr H CH3 H 6120 H H iPr H H CD3 6121 H H iPr H H CH3 6122 H H iPr H HH 6123 H iPr CD3 H H H 6124 H iPr CH3 H H H 6125 H iPr H CD3 H H 6126 HiPr H CH3 H H 6127 H iPr H H CD3 H 6128 H iPr H H CH3 H 6129 H iPr H H HCD3 6130 H iPr H H H CH3 6131 H iPr H H H H 6132 iPr CD3 H H H H 6133iPr CH3 H H H H 6134 iPr H CD3 H H H 6135 iPr H CH3 H H H 6136 iPr H HCD3 H H 6137 iPr H H CH3 H H 6138 iPr H H H CD3 H 6139 iPr H H H CH3 H6140 iPr H H H H CD3 6141 iPr H H H H CH3 6142 iPr H H H H H

LA6143 to LA6363 based on structure:

LA # R11 R12 R13 R32 R33 R34 6143 CD3 C3 H H H H 6144 CD3 CH3 H H H H6145 CD3 H 2,6DIP H H H 6146 CD3 H 2,6DMB H H H 6147 CD3 H CD3 H H H6148 CD3 H CH3 H H H 6149 CD3 H H 2,6DIP H H 6150 CD3 H H 2,6DMB H H6151 CD3 H H CD3 H H 6152 CD3 H H CH3 H H 6153 CD3 H H H 2,6DIP H 6154CD3 H H H 2,6DMB H 6155 CD3 H H H CD3 H 6156 CD3 H H H CH3 H 6157 CD3 HH H H 2,6DIP 6158 CD3 H H H H 2,6DMB 6159 CD3 H H H H CD3 6160 CD3 H H HH CH3 6161 CD3 H H H H H 6162 CD3 H H H H iPr 6163 CD3 H H H iPr H 6164CD3 H H iPr H H 6165 CD3 H iPr H H H 6166 CD3 iPr H H H H 6167 CH3 CD3 HH H H 6168 CH3 CH3 H H H H 6169 CH3 H 2,6DIP H H H 6170 CH3 H 2,6DMB H HH 6171 CH3 H CD3 H H H 6172 CH3 H CH3 H H H 6173 CH3 H H 2,6DIP H H 6174CH3 H H 2,6DMB H H 6175 CH3 H H CD3 H H 6176 CH3 H H CH3 H H 6177 CH3 HH H 2,6DIP H 6178 CH3 H H H 2,6DMB H 6179 CH3 H H H CD3 H 6180 CH3 H H HCH3 H 6181 CH3 H H H H 2,6DIP 6182 CH3 H H H H 2,6DMB 6183 CH3 H H H HCD3 6184 CH3 H H H H CH3 6185 CH3 H H H H H 6186 CH3 H H H H iPr 6187CH3 H H H iPr H 6188 CH3 H H iPr H H 6189 CH3 H iPr H H H 6190 CH3 iPr HH H H 6191 H 2,6DIP H CD3 H H 6192 H 2,6DIP H CH3 H H 6193 H 2,6DIP H HCD3 H 6194 H 2,6DIP H H CH3 H 6195 H 2,6DIP H H H CD3 6196 H 2,6DIP H HH CH3 6197 H 2,6DIP H H H H 6198 H 2,6DMB H CD3 H H 6199 H 2,6DMB H CH3H H 6200 H 2,6DMB H H CD3 H 6201 H 2,6DMB H H CH3 H 6202 H 2,6DMB H H HCD3 6203 H 2,6DMB H H H CH3 6204 H 2,6DMB H H H H 6205 H CD3 CD3 H H H6206 H CD3 CH3 H H H 6207 H CD3 H 2,6DIP H H 6208 H CD3 H 2,6DMB H H6209 H CD3 H CD3 H H 6210 H CD3 H CH3 H H 6211 H CD3 H H 2,6DIP H 6212 HCD3 H H 2,6DMB H 6213 H CD3 H H CD3 H 6214 H CD3 H H CH3 H 6215 H CD3 HH H 2,6DIP 6216 H CD3 H H H 2,6DMB 6217 H CD3 H H H CD3 6218 H CD3 H H HCH3 6219 H CD3 H H H H 6220 H CD3 H H H iPr 6221 H CD3 H H iPr H 6222 HCD3 H iPr H H 6223 H CD3 iPr H H H 6224 H CH3 CD3 H H H 6225 H CH3 CH3 HH H 6226 H CH3 H 2,6DIP H H 6227 H CH3 H 2,6DMB H H 6228 H CH3 H CD3 H H6229 H CH3 H CH3 H H 6230 H CH3 H H 2,6DIP H 6231 H CH3 H H 2,6DMB H6232 H CH3 H H CD3 H 6233 H CH3 H H CH3 H 6234 H CH3 H H H 2,6DIP 6235 HCH3 H H H 2,6DMB 6236 H CH3 H H H CD3 6237 H CH3 H H H CH3 6238 H CH3 HH H H 6239 H CH3 H H H iPr 6240 H CH3 H H iPr H 6241 H CH3 H iPr H H6242 H CH3 iPr H H H 6243 H H 2,6DIP CD3 H H 6244 H H 2,6DIP CH3 H H6245 H H 2,6DIP H CD3 H 6246 H H 2,6DIP H CH3 H 6247 H H 2,6DIP H H CD36248 H H 2,6DIP H H CH3 6249 H H 2,6DIP H H H 6250 H H 2,6DMB CD3 H H6251 H H 2,6DMB CH3 H H 6252 H H 2,6DMB H CD3 H 6253 H H 2,6DMB H CH3 H6254 H H 2,6DMB H H CD3 6255 H H 2,6DMB H H CH3 6256 H H 2,6DMB H H H6257 H H CD3 2,6DIP H H 6258 H H CD3 2,6DMB H H 6259 H H CD3 CD3 H H6260 H H CD3 CH3 H H 6261 H H CD3 H 2,6DIP H 6262 H H CD3 H 2,6DMB H6263 H H CD3 H CD3 H 6264 H H CD3 H CH3 H 6265 H H CD3 H H 2,6DIP 6266 HH CD3 H H 2,6DMB 6267 H H CD3 H H CD3 6268 H H CD3 H H CH3 6269 H H CD3H H H 6270 H H CD3 H H iPr 6271 H H CD3 H iPr H 6272 H H CD3 iPr H H6273 H H CH3 2,6DIP H H 6274 H H CH3 2,6DMB H H 6275 H H CH3 CD3 H H6276 H H CH3 CH3 H H 6277 H H CH3 H 2,6DIP H 6278 H H CH3 H 2,6DMB H6279 H H CH3 H CD3 H 6280 H H CH3 H CH3 H 6281 H H CH3 H H 2,6DIP 6282 HH CH3 H H 2,6DMB 6283 H H CH3 H H CD3 6284 H H CH3 H H CH3 6285 H H CH3H H H 6286 H H CH3 H H iPr 6287 H H CH3 H iPr H 6288 H H CH3 iPr H H6289 H H H 2,6DIP H CD3 6290 H H H 2,6DIP H CH3 6291 H H H 2,6DIP H H6292 H H H 2,6DMB H CD3 6293 H H H 2,6DMB H CH3 6294 H H H 2,6DMB H H6295 H H H CD3 CD3 H 6296 H H H CD3 CH3 H 6297 H H H CD3 H 2,6DIP 6298 HH H CD3 H 2,6DMB 6299 H H H CD3 H CD3 6300 H H H CD3 H CH3 6301 H H HCD3 H H 6302 H H H CD3 H iPr 6303 H H H CD3 iPr H 6304 H H H CH3 CD3 H6305 H H H CH3 CH3 H 6306 H H H CH3 H 2,6DIP 6307 H H H CH3 H 2,6DMB6308 H H H CH3 H CD3 6309 H H H CH3 H CH3 6310 H H H CH3 H H 6311 H H HCH3 H iPr 6312 H H H CH3 iPr H 6313 H H H H 2,6DIP H 6314 H H H H 2,6DMBH 6315 H H H H CD3 CD3 6316 H H H H CD3 CH3 6317 H H H H CD3 H 6318 H HH H CD3 iPr 6319 H H H H CH3 CD3 6320 H H H H CH3 CH3 6321 H H H H CH3 H6322 H H H H CH3 iPr 6323 H H H H H 2,6DIP 6324 H H H H H 2,6DMB 6325 HH H H H CD3 6326 H H H H H CH3 6327 H H H H H H 6328 H H H H H iPr 6329H H H H iPr CD3 6330 H H H H iPr CH3 6331 H H H H iPr H 6332 H H H iPrCD3 H 6333 H H H iPr CH3 H 6334 H H H iPr H CD3 6335 H H H iPr H CH36336 H H H iPr H H 6337 H H iPr CD3 H H 6338 H H iPr CH3 H H 6339 H HiPr H CD3 H 6340 H H iPr H CH3 H 6341 H H iPr H H CD3 6342 H H iPr H HCH3 6343 H H iPr H H H 6344 H iPr CD3 H H H 6345 H iPr CH3 H H H 6346 HiPr H CD3 H H 6347 H iPr H CH3 H H 6348 H iPr H H CD3 H 6349 H iPr H HCH3 H 6350 H iPr H H H CD3 6351 H iPr H H H CH3 6352 H iPr H H H H 6353iPr CD3 H H H H 6354 iPr CH3 H H H H 6355 iPr H CD3 H H H 6356 iPr H CH3H H H 6357 iPr H H CD3 H H 6358 iPr H H CH3 H H 6359 iPr H H H CD3 H6360 iPr H H H CH3 H 6361 iPr H H H H CD3 6362 iPr H H H H CH3 6363 iPrH H H H H

wherein 2,6DIP is 2,6 diisopropyl benzene, 2,6DMB is 2,6 dimethylbenzene, and i-Pr is isopropyl.
 12. The compound of claim 1, wherein thecompound has a formula of M(L_(A))_(n)(L_(B))_(m-n); wherein M is Ir orPt; L_(B) is a bidentate ligand; and wherein when M is Ir, m is 3, and nis 1, 2, or 3; when M is Pt, m is 2, and n is 1, or
 2. 13. The compoundof claim 12, wherein the compound has a formula selected from the groupconsisting of Ir(L_(A))₃, Ir(L_(A))(L_(B))₂, and Ir(L_(A))₂(L_(B)),wherein L_(B) is different from L_(A). 14.-15. (canceled)
 16. Thecompound of claim 12, wherein the compound has a formula ofPt(L_(A))(L_(B)); and wherein L_(A) and L_(B) can be same or different.17.-18. (canceled)
 19. The compound of claim 12, wherein L_(B) isselected from the group consisting of:

wherein each X¹ to X¹³ are independently selected from the groupconsisting of carbon and nitrogen; wherein X is selected from the groupconsisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO₂, CR′R″, SiR′R″, andGeR′R″; wherein R′ and R″ are optionally fused or joined to form a ring;wherein each R_(a), R_(b), R_(c), and R_(d) may represent from monosubstitution to the possible maximum number of substitution, or nosubstitution; wherein R′, R″, R_(a), R_(b), R_(c), and R_(d) are eachindependently selected from the group consisting of hydrogen, deuterium,halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl,heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof; and wherein any two adjacent substituents of R_(a), R_(b),R_(c), and R_(d) are optionally fused or joined to form a ring or form amultidentate ligand. 20.-21. (canceled)
 22. The compound of claim 11,wherein the compound is Compound Ax having the formula Ir(L_(Ai))₃; andwherein x=i; i is an integer from 1 to
 6363. 23. The compound of claim11, wherein the compound is the Compound By having the formulaIr(L_(Ai))(L_(j))₂ or Compound Cz having the formula Ir(L_(Ai))₂(L_(j));wherein y=39i+j−39; i is an integer from 1 to 6363, and j is an integerfrom 1 to 39; wherein z=39i+j−39; i is an integer from 1 to 6363, and jis an integer from 1 to 39; and wherein L₁ to L₃₉ have the followingstructure:


24. An organic light emitting device (OLED) comprising: an anode; acathode; and an organic layer, disposed between the anode and thecathode, comprising a compound comprising a ligand L_(A) selected fromthe group consisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclicring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each representfrom mono-substitution to the possible maximum number of substitution,or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independentlyselected from the group consisting of N and CR; wherein at least one ofZ¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the groupconsisting of O, S, and Se; wherein each R, R¹ R², and R³ areindependently selected from the group consisting of hydrogen, deuterium,halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl,heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof; wherein any adjacent substituents of R, R¹ R², and R³ areoptionally joined or fused into a ring; wherein the ligand L_(A) iscoordinated to a metal M; and wherein the ligand L_(A) is optionallylinked with other ligands to comprise a tridentate, tetradentate,pentadentate or hexadentate ligand.
 25. The OLED of claim 24, whereinthe OLED is incorporated into a device selected from the groupconsisting of a consumer product, an electronic component module, and alighting panel.
 26. The OLED of claim 24, wherein the organic layer isan emissive layer and the compound is an emissive dopant or anon-emissive dopant.
 27. (canceled)
 28. The OLED of claim 24, whereinthe organic layer further comprises a host, wherein host comprises atleast one chemical group selected from the group consisting oftriphenylene, carbazole, dibenzothiophene, dibenzofuran,dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene,aza-dibenzofuran, and aza-dibenzoselenophene.
 29. The OLED of claim 24,wherein the organic layer further comprises a host, wherein the host isselected from the group consisting of:

and combinations thereof.
 30. (canceled)
 31. A formulation comprising acompound comprising a ligand L_(A) selected from the group consisting ofFormula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclicring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each representfrom mono-substitution to the possible maximum number of substitution,or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independentlyselected from the group consisting of N and CR; wherein at least one ofZ¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the groupconsisting of O, S, and Se; wherein each R, R¹ R², and R³ areindependently selected from the group consisting of hydrogen, deuterium,halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy,amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl,heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile,isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinationsthereof; wherein any adjacent substituents of R, R¹ R², and R³ areoptionally joined or fused into a ring; wherein the ligand L_(A) iscoordinated to a metal M; and wherein the ligand L_(A) is optionallylinked with other ligands to comprise a tridentate, tetradentate,pentadentate or hexadentate ligand.